ライフサイエンスコーパス: ionic current

1 itions of the probe and channel activity via ionic current.

2 nd is responsible for a mechanically induced ionic current.

3 on with 400-520 nm light to generate a large ionic current.

4 te, reduce the proton current along with the ionic current.

5 ndocytosis and consequent attenuation of its ionic current.

6 cale pore leading to detectable blockades of ionic current.

7 luoresces a calcium ion wave at a controlled ionic current.

8 l molecules by measuring the electrochemical ionic current.

9 feedback mode as well as measuring localized ionic currents.

10 is and hypertrophy and by modulating cardiac ionic currents.

11 to identify the genes that encode different ionic currents.

12 that are defined by different complements of ionic currents.

13 e experimentally-observed variability in the ionic currents.

14 nation among the four tags based on nanopore ionic currents.

15 mechanism of AMPK action is modification of ionic currents.

16 th serotonin transport and serotonin-induced ionic currents.

17 fraction of the tubes pass anomalously high ionic currents.

18 cemaking dynamics with a small complement of ionic currents.

19 tterns via coordinate regulation of a set of ionic currents.

20 KChIP2 is a multimodal regulator of cardiac ionic currents.

21 inks variations in temperature to changes in ionic currents.

22 duced large changes in the levels of several ionic currents.

23 accurate characterization of the underlying ionic currents.

24 fit experimental iPSC-CM data for all major ionic currents.

25 r (sub muW) and high-bandwidth (0.1-0.5 kHz) ionic currents.

26 nge of metabolites, signaling molecules, and ionic currents.

27 on via LOX-1-mediated alteration sarcolemmal ionic currents.

28 Rectification of ionic current, a frequently observed phenomenon with asy

29 Blocking inhibitory ionic currents abolishes small object sensitivity and fa

30 By monitoring the ionic current across a single protein nanopore, differen

31 The ionic current across each micropore channel was continuo

32 hesis that transient pores open by measuring ionic currents across phospholipid bilayers and cell mem

33 an electrostatic potential gradient, induce ionic currents across planar phospholipid bilayers, as w

34 ltaneously detect conformational changes and ionic currents across the membrane.

35 gated potassium channel that shows very slow ionic current activation kinetics, and an unusual underl

36 tials (A735V) or at later times (G752R) than ionic current activation, indicating that the DII-VSD al

37 poles, I study how certain voltage-dependent ionic currents affect firing thresholds and contribute t

38 rease in the voltage-dependent transmembrane ionic currents after pulse treatment.

39 spiratory synaptic inputs, and expression of ionic currents, albeit all neurons presented persistent

40 nic conductance amplitudes between different ionic currents also exists in vertebrates, and we argue

41 analysis was used to predict how changes in ionic currents alter action potential duration, and thes

42 Analysis of the ionic current amplitude and noise, as the protein unfold

43 te on the millisecond time scale between two ionic current amplitude states when captured atop the al

44 d from KF-DNA-dNTP complexes on the basis of ionic current amplitude.

45 by Piezo1 dependence of shear-stress-evoked ionic current and calcium influx in endothelial cells an

46 and electrolyte concentration calculates the ionic current and corresponding rectification factor at

47 solution reservoir is capable of rectifying ionic current and enrichment of ionic species.

48 e, which filters the microtubules but allows ionic current and flow to pass through it.

49 al role of endolymph in the delivery of both ionic current and fluid pressure, coupled with the cupul

50 e ability to simultaneously monitor both the ionic current and fluorescence from membrane channels an

51 ias are examined for their influences on the ionic current and rectification factor, and the mechanis

52 ral pore induced inward rectification of the ionic current and shifted reversal potential by approxim

53 the overall regulatory effect of miRs on the ionic currents and action potentials.

54 cause inhibition or augmentation of various ionic currents and alter functioning of neurons and myoc

55 s of celecoxib, rofecoxib, and diclofenac on ionic currents and calcium signaling in vascular smooth

56 ace topography and is suitable for measuring ionic currents and conductance of biological ion channel

57 and consequent modification of the relevant ionic currents and discharge patterns, of STN neurons.

58 ted for residues 105-125 exhibit spontaneous ionic currents and hypersensitivity to certain classes o

59 pronounced implications for the dynamics of ionic currents and the signaling pathways that they regu

60 channel alpha-subunit expression with native ionic currents and their pharmacological sensitivity in

61 ation methods to display the dynamics of the ionic currents and to display the models' response to pe

62 t underlie the modulation of the macroscopic ionic currents and V(z) by different AChR activation are

63 atterns of activity combining a large set of ionic currents and variable conductance levels.

64 pairs ECC by changing the density of several ionic currents (and thus AP repolarization) causing alte

65 re missing], ribbon synapse numbers, outward ionic currents, and efferent innervation.

66 rication, ease of scaling up to support high ionic currents, and flexibility.

67 ed the relationship between gene expression, ionic currents, and neuronal firing capacity.

68 amp to measure action potential duration and ionic currents, and quantitative polymerase chain reacti

69 In nanopore sensing, changes in ionic current are used to analyse single molecules in so

70 duced nociception, neuropeptide release, and ionic currents are suppressed by cold, it is not known i

71 Mathematical models of ionic currents are used to study the electrophysiology o

72 The nucleic acid molecule transiently blocks ionic current as it is translocated through the pore, an

73 re determined by the detection of changes in ionic current as the proteins interact with the nanopipe

74 These novel probes measure ionic currents as small as picoampere while providing na

75 onal framework to investigate how individual ionic currents, as well as cellular and tissue level fac

76 he N-terminal domain abolish the spontaneous ionic currents associated with neurotoxic mutants of PrP

77 in recording very small ( approximately pA) ionic currents at a bandwidth consistent with fast trans

78 gested roles in cell adhesion, regulation of ionic currents at the cell membrane and neuroprotection.

79 These data show that a set of ionic currents at the preBotC imparts the network with r

80 e the advantage of providing relatively high ionic currents at very small pore sizes.

81 Measurements of surface-charge governed ionic currents between BN nanosheets in a variety of sal

82 Ionic current blockade signal processing, for use in nan

83 This produces a unique ionic current blockade signature due to the tag's distin

84 g is based upon what has come to be known as ionic-current blockade sensing, there is a vast, growing

85 es and biophysical model systems because the ionic current blockades they produce contain information

86 display characteristic macromolecule-induced ionic current blockades.

87 By microperfusing ionic current blockers into the preBotC of adult rats, w

88 eport that RhoA elicits suppression of Kv1.2 ionic current by modulating channel endocytosis.

89 cal pacemaking can be achieved by modulating ionic currents by gene transfer or by delivering enginee

90 ructures elicited well-defined transmembrane ionic currents by inducing pore formation in the underly

91 es by ginsenosides CK and Rd caused enhanced ionic currents, Ca(2+) influx and YOPRO-1 uptake in stab

92 This feedback mechanism explains how net ionic current can be constrained to <1-2 pA but reliably

93 Moreover, the ionic currents can also be used to image structures.

94 A number of voltage-gated ionic currents can contribute to the generation or ampli

95 ABSTRACT: Imbalances of ionic currents can destabilize the cardiac action potent

96 Imbalances of ionic currents can destabilize the cardiac action potent

97 o predicts that circadian control of certain ionic currents can induce hyperexcited states.

98 plets allow the measurement of transmembrane ionic currents carried by individual channels and pores.

99 signal in such experiments is the change in ionic current caused by the nanoparticle translocation t

100 yte action potential suggests that the major ionic current change causing action potential duration p

101 g specific parameter values corresponding to ionic current conductances and kinetics.

102 Here, we explore how individual ionic currents contribute to these hyperexcited states,

103 es with the capability to generate a tunable ionic current could pave the way towards precise ion-sys

104 critical for understanding how flow-induced ionic currents, deformations of transmembrane proteins,

105 that uses SUMOylation to continuously adjust ionic current densities according to changes in activity

106 vity can regulate SUMOylation to reconfigure ionic current densities over minutes, and this regulatio

107 without electrode damage, and the impact of ionic current density gradients on velocity profiles ove

108 The ionic current density, j, was generated in 0.095 M K3Fe(

109 The ionic currents described here are distinct from those pr

110 Here we report ionic current detection of all twenty proteinogenic amin

111 median durations of approximately 28 ms and ionic current differences of up to 40 pA.

112 their target proteins caused a change in the ionic current due to a partial blockade or an altered su

113 The ionic currents during a mouse ventricular AP showed a fa

114 These include genetic suppression of an ionic current, embryonic as well as adult stem cell ther

115 coeruleus produced a rapid inhibition of the ionic currents evoked by multiple agonists of the mu-opi

116 cking to the cell surface, leading to little ionic current expression (loss-of-function).

117 otein pore can be monitored by observing the ionic current flow through the pore, which acts as a nan

118 onitored by observing the time-dependence of ionic current flow through the pore, which responds to b

119 probe microscopy technique that utilizes the ionic current flowing between an electrode inserted insi

120 During spontaneous firing, net ionic current flowing between spikes was calculated from

121 ctions on the nanopipette tip surface affect ionic current flowing through a 50-nm pore.

122 olecules is observed as the modulation of an ionic current flowing through a single engineered protei

123 h, individual analyte molecules modulate the ionic current flowing through a single nanopore.

124 tial difference, and measuring the resulting ionic current flowing through the nanopore.

125 through a nanopore will uniquely modulate an ionic current flowing through the pore, allowing the rec

126 equency-dependent gating and ii) generate an ionic current for termination of the detected arrhythmia

127 We find that the distribution of ionic currents for each of the 20 proteinogenic amino ac

128 ear-infrared pulses to modulate light-evoked ionic current from Channelrhodopsin-2 (ChR2) in brain ti

129 s silicon chips tailored to monitor cellular ionic currents from cultured cells stably expressing a p

130 Here, by recording ionic currents from spermatozoa of an infertile CatSper-

131 Coexpression of ionic currents has been observed in an increasing number

132 the transport of NH3 and the lack of coupled ionic currents has been provided for many Rh proteins.

133 Several ionic currents have been identified that regulate SCN fi

134 athematical modeling to determine whether an ionic current having the biophysical characteristics of

135 41R mutations differentially impact multiple ionic currents, highlighting the complexity of Cav3 regu

136 rotein kinase A (PKA) pathway enhances Kv1.2 ionic current; however, the mechanisms for this are not

137 ximately 140 muA/cm(2)), and the peak inward ionic current (I(ion)) during depolarization was approxi

138 CN4, and downregulation of the corresponding ionic current, I(f), in the sinus node.

139 tide gated channel 4), and the corresponding ionic current, If, underlies exercise training-induced s

140 downregulation of HCN4 and the corresponding ionic current, If.

141 Additionally, the same ionic current (IMI) can play different roles under these

142 in NaV1.5, N1764A and N1764C, produce little ionic current in transfected mammalian cells, they both

143 The species recognized by SPR generate ionic currents in artificial lipid bilayers and inhibit

144 ular free Ca(2)(+) concentration signals and ionic currents in freshly isolated DRG neurons.

145 on the characterization of voltage-activated ionic currents in GnRH-containing TN cells in zebrafish.

146 revious reports suggest that elevated inward ionic currents in HF promote action potential (AP) prolo

147 ysis allows the measurement of transmembrane ionic currents in intact hearts.

148 Ionic currents in liquid crystals that have been traditi

149 n an orchestrated interplay of transmembrane ionic currents in myocardial cells.

150 We find that DeltaCR PrP induces abnormal ionic currents in neurons in culture and in cerebellar s

151 ficantly reduced NMDAR-mediated synaptic and ionic currents in PFC pyramidal neurons, which was media

152 a loose patch clamp technique which examined ionic currents in response to superimposed 10-ms V(1) st

153 brain synaptosomes and transporter-mediated ionic currents in SERT-expressing Xenopus oocytes.

154 s, a two-compartment model with five crucial ionic currents in the apical dendrites reproduces all fe

155 ique allowed the dissection of transmembrane ionic currents in the intact heart.

156 n the magnetic field and naturally occurring ionic currents in the labyrinthine endolymph fluid.

157 the morphology and functional expression of ionic currents in trans-differentiated hair cells resemb

158 Here, we used specific computer-simulated ionic currents in vitro to selectively replicate or supp

159 Moreover, SecA-liposomes elicit ionic currents in Xenopus oocytes.

160 molecule under the same conditions causes an ionic current increase.

161 correlation of the kinetics of S4 motion and ionic current indicated that slowing of sensor movement

162 Comparison of gating and ionic currents indicates only 2% of the surface channels

163 The frequency and character of ionic current instabilities are regulated by the potenti

164 Cell viability, ionic currents, intracellular calcium, and pericyte cont

165 Among the panoply of sarcolemmal ionic currents investigated (I(Na)(+)/I(CaL)(+)/I(Kr)(+)

166 that accompanying KCNQ1 channel opening, the ionic current is suppressed by a rapid process called in

167 beta-adrenergic signaling and modulation of ionic currents is blunted in heart failure.

168 Homeostatic regulation of ionic currents is of paramount importance during periods

169 erred frequency results from the dynamics of ionic currents, it can be assumed to depend on parameter

170 tal and theoretical approach, we explain how ionic currents lead to the unusual electrophysiological

171 roduce mutation-specific changes in multiple ionic currents leading to different primary causes of AP

172 Collectively, this plasticity of ionic currents leads to increased action potential firin

173 etic algorithm, which allowed us to estimate ionic current levels in each of the cells studied.

174 A, we observe well-resolved and reproducible ionic current levels with median durations of approximat

175 he nominal model showed that coregulation of ionic currents may preserve the key characteristics of m

176 ric mutant G85R SOD1YFP had no effect on net ionic currents measured under voltage clamp.

177 nductances, reversal potentials, kinetics of ionic currents, measurement and intrinsic noise, based o

178 current nanopore sequencing methods rely on ionic current measurements from individually addressed p

179 Ionic current measurements through electrolyte-filled na

180 NavBeta1 subunits has been explored through ionic current measurements, but the molecular mechanism

181 have been demonstrated with nanopores using ionic current measurements, direct sequencing has not be

182 Actin filaments are conductive to ionic currents, mechanical and voltage solitons.

183 Two critical ionic current mechanisms are the inwardly rectifying pot

184 By optimizing ionic current model parameters to multiple experimental

185 Here, we present an ionic current model that reproduces the basic electrophy

186 n potential propagation begins with detailed ionic current models for a patch of membrane within a di

187 of single DNA molecules through detection of ionic current modulations as DNA passes through a pore's

188 The ionic currents necessary for spike production have been

189 hosphorylation-mediated suppression of Kv1.2 ionic current occurs by endocytosis of the channel prote

190 Moreover, the fast OPN4-activated ionic current of Drosophila photoreceptors relative to t

191 gh a synthetic nanochannel and measuring the ionic current of each amino acid through an intersecting

192 ocyte voltage-clamp recordings of gating and ionic currents of the Shaker Kv channel expressed in Xen

193 Size and ionic currents of unexcitable cells electrically coupled

194 The analysis identified a variety of FRD ionic current perturbations and generated specific predi

195 We propose that a set of ionic currents plays a key role in generating respirator

196 of VSDs II and III were compatible with the ionic current properties, suggesting that these voltage

197 ess EADs due to the complex effects of Ca on ionic current properties; 2) spontaneous Ca waves also e

198 ailed characterization of folded proteins by ionic current recordings.

199 The behavior of ionic current rectification (ICR) in a conical nanopore

200 Ionic current rectification behaviors are observed using

201 not only for gaining physical insights into ionic current rectification but also for providing pract

202 The method takes advantage of ionic current rectification effect discovered in nanoflu

203 tration polarization dynamics in addition to ionic current rectification inside conical nanopores and

204 We study ionic current rectification observed in a nanofluidic de

205 and nanochannels have been reported to yield ionic current rectification, with the aim to control the

206 ced nanofluidic device designs for tailoring ionic current rectification.

207 ng/ml to 3 mug/ml) using the modification of ionic current rectification.

208 Ionic-current rectification was observed under these con

209 to the pore, and further modulations of the ionic current reflect enzyme function at the single-mole

210 The ionic currents regulated by shear stress remain poorly u

211 In experiments and simulations, the ionic current relative to that in the absence of DNA can

212 The unique combination of PZ ionic current remodeling and different degrees of Mfb in

213 Ionic current remodeling in PZ was also included.

214 ensity; the latter arises predominantly from ionic current remodeling in PZ.

215 overcoming the arrhythmogenic effects of PZ ionic current remodeling.

216 e NRVMs to a dynamic clamp model of HEK cell ionic current reproduced the cardiac maximal diastolic p

217 nsed as a transient decrease in the measured ionic current (resistive-pulse analysis).

218 rs do not bind glutamate and do not generate ionic current, resulting in difficulty in studying the f

219 The dynamics of different ionic currents shape the bursting activity of neurons an

220 tween Na(v)1.5 and Kir2.1 and the respective ionic currents should be important in the ability of the

221 e number of modifications, the corresponding ionic current signal levels, as well as mixing proportio

222 We measure the ionic current signal of translocating DNA carriers as a

223 ogies MinION using this nanopore sequencer's ionic current signal.

224 Ionic current signals during electrophoretically driven

225 rd Nanopore Technologies nanopore-sequencing ionic current signals.

226 Protein bound to the aptamer produces unique ionic current signatures which facilitates accurate targ

227 nnel resolution, imaging their structure and ionic currents simultaneously is difficult.

228 le structures and can be modified to measure ionic currents simultaneously.

229 dentification was based on three consecutive ionic current states that correspond to passage of modif

230 cision boundaries based on three consecutive ionic current states were implemented to call mC, hmC, c

231 equences by analyzing the sequence-dependent ionic current steps produced as biomolecules pass throug

232 This can be achieved with specific ionic currents, such as A-type potassium currents, which

233 Comparison of nucleotide-binding with ionic currents suggests a model in which each nucleotide

234 quantitative understanding of modulations in ionic current that arise from the rotational dynamics of

235 magnetic field oriented perpendicular to the ionic current that crosses the gap between two arrays of

236 These observations identify Ih as an ionic current that is regulated in a cyclical manner by

237 Notably, S1P evoked a small excitatory ionic current that resulted in nociceptor depolarization

238 robust Ca(2+)-dependent PLS coinciding with ionic currents that are explained by ionic leak during p

239 Voltage-gated ion channels generate dynamic ionic currents that are vital to the physiological funct

240 n cultured cells, DeltaCR PrP induces large, ionic currents that can be detected by patch-clamping te

241 ts (Delta105-125) induces large, spontaneous ionic currents that can be detected by patch-clamping te

242 However, little is known about ionic currents that control the duration and probability

243 e genetic defects lead to alterations in the ionic currents that determine the morphology and duratio

244 We analyzed the ionic currents that drive pacemaking in dopaminergic VTA

245 tworks may impact cardiomyocyte function and ionic currents that impact AF risk.

246 er sarcoplasmic reticulum Ca(2+) content and ionic currents that reduce excitation threshold and prom

247 We analyzed ionic currents that regulate pacemaking in dopaminergic

248 dinated expression of multiple voltage-gated ionic currents that they do not acutely modulate.

249 its accurate assessment of metabolic cost of ionic currents that underlie AP conduction along the axo

250 , modulates I-SK and I-TRPC channel-mediated ionic currents that we have shown previously to regulate

251 echanical forces results in a characteristic ionic current, the release of serotonin and stimulation

252 nd I(KCa) are positively correlated, yet the ionic currents themselves are negatively correlated, acr

253 During a resistive pulse experiment, the ionic current through a conducting channel is monitored

254 ent ionic solution results in an oscillating ionic current through a conical nanopore.

255 Because the ionic current through a nanopore is inversely proportion

256 red through observation of the modulation of ionic current through a single nanopore.

257 within the pore, substantially affecting the ionic current through it.

258 We demonstrate that the ionic current through the engineered Mycobacterium smegm

259 een two electrolytes, and monitoring how the ionic current through the nanopore changes as single mol

260 In this demonstration of the phenomenon, the ionic current through the nanopore decreases when the ds

261 Changes in the flow of ionic current through the pore reflect the individual st

262 s a cation-stabilized quadruplex, alters the ionic current through the pore.

263 anoprecipitates, which temporarily block the ionic current through the pore.

264 solutions on either side to pass a constant ionic current through the pores.

265 This technique monitors the ionic current through the small opening of an electrolyt

266 by electrophysiology, where fluctuations in ionic current through these pores inserted in model memb

267 Ionic currents through AMPA receptor channels can be all

268 ixyl acetate as blockers of Ca(2+) entry and ionic currents through diacylglycerol- or receptor-activ

269 and submillisecond temporal resolution from ionic current time traces recorded when individual DNAP

270 The ionic current to generate the action potential is conduc

271 ectrodes embedded within the droplets allows ionic currents to be driven across the interface and mea

272 feedback control mechanisms dynamically tune ionic currents to maintain this optimal range.

273 Targeting these ionic currents to normalize their balance may have signi

274 the respiratory network, the contribution of ionic currents to respiratory rhythm is unclear.

275 ge of this fact, we linked the peak phase of ionic currents to their amplitude, in order to provide a

276 of human Orai1 and comparing in detail their ionic currents to those of native CRAC channels and chan

277 , we used a patch clamp amplifier to acquire ionic current traces caused by phi29 DNA polymerase-cont

278 state and the post-translocation state from ionic current traces of captured phi29 DNAP-DNA binary c

279 ranslocation fluctuations can be observed in ionic current traces when individual complexes are captu

280 ith single-nucleotide precision in real-time ionic current traces when individual complexes are captu

281 -translocation states can be quantified from ionic current traces, when individual Phi29 DNAP-DNA com

282 Channel activity was assayed as ionic currents under patch clamp and as optical signals

283 re that conducts ions, and the change in the ionic current versus time is monitored.

284 Simulations of stable propagation using the ionic current versus transmembrane potential relationshi

285 ion of interest through the drift cell, and ionic current was measured at the detector.

286 This ionic current was preserved in "cation-free" solution an

287 ed using the fura-2 Ca(2+) indicator dye and ionic current was recorded by whole cell patch-clamp.

288 well as AMPAR-mediated synaptic response and ionic current was selectively decreased in APP transgeni

289 ed the range of voltages where TRPM8-induced ionic currents were measured and made careful measuremen

290 trast to the wild type AtAMT1;2 transporter, ionic currents were not associated with the substrate tr

291 id residues display neither Ca(2+) entry nor ionic currents when expressed alone.

292 further evidenced by its ability to mediate ionic currents when expressed in Xenopus laevis oocytes.

293 Ionic currents, whether measured as conductance amplitud

294 ge moved approximately threefold faster than ionic current, which suggests the presence of additional

295 to opposite sides of the NCM did not rectify ionic current; while a NCM connected between fluid baths

296 ough a solid-state nanopore and generates an ionic current whose change allows for the detection of t

297 at the end of the nanopipette, generates an ionic current with a greatly reduced electric field stre

298 ded at 0 mV voltage bias and 0 pA background ionic current with high signal-to-noise ratio as the par

299 These properties derive from ionic current within the MOF and the deposition of nanom

300 which is capable of rectifying and switching ionic currents without electrochemical reactions.