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1 etabolite chorismate into salicylic acid via isochorismate.
2 l to allow formation of a hydrogen bond with isochorismate.
3 njugate addition of alpha-ketoglutarate with isochorismate.
4 cular Arg106 are critical for recognition of isochorismate.
5 om chorismate and water via the intermediate isochorismate.
6 of the inactive D38A variant in complex with isochorismate.
7 e enzymatic hydroxymutation of chorismate to isochorismate.
8 gation of glutamate to isochorismate to form isochorismate-9-glutamate, which is then used to produce
9 tic data indicate that for the production of isochorismate, a high magnesium ion concentration suppre
10 bidopsis, a major part of SA is derived from isochorismate, a key intermediate produced by the isocho
11 initiated by the conversion of chorismate to isochorismate, a reaction that is catalyzed by the menaq
13 se two residues are important for binding of isochorismate and for stabilizing the cofactor position.
14 he crystal structure of EntC in complex with isochorismate and Mg(2+)at 2.3 A resolution, the first s
15 s to establish the kinetic mechanisms of the isochorismate and salicylate synthase enzymes of siderop
17 residues in the conversion of chorismate to isochorismate and to obtaining clues about the pyruvate
18 f L-glutamate primarily to the 8-carboxyl of isochorismate and yields the key SA biosynthetic interme
19 ecent work has shown that AtGH3.12/PBS3 uses isochorismate as a substrate, forming an isochorismate-g
21 sicaceae plants is uniquely accelerated from isochorismate by EPS1, a newly identified enzyme in the
22 lyzes hydrolysis of the related vinyl ethers isochorismate, chorismate, and 4-amino-4-deoxychorismate
23 orders of magnitude higher affinity for the isochorismate complex relative to the chorismate complex
24 lyzed activities, as well as the uncatalyzed isochorismate decomposition, are reported from temperatu
27 our data indicate a PBS3-independent path to isochorismate-derived SA at later stages of bacterial in
30 ismate synthase (ICS) converts chorismate to isochorismate for the biosynthesis of phylloquinone, an
31 ically produces salicylate and pyruvate from isochorismate for ultimate incorporation of the salicyla
32 ses isochorismate as a substrate, forming an isochorismate-glutamate conjugate that converts into sal
33 , catalyzing the conversion of chorismate to isochorismate (IC) in a reaction that operates near equi
35 wo-step metabolic pathway to produce SA from isochorismate in Arabidopsis, which is distinct from how
40 btI at 2.5 A resolution and demonstrate that isochorismate is a kinetically competent intermediate in
41 dicates that the methylene pyruvyl carbon of isochorismate is adjacent to the side chain carboxylate
45 encoded by angB and designated AngB, has an isochorismate lyase activity necessary for the synthesis
47 show that EntB, previously described as the isochorismate lyase required for production of 2,3-DHB,
48 monophosphate ligase, VibB is a bifunctional isochorismate lyase-aryl carrier protein (ArCP), and Vib
49 the enzymes of phylloquinone synthesis from isochorismate may form a complex in the chloroplast stro
50 icantly extended biochemical scheme of plant isochorismate metabolism that involves an alternative ge
51 ntC, MenF and Irp9 all convert chorismate to isochorismate, only Irp9 subsequently exhibits isochoris
53 lant Arabidopsis, it was discovered that the isochorismate pathway is the major source of SA during S
54 -ketoglutarate and with the second substrate isochorismate positioned to accept nucleophilic attack h
56 ochorismate, only Irp9 subsequently exhibits isochorismate pyruvate lyase activity resulting in the f
57 o this class is the enzyme PchB, an 11.4-kDa isochorismate pyruvate lyase from Pseudomonas aeruginosa
58 smate mutase activity similar to that of the isochorismate pyruvate lyase, PchB, from Pseudomonas aer
64 ase (MenF) is distinct from the entC-encoded isochorismate synthase (EntC) involved in enterobactin b
65 d (SA) biosynthesis in plants occurs via the isochorismate synthase (ICS) and phenylalanine ammonia-l
69 induced SA biosynthesis proceeds through the isochorismate synthase (ICS) pathway, with cold inductio
71 ing that SA synthesized via PAL, and not via isochorismate synthase (ICS), mediates lesion developmen
74 ed in chloroplasts from chorismic acid by an isochorismate synthase (ICS1); SA biosynthesis is negati
75 so inhibit two other enzymes in this family, isochorismate synthase (IS) and anthranilate synthase (A
76 hsis and shares a common core mechanism with isochorismate synthase (IS) and anthranilate synthase (A
77 amino-4-deoxychorismate synthase (ADCS), and isochorismate synthase (IS) are homologous enzymes that
78 (AS), aminodeoxychorismate synthase (ADCS), isochorismate synthase (IS), and salicylate synthase (SS
86 have evolved two pathways to produce SA: the isochorismate synthase and phenylalanine ammonia lyase (
89 he role of magnesium ions, which inhibit the isochorismate synthase enzymes but not the salicylate sy
90 is of SA and Ybt by DC3000 requires pchA, an isochorismate synthase gene in the Ybt genomic cluster,
94 lts led to the demonstration of an alternate isochorismate synthase specifically involved in menaquin
96 35% identical to the Bs menaquinone-specific isochorismate synthase, MenF, illustrating an example of
98 ther chorismate-utilizing enzymes, including isochorismate synthase, suggests that they too may bind
99 orismate, a key intermediate produced by the isochorismate synthase, which is reminiscent of SA biosy
100 stress-induced accumulation of SA depends on ISOCHORISMATE SYNTHASE1 (ICS1) and also requires the pre
101 ing to the promoter of the SA-synthesis gene ISOCHORISMATE SYNTHASE1 (ICS1) and increases SA producti
102 ing for wild-type and SA biosynthetic mutant isochorismate synthase1 (ics1) Arabidopsis from 0 to 7 d
104 sion of the salicylic acid biosynthetic gene ISOCHORISMATE SYNTHASE1, which leads to spontaneous defe
105 perception pathways, since they are lost in isochorismate synthase1/salicylic acid induction deficie
106 ancestor (the MST family), that includes the isochorismate synthases and anthranilate synthases.
109 y catalyzing the conjugation of glutamate to isochorismate to form isochorismate-9-glutamate, which i
110 e lyase (IPL) that catalyzes the turnover of isochorismate to pyruvate and SA, plants do not contain
111 njugate addition of alpha-ketoglutarate with isochorismate to release 2-succinyl-5-enolpyruvyl-6-hydr
112 THASE1 (ICS1) and also requires the presumed isochorismate transporter ENHANCED DISEASE SUSCEPTIBILIT
113 tamin K2) is the conversion of chorismate to isochorismate, which is mediated by an isochorismate syn