ライフサイエンスコーパス: isocyanide

1 erocoupling product of CO with isoelectronic isocyanide.

2 l iodide, dimethyl disulfide, and tert-butyl isocyanide.

3 the right amine, acid, aldehyde/ketone, and isocyanide.

4 cm(-1) compared to 2118 cm(-1) for the free isocyanide.

5 f the oxo ligands, and the pi* orbital of CO/isocyanide.

6 he ordered water molecule to hydrate organic isocyanides.

7 monoxide, nitric oxide, and methyl and ethyl isocyanides.

8 leaving the R-NC bond in a series of organic isocyanides.

9 a multicomponent reaction with peptides and isocyanides.

10 s alkene, pyridine, imine, carbodiimide, and isocyanides.

11 des an efficient, direct synthesis of alkene isocyanides.

12 eaction of 4 and 3, respectively, with CO or isocyanides.

13 yzed reaction of thiocarboxylic acids 2 with isocyanides 3.

14 a-h, amines 2a-d, 2-chloroacetic acid 3, and isocyanides 4a, 4b for the synthesis of versatile precur

15 Isocyanide 5 and synthetic diastereomers 5a and 5c showe

16 l azide 4, singlet benzoylnitrene (1)4N, and isocyanide 5, as revealed by IR spectroscopy.

17 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-

18 c evidence confirmed a radical pathway where isocyanides acted as radical geminal acceptors generatin

19 role in controlling the stereoselectivity of isocyanide addition, and the carboxylate group of l-prol

20 f the reaction was found to be determined by isocyanide addition, while the rate-limiting step was fo

21 SiCl(4) promotes isocyanide additions to oxoalkenenitriles to selectively

22 l structure of the more sterically demanding isocyanide adduct, [Ni(CNCy)(PCy2NBz2)2]2(BF4)2, 4.

23 withC bond and enhanced reactivity of phenyl isocyanide adsorbed at the Pd step edge compared with th

24 to the carbene nucleus with various organic isocyanides afforded a new class of ketenimines in yield

25 eir reactions with phenylacetylene and xylyl isocyanide, affording in the case of each reagent two di

26 The reaction is also successful for other isocyanides, albeit with reduced enantioselectivity.

27 2 react rapidly with representative cyanide, isocyanide, alkyne, N 2, alkene, diazene, azide, CO 2, c

28 The apparent transfer of the isocyanide alpha-carbon to protic solvents as a formyl g

29 rvations in multicomponent reactions between isocyanides, alpha-amino acids, and monofunctional aldeh

30 e building block Asmic (anisylsulfanylmethyl isocyanide), an alkyl halide, and an acid chloride or ni

31 propylphenylisocyanide)tantalum is the first isocyanide analogue of the highly unstable Ta(CO)6 and r

32 antalum complex, Ta(CNXyl)(5)NO, which is an isocyanide analogue of the unknown Ta(CO)(5)NO.

33 I, or cis-[M(CNXyl)(4)(NO)(2)](+), which are isocyanide analogues of the unknown carbonyl complexes [

34 ullie-Ugi reaction) of cyclic imines with an isocyanide and acetylenedicarboxylates under catalyst-fr

35 situ Bronsted acid-catalyzed reaction of the isocyanide and aldehyde to yield an imine that participa

36 In two cases, the isocyanide and azide undergo a [3 + 2] cycloaddition to

37 kene moiety can be thermally displaced by an isocyanide and carbon monoxide.

38 with tighter binding by the more hydrophobic isocyanides and 200-300-fold tighter binding to the ferr

39 e gold species for the aldol condensation of isocyanides and aldehydes to form oxazolines.

40 imides was described via cascade reaction of isocyanides and alpha-diazoketones.

41 rrangement is carried out in the presence of isocyanides and carboxylic acids/silanols, the photoreac

42 Ru(H(2)IMes)(CH(i-PrOC(6)H(4)))Cl(2) by aryl isocyanides and small phosphites but only after initial

43 ve coupling of aromatic tertiary amines with isocyanides and water leads to amide products under very

44 Finally, we show that poly(acrylate-co-isocyanide) and poly(acrylate-co-ketone) are photodegrad

45 multicomponent reaction of 3-diazo oxindole, isocyanide, and aniline has been developed.

46 sing sulfonylazides, p-toluenesulfonylmethyl isocyanide, and beta-keto sulfones as sulfonyl source, i

47 eaction between an aziridine aldehyde dimer, isocyanide, and l-proline to afford a chiral piperazinon

48 catalyzed tandem coupling of sulfonyl azide, isocyanide, and water in aqueous media.

49 t reactions using a variety of beta-lactams, isocyanides, and amines.

50 g differently substituted 3-diazo oxindoles, isocyanides, and anilines as starting material and obtai

51 mponent reaction that combines aryl halides, isocyanides, and diamines provides access to 2-aryl-2-im

52 ituted complexes by carbon monoxide and aryl isocyanides, and for the phosphine-free Hoveyda-Blechert

53 c aldehydes, primary amines, propiolic acid, isocyanides, and hydrazides has been developed in order

54 ree-component reaction among Z-chlorooximes, isocyanides, and hydroxylamines by exploiting the prefer

55 oles from cyclic 1,3-dicarbonyls, aldehydes, isocyanides, and maleimides.

56 ticomponent reaction of 3-carbonylchromones, isocyanides, and nonsymmetric dienophiles.

57 rini three-component reactions of aldehydes, isocyanides, and strong carboxylic acids (i.e., pK(a) <

58 e report a three-component reaction in which isocyanides are able to open the epoxide intermediate of

59 The intermediate metalated isocyanides are efficiently trapped with electrophiles t

60 Isocyanides are exceptional building blocks, the wide de

61 The substituted isocyanides are ideally functionalized for elaboration i

62 r when it is treated with 2,6-dimethylphenyl isocyanide (ArNC), leading to the corresponding isothioc

63 t 3 nm resolution in real space using phenyl isocyanide as a probe molecule (Fig.

64 t 3 nm resolution in real space using phenyl isocyanide as a probe molecule.

65 tric assay for ICH activity using 2-naphthyl isocyanide as a substrate.

66 C that is trigonal bipyramidal with an axial isocyanide as demonstrated by X-ray crystallography.

67 c acids (alpha, beta, gamma), aldehydes, and isocyanides as reactants and alcohols as solvents, these

68 means of Ugi reactions incorporating lipidic isocyanides as surrogates of sphingolipids.

69 Complex 10 adds alkyl isocyanides as well as pivalonitrile at a lateral site a

70 An unusual Pd-catalyzed isocyanide assisted 5-exo-dig reductive cyclization of 1

71 Reactions of 2 and 3 with isocyanide at room temperature produced complexes 8-(CNB

72 Bulky substituents at the isocyanide backbone furthermore protect the Ni(II) cente

73 her by using purified components or by using isocyanide-based activation chemistry, reduces the error

74 se conditions facilitate not only the methyl isocyanide-based activation of ribonucleotide 5'-monopho

75 digms crucial to design efficient photoredox isocyanide-based domino transformations.

76 the coordination between silver(I) salt and isocyanide-based monomers at ambient condition.

77 These factors are similar to traditional isocyanide-based multicomponent reactions, such as the U

78 onally unstable in some synthetically useful isocyanide-based multicomponent reactions.

79 nd macrocyclization of peptides arising from isocyanide-based multicomponent reactions.

80 g step was found to deviate from traditional isocyanide-based multicomponent reactions.

81 demonstrated a potentially prebiotic methyl isocyanide-based nucleotide activation chemistry.

82 an efficient activating agent for azines in isocyanide-based reactions, which then proceed through a

83 A visible-light-promoted three-component isocyanide-based synthesis of iminofurans is herein repo

84 As N(2), CO, and isocyanides belong to the archetypical ligands in transi

85 The heme ligand n-butyl isocyanide (BIC) was used to probe the mechanism of NO a

86 TIR spectroscopy for methyl through n-pentyl isocyanide bound to a series of 20 different distal pock

87 ructures of methyl, ethyl, propyl, and butyl isocyanide bound to sperm whale myoglobin (Mb) reveal tw

88 idazoles are synthesized in one pot from the isocyanide building block Asmic (anisylsulfanylmethyl is

89 The versatile isocyanide building block Asmic, anisylsulfanylmethyliso

90 d exposure to the often toxic and malodorous isocyanide building blocks, the continuous approach was

91 of a dative bond to the surface through the isocyanide carbon.

92 e study has been carried out using different isocyanides, carboxylic acids, and phenols showing the s

93 In eons of evolution, isocyanides carved out a niche in the ecological systems

94 ce oligonucleotides, all activated by methyl isocyanide chemistry, that direct the uniform copying of

95 d metal is observed to catalyze reactions of isocyanides (CN-R) with primary amines (H2N-R') and O2 t

96 hat are derivatives of 2,6-diisopropylphenyl isocyanide (CNdipp) have been developed; tungsten comple

97 The FTIR spectra for alkyl isocyanides (CNRs) change from a single nu(CN) band cent

98 Alkyl isocyanides (CNRs) identify pathways for diatomic ligand

99 Zn bond in the 37.4 kJ mol(-1) higher energy isocyanide CNZnZnNC, and a longer 4.024 angstrom bond in

100 luminescence quantum yield of a chromium(0) isocyanide complex by nearly 2 orders of magnitude, acco

101 p2))(2), which is the first stable monomeric isocyanide complex of zerovalent palladium.

102 but the components do not form a stable tris-isocyanide complex.

103 we show that bis-cyclometalated iridium bis-isocyanide complexes (1) react with azide (N(3)(-)) to f

104 The ruthenium isocyanide complexes [PhBP(Ph)3]Ru(H)(CNXyl)(eta(2)-HSiH

105 prepared in two steps from the corresponding isocyanide complexes.

106 lycomimetics comprising aldehyde, amine, and isocyanide components related to isopropylidene-protecte

107 reported of the first two-coordinated Si(0)-isocyanide compound (SIDipp)Si C N-Ar(Mes) (1: SIDipp (N

108 ve to those of the parent 2,6-dimethylphenyl isocyanide compound Cu1.

109 Specifically, one of the m-terphenyl isocyanide compounds, Cu3, displays an excited-state lif

110 w the richness in biological activity of the isocyanide-containing molecules, to support the idea of

111 In addition, valine isocyanide contributes to biosynthesis of a family of ac

112 Isocyanides coordinate to both ferric and ferrous HO-bou

113 E atom transfer from Na(OCE) (E=P, As) to an isocyanide coordinated to the tetrahedral Ti(II) complex

114 synthesizes nonalternating poly(acrylate-co-isocyanide) copolymers with tunable incorporation using

115 nd carbon monoxide and nitric oxide, but not isocyanide, cyanide, or azide.

116 hown for the first time that singlet-excited isocyanides decompose acyl peroxides into aryl/alkyl rad

117 R titrations of rHb (alphaH87G) with n-butyl isocyanide demonstrate the alpha-chains to be of high af

118 enching and removal of the catalyst using an isocyanide derivative afforded macrocyclic oligo(5-acety

119 spergillus fumigatus, xanthocillin and other isocyanides derived from the xan biosynthetic gene clust

120 l chlorides are proposed as stable and novel isocyanide dichloride synthetic equivalents.

121 olipid frameworks by condensation of lipidic isocyanides either with lipidic amines and oligosacchari

122 The chemical behavior of these azido-isocyanides endowed with an aryl-triazolyl linker has be

123 acts with the unsaturated substrates such as isocyanide, ethylene, and ketone, concomitant with the c

124 B(Ar(F))(4)] reacts with SiBr(2)(SIDipp) via isocyanide exchange to afford the disilicon(II) salt [Si

125 he oxidative coupling of bisnucleophiles and isocyanides, facilitating the further implementation of

126 of aldehydes and ketones with 2 equiv of an isocyanide followed by a molecular rearrangement that in

127 zed coupling between arylpropiolic acids and isocyanides followed by a dehydro-Diels-Alder (DDA) reac

128 ing opening of oxazolones by cupriomethylene isocyanides followed by sequential construction of two o

129 n ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine derivatives, accor

130 clic compounds by integration of the in-line isocyanide formation and photochemical cyclization has b

131 Isocyanide (formerly isonitrile) hydratase (EC 4.2.1.103

132 hich are related to brassicicolin A, a known isocyanide from Alternaria brassicicola.

133 molecules, to support the idea of using the isocyanide functional group as an unconventional pharmac

134 Isocyanide functional groups can be found in a variety o

135 Rhabduscin is one such isocyanide-functionalized immunosuppressant produced in

136 d a novel oxidative coupling of diamines and isocyanides furnishing valuable guanidine-containing het

137 6)H(2)-2,4,6-(CH(3))(3))(2)] with tert-butyl isocyanide gave the Lewis adduct species (Ar(Me(6)))(2)G

138 sponding molecular junction terminated by an isocyanide group due to charge transport primarily throu

139 meta-terphenyl unit was substituted with an isocyanide group on each of its two terminal aryls to af

140 and *COOH on the active carbon sites of the isocyanide groups rather than on silver sites.

141 hanols with readily available isocyanoesters/isocyanides has been reported in this work.

142 ylene]-5-oxazolones with activated methylene isocyanides has been reported.

143 at the beginning of XXI century, hundreds of isocyanides have been isolated both in prokaryotes and e

144 Isocyanides have emerged as valuable C1 building blocks

145 Notwithstanding, the isocyanides have not gained a good reputation among medi

146 reactions with carbon monoxide and 2,6-xylyl isocyanide highlight the metallomimetic (ambiphilic) beh

147 The discovery of hydrogen isocyanide (HNC) in comet Hyakutake with an abundance (r

148 Here we report the detection of hydrogen isocyanide (HNC) in comet Hyakutake.

149 order to understand the structural basis for isocyanide hydratase (ICH) catalysis, we determined the

150 haracterize how covalent catalysis modulates isocyanide hydratase (ICH) conformational dynamics throu

151 azine, followed by nucleophilic attack of an isocyanide in a Reissert-type process.

152 3-(tritylthio)propanoate as a novel class of isocyanide in MCR.

153 mmetric dialkylcarbodiimides from azides and isocyanides in a process involving the Nb(V)/Nb(III) red

154 In contrast, all four isocyanides in P6 crystals of wild-type recombinant Mb o

155 Here we use isocyanides in place of carbon monoxide in a copolymeriz

156 We have evaluated a range of functionalized isocyanides in the aziridine aldehyde-driven multicompon

157 vestigate the intramolecular interactions of isocyanides in the solid state, excluding isocyanide-met

158 l acetoacetate with 1:1 acetylenecarboxylate-isocyanides in toluene.

159 to those of amine reactions with coordinated isocyanides in transition metal complexes.

160 nctionalized isocyanides refers to all those isocyanides in which a neighbouring functional group can

161 In this manuscript, we have reviewed all the isocyanides in which the pendant functional group causes

162 study on the homo- and heterodimerization of isocyanides, in particular on the influence of the subst

163 ing hydrogen peroxide (H2O2) using rhodamine isocyanide incorporated calcium phosphate nanoparticles

164 d with electrophiles to generate substituted isocyanides incorporating contiguous tri- and tetra-subs

165 o-(pseudo)halobenzoates and hydrazines with isocyanide insertion allowing straightforward access to

166 We also achieved the isocyanide insertion between C(sp(2))-H and oxygen heter

167 and further nickel-catalyzed intramolecular isocyanide insertion has also been demonstrated.

168 The scope of this isocyanide insertion reaction is rather broad, toleratin

169 ization of 2H-indazole at C3-position via an isocyanide insertion strategy for the synthesis of unpre

170 nickel-catalyzed ligand-/base-free oxidative isocyanide insertion under aerobic conditions with intra

171 second equivalent of the same or a different isocyanide inserts into the N-Si bond leading to the fin

172 then proceed through a key insertion of the isocyanide into a N-Si bond.

173 amino acids, aziridine aldehyde dimers, and isocyanides into chiral piperazinones have been investig

174 coupling cascade rapidly transforms aromatic isocyanides into highly functionalized cyclohexadienes.

175 stallographic Database-supported analysis of isocyanide intramolecular interactions to investigate th

176 es form a mixture of aminonitrene complexes, isocyanide iridium(III) dihydride complexes, and ammonia

177 2-Nitrophenyl isocyanide is introduced as a convertible isocyanide wit

178 rst conjugate addition/alkylation to alkenyl isocyanides is described, which addresses this deficienc

179 rdination networks using ditopic m-terphenyl isocyanides is described.

180 5-dimethylpyrazolyl)borate and L = neopentyl isocyanide, is used to investigate C-H bond activation i

181 omponent reaction with alpha-amino acids and isocyanides, is described.

182 ve examined the equilibrium binding of three isocyanides, isopropyl, n-butyl, and benzyl, to the two

183 surface anchoring groups such as thiols and isocyanides largely undergo reductive stripping before c

184 col to the coupling of anthranilic acids and isocyanides leading to medicinally relevant 2-aminobenzo

185 rcaptoethyl)amine (NS3)) and the monodentate isocyanide ligand (CN-peptide).

186 pecies (Ar(Me(6)))(2)GeCNBu(t), in which the isocyanide ligand displays a decreased C-N stretching fr

187 )MC states, whereas pyrene decoration of the isocyanide ligand framework provides control over intral

188 se Au...Au contact despite the fact that the isocyanide ligand has less steric bulk.

189 reaction in which a nitrene fragment from an isocyanide ligand is exchanged with a nitrene fragment o

190 ncer supporting ligand is supplemented by an isocyanide ligand that can accept electron density, faci

191 ively charged carbon atom of the carbonyl or isocyanide ligand, and illustrate a novel (non-hydrogen

192 the synthesis of a macrocyclic, tetradentate isocyanide ligand, CN(4), and facile coordination to rho

193 The encumbering m-terphenyl isocyanide ligand, CNAr(Mes2) (Mes = 2,4,6-Me(3)C(6)H(2)

194 ermanium atom and the C-N pi* orbital of the isocyanide ligand.

195 by the formation of an unusual chelating di(isocyanide) ligand, which suggests that other metal cent

196 umbered 2,6-diisopropylphenyl or m-terphenyl isocyanide ligands (Cu2-Cu4) exhibit prolonged excited-s

197 ein, we show that two sterically encumbering isocyanide ligands can destabilize the MnMn bond leading

198 ese simple molecules with two cyanide or two isocyanide ligands have two of the shortest and stronges

199 ize the adsorption of individual m-terphenyl isocyanide ligands on a reconstructed Au(111) surface th

200 es precedent for an ensemble of carbonyl and isocyanide ligands to function in a redox non-innocent m

201 Complex 2 reacts with Me3SiN3 to make the isocyanide ligated azide complex {(C5Me5)2La[CNN(SiMe3)2

202 ects are attributed to sigma-donation of the isocyanide lone pair electrons to the surface.

203 Cr(0) complexes with carbonyl or monodentate isocyanides, manifesting in comparatively slow photodegr

204 of isocyanides in the solid state, excluding isocyanide-metal complexes.

205 Isocyanides might dimerize forming 1,4-diazabutatrienes,

206 nditions and replacement of the nucleophilic isocyanide moiety with different electrophiles (i.e., is

207 ew structure with respect to a mixed cyanide/isocyanide monolayer and propose a bonding scheme consis

208 d scope in terms of its amine, aldehyde, and isocyanide nature.

209 The carbonyl (CO) and isocyanide (NC) groups of the self-assembled monolayer (

210 Thus, the diatomic cyanide (-CN) and isocyanide (-NC) ligands are as capable of stabilizing t

211 irect attachment of an C(O)OSiR3 group to an isocyanide nitrogen atom.

212 olled, solid-state preparation of Cu(I) tris-isocyanide nodes with a labile solvent ligand in a manne

213 x = 2, 3) affords a family of mixed carbonyl-isocyanides of the type [Fe(2)(S(2)C(n)H(2n)(CO)x(CNMe)(

214 sent the first detailed mechanistic study of isocyanide oligomerization by a p-block element species.

215 udies show that the adsorption of tert-butyl isocyanide on the (100) surface of germanium, measured u

216 ion occurs by initial eta1-adsorption of the isocyanide on the Au surface, which activates the isocya

217 er cleavage strategy, (p-tolysulfonyl)methyl isocyanide or ethyl isocyanoacetate was employed to reac

218 rmediates of CN(-) reduction, including iron isocyanides (P(3)(Si)FeCNH(+/0)) and terminal iron amino

219 chiral, rod-coil BCPs composed of poly(aryl isocyanide) (PAIC) rigid-rod and poly(ethylene glycol) (

220 Bis-isocyanide Pd(CNAr(Dipp2))(2) is active for oxidative ad

221 vides the isolable, two-coordinate Pd(0) bis-isocyanide, Pd(CNAr(Dipp2))(2), which is the first stabl

222 Isocyanides possess a rich history in the world of synth

223 lized isothiocyanates from the corresponding isocyanide precursors, achieving high to excellent yield

224 The cyanide and isocyanide products were increased markedly by mercury a

225 d the copper-chelating properties of xan BGC isocyanide products.

226 he use of a catalytic loading of an aromatic isocyanide promotes the oxidative coupling of N-phenyl-1

227 during imine formation is indicative of new isocyanide reactivity.

228 itiated mechanism involving an unprecedented isocyanide rearrangement followed by radical-radical ani

229 Complex 1c mediates a catalytic isocyanide reductive coupling to furnish an alkene produ

230 The term functionalized isocyanides refers to all those isocyanides in which a n

231 Two broader bands in the isocyanide region at 2098.2 and 2089.6 cm(-1) were assig

232 holate dianion in the presence of cyclohexyl isocyanide results in the formation of [(o-(Ph2P)C6H4)3(

233 enyl isocyanides to rapidly assemble diverse isocyanide scaffolds.

234 These correlations indicate that alkyl isocyanides serve as transition state analogues for the

235 rse bacteria and fungi, and synthetic valine isocyanide shows antibacterial activity.

236 ynthesis of 1 involves a 2e reduction of the isocyanide-stabilized silyliumylidene salt [SiBr(CNAr(Me

237 saturated substrates such as isocyanates and isocyanides, suggesting the intermediacy of a "normal" F

238 Isocyanide-supported cyclometalated platinum compounds u

239 nitrido wall by incorporating a redox-active isocyanide supporting ligand, which accommodates two ele

240 from the reaction of 1 and cyclopropylmethyl isocyanide supports the notion of a radical-based mechan

241 ated radical polymerization of acrylates and isocyanides synthesizes nonalternating poly(acrylate-co-

242 New multicomponent reactions involving an isocyanide, terminal or internal alkynes, and endohedral

243 lomics, that CrmA generates a valine-derived isocyanide that contributes to two distinct biosynthetic

244 Cyclic oxoalkenenitriles add 2 equiv of an isocyanide that installs the two core atoms of an acylpy

245 In the case of the Ugi reaction with benzyl isocyanide, the N-substituted tetrazoles can be easily d

246 Using benzyl isocyanide, the prepared N-benzyl tetrazoles can be depr

247 and steric interactions, and, for the longer isocyanides, the unfavorable hydrophobic effect of placi

248 A novel one-step addition of an isocyanide to a hydrazine derived Schiff base affords un

249 selectivities for the addition of tert-butyl isocyanide to a wide range of aldehydes (aromatic, heter

250 acyclic oxoalkenenitriles add 1 equiv of an isocyanide to afford 2-aminofurans; subsequent air oxida

251 anide on the Au surface, which activates the isocyanide to attack by the amine.

252 Mechanistically, BF(3).OEt(2) activates the isocyanide to facilitate deprotonation evolving to a zwi

253 ydrin adduct) can be trapped with tert-butyl isocyanide to form an alpha-hydroxy lactone with good se

254 Complex 4a reacts with n-butyl isocyanide to give the coordination product 6, which has

255 alyst-promoted proton transfer from hydrogen isocyanide to imine to generate diastereomeric iminium/c

256 reeing rotation of His64, causes bound butyl isocyanide to point completely outward in P6 crystals.

257 (H)L(iPr)Cr]2 reductively couples cyclohexyl isocyanide to produce various novel nitrogen heterocycle

258 as completely stopped by coordination of the isocyanide to the verdoheme intermediate rather than to

259 talytic, enantioselective alpha-additions of isocyanides to aldehydes has been demonstrated (Passerin

260 hydrogenation of nitroarenes, nitriles, and isocyanides to corresponding amines with excellent activ

261 sed to measure the binding parameters of the isocyanides to ferrous hHO-1.

262 nes by exploiting the preferential attack of isocyanides to nitrile N-oxides via a [3 + 1] cycloaddit

263 beta,beta-disubstituted arylsulfonyl alkenyl isocyanides to rapidly assemble diverse isocyanide scaff

264 y calculations suggest the substitution with isocyanides to take place via a stepwise addition/elimin

265 Addition of L = carbon monoxide or aryl isocyanides to the Grubbs second-generation carbene comp

266 enzyme of the DJ-1 superfamily that hydrates isocyanides to yield the corresponding N-formamide.

267 nd organic electrophiles (aldehyde, ketones, isocyanide) to form hydrogenated C(3) and C(4) carbon ch

268 CO and a hydrophobic cyanide analogue, butyl isocyanide, to dithionite-reduced b(6) f complex perturb

269 lino)-alpha-methoxy acetate with tosylmethyl isocyanide (TosMIC) reagent to give 1-(o-nitrophenyl)imi

270 single pot from aryl-substituted tosylmethyl isocyanide (TosMIC) reagents and imines generated in sit

271 erent surface-binding chemistries (thiol and isocyanide) under three different preparation conditions

272 Ar(Dipp2) revealed that free and coordinated isocyanide undergo rapid exchange, but the components do

273 The products include imide, isocyanide, vinyl, alkyl, azide, triazenido, benzo[ c]ci

274 ized by humans and in 1950 the first natural isocyanide was discovered.

275 ns, particularly the rate of addition of the isocyanide was found to be crucial for good yields and h

276 This bifunctional isocyanide was found to undergo mild cyclodehydration to

277 reaction between 4-hydroxydithiocoumarin and isocyanide was investigated, yielding substituted (E)-3-

278 High diasteroselectivity for each isocyanide was observed.

279 In 1859 the first isocyanide was synthesized by humans and in 1950 the fir

280 ady-state activity assays showed that benzyl isocyanide was the most potent uncompetitive inhibitor w

281 Benzyl isocyanide was the strongest ligand to ferrous heme in a

282 ides from electron-poor organic bromides and isocyanides was developed.

283 The cyclization of allenoates with activated isocyanides was reported for the first time.

284 To illustrate the broader applicability of isocyanides, we have recently developed a novel oxidativ

285 nt nucleophilicity of aromatic and aliphatic isocyanides, we selectively react aliphatic isocyano gro

286 Substituted tosylmethyl isocyanides were found to be the key intermediates in co

287 yl imidazolylidene (NHC) does not react with isocyanides, whereas anti-Bredt di(amino)carbene (pyr-NH

288 and (ii) those with more strongly pai-acidic isocyanides, which adopt a "contracted" structure with a

289 groups: (i) those with moderately pai-acidic isocyanides, which adopt a "typical" structure character

290 Reaction of the isocyanide with an ergot alkaloid precursor results in c

291 yl isocyanide is introduced as a convertible isocyanide with demonstration of its feasibility and app

292 and copper complexes with phenanthroline and isocyanides with almost millesecond emission lifetimes t

293 med in situ via a catalytic sulfurization of isocyanides with elemental sulfur, preventing the exposu

294 The radical fluoroalkylation of isocyanides with fluorinated sulfones is enabled by visi

295 iphatic, dipeptidic, glucosidic, and lipidic isocyanides with several amino acids, thus giving access

296 vity for coupling tosyl azide and tert-butyl isocyanide, with Mn and Co derivatives showing the faste

297 rongly reinforced by the reaction of 1a with isocyanide Xyl-NC (Xyl = 2,6-Me(2)C(6)H(3)), isoelectron

298 bstituted oxazolones and activated methylene isocyanides, yielding bisoxazoles with three potential p

299 ZnCN and NCZnZnCN cyanides and higher energy isocyanides ZnNC, CNZnNC, and CNZnZnNC, which were isola

300 -2H-chromen-2-ones with acetylenecarboxylate-isocyanide zwitterionic intermediates through Michael ad