ライフサイエンスコーパス: iron absorption

1 tinal epithelium but not involved in dietary iron absorption.

2 enting iron recycling and decreasing dietary iron absorption.

3 tivated in the intestine and is essential in iron absorption.

4 affected inflammation biomarkers nor altered iron absorption.

5 creases serum hepcidin and decreases dietary iron absorption.

6 However, calcium administration may inhibit iron absorption.

7 hepcidin (HAMP), the hormone that regulates iron absorption.

8 l tranporter-1, as well as enhanced duodenal iron absorption.

9 n normal hematologic values due to increased iron absorption.

10 e expression of key genes that contribute to iron absorption.

11 gle meals cannot be used to estimate dietary iron absorption.

12 3 months following disruption of intestinal iron absorption.

13 n solubility and bioavailability and improve iron absorption.

14 uodenal enterocytes, is required for optimal iron absorption.

15 a battery of genes essential for intestinal iron absorption.

16 ich increased the surface area available for iron absorption.

17 a regulatory mechanism for limiting further iron absorption.

18 ermore, hypoxia can also affect and increase iron absorption.

19 would further exacerbate anemia and increase iron absorption.

20 cted 36% of the interindividual variation in iron absorption.

21 epithelial cells leads to loss of intestinal iron absorption.

22 epcidin explain interindividual variation in iron absorption.

23 p transcription, permitting enhanced dietary iron absorption.

24 ly to be due to a TNF-alpha-induced block in iron absorption.

25 ys a pivotal role as a negative regulator of iron absorption.

26 lity to modulate iron metabolism and dietary iron absorption.

27 heme intakes, zinc intakes may increase heme-iron absorption.

28 tely predict the influence of polyphenols on iron absorption.

29 w Hamp1 levels are responsible for increased iron absorption.

30 that higher zinc intakes would decrease heme-iron absorption.

31 of an iron-sensing mechanism that regulates iron absorption.

32 dietary inhibitor of both heme- and nonheme-iron absorption.

33 role in determining the level of intestinal iron absorption.

34 a multicopper oxidase essential for enteric iron absorption.

35 no significant effect of dietary calcium on iron absorption.

36 hypercoagulability, and increased intestinal iron absorption.

37 d doses increases serum hepcidin and reduces iron absorption.

38 thereby possibly reflecting greater colonic iron absorption.

39 s gastric acid production, which can inhibit iron absorption.

40 itory effect, resulting in increased nonheme iron absorption.

41 s gastric acid production, which can inhibit iron absorption.

42 ingested tracer underestimated true maternal iron absorption.

43 act on nutrition whereby they interfere with iron absorption.

44 ation and serum hepcidin and thereby improve iron absorption.

45 1.41, -0.28)] were significant predictors of iron absorption.

46 rge variations were observed in mean nonheme-iron absorption (0.7-22.9%) between studies, which depen

47 dividuals (all from US studies): log[nonheme-iron absorption, %] = -0.73 log[ferritin, mug/L] + 0.11

48 Longitudinal, paired iron-absorption ((5)(8)Fe) studies were conducted in 59

49 ctivity is essential for intestinal non-heme iron absorption after birth.

50 Our objective was to re-evaluate maternal iron absorption after factoring in these losses and iden

51 e essential role of HIF-2alpha in regulating iron absorption and also demonstrate that hypoxia sensin

52 We measured iron absorption and body composition with the use of dua

53 understanding of the mechanisms that control iron absorption and body iron stores.

54 iron homeostasis, hepcidin, block intestinal iron absorption and cause iron retention in reticuloendo

55 ghts a role of HIF-2 in the dysregulation of iron absorption and chronic iron accumulation, as observ

56 activity of ferroportin, hepcidin modulates iron absorption and delivery from the body's stores.

57 ial for all cells but is toxic in excess, so iron absorption and distribution are tightly regulated.

58 the necessity of the gastric proton pump for iron absorption and effective erythropoiesis.

59 odulates erythropoiesis by affecting dietary iron absorption and erythroid iron intake.

60 a transmembrane protein crucial for duodenal iron absorption and erythroid iron transport.

61 We examined iron absorption and growth in exclusively breastfed infa

62 Hepcidin-25 is a peptide hormone involved in iron absorption and homeostasis and found at increased s

63 thesized in the liver, is a key regulator of iron absorption and homeostasis in mammals.

64 es examined a variety of genes that regulate iron absorption and homeostasis.

65 Inflammation reduces duodenal iron absorption and increases macrophage iron retention,

66 At the whole-body level, dietary iron absorption and iron export from the tissues into th

67 ystemic iron levels by inhibiting intestinal iron absorption and iron recycling.

68 r, has been shown to inhibit both intestinal iron absorption and iron release from macrophages.

69 negative-feedback mechanism between dietary iron absorption and iron status.

70 gastric bypass (RYGBP) on heme- and nonheme-iron absorption and iron status.

71 n (Hp) plays an important role in intestinal iron absorption and is predicted to be a ferroxidase bas

72 major transporter responsible for intestinal iron absorption and its expression is regulated by body

73 iency of hepcidin, the hormone that controls iron absorption and its tissue distribution, is the caus

74 rmone hepcidin is the principal regulator of iron absorption and its tissue distribution.

75 f iron metabolism, hepcidin inhibits dietary iron absorption and macrophage iron recycling.

76 a peptide hormone that decreases intestinal iron absorption and macrophage iron release, is a potent

77 produced by the liver that inhibits dietary iron absorption and macrophage iron release.

78 d TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release.

79 -like peptide hormone that inhibits duodenal iron absorption and macrophage iron release.

80 tory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia.

81 However, iron absorption and management in the PNS are poorly und

82 of vitamin C that result from its effects on iron absorption and metabolism has not been confirmed in

83 alternate days and in single doses optimises iron absorption and might be a preferable dosing regimen

84 regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.

85 iron-regulatory hormone hepcidin to increase iron absorption and mobilization of iron from stores.

86 cell types leads to the increased intestinal iron absorption and plasma iron levels characteristic of

87 Hepcidin regulates iron absorption and recycling by inducing the internaliz

88 Correction of unbalanced iron absorption and recycling by induction of hepcidin s

89 ne 6 (TMPRSS6) gene, an enzyme that promotes iron absorption and recycling by inhibiting hepcidin ant

90 te to anemia, but their influence on dietary iron absorption and recycling is unknown.

91 roportin in the gut and spleen, the sites of iron absorption and recycling respectively.

92 in (FPN) in the gut and spleen, the sites of iron absorption and recycling, respectively.

93 levels of hepcidin, a negative regulator of iron absorption and recycling, underlie the pathophysiol

94 diated by Hamp up-regulation, which inhibits iron absorption and recycling.

95 ating iron balance by controlling intestinal iron absorption and recycling.

96 is, is deficient in HH, leading to unchecked iron absorption and subsequent iron overload.

97 ing porridge meal leads to decreased nonheme iron absorption and that a 1-h time interval between a m

98 o meet these iron requirements, both dietary iron absorption and the mobilization of iron from stores

99 e genetic disorder with increased intestinal iron absorption and therefore iron Overload.

100 cessive condition characterized by increased iron absorption and tissue deposition.

101 iron-loading anemias whereby both increased iron absorption and transfusion therapy contribute to th

102 Defects in iron absorption and utilization lead to iron deficiency

103 nding of the genetic circuitry that controls iron absorption and utilization.

104 Iron absorption and zinc absorption from the food produc

105 ting amino acid in maize), phytase (enhances iron absorption), and other nutrients.

106 romatosis (involved in venous ulceration and iron absorption), and various types of collagen (contrib

107 at leads to increased EPO production, better iron absorption, and amelioration of anemia in chronic k

108 ncy in CKD, including blood losses, impaired iron absorption, and chronic inflammation.

109 microcytic anemia due to impaired intestinal iron absorption, and defective iron utilization in red c

110 one marrow iron stores, increased intestinal iron absorption, and hemoglobin response to SF) among no

111 o measure inflammation biomarkers, hepcidin, iron absorption, and utilization pre- and posttreatment

112 alues, 36% of interindividual differences in iron absorption are explained by differences in circulat

113 ed hepatic peptide that regulates intestinal iron absorption as well as maternal-fetal iron transport

114 e iron bioavailability (total and fractional iron absorption), assessed by measuring the isotopic lab

115 t-milk copper (P < 0.01) predicted increased iron absorption at 5M.

116 interactive program for calculating dietary iron absorption at any concentration of serum ferritin i

117 e used to develop a model to predict dietary iron absorption at different serum ferritin concentratio

118 In these women, iron absorption averaged 14.71 +/- 10.7% from the supple

119 There was no significant difference in iron absorption between ferritin and ferrous sulfate: lo

120 The difference in whole-body iron absorption between heat-treated (24.6 +/- 20.8%; n

121 isotope studies have shown no difference in iron absorption between infants with high or low hemoglo

122 The difference in whole-body iron absorption between the groups given lactoferrin (20

123 y was to evaluate the influence of inulin on iron absorption, bifidobacteria, total bacteria, short-c

124 nflammation, increases hepcidin, and reduces iron absorption but not utilization.

125 en shown to be a potent inhibitor of nonheme iron absorption, but it remains unclear whether the timi

126 to MNP and MNP+RUTF significantly increased iron absorption by 1.85-fold (95% CI: 1.49-, 2.29-fold;

127 0.001).GOS consumption by infants increased iron absorption by 62% from an MNP containing FeFum+NaFe

128 Increasing intestinal iron absorption by activation of HIF-2alpha or parentera

129 regulatory hormone hepcidin enable excessive iron absorption by ferroportin, the unique cellular iron

130 orchestrate hepatic hepcidin production and iron absorption by the intestine.

131 hat regulates iron homeostasis by inhibiting iron absorption by the small intestine and release of ir

132 ) and that from FeSO4 (34.3 +/- 23.6%) or in iron absorption calculated from red blood cell incorpora

133 blood transfusions and excessive intestinal iron absorption can be a complication of chronic anemias

134 enotype stems from impaired gastrointestinal iron absorption caused by a point mutation of the gastri

135 to repeated blood transfusions and increased iron absorption, chronic hemolysis is the major cause of

136 ) transporter internalization, impairing the iron absorption; clinically manifested as anemia of infl

137 e days increases PHep and modestly decreases iron absorption compared with alternate day dosing, and

138 Iron absorption correlated with fecal pH in the placebo

139 1% [8.2, 20.7] twice daily; p=0.33) or total iron absorption (day 1-3: 44.3 mg [29.4, 66.7] once dail

140 Nonheme-iron absorption decreased from 11.1% to 4.7% (P < 0.0001

141 Dietary iron intake and iron absorption did not change during the study.

142 good quantitative and dynamic description of iron absorption, distribution, storage and mobilization

143 wn about the molecular mechanisms regulating iron absorption during infancy.

144 Maternal iron absorption during pregnancy can be evaluated using

145 fine structure range beyond the onset of the iron absorption edge.

146 Dietary factors affecting iron absorption, eg, ascorbic acid, phytate, and calcium

147 ulated to play important roles in intestinal iron absorption, erythroid iron utilization, hepatic iro

148 Because high PHep decreases fractional iron absorption (FIA), alternate day iron dosing in the

149 Median percentage increases in iron absorption for -AA to +AA meals were 56% in the NW

150 2 x 2 factorial experiments compared women's iron absorption from 2 maize varieties (ACR and TZB; n =

151 In this study, we compared iron absorption from a meal with ascorbic acid (+AA) and

152 ermine whether prebiotic consumption affects iron absorption from a micronutrient powder (MNP) contai

153 h an iron-fortified maize meal and 2) assess iron absorption from a micronutrient powder (MNP) given

154 increase in serum hepcidin and a decrease in iron absorption from adiposity-related inflammation.

155 tion was observed between serum ferritin and iron absorption from both ferritin and FeSO4, which sugg

156 Infant iron absorption from breast milk averaged 7.1% and 13.9%

157 The median percentages of fractional iron absorption from FeFum+NaFeEDTA and from FeSO4 in th

158 ore or with the meal significantly increased iron absorption from FePP by 2.55-fold (95% CI: 1.48-, 4

159 ls, the addition of lipids more than doubles iron absorption from FePP.

160 mineral (animal-type) and to compare it with iron absorption from ferrous sulfate.

161 orhydria reduced the normal increase in heme-iron absorption from hemoglobin in response to iron defi

162 stimated from predictive algorithms, nonheme iron absorption from meals, and models of iron intake, s

163 Our study aim was to compare iron absorption from oral iron supplements given on cons

164 The objective was to examine iron absorption from purified soybean ferritin.

165 was no significant difference in whole-body iron absorption from soybean ferritin (29.9 +/- 19.8%) a

166 g might increase serum hepcidin and decrease iron absorption from subsequent doses.

167 t prohepcidin, was inversely associated with iron absorption from supplemental and food-based nonheme

168 iron regulatory hormone capable of blocking iron absorption from the duodenum and iron release from

169 riately raised hepcidin levels, which impair iron absorption from the gut, may be a factor.

170 ron exporter ferroportin, hepcidin decreases iron absorption from the intestine and iron release from

171 Iron absorption from the iron-casein complex was compare

172 In contrast with iron absorption from the low-bioavailability diet, that

173 (P < 0.05), it accurately predicted relative iron absorption from the maize meals.

174 ective was to conduct a systematic review of iron absorption from whole diets.

175 cal effectors mediating the up-regulation of iron absorption genes are unknown.

176 a in the intestine abolished the increase in iron absorption genes as assessed by quantitative real-t

177 Fractional iron absorption (geometric mean; -SD, +SD) from the iron

178 receptors for lactoferrin, a role for it in iron absorption has been suggested.

179 se dependence, and its effects on subsequent iron absorption have not been characterized in humans.

180 t developmental changes in the regulation of iron absorption; however, little is known about the mole

181 ed on the modulation of pathways that reduce iron absorption (ie, using hepcidin activators like Tmpr

182 less well understood than the regulation of iron absorption in adults, which is inverse to iron stat

183 time interval of tea consumption on nonheme iron absorption in an iron-containing meal in a cohort o

184 and oligofructose have been shown to improve iron absorption in animals through colonic uptake, but t

185 Iron absorption in Arabidopsis root epidermal cells requ

186 The mechanism of increased iron absorption in beta-thalassemia is unclear.

187 Fractional iron absorption in children was significantly affected b

188 the effect of iron and zinc intakes on heme-iron absorption in children.

189 The same compound promotes gut iron absorption in DMT1-deficient rats and ferroportin-d

190 export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through r

191 ion between serum or urinary prohepcidin and iron absorption in healthy premenopausal women.

192 y prohepcidin concentrations were related to iron absorption in healthy women.

193 (CA/TSC) mixture before extrusion increases iron absorption in humans from FePP-fortified extruded r

194 isotopes has provided valuable insights into iron absorption in humans, but the data have been limite

195 dies have examined the effect of hepcidin on iron absorption in humans.

196 cidin agonists might help treat the abnormal iron absorption in individuals with beta-thalassemia and

197 Whether consumption of prebiotics increases iron absorption in infants is unclear.We set out to dete

198 th a reduction in the normal upregulation of iron absorption in iron-deficient obese subjects, and th

199 be reproduced by increasing the setpoint of iron absorption in the duodenum to a level where the sys

200 n homeostasis is maintained by regulation of iron absorption in the duodenum, iron recycling from ery

201 uction of Fe(III) to Fe(II) is essential for iron absorption in the gastrointestinal tract.

202 nderstanding why probiotic bacteria increase iron absorption in the gastrointestinal tract.

203 of full-length mRNA would predict deficient iron absorption in the intestine and deficient iron util

204 Mean fractional iron absorption in the inulin (15.2%; 95% CI: 8.0%, 28.9

205 hepcidin and serum prohepcidin with nonheme-iron absorption in the presence and absence of food with

206 Dietary iron absorption in the small intestine is required for s

207 Heme-iron absorption in these subjects has not been reported.

208 ective of the study was to ascertain whether iron absorption in women adapts to dietary iron bioavail

209 ivity, we were unable to show an increase in iron absorption in women with low iron status.

210 Geometric mean iron absorptions in the afebrile malaria and hookworm gr

211 Geometric mean (95% CI) iron absorptions in the NW and OW/OB were 19.0% (15.2%,

212 ascorbic acid (or other luminal enhancers of iron absorption) in obese individuals to improve iron st

213 t subjects (n = 17), geometric mean (95% CI) iron absorption increased by 28% [from 9.7% (6.5%, 14.6%

214 istribution of iron by inhibiting intestinal iron absorption, iron recycling by macrophages, and iron

215 iron homeostasis by coordinately regulating iron absorption, iron recycling, and mobilization of sto

216 Iron absorption is controlled chiefly by hepcidin, the i

217 The magnitude of the decrease in heme-iron absorption is greater than that of nonheme iron.

218 iron during erythropoiesis, small intestinal iron absorption is increased through an undefined mechan

219 The function of hepcidin in regulating iron absorption is modeled through an inverse relationsh

220 Excessive iron absorption is one of the main features of beta-thal

221 and the enhancing effect of ascorbic acid on iron absorption is one-half of that in normal-weight wom

222 The effect of bariatric surgery on iron absorption is only partially known.

223 Iron absorption is proposed to be regulated by circulati

224 In neonates, efficient intestinal iron absorption is required to scavenge as much iron as

225 In overweight and obese women, iron absorption is two-thirds that in normal-weight wome

226 liver-derived protein that restricts enteric iron absorption, is the key regulator of body iron conte

227 As a consequence, iron absorption must be strictly regulated to ensure ade

228 der the normal regulatory control of dietary iron absorption, namely via ferroportin-dependent efflux

229 e objectives were to 1) assess the effect on iron absorption of a lipid emulsion given 20 min before

230 st the possibility of an enhancing effect on iron absorption of lipid-rich RUTFs, but more research i

231 iron-induced increase in hepcidin influences iron absorption of successive daily iron doses and twice

232 se serum hepcidin, and it does not influence iron absorption or utilization.

233 molar ratios of AA:iron) roughly tripled the iron absorption (P < 0.0001) from all test meals.

234 and serum hepcidin (P = 0.004) and improved iron absorption (P = 0.003).

235 significant group-by-compound interaction on iron absorption (P = 0.011).

236 gastric residence time, which could increase iron absorption, particularly from poorly soluble iron c

237 Iron absorption, plasma iron concentrations, and tissue

238 e hypothesized that HIF-2 could mediate high iron absorption rates in HH.

239 he duodenum, spleen, and liver, the sites of iron absorption, recycling, and storage respectively.

240 ith iron-unresponsive anemia due to impaired iron absorption/redistribution from tuberculosis-associa

241 iron without significantly affecting nonheme-iron absorption, regardless of meal bioavailability.

242 Mammalian nonheme iron absorption requires reduction of dietary iron for u

243 SO4, which suggested that sensors regulating iron absorption respond similarly to iron provided as fe

244 Caco-2 predictions confirmed human iron absorption results for maize meals but not for bean

245 e genotyping of 103 participants in previous iron-absorption studies, 5 C282Y-heterozygous subjects w

246 Stored samples from a human iron absorption study were used to test the hypothesis t

247 certain whether luminal enhancers of dietary iron absorption such as ascorbic acid can be effective i

248 ed particles (50 nm in diameter) had a lower iron absorption than unexposed or chronically exposed bi

249 atosis is an inherited disorder of increased iron absorption that can result in cirrhosis, diabetes,

250 mechanistic understanding for the increased iron absorption that is present in this disorder.

251 mals requires sustained postnatal intestinal iron absorption that maintains intracellular iron concen

252 HH) is characterized by increased intestinal iron absorption that may result in iron overload.

253 In the present study, we report a defect in iron absorption that results in iron-deficiency anemia,

254 mRNA levels of most of the genes involved in iron absorption that were tested; however, it did corres

255 By this mechanism, hepcidin inhibits dietary iron absorption, the efflux of recycled iron from spleni

256 ort of heme across membranes is critical for iron absorption, the formation of hemoglobin and other h

257 ad due to both transfused iron and increased iron absorption, the latter mediated by suppression of t

258 e intrinsic ability to regulate the rates of iron absorption, the spotlight in the past decade has be

259 hough hepcidin is proposed as a regulator of iron absorption, this has not been assessed in humans.

260 on of hepcidin expression serves to modulate iron absorption to meet body iron demand.

261 a level where the system cannot downregulate iron absorption to meet the iron excretion rate.

262 showed that dysregulation of the intestinal iron absorption transporter divalent metal transporter-1

263 abel, randomised controlled trials assessing iron absorption using ((54)Fe)-labelled, ((57)Fe)-labell

264 nd hematologic indexes and heme- and nonheme-iron absorption-using a standardized meal containing 3 m

265 e-day group (p=0.0013), and cumulative total iron absorption was 131.0 mg (71.4, 240.5) versus 175.3

266 Heme-iron absorption was 23.9% before and 6.2% 12 mo after su

267 Mean (+/-SD) iron absorption was 36 +/- 19% (range: 4-81%), and serum

268 by the erythrocyte iron incorporation method.Iron absorption was 5.7% +/- 8.5% (TM-1), 3.6% +/- 4.2%

269 Iron absorption was assessed by isotope incorporation in

270 Iron absorption was calculated from erythrocyte incorpor

271 e control subjects were recruited, and their iron absorption was compared by using a hamburger test m

272 cidin was increased (P < .01) and fractional iron absorption was decreased by 35% to 45% (P < .01).

273 A regression equation to calculate iron absorption was derived by pooling data for iron sta

274 Iron absorption was determined by analyzing blood sample

275 e, blood samples were collected for 8 h, and iron absorption was estimated by erythrocyte incorporati

276 Fractional iron absorption was estimated by the erythrocyte iron in

277 Mean fractional iron absorption was found to be significantly higher (2.

278 In this study, erythropoietic induction of iron absorption was further investigated.

279 Between groups, iron absorption was greater from the FeFum+NaFeEDTA (P =

280 0.0375), but, contrary to expectations, heme-iron absorption was higher at higher zinc intakes.

281 Absolute heme-iron absorption was higher in the group with higher zinc

282 Iron absorption was measured after 3 wk of inulin and pl

283 Iron absorption was measured as the erythrocyte incorpor

284 ion, and dietary intakes were also assessed; iron absorption was measured in a subgroup of women.

285 Iron absorption was measured in a whole-body counter aft

286 Iron absorption was measured in a whole-body counter aft

287 At 3 wk, iron absorption was negatively correlated with fecal pH

288 Log iron absorption was negatively correlated with serum fer

289 Iron absorption was predicted from serum ferritin concen

290 Fractional iron absorption was significantly higher from CA/TSC-ext

291 Serum ferritin and iron absorption were inversely correlated in subjects wh

292 metric mean (-SD, +SD) cumulative fractional iron absorptions were 16.3% (9.3, 28.8) in the consecuti

293 g, exclusively breastfed infants upregulated iron absorption when iron stores were depleted at both 2

294 lassemia, results in sustained elevations in iron absorption, which cause iron overload with associat

295 signals induced dysregulation of intestinal iron absorption, which contributed to liver iron overloa

296 not from FeSO4 There was a trend to increase iron absorption with the MNP+RUTF meal, which did not re

297 rations of 15, 30, and 60 mg/L, mean dietary iron absorption would be 22.3%, 16.3%, and 11.6%, respec

298 We hypothesized that fractional heme-iron absorption would decrease as heme-iron intake incre

299 zinc (1 or 9 mg); successful measurements of iron absorption, zinc absorption, or both were made in 4

300 Mean iron absorption, zinc absorption, protein quality and be