ライフサイエンスコーパス: ion current

1 cale mapping of surface topography and local ion current.

2 a large isotopic fractionation and a low AMS ion current.

3 transduction pathway that is independent of ion current.

4 plication does not affect basal apertures or ion currents.

5 tivity globally via coordinate expression of ion currents.

6 stent left-right asymmetry requires specific ion currents.

7 cted cell line devoid of confounding cardiac ion currents.

8 ulty of measuring spermatozoan transmembrane ion currents.

9 ty ions reduces space charge effects at high ion currents.

10 on-Nernst-Planck theory (PMFPNP), to compute ion currents.

11 the effects of As2O3 on repolarizing cardiac ion currents.

12 nd episodic secretion by regulating membrane ion currents.

13 ed by the interplay of approximately a dozen ion currents.

14 d effectors, of soluble second messengers or ion currents.

15 ere characterized by expression of different ion currents.

16 lar heparin also failed to block PDGF-evoked ion currents.

17 esult in substantially changed properties of ion currents.

18 es into and across nanopores, one often uses ion currents.

19 icating similar magnitudes of five principal ion currents.

20 Our model contains Hodgkin-Huxley-type ion currents, a recently discovered voltage-gated chlori

21 ilayer, which produced stepwise increases of ion current across the bilayer.

22 By measuring ion currents across a 50-mum-diameter black lipid membra

23 ocytic leukemia cells to study transmembrane ion currents activated through the G-protein-coupled thr

24 nd to JRFL and an inhibitor of CXCR4 blocked ion current activation by IIIB.

25 ops in advance of and much more rapidly than ion current activation, suggesting that BK channel openi

26 kin-Huxley-type description of transmembrane ion currents, allows for ion concentrations as well as v

27 lower S/N is attributed to the dispersion of ion current among numerous fragment ion channels (a,b,c,

28 , respond to sub-nA gate currents, and offer ion current amplification with a gain up to ~300.

29 brane electric field is applied, inducing an ion current and allowing conclusions to be drawn on appa

30 The general biophysical principles of the ion current and diffusion-based models presented here to

31 Rectification of ion current and electroosmotic flow increased with incre

32 n a large number of nanotube pores allow the ion current and ion flux to be measured independently.

33 eparation in the FF module using both direct ion current and MS measurements.

34 This leads to a polarity-dependent ion current and surface-induced rectification as the bia

35 es is marked by large transient increases in ion current and was confirmed by polymerase chain reacti

36 rrelate positively with reliable and intense ion currents and accuracy, precision, and sensitivity of

37 e based on differential comparisons in which ion currents and background water levels are precisely e

38 ocyte electrophysiology either by modulating ion currents and electrical coupling or by stimulating f

39 The effect of HF on fibroblast ion currents and its potential role in AF are unknown.

40 Many processes in life are based on ion currents and membrane voltages controlled by a sophi

41 inutes) that are mediated through changes in ion currents and second messengers.

42 n funnel has provided considerably increased ion currents and thus a basis for improved sensitivity a

43 sms into lipid membranes was investigated by ion-current and fluorescence measurements.

44 ting, artifactual enhancement of the mass 45 ion current (and analogous enhancement of the mass 46 io

45 ediated gating differed between small atomic ions (current) and fluorescent dye permeants, indicating

46 ts consisting of mass to charge ratio (m/z), ion current, and x,y coordinate location.

47 fect of the mutations on reversal potential, ion currents, and amantadine resistance were measured.

48 assays, measured flux- and efflux-associated ion currents, and assessed GABA exchange in multiple exp

49 of the electrostatic potential, ion density, ion currents, and equilibrium properties.

50 igate the effects of HF on atrial fibroblast ion currents, and mathematical computation to assess the

51 Sample-related ion currents appeared as peaks with widths of 3-30 s.

52 ographic peaks are recognized only where the ion currents are shown to differentiate the classes.

53 o dynamic modulation of sodium and potassium ion currents around neurons.

54 res can be used to analyse DNA by monitoring ion currents as individual strands are captured and driv

55 3)/(mass 2) ion-current ratio, and i2 is the ion current at mass 2.

56 It blocks various cardiac ion currents at different potencies and has atrial-predo

57 eduction of metastable decay can make larger ion currents available for detection and possible tandem

58 hloride handling, and formulations for major ion currents based on canine ventricular data.

59 ains a challenge for accurate, time-resolved ion-current-based fingerprinting.

60 ethod, and MAM proteome was quantified by an ion-current-based MS1 method combined with nanoLC-MS/MS.

61 ion-current match; and (iv) well-controlled ion-current-based quantification.

62 gly, we find a transition in the fraction of ion current blocked by DNA, from a length-independent re

63 lamp showed dose-dependent block of the AQP1 ion current by 5HMF (IC(50) 0.43 mM), 5NFA (IC(50) 1.2 m

64 nt (and analogous enhancement of the mass 46 ion current by transfer of hydrogen to mass 45 species)

65 We conclude that the shutdown of membrane ion currents by elevated pi(o) is not selective, but the

66 ds, and integrated peak areas based on total ion current can be used for statistical analyses and pat

67 choline, however, attenuated choline-induced ion current changes, suggesting that phosphocholine may

68 h I(CRAC) (calcium release activated calcium ion current) characteristics, and several later, larger

69 en, this is initially performed on the total ion current chromatogram (TIC), which is the summed sign

70 hodology is based upon forming reconstructed ion current chromatograms (RICCs) of m/z values of produ

71 The UV and total ion current chromatograms demonstrated that the phosphop

72 The parts of the total ion current chromatograms in the LC-MS acquired data cor

73 olate fatty acid methyl esters on TIC (total ion current) chromatograms, using the 74 Da fragment ion

74 m-i.d. fused-silica tubing was shown to give ion current comparable to that from a commercial 8 micro

75 modulated SICM, which induces an alternating ion current component (AC) by periodically modulating th

76 th were black in color, both produced robust ion current consistently, their FT-IR spectra had the sp

77 -QT syndrome in which alterations in several ion currents contribute to arrhythmogenic drug activity.

78 mine (GPE), and the fraction of GPE negative ion current contributed by plasmenylethanolamine species

79 e ion current of each level, we measured the ion current corresponding to all 256 four-nucleotide com

80 Ion currents could be detected for all 12 pairs of MS/MS

81 surface in electrolyte solution, the direct ion current (DC), driven by an applied bias between a qu

82 Additionally, the ion current displays high sensitivity to redox species,

83 To predict this ion current-distance behavior, we provide a new numerica

84 ting the numerical model to the experimental ion current-distance data and verify this method using p

85 cribed quadrupole system provided acceptable ion current electropherograms from fmole levels from ana

86 PI III quadrupole system provided acceptable ion current electropherograms from subpicomole levels of

87 ignment methods are often based on the total-ion-current elution profile of the spectrum and are unab

88 e cell, maximizing the use of the continuous ion current emanating from the electrospray ionization s

89 ce microscopy (SICM) was used to interrogate ion currents emanating from nanometer-scale pores of a p

90 cillate the probe to generate an oscillating ion current feedback signal, as needed for conventional

91 dback signal to be generated without any net ion current flow, ensuring that any polarization of the

92 by the corresponding stepped changes in the ion current flowing through the pore under an applied tr

93 Moreover, the ion currents flowing through the blocked pore with eithe

94 and measuring in a potential region where no ion current flows, we find characteristic peaks in the d

95 The respective ion-current fluctuations caused by the presence of the a

96 accurate description of the behavior of the ion current for a varying tip-sample distance.

97 duced the strong, reliable, and reproducible ion currents for high-throughput AMS analysis (270 targe

98 oped and monitors in real-time the extracted ion current from each sprayer channel.

99 vored over benzofuran hydroxylation based on ion current from LC/MS.

100 ntribute the majority of the ESI/MS negative ion current from rat and human islet glycerophosphoethan

101 To better estimate these localized ion currents, Goldman-Hodgkin-Katz (GHK) theory was used

102 An ion current has been measured from primary cilia of kidn

103 Although the role of stretch-activated ion currents has been investigated using computational m

104 eakly on the precision with which background ion currents have been measured.

105 ) values, peak width (fwhm), and transmitted ion current I(output).

106 y associates with the slow outward potassium ion current (I(Ks)) and recruits both PKA and PP1 to reg

107 ortical neurons based on just four simulated ion currents: I(Na), I(K), I(T), and I(AHP).

108 , which increases the slow outward potassium ion current (IKS).

109 f individual pores was measured by examining ion current images and corresponding topographic images

110 annel with high affinity, potently inhibited ion current in a patch-clamp experiment, and caused a do

111 that an applied shear stress induces a K(+) ion current in cells expressing the endothelial Kir2.1 c

112 in cytosolic free calcium and evoked inward ion current in HEK293 cells expressing the transient rec

113 eam current with the amplitude of the pulsed ion current in IFT-IMS experiments using a Faraday plate

114 tins; ii) globally- or segmentally-decreased ion current in isolated LC-MS analyses; and iii) oxidize

115 samples up to 100% of the peptide precursor ion current in m/z and mobility windows.

116 onic conductance reaching muS that rectifies ion current in salt concentrations as high as 1 M.

117 ion by acting on the same androgen-sensitive ion current in the electrocytes.

118 ns acting in opposite directions on the same ion current in the electrocytes.

119 r extraction accounted for >95% of the total ion current in the ESI mass spectra.

120 Further, greater than 90% of the product ion current in the IRMPD mass spectra of doubly charged

121 g techniques, we have examined voltage-gated ion currents in a cultured human intestinal smooth muscl

122 ll patch-clamp technique was used to measure ion currents in cardiomyocytes isolated from the left ve

123 Con-T and con-R[1-17] attenuated ion currents in cells expressing NR1a/NR2A or NR1a/NR2B.

124 seconds by one m/z unit each, and the total ion currents in corresponding segments as specified by t

125 e molecular components underlying individual ion currents in heart have been cloned.

126 generalized depression of voltage-dependent ion currents in isolated neurons, caused by sudden, brie

127 Detailed electrophysiological comparison of ion currents in roots of both species showed that, unlik

128 EOD pulse duration is determined by ion currents in the electrocytes, and androgens influenc

129 ent capacitive device models neglect lateral ion currents in the transistor channel and therefore fai

130 uld be traced to the different expression of ion currents in the two.

131 e clamp were used to measure cell volume and ion currents in ventricular myocytes isolated from norma

132 rough the membrane) to an "on" state (higher ion current) in response to the presence of a chemical s

133 he cardiac sodium channel [persistent sodium ion current (INa)].

134 + interacts with the plasma membrane via the ion current (INaCa) produced by the Na+/Ca2+ exchanger a

135 nd thus the QT interval by altering multiple ion currents, including the persistent sodium current IN

136 dronedarone is a potent blocker of multiple ion currents, including the rapidly activating delayed-r

137 Both types of reagents prevent ion currents indicating that pore blockage is primarily

138 h the amplitude and phase of the oscillating ion current, induced by the oscillating bias and extract

139 It has been shown to reduce NMDA-active ion currents, inhibit NMDA-evoked electrophysiological r

140 nitiated by electromagnetic transmission, an ion current inside the capillary, which is responsible f

141 antitation using summed dissociation-product ion-current intensities is accurate, albeit variable fro

142 , the error will be 0.26/1000 if the mass 18 ion current is 100 times smaller than that at mass 44).

143 larization, a phenomenon that occurs when an ion current is passed through ion-selective membranes.

144 individual ion-channel genes results in such ion currents is discussed.

145 time course of development of voltage-gated ion currents is well reproduced in activin-induced muscl

146 he interaction of two subthreshold-activated ion currents, is a hallmark of SPON neurons.

147 dies showed that E2 affected the electrocyte ion currents kinetics: the sodium inactivation time cons

148 model is presented, which shows that lateral ion currents lead to an accumulation of ions at the drai

149 ith increased TASK-1 transcript, protein and ion current levels leading to shortened action potential

150 d DNA control to interpret the procession of ion current levels observed during the translocation of

151 This quadromer map is highly predictive of ion current levels of previously unmeasured sequences de

152 cients of K+ and Cl- to scale the individual ion current magnitudes.

153 d small magnesium-nucleotide-regulated metal ion currents (MagNuM) with regulation and permeation pro

154 both in-depth profiling and accurate peptide ion-current match; and (iv) well-controlled ion-current-

155 These actions of adenosine on ion currents may contribute to the effect of this nucleo

156 that the proposed pore structure can sustain ion currents measured in single-channel experiments.

157 The N(2)(+) ion currents, measured by the mass spectrometer, i(N(2)(

158 control of emitter heating current based on ion current measurement.

159 Ion current measurements and ion mobility (IM) spectrome

160 h-m/z cutoffs) are presented based upon both ion current measurements and mass spectra.

161 Ion current measurements indicate a capacity of approxim

162 These results were consistent with ion current measurements obtained using the whole-cell a

163 The ion current measurements on the mass spectrometer reflec

164 elevator and escalator components based upon ion current measurements providing essentially lossless

165 tial bolus model, suggesting that either the ion current model or a diffusion-based model is more lik

166 models-an initial bolus formation model, an ion current model, and a diffusion-based model-show part

167 The initial bolus and ion current models give mathematically equivalent predic

168 We use ion current modulation through the protein nanopore MspA

169 le LC-MS runs are evaluated to generate mean ion currents (mu) and standard deviations (sigma).

170 on the associated pore translocation times, ion-current noise, and blockage currents.

171 Interestingly, the total ion current observed with SAII and this electrosprayed i

172 was accurately quantified by integrating the ion current of a selected ion using extracted-ion chroma

173 As approximately four nucleotides affect the ion current of each level, we measured the ion current c

174 phase transition occurred in which the total ion current of the oligomers goes to nearly zero.

175 < or = 0.1/1000 for samples yielding mass 44 ion currents of 10 nA.

176 stoichiometry are measured by monitoring the ion currents of a phosphopeptide and its unmodified cogn

177 f piperidine, a significant reduction in the ion currents of all charge states was observed during th

178 I(KSper) is one of two dominant ion currents of capacitated sperm cells.

179 by monitoring the changes in the normalized ion currents of the phosphopeptide(s) of interest.

180 on monitoring mode by integrating the summed ion currents of the singly, doubly, and triply charged m

181 In the present study, the ion currents of the symbiosome membrane of the model leg

182 tection of oxygen and product CO(2) from the ion currents of their respective mass peaks.

183 nt) and relative abundance (normalized total ion current) of the polypeptides detected by mass spectr

184 demonstration of cyclic-nucleotide-dependent ion currents) of a plant cng channel has not yet been ac

185 This mass spectrometer allows for large ion currents, on the order of nanoamperes, to be produce

186 The time-domain ion current, once Fourier transformed, reveals a standar

187 e applicable to voltage- and light-sensitive ion currents operating in excitable cells, e.g. cardiomy

188 pharmacologic actions, produced no change in ion currents or action potentials in adult mouse cardiom

189 rded from a big number of receptors, such as ion currents or fluorescence changes of suitably labeled

190 nopore exhibiting memory in the frequency of ion current oscillations induced by the dynamic formatio

191 ical effects of existing drugs on individual ion currents, our aim is to compute optimal combinations

192 demonstrated its ability to produce a stable ion current over a 45-min time period at 7 T resulting i

193 Localized ion currents over individual nanopores were generated by

194 munoassay), cell membrane potential, various ion currents (patch-clamp), mitochondrial membrane poten

195 e relative standard deviations for the total ion current peak areas of 500 fmol of angiotensin I were

196 Multicellular action potentials, membrane ion-currents (perforated patch-clamp), or simultaneous m

197 d on the magnitude of the LC/MS/MS extracted ion current predicted FAP substrates that were cleaved w

198 We sought to determine which ion current predominantly affects defibrillation outcome

199 mplexes pulls the two molecules apart, while ion current probes the dissociation rate of the complex.

200 To accommodate the larger ion current produced by the emitter array, a multicapill

201 Experimental ion current profiles over a single pore fit well with th

202 show that the combination of topography and ion current provides insight into the local electrochemi

203 for qualitative analysis and proteome total ion current (pTIC) calculation for quantitative analysis

204 basis of the cleavage sites with the highest ion current rankings, and kinetic parameters for FAP hyd

205 Calibration of the O(2)/Ar ion current ratio (32/40) is performed automatically eve

206 MyHC was digested by trypsin and the ion current ratio determined for the two tryptic peptide

207 The ion current ratio was converted to the peptide ratio and

208 ystematic error is proportional to the 18/44 ion current ratio.

209 can predict the effect of signal intensity, ion-current ratio magnitude, and internal standard or tr

210 d to labeled analogues is determined from an ion-current ratio measured by a mass spectrometer.

211 The precision of the ion-current ratio measurement defines the detection limi

212 of noise to develop a method that evaluates ion-current ratio noise (i) that varies with the signal

213 produces a simple equation that defines the ion-current ratio precision using constants that can be

214 2 ratio, R is the observed (mass 3)/(mass 2) ion-current ratio, and i2 is the ion current at mass 2.

215 alibration curve was constructed by plotting ion current ratios against molar ratios of the two pepti

216 egression for the calculation of the peptide ion current ratios from the mass spectrometry-derived io

217 s in analyses of 13C based on measurement of ion current ratios in the mass spectrum of CO2.

218 The measured ion current ratios of synthetic alpha-MyHC (726-741), be

219 The measured ion current ratios were converted to the actual quantiti

220 determined from only two readily observable ion-current ratios (45/44 and 46/44).

221 ated empirically from the measurement of two ion-current ratios from a single standard measured multi

222 Ion-current recordings revealed saw-tooth patterns, indi

223 Of late, ion current rectification (ICR) biosensing measurements

224 ection was achieved by monitoring changes in ion current rectification (ICR) following probe-target h

225 within a cylindrical nanochannel, utilizing ion current rectification (ICR) induced by the nonunifor

226 were examined and demonstrated variations in ion current rectification (ICR) ratios due to the small

227 To elucidate the underlying mechanism of ion current rectification (ICR), a continuum model based

228 nd bulk salt concentration on the associated ion current rectification behavior are examined.

229 The ion current rectification behavior of bioinspired nanopo

230 y of the nanofluidic funnel induces not only ion current rectification but also electroosmotic flow r

231 We tracked ion current rectification by current-voltage (I-V) respo

232 The ion current rectification decreased when redox species w

233 rt surface charge through the measurement of ion current rectification of a nanopipette brought in cl

234 sults obtained show that, in addition to the ion current rectification phenomenon, a reversed ion sel

235 of trace amounts of Pd(2+) and Co(2+) using ion current rectification, in cyclam-functionalized quar

236 including ion concentration polarization and ion current rectification.

237 Here, we report boron hydride (BH) with ion currents rectification activity that can enhance the

238 e binding can be detected as a change of the ion-current rectification of single nanopores defined as

239 ion polarization, electroosmotic flow (EOF), ion current, rectification, and ion selectivity.

240 is rectified EOF phenomenon is the result of ion current-rectification observed in such asymmetric-po

241 In this report, ion current rectifying quartz nanopipettes with ca. 109

242 We conclude that HF induces fibroblast ion-current remodeling with IKv,fb downregulation and IK

243 andard of methylphenidate was used to obtain ion current response ratios between the parent drug and

244 Chromatographic integrity and ion current response remained relatively constant for th

245 Peptides that produce the highest ion-current response (high-responding peptides) are like

246 st to choline, phosphocholine does not evoke ion current responses in Xenopus laevis oocytes, which h

247 ates the nanopore, it transiently blocks the ion current, resulting in a downward current pulse.

248 This ion current shares the properties of the shear-induced c

249 signal down to low S/N analyte signal (total ion current signal intensity at analyte peak maximum S/N

250 ut surface treatment of the polymer-abundant ion current signals and baseline separation of these com

251 ing controlled ion conductance, with a large ion current signature that can be used to accurately qua

252 fied PLM to lipid bilayers generates similar ion currents, suggesting that the PLM molecule itself mi

253 only approximately 17% (1.3 pA) of the total ion current that correlate to CV = 11.8 V, entered the c

254 quently, they often failed to produce robust ion currents that are required for reliable, accurate, p

255 lex beat-to-beat changes in Ca(2+)-regulated ion currents that determine alternans of AP morphology.

256 In this review, the ion currents that underlie the action potential are firs

257 lso report an interesting effect whereby the ion current though a nanopipette can increase under cert

258 -Hodgkin-Katz (GHK) theory was used to model ion current through a permeable membrane under gradients

259 A composite continuum theory for calculating ion current through a protein channel of known structure

260 High-bandwidth measurements of the ion current through hafnium oxide and silicon nitride na

261 alcium ion channels, which decreases calcium ion current through the affected channels and disrupts c

262 n be switched from an "off" state (no or low ion current through the membrane) to an "on" state (high

263 We show that the modulation of the ion current through the nanopore upon the DNA origami tr

264 the pore in single-nucleotide steps, and the ion current through the pore is recorded.

265 potentiated LPA-induced oscillatory chloride ion currents through a pertussis toxin-insensitive pathw

266 steroid and peptide hormones that influence ion currents through changes in gene expression or phosp

267 Among P2X receptors, ion currents through homomeric P2X4 receptors exhibit in

268 Ion currents through potassium channels are gated.

269 uced from the effects of polymer addition on ion currents through single OmpF channels reconstituted

270 Recent measurements of ion currents through single or few carbon nanotube chann

271 he forces on the DNA molecules, and also the ion currents through the nanopore, change as the molecul

272 ntrations in cells lacking lipin-2 decreases ion currents through the P2X7 receptor, and downstream e

273 In the initial conception, manipulations of ion currents through the tip of the pipette and appropri

274 (SNRs) of 4 major peaks of the HPLC-MS total ion current (TIC) chromatograms of celery seed extracts.

275 lex samples when compared to using the total ion current (TIC), extracted ion chromatograms/profiles

276 orkflow based on the monitoring of the total ion current to restrain the pixel-to-pixel m/z shift.

277 racellular Ca cycling, coupled with membrane ion currents, to investigate the dynamics of V(m) and Ca

278 ACC activates Ca(2+)-containing ion currents via GLUTAMATE RECEPTOR-LIKE (GLR) channels

279 occupancy, developed on the basis of single ion current-voltage relationships, are in agreement with

280 the relative standard deviation of the total ion current was <5% and the magnitude of the mass error

281 d by IMER were infused until a maximum total ion current was achieved, followed by washing with a buf

282 Total ion current was also examined at pressures from ambient

283 5-HT3 receptor-mediated ion current was recorded from NCB-20 neuroblastoma cells

284 The effect of laser power on total ion current was shown to differ for samples with and wit

285 The most efficient inhibition of ion currents was detected for muscle nAChR by R16 (IC(50

286 ila being a valuable tool for characterizing ion currents, we estimated the SIZ location and quantifi

287 Measurements of the total ion current were also performed in static mode with an o

288 mobility on resolving power, resolution, and ion current were investigated using a small, stand-alone

289 The transmitted ion currents were a factor of 30-56 greater than those o

290 A wide range of ion currents were downregulated, including total, fast a

291 or observation and subtraction of background ion currents were examined experimentally and theoretica

292 Higher total electrospray ion currents were observed as the number of electrospray

293 Action potentials, calcium handling, and ion currents were recorded in ventricular myocytes.

294 Electrocardiograms, action potentials and ion-currents were analyzed.

295 ce and synapses, where they conduct chloride ion current when activated by GABA.

296 Total ion current, when investigated with pressure, was found

297 ICM produced low and variable ion current whereas the opposite was true for the graphi

298 ed the expression of bTREK-1 transcripts and ion current with a temporal pattern, potency, and effect

299 or the experimentally observed saturation of ion current with increase of the electrolyte concentrati

300 These ion sources may comprise high ion currents with compositions that change quickly and r