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1 caused by immune pathology in the CNS can be irreparable.
2 n the continuous strand, the heteroduplex is irreparable.
3                This behavioral defect is not irreparable.
4                   A subset of these DSBs are irreparable.
5  synthesis is observed on both reparable and irreparable 3' and 5' heteroduplexes as judged by [32P]d
6 al a profound toxicity of strand breaks with irreparable 3' blocking lesions, and extend the function
7                            Processing of the irreparable 3' heteroduplex is also associated with inci
8 hallenge the traditional view of the static (irreparable) adult brain.
9 nduce DNA double-strand breaks that might be irreparable and lead to cell death in nearby exposed tum
10                            These lesions are irreparable and persistent in the short term, but their
11                          The accumulation of irreparable cellular damage restricts healthspan after a
12 s during near-infrared irradiation can cause irreparable cellular damage to the prostate cancer cells
13 G explains the transient resistance, whereas irreparable chromosomal fragmentation explains subsequen
14  though they remove PDs normally, suggesting irreparable chromosome lesions.
15 ients, if not predicted in time, can lead to irreparable complications and even death.
16  in children with end-stage heart failure or irreparable congenital heart disease.
17 transplantations are surgeries performed for irreparable corneal diseases and damage.
18 these proteinases are released and can cause irreparable damage by degrading host connective tissue p
19                It is associated with severe, irreparable damage in the GI tract and extremely low sur
20 to help protect the developing embryo before irreparable damage is done.
21                            The extensive and irreparable damage of the foreign DNA by shredding makes
22 irs cognitive function and ultimately causes irreparable damage to brain tissue.
23 xternalities." Specifically, the potentially irreparable damage to fisheries because of mangrove loss
24                 Concerned about the possibly irreparable damage to the environment and to native comm
25 ias, which may be immediately fatal or cause irreparable damage to the heart sustained over long peri
26 lated event that would be expected to reduce irreparable damage to the mitochondria.
27 eservoir develops, the immune system suffers irreparable damage, and the infected (often unsuspecting
28 ow for either DNA repair or, in the event of irreparable damage, commitment to apoptosis.
29 led to prevent it from spreading and causing irreparable damage.
30 g late gestation and early infancy can cause irreparable deafness in both humans and rodents.
31 llowing enzymatic dissociation comes from an irreparable disruption of E-cadherin signaling, which th
32 ves indicate that a single event, such as an irreparable DNA break, may be sufficient to induce arres
33 ignaling cannot be sustained and nuclei with irreparable DNA damage progress into meiosis.
34 responses to replication stress, accumulated irreparable DNA damage, and permanently exited the cell
35 ay cell cycle progression or, in response to irreparable DNA damage, induce cell cycle exit or cell d
36 by minimizing propagation of cells that have irreparable DNA damage.
37 ggered by neurotrophic factor deprivation or irreparable DNA damage.
38 ulating S. pombe cells induced misrepair and irreparable DNA double strand breaks causing chromosome
39 ave suggested that ionizing radiation causes irreparable DNA double-strand breaks in mice and cell li
40 gy within a few cell diameters, resulting in irreparable DNA double-strand breaks while minimizing of
41 on of damaged templates and, in the event of irreparable DNA lesions, induction of apoptosis.
42 enhance EcoRI inactivation of foreign DNA by irreparable double-strand cuts, in preference to readily
43 epairable double-strand breaks and then into irreparable double-strand gaps may be behind lethality o
44 nce of Slx4 or Rtt107, Rad9 binding near the irreparable DSB is increased, leading to robust checkpoi
45                   In budding yeast, a single irreparable DSB is sufficient to activate the DDC and in
46 x4 is recruited within a few kilobases of an irreparable DSB, through the interaction with Rtt107 and
47 rigger permanent cell cycle arrest, germline irreparable DSBs are propagated to oocytes.
48                              However, unlike irreparable DSBs generated in other systems, which trigg
49 Bs that are generated by R-loops can lead to irreparable DSBs that evade cellular machineries designe
50 y or Sae2 are required for Mec1 signaling at irreparable DSBs.
51 ted as large-budded cells when faced with an irreparable dsDNA break in a nonessential chromosome.
52                                       Large, irreparable, endosomal holes are recognized by cytosolic
53                                   Cells with irreparable genomic damage pose a problem for developmen
54 nucleolytic activity, which otherwise causes irreparable genomic damage.
55 ctosidase (SA beta-gal) activity, apparently irreparable genomic DNA breaks, and elevation of p21(Cip
56 GE axis may provide a novel means to prevent irreparable glomerular injury in diabetes and other scle
57 s when exploiting natural resources leads to irreparable harm to the environment.
58               The treatment of neonates with irreparable heart valve dysfunction remains an unsolved
59 s may improve the treatment of neonates with irreparable heart valve dysfunction.
60 DSBs, a majority of complex DNA lesions were irreparable in organotypic 3D culture.
61 uent excision and chromosomal fragmentation, irreparable in the absence of RecBCD-catalyzed repair an
62  drive the establishment of a productive and irreparable infection(1)(,)(2).
63 es harmful immune responses that can lead to irreparable injury to innocent bystander cells that are
64 prompting avoidance of further damage to the irreparable inner ear.
65 ay lead to prompt treatment and avoidance of irreparable late sequelae.
66 replication over any remaining unrepaired or irreparable lesions in the DNA.
67 al DNA polymerase, pol gamma, interacts with irreparable lesions such as T-T.
68  in translesion synthesis over unrepaired or irreparable lesions.
69 verity of kidney injury at day 1, suggesting irreparable microvascular damage.
70                  Cells exposed to severe and irreparable mitochondrial damage agents such as valinomy
71 vin and light (Mirasol PRT treatment) causes irreparable modification of nucleic acids.
72 s demonstrated that newly synthesized DNA on irreparable molecules is subject to re-excision in a rea
73 search supports the view that degradation of irreparable O(6)-mG-T mispair-containing DNA by the MMR
74 uggest that CAF-1-dependent incorporation of irreparable O(6)-mG-T mispair-containing DNA into nucleo
75 -free extracts, CAF-1-dependent packaging of irreparable O(6)-mG-T mispair-containing DNA into nucleo
76 vity of the MMR system causes degradation of irreparable O(6)-mG-T mispair-containing DNA, triggering
77  appears diverse, a final common pathway for irreparable optic nerve injury may exist.
78 ue that occurs in response to injury, causes irreparable organ damage and may result in organ failure
79 radical production feasible and resulting in irreparable oxidative damage to the chromosome.
80 t disease progression and limit or eliminate irreparable retinal damage and vision loss associated wi
81                          Here we use massive irreparable rotator cuff tear as a model to study the im
82                                      Massive irreparable rotator cuff tear was used as a model to stu
83                          Participants had an irreparable rotator cuff tear, which had not resolved wi
84 eness of the InSpace balloon for people with irreparable rotator cuff tears.
85 end the InSpace balloon for the treatment of irreparable rotator cuff tears.
86 osure (1 kJ/m(2) three times weekly) induced irreparable skin damage in high PKCepsilon-overexpressin
87 butes by allowing these DSBs to transit into irreparable states.
88                                              Irreparable stresses downregulate the ciliary ARLs and r
89 onate with persistent truncus arteriosus and irreparable truncal valve dysfunction and a donor neonat
90 ng in a pathway that allows the tolerance of irreparable UV lesions.
91 ue problem when considering intervention for irreparable valvular abnormalities.
92  for kidneys that have minuscule function of irreparable vascular anomalies.