ライフサイエンスコーパス: ischemic preconditioning

1 followed by 15 min of reflow before harvest (ischemic preconditioning).

2 es in patients refractory to low-dose remote ischemic preconditioning.

3 rts where the expected loss was prevented by ischemic preconditioning.

4 nd loss of the cardioprotection conferred by ischemic preconditioning.

5 major adverse events were related to remote ischemic preconditioning.

6 tion and showed no protection in response to ischemic preconditioning.

7 PKMzeta levels were elevated 3 days after ischemic preconditioning.

8 cate key roles of PKMzeta and Na/K ATPase in ischemic preconditioning.

9 compounds blocked neuroprotection following ischemic preconditioning.

10 tion comparable to wild-type mice exposed to ischemic preconditioning.

11 lation of Src and Cav-1 after isoflurane and ischemic preconditioning.

12 idative injury and abolish the late phase of ischemic preconditioning.

13 infarction by a mechanism similar to that of ischemic preconditioning.

14 e hypothesis that cardiac nerves may mediate ischemic preconditioning.

15 onged ischemic insult, a phenomenon known as ischemic preconditioning.

16 arct size observed in WT after a protocol of ischemic preconditioning.

17 protective effect that normally occurs after ischemic preconditioning.

18 by very short periods of ischemia, so-called ischemic preconditioning.

19 7 is upregulated in the retina after retinal ischemic preconditioning.

20 to learning and memory, drug tolerance, and ischemic preconditioning.

21 ntributes to the early protective effects of ischemic preconditioning.

22 rdiac myocytes during ischemia is delayed by ischemic preconditioning.

23 teatosis were also particularly protected by ischemic preconditioning.

24 lethal ischemic insult, in a process termed ischemic preconditioning.

25 factors affecting the protective effects of ischemic preconditioning.

26 spase cleavage of PARP-1 could contribute to ischemic preconditioning.

27 the kidney protection afforded by 30 min of ischemic preconditioning.

28 ion injury, and epsilon-PKC activator mimics ischemic preconditioning.

29 naling pathway may play an important role in ischemic preconditioning.

30 role in protecting the heart from injury in ischemic preconditioning.

31 se channels as key players in the process of ischemic preconditioning.

32 r, could suffice to mediate local and remote ischemic preconditioning.

33 ges and further explore mechanisms of remote ischemic preconditioning.

34 ficantly reduced in mice treated with remote ischemic preconditioning.

35 No adverse events were reported with remote ischemic preconditioning.

36 y component of signaling cascades leading to ischemic preconditioning.

37 ctor-binding protein 7 in response to remote ischemic preconditioning.

38 nd reperfusion, a phenomenon known as remote ischemic preconditioning.

39 -reperfusion injury, and cardioprotection by ischemic preconditioning.

40 ene transcription and is required for remote ischemic preconditioning.

41 f metalloproteinases 2 after surgery (remote ischemic preconditioning, 0.36 vs control, 0.97 ng/mL2/1

42 nts [27.7%], respectively; hazard ratio with ischemic preconditioning, 0.95; 95% confidence interval,

43 schemic preconditioning, or 3 x 5 min remote ischemic preconditioning + 2 x 10 min remote ischemic pr

44 Some hypothesized mechanisms include (1) ischemic preconditioning; (2) posttransplant and host fa

45 Ischemic preconditioning 24 hours before ischemia-reperf

46 tion comparable to that of the late phase of ischemic preconditioning (29+/-3%, P<0.01 group II versu

47 Patients received either remote ischemic preconditioning (3 cycles of 5-minute ischemia

48 injury was significantly reduced with remote ischemic preconditioning (45 of 120 patients [37.5%]) co

49 R-21 in the infarcted areas was inhibited by ischemic preconditioning, a known cardiac protective met

50 channels in the heart is believed to mediate ischemic preconditioning, a phenomenon whereby brief per

51 In ischemic preconditioning, a sublethal ischemic insult pr

52 These findings indicate that ischemic preconditioning acts at step(s) upstream from s

53 whether the cardioprotective intervention of ischemic preconditioning affected mitochondrial protein

54 Ischemic preconditioning affords robust protection of CA

55 A brief period of ischemia, i.e., ischemic preconditioning, affords robust protection of C

56 MCC-134 also attenuated the effect of ischemic preconditioning against myocardial infarction i

57 Thus, although ischemic preconditioning allowed hepatocytes to better w

58 Ischemic preconditioning also induces autophagy, but the

59 erved for comparisons involving xanthine and ischemic preconditioning, although the impact of NAC and

60 jury (IRI) and may signal the development of ischemic preconditioning, an adaptive state that is prot

61 ilon gene blocked cardioprotection caused by ischemic preconditioning and alpha(1)-adrenergic recepto

62 out the role of bone marrow-derived cells in ischemic preconditioning and also reveal that distinct m

63 tivate signaling pathways that contribute to ischemic preconditioning and cardioprotection, high leve

64 e to hypoxic stress with involvement in both ischemic preconditioning and delayed neuroprotection.

65 Ischemic preconditioning and GluR2 antisense knockdown a

66 adaptive mechanisms such as those related to ischemic preconditioning and hibernation.

67 s have been reported to mediate both cardiac ischemic preconditioning and ischemia/reperfusion injury

68 erase-5 inhibitors and beneficial actions of ischemic preconditioning and ischemic postconditioning b

69 heart against ischemia-reperfusion injury by ischemic preconditioning and K(ATP) channel openers is k

70 Brain is also protected by ischemic preconditioning and K(ATP) channel openers, and

71 over, ethanol abolished protection from both ischemic preconditioning and mitochondrial KATP channel

72 an effector of the cell-survival program of ischemic preconditioning and the Mediterranean diet.

73 l ischemia of internal organs induces local (ischemic preconditioning) and systemic (RIPC) resistance

74 es in the regulation of cardiac contraction, ischemic preconditioning, and hypertrophy/failure.

75 ts of ischemic preconditioning (IPC), remote ischemic preconditioning, and ischemic postconditioning

76 Although xanthine, NAC, NaHCO3, NAC+NaHCO3, ischemic preconditioning, and natriuretic peptide may ha

77 id, xanthine, dopaminergic agent, peripheral ischemic preconditioning, and natriuretic peptide.

78 n of the cGMP-degrading phosphodiesterase-5, ischemic preconditioning, and postconditioning regimens.

79 c mitoK(ATP) channels play a pivotal role in ischemic preconditioning, and thus represent interesting

80 Ischemic preconditioning appears to sustain the benefici

81 to evaluate the clinical evidence for remote ischemic preconditioning as a potential strategy to prot

82 This study establishes ischemic preconditioning as a protective strategy agains

83 Remote ischemic preconditioning before contrast medium use prev

84 Little data exist regarding the use of ischemic preconditioning before sustained hepatic cold s

85 that is at least as powerful as traditional ischemic preconditioning but is mediated through radical

86 Tolerance was observed at 24 hours after ischemic preconditioning, but not at 72 hours.

87 an important role in cardiac development and ischemic preconditioning, but the mechanism underlying t

88 an obligatory mediator of the late phase of ischemic preconditioning, but the mechanisms of its card

89 reconcile the controversy over the basis of ischemic preconditioning by demonstrating that SDH is a

90 ain how mitoK(ATP) channel activation mimics ischemic preconditioning by protecting mitochondria as t

91 However, ischemic preconditioning cannot be used to reduce infarc

92 otection is unknown, NO is a mediator of the ischemic preconditioning cell-survival program.

93 patients undergoing cardiac surgery, remote ischemic preconditioning compared with no ischemic preco

94 Ischemic preconditioning confers powerful protection aga

95 fter induction of anesthesia) or sham remote ischemic preconditioning (control), both via blood press

96 onditioning in nonresponders) or sham-remote ischemic preconditioning (control).

97 mote ischemic preconditioning or sham remote ischemic preconditioning (control).

98 High-dose remote ischemic preconditioning could stimulate [tissue inhibit

99 to the temporally distinct acute and delayed ischemic preconditioning cytoprotective phenotypes, we r

100 th controls, fewer patients receiving remote ischemic preconditioning developed acute kidney injury w

101 Remote ischemic preconditioning did not improve clinical outcom

102 receive either one of four different remote ischemic preconditioning doses (3 x 5 min, 3 x 7 min, 3

103 e hypothesized that RIC before shock (remote ischemic preconditioning), during shock (remote ischemic

104 ic transgenic activation of PKCepsilon or by ischemic preconditioning enhances the formation of PKCep

105 e propose that, at 48 h of reperfusion after ischemic preconditioning, epsilonPKC is poised at synapt

106 cted to sublethal transient global ischemia (ischemic preconditioning) exhibit neuroprotection agains

107 Despite the potential of ischemic preconditioning for organ protection, long-term

108 n, patients were randomly assigned to remote ischemic preconditioning (four 5-minute inflations and d

109 rate at 6 years remained lower in the remote ischemic preconditioning group (hazard ratio, 0.58; 95%

110 the control group and 6 (12%) in the remote ischemic preconditioning group (odds ratio, 0.21; 95% co

111 12 months between the patients in the remote ischemic preconditioning group and those in the control

112 is early benefit in MACCE rate in the remote ischemic preconditioning group was sustained long-term.

113 parable in the intermittent clamping and the ischemic preconditioning group, whereas intermittent cla

114 nts (811 in the control group and 801 in the ischemic-preconditioning group) at 30 cardiac surgery ce

115 n 7] were significantly higher in all remote ischemic preconditioning groups when compared with contr

116 protein 7] across the four different remote ischemic preconditioning groups, in the 15 patients fail

117 Ischemic preconditioning has been demonstrated in animal

118 synthase kinase (GSK) inhibition produced by ischemic preconditioning has been previously shown to be

119 Ischemic preconditioning has been successfully applied t

120 The Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Ste

121 Remote ischemic preconditioning in humans has two phases of pro

122 e randomized study to evaluate the impact of ischemic preconditioning in liver surgery.

123 ischemic preconditioning + 2 x 10 min remote ischemic preconditioning in nonresponders) or sham-remot

124 c postconditioning and all studies on remote ischemic preconditioning in patients with AMI reported r

125 We determined consequences of hepatic ischemic preconditioning in rats, including cell transpl

126 l uncoupling proteins 2 and 3 during delayed ischemic preconditioning in the rat.

127 p27 is a gene-specific event associated with ischemic preconditioning in the retina.

128 ent of the neuroprotective events induced by ischemic preconditioning in the retina.

129 ve shown tissue-protective effects of remote ischemic preconditioning in various target organs, inclu

130 ethanol exposure has been reported to mimic ischemic preconditioning in vitro, but it failed to prot

131 Ischemic preconditioning in vivo increased the formation

132 ATP content in liver tissue was preserved by ischemic preconditioning in young but not older patients

133 te analysis revealed an increased benefit of ischemic preconditioning in younger patients, in patient

134 In this study, we demonstrate that remote ischemic preconditioning increases plasma IL-10 levels a

135 Here we report that ischemic preconditioning induced a small, transient down

136 -10) levels play an important role in remote ischemic preconditioning induced by clamping the femoral

137 ippocampal neurons, the protective effect of ischemic preconditioning induced by oxygen-glucose depri

138 genomic profile of cardioprotection between ischemic preconditioning induced by RCS and that induced

139 ar mechanisms differ markedly when mediating ischemic preconditioning induced by repetitive episodes

140 Furthermore, hindlimb remote ischemic preconditioning induced MCUb expression in the

141 Ischemic preconditioning induced persistent alterations;

142 Mitigation of ischemic preconditioning-induced DNA damage and deleteri

143 hort- and long-term clinical consequences of ischemic preconditioning (IP) during percutaneous corona

144 Ischemic preconditioning (IP) has been shown in animal m

145 The discovery of ischemic preconditioning (IP) has raised hopes that natu

146 recovery in CA donors, and that CA triggers ischemic preconditioning (IP) in liver grafts.

147 Ischemic preconditioning (IP) is a well-established phen

148 h little information regarding their role in ischemic preconditioning (IP) of stem cells.

149 Ischemic preconditioning (IP) renders tissues more toler

150 ethal ischemic insult, a phenomenon known as ischemic preconditioning (IP).

151 /L) abolished the protection associated with ischemic preconditioning (IPC) (20.2+/-3.6% versus 45.9+

152 Ischemic preconditioning (IPC) activates cell signaling

153 silon activation is necessary for myocardial ischemic preconditioning (IPC) and PKC activators increa

154 vascular bundle was compared against direct ischemic preconditioning (IPC) and the standard of care

155 disease, this study compares the effects of ischemic preconditioning (IPC) and therapies targeting v

156 In the brain, ischemic preconditioning (IPC) diminishes mitochondrial

157 In the rodent, ischemic preconditioning (IPC) has been shown to improve

158 Ischemic preconditioning (IPC) has been shown to involve

159 Ischemic preconditioning (IPC) has been studied predomin

160 ing factors in the induction of tolerance by ischemic preconditioning (IPC) in the brain.

161 2-LO) has been shown to be a factor in acute ischemic preconditioning (IPC) in the isolated rat heart

162 Ischemic preconditioning (IPC) is a robust neuroprotecti

163 Their role in ischemic preconditioning (IPC) is currently unknown.

164 PURPOSE OF REVIEW: Ischemic preconditioning (IPC) is gaining attention as a

165 Ischemic preconditioning (IPC) may increase the hepatic

166 Ischemic preconditioning (IPC) may prevent dysregulation

167 It is unclear whether ischemic preconditioning (IPC) of solid organs induces r

168 ma-based AAR (% of left ventricle) following ischemic preconditioning (IPC) or cyclosporin-A (CsA) tr

169 We investigated whether ischemic preconditioning (IPC) prevents cardiac RAS acti

170 Ischemic preconditioning (IPC) protects the rat retina a

171 Acute as well as delayed ischemic preconditioning (IPC) provides protection again

172 ction against cerebral ischemia conferred by ischemic preconditioning (IPC) requires translocation of

173 ive mechanism similar to what is observed in ischemic preconditioning (IPC) response.

174 This study assessed the ability of remote ischemic preconditioning (IPC) to attenuate cardiac trop

175 up of isolated rabbit hearts were exposed to ischemic preconditioning (IPC) via 2 episodes of flow in

176 g; IP) on retinal neuroprotection induced by ischemic preconditioning (IPC) were evaluated.

177 Ischemic preconditioning (IPC), a brief period of ischem

178 27 is specifically upregulated after retinal ischemic preconditioning (IPC), and this upregulation ac

179 K(ATP)) is implicated in cardioprotection by ischemic preconditioning (IPC), but the molecular identi

180 This process, called ischemic preconditioning (IPC), can be induced in adult

181 schemic injury in a natural process known as ischemic preconditioning (IPC), induced a rapid release

182 l infarct size and the protective effects of ischemic preconditioning (IPC), remote ischemic precondi

183 obal ischemia and the tolerance conferred by ischemic preconditioning (IPC), would reveal new neuropr

184 nged ischemic episode, a phenomenon known as ischemic preconditioning (IPC).

185 wn to be an important signaling messenger in ischemic preconditioning (IPC).

186 generation of cytoprotective NO during liver ischemic preconditioning (IPC).

187 ts that chloride channels may be involved in ischemic preconditioning (IPC).

188 a-reperfusion injury (IRI) and is reduced by ischemic preconditioning (IPC).

189 nomenon whereby a sublethal ischemic insult [ischemic preconditioning (IPC)] provides robust protecti

190 5+/-4.1% (P<0.01), an effect comparable with ischemic preconditioning (IPC; 27.5+/-2.3%; P<0.01).

191 e short episodes of forearm ischemia (remote ischemic preconditioning [IPC]) reduce exercise-induced

192 Ischemic preconditioning is a natural adaptive process w

193 Ischemic preconditioning is a phenomenon in which low-le

194 Ischemic preconditioning is an effective protective stra

195 Neuronal ischemic preconditioning is an endogenous mechanism that

196 Neuronal ischemic preconditioning is an endogenous neuroprotectiv

197 Understanding the mechanisms responsible for ischemic preconditioning is important for formulating th

198 sp70.3 gene in the myocardium in response to ischemic preconditioning is NF-kappaB-dependent and nece

199 Ischemic preconditioning is the phenomenon whereby brief

200 Ischemic preconditioning is used to describe the protect

201 This phenomenon, known as ischemic preconditioning, is mediated by signaling pathw

202 t, which abrogates the protective effects of ischemic preconditioning, is not associated with ischemi

203 is area, the appropriate intensity of remote ischemic preconditioning, its mechanisms of action, and

204 infarct-sparing effect of the late phase of ischemic preconditioning (late PC) lasts for 72 hours.

205 Remote ischemic preconditioning may offer a novel, noninvasive,

206 Remote ischemic preconditioning may result in reduction in infa

207 schemia/reperfusion-induced brain injury and ischemic preconditioning-mediated neuroprotection.

208 In mice subjected to ischemic preconditioning, myocardial SDF-1alpha mRNA was

209 atio to standard care with (n=50) or without ischemic preconditioning (n=50; intermittent arm ischemi

210 ice was similar to wild-type mice undergoing ischemic preconditioning; no increased protection was ob

211 In mouse hearts subjected to in vivo ischemic preconditioning, O-GlcNAc levels were significa

212 First, we show that cardiac ischemic preconditioning of the in vivo mouse heart resu

213 e secondary to recruitment of collaterals or ischemic preconditioning of the myocardium, and they app

214 e-dependent kinase-1 (PDK1) is essential for ischemic preconditioning of the myocardium.

215 Interestingly, ischemic preconditioning of Wt mice resembles the benefi

216 rger trial to establish the effect of remote ischemic preconditioning on clinical outcomes.

217 led trial was to assess the impact of remote ischemic preconditioning on contrast medium-induced acut

218 There was no significant effect of remote ischemic preconditioning on myocardial infarction, strok

219 It has been recently demonstrated that ischemic preconditioning or adenosine receptor modulatio

220 Brief periods of ischemia (ischemic preconditioning or IPC) can reduce neuronal dea

221 This phenomenon has been termed ischemic preconditioning or ischemic tolerance.

222 We randomized them to receive remote ischemic preconditioning or sham remote ischemic precond

223 Cerebral ischemic preconditioning or tolerance is a powerful neur

224 of coronary occlusion/reperfusion preceding (ischemic preconditioning) or following (ischemic postcon

225 short period of ischemia before transection (ischemic preconditioning), or pharmacological preconditi

226 ses (3 x 5 min, 3 x 7 min, 3 x 10 min remote ischemic preconditioning, or 3 x 5 min remote ischemic p

227 Nonetheless, ischemic preconditioning partially protected from toxic

228 ic acid (aspirin) (ASA) on the late phase of ischemic preconditioning (PC) against myocardial stunnin

229 endothelial nitric oxide synthase (eNOS) in ischemic preconditioning (PC) and cardioprotection is po

230 ecent studies suggest that the late phase of ischemic preconditioning (PC) can be mimicked by pretrea

231 ardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked pharmacolo

232 Although the late phase of ischemic preconditioning (PC) is known to confer cardiop

233 ed the hypothesis that cardioprotection with ischemic preconditioning (PC) is lost in the aging, or s

234 To investigate its role in the late phase of ischemic preconditioning (PC), conscious rabbits underwe

235 rigger and the mediator of the late phase of ischemic preconditioning (PC), it is unknown whether NO

236 S)-mediated signaling is implicated in early ischemic preconditioning (PC).

237 eptors (GPCRs) in the protection afforded by ischemic preconditioning (PC).

238 nositol-3-kinase (PI3-kinase) is involved in ischemic preconditioning (PC).

239 cription (STAT) pathway in the late phase of ischemic preconditioning (PC).

240 ardioprotective effects of the late phase of ischemic preconditioning (PC); however, the signaling pa

241 neurons overexpressing NCX1 and subjected to ischemic preconditioning (PC+OGD/RX), the neurotoxic eff

242 Remote ischemic preconditioning prevents IR-induced endothelial

243 In brief, ischemic preconditioning promoted significant increases

244 Delayed ischemic preconditioning promotes cardioprotection via g

245 The data indicate that ischemic preconditioning protects the liver from sustain

246 surgery to either receive or not receive an ischemic preconditioning protocol (10 minutes of ischemi

247 Fewer patients receiving remote ischemic preconditioning received renal replacement ther

248 ; 95% CI, 2.25%-17.75%; P = .01), and remote ischemic preconditioning reduced intensive care unit sta

249 (CRISP Stent) study demonstrated that remote ischemic preconditioning reduced procedural symptoms, EC

250 We have previously shown that remote ischemic preconditioning reduces acute kidney injury (ac

251 Ischemic preconditioning reduces local tissue injury cau

252 Remote ischemic preconditioning reduces the incidence of postpr

253 In mice subjected to S/R, remote ischemic preconditioning, remote ischemic "PER"condition

254 Ischemic preconditioning renders the mouse kidney resist

255 This biological phenomenon, termed ischemic preconditioning, results in improved clinical o

256 Remote ischemic preconditioning (RIPC) by brief arm ischemia/re

257 Remote ischemic preconditioning (RIPC) by repeated brief cycles

258 Remote ischemic preconditioning (RIPC) by repeated brief cycles

259 We assessed whether remote ischemic preconditioning (RIPC) improves myocardial, ren

260 y assess the renoprotective effect of remote ischemic preconditioning (RIPC) in patients undergoing a

261 Remote ischemic preconditioning (RIPC) is a phenomenon whereby

262 Remote ischemic preconditioning (RIPC) is a practicable and non

263 Remote ischemic preconditioning (RIPC) is reported to reduce bi

264 Additionally, remote ischemic preconditioning (RIPC) may have higher translat

265 time course and neuronal mechanism of remote ischemic preconditioning (RIPC) of the vasculature in hu

266 Remote ischemic preconditioning (RIPC) protects against liver i

267 f this study was to determine whether remote ischemic preconditioning (RIPC) protects aged liver agai

268 Remote ischemic preconditioning (rIPC) with short episodes of i

269 Remote ischemic preconditioning (rIPC), defined as transient br

270 In remote ischemic preconditioning (RIPC), ischemia to one organ p

271 duction of myocardial infarct size by remote ischemic preconditioning (RIPC), that is, cycles of isch

272 Remote ischemic preconditioning (RIPC), the repetitive transien

273 nst ischemia-reperfusion (IR) injury (remote ischemic preconditioning [RIPC]).

274 Remote ischemic preconditioning significantly attenuated the re

275 Ischemic preconditioning significantly improved hepatic

276 All doses of remote ischemic preconditioning significantly increased [tissue

277 r results between centers and confirmed that ischemic preconditioning significantly reduced infarct s

278 te ischemic preconditioning compared with no ischemic preconditioning significantly reduced the rate

279 ked the protection afforded by both NMDA and ischemic preconditioning significantly, suggesting a sig

280 Following ischemic preconditioning, SNO occupancy increased to an

281 ium channel function plays a central role in ischemic preconditioning, stunned myocardium, and in ane

282 ) or a traditional protocol of second-window ischemic preconditioning (SWIPC).

283 on angina may act as a clinical surrogate of ischemic preconditioning that may reduce infarct size an

284 This model identified two regulators of ischemic preconditioning: the atypical protein kinase M

285 enation-dependent Nrf-2 activity facilitates ischemic preconditioning through the induction of antiox

286 Here, we used ischemic preconditioning to induce a stress-tolerant sta

287 to determine the optimal intensity of remote ischemic preconditioning to induce required [tissue inhi

288 To validate CAESAR, we tested the ability of ischemic preconditioning to reduce infarct size in 3 spe

289 Whether remote ischemic preconditioning (transient ischemia and reperfu

290 Remote ischemic preconditioning, triggered by brief episodes of

291 Remote ischemic preconditioning, using cycles of upper limb isc

292 Ischemic preconditioning was blocked in rat hearts perfu

293 Ischemic preconditioning was elicited in 80% of patients

294 The protective effect of ischemic preconditioning was reversed after VEGF-A inhib

295 een caspase activation, PARP-1 cleavage, and ischemic preconditioning was supported by studies using

296 naling molecules and have been implicated in ischemic preconditioning, we examined diazoxide-induced

297 Intermittent inflow occlusion and ischemic preconditioning were both protective against is

298 ion of Hsp in the rat retina associated with ischemic preconditioning were evaluated.

299 Fifteen minutes of prior ischemic preconditioning, which does not result in the d

300 long term protection afforded the kidney by ischemic preconditioning, which results in persistent re