ライフサイエンスコーパス: isoleucine residue

1 functionality depends on the presence of an isoleucine residue.

2 aline, and the indistinguishable leucine and isoleucine residues.

3 es, including differentiation of leucine and isoleucine residues.

4 formation with a hinge region around the two isoleucine residues.

5 lkyl aryl ether linkage between the dopa and isoleucine residues.

6 Both the deletion of the isoleucine residue 141 and its substitution to valine in

7 mediated by the GCI (glycine, cysteine, and isoleucine) residues (188-190) of RhoB.

8 ucine residue and the other a deletion of an isoleucine residue (881).

9 cell culture and mice, indicating that this isoleucine residue acts as a gate that controls ADP-ribo

10 n bonds involving the methyl groups of three isoleucine residues and the O2 and N3 atoms of the two c

11 Leucine and isoleucine residues are readily distinguished in L-Ala-L

12 in one allele, which leads to the loss of an isoleucine residue at codon 141, and a 423A-->G transver

13 man population response were dependent on an isoleucine residue at position 129.

14 In addition, we show that the mutating the isoleucine residue at position 44 interferes with protea

15 Mutation of the isoleucine residue at position 49 to glycine (I49G) redu

16 of vertebrate insulins contains an invariant isoleucine residue at position A2.

17 nding PDZ domains is the accommodation of an isoleucine residue at the C-terminal position (P(0)), a

18 mino acid 97, we systematically replaced the isoleucine residue at this position with 18 other amino

19 dditional conformational change, implicating isoleucine residues at position 398 along the pore linin

20 impacts were specific to substitutions with isoleucine residues because functional modulation was pa

21 The mutation is the deletion of an isoleucine residue from a highly conserved hydrophobic d

22 Targets included adjacent aspartate/isoleucine residues implicated as important for determin

23 cificity of CnCda4 by converting an atypical isoleucine residue in a flexible loop region to the bulk

24 Disruption of either isoleucine residue in the eIF1A C-terminal sequence DIDD

25 Mutation of a highly conserved isoleucine residue in the FH2 domain does not inhibit bu

26 biophysical approaches, we have uncovered an isoleucine residue in the kinase domain of the Tec famil

27 rm the identity of nearly 60% of leucine and isoleucine residues in a synthetic peptide mixture.

28 f Keap1 comprised of hydrophobic leucine and isoleucine residues in agreement with a traditional NES

29 1, C(gamma)2, and C(delta) shifts in the two isoleucine residues in bovine pancreatic trypsin inhibit

30 ments were made at five different leucine or isoleucine residues in the alpha subunit of tryptophan s

31 ondary structure, the hydrophobic triplet of isoleucine residues in the center of the IC3 is found in

32 Conserved isoleucine residues in the center of the pore serve as t

33 that the first layer of the highly conserved isoleucine residues in the filter is primarily responsib

34 rentiation of prominent isomeric leucine and isoleucine residues in the HLA-A*02:01 motif.

35 The altered isoleucine residue lies within the third conserved alpha

36 r Waals interactions with either a valine or isoleucine residue located either seven or eight residue

37 results suggest that the targeted aspartate/isoleucine residues may contribute to regulator binding

38 les describing retroviral cleavage sites, an isoleucine residue placed at the P1 position of the NC-P

39 of serotonin transporter (SERT) contains two isoleucine residues previously proposed to be involved i

40 Rho GTPases due to a distinctive switch one isoleucine residue reminiscent of the constitutively act

41 tightly packed hydrophobic core, clusters of isoleucine residues, salt-bridges, and the presence of p

42 In particular, we have focused on an isoleucine residue that interacts with the adenine moiet

43 an allosteric communication with a conserved isoleucine residue that lines the binding channel for hi

44 id residue to aspartic acid, or changing the isoleucine residue that precedes the motif to proline, p

45 To mimic interacting leucine and isoleucine residues, we have created new amino acids tha

46 arameters for all methyl groups of the seven isoleucine residues were determined.

47 sis showed that more than 93% of the encoded isoleucine residues were replaced by 5TFI.

48 to-cell fusion, the six heptadic leucine and isoleucine residues were replaced with alanine by site-d

49 n two of the four middle heptadic leucine or isoleucine residues were replaced with alanine.

50 d w-type ions, 45 of 50 detected leucine and isoleucine residues were successfully distinguished and

51 acetylated and interacts with a pore-lining isoleucine residue where RNA editing regulates fast inac

52 cids in the range from valine to leucine and isoleucine residues, will be more robust in the face of

53 gammaB-crystallin gene that replaces the 4th isoleucine residue with a phenylalanine (gammaB-I4F).

54 Moreover, mutation of the isoleucine residue within an NPIR-like motif of the prop

55 anine or a serine substitution at a critical isoleucine residue within the zipper region were also ge

56 is of the HeV G stalk, targeting a series of isoleucine residues within a hydrophobic alpha-helical d

57 f helix-destabilizing, ss-branched valine or isoleucine residues within the TMD restores normal secre