1 We have previously shown that limitation for
isoleucyl-tRNA can initiate a ribosome bypass when an AU
2 t less error-prone and kinetically optimized
isoleucyl-tRNA(
Ile) synthesis under cellular conditions.
3 olo-form while MupM is a mupirocin-resistant
isoleucyl tRNA synthase, preventing self-poisoning.
4 d mutations in the P. falciparum cytoplasmic
isoleucyl tRNA synthetase (cIRS).
5 ity determinant for proper aminoacylation by
isoleucyl tRNA synthetase (IleRS) and codon recognition
6 orf, whose function is unknown; divIVA; and
isoleucyl tRNA synthetase (ileS).
7 In cattle, cytosolic
isoleucyl-tRNA synthetase (IARS) missense mutations caus
8 For example, the close homologs
isoleucyl-tRNA synthetase (IleRS) and valyl-tRNA synthet
9 Using Escherichia coli
isoleucyl-tRNA synthetase (IleRS) as a model enzyme, we
10 Isoleucyl-tRNA synthetase (IleRS) catalyzes transfer of
11 Escherichia coli
isoleucyl-tRNA synthetase (IleRS) exploits both the tRNA
12 Isoleucyl-tRNA synthetase (IleRS) is an aminoacyl-tRNA s
13 Isoleucyl-tRNA synthetase (IleRS) is unusual among amino
14 milar amino acids, valine and isoleucine, by
isoleucyl-tRNA synthetase (IleRS) results, in part, from
15 he rate of activation of 5TFI by the E. coli
isoleucyl-tRNA synthetase (IleRS) yielded a specificity
16 Leucyl-tRNA synthetase (LeuRS),
isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthe
17 Leucyl-tRNA synthetase (LeuRS),
isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthe
18 he Staphylococcus aureus ileS gene, encoding
isoleucyl-tRNA synthetase (IleRS), contains a long mRNA
19 We show that in the synthetic site of
isoleucyl-tRNA synthetase (IleRS), Nva and Val are activ
20 Here, it is shown that
isoleucyl-tRNA synthetase (IleRS), which occasionally mi
21 e analog that inhibits the essential enzyme,
isoleucyl-tRNA synthetase (IleRS).
22 ereas mupirocin targets the essential enzyme
isoleucyl-tRNA synthetase (IleRS).
23 electively inhibiting eukaryotic cytoplasmic
isoleucyl-tRNA synthetase (IleRS).
24 Administration of mupirocin, an inhibitor of
isoleucyl-tRNA synthetase activity, resulted in changes
25 Here I show that
isoleucyl-tRNA synthetase aminoacylates CoA-SH with vali
26 ied small molecules that inhibit recombinant
isoleucyl-tRNA synthetase and that are lethal to the par
27 , which are also conserved in the homologous
isoleucyl-tRNA synthetase and valyl-tRNA synthetase edit
28 Together with prior analyses of
isoleucyl-tRNA synthetase and valyl-tRNA synthetase, the
29 Using
isoleucyl-tRNA synthetase as an example, we placed mutat
30 s reliance on post-transfer editing, whereas
isoleucyl-tRNA synthetase differs in retaining a distinc
31 ese eukaryote-like features, M. tuberculosis
isoleucyl-tRNA synthetase exhibited highly specific cros
32 As an example, discrete sites in
isoleucyl-tRNA synthetase for amino acid activation and
33 y halted before isoleucine codon by reducing
isoleucyl-tRNA synthetase from reaction mixture of in vi
34 Methanosarcina species by mutagenesis of the
isoleucyl-tRNA synthetase gene (ileS) from Methanosarcin
35 In this study, a novel group of
isoleucyl-tRNA synthetase gene (ileS) T box leader seque
36 The monomeric Escherichia coli
isoleucyl-tRNA synthetase has a zinc-containing peptide
37 We showed by RNAi knockdown that T. brucei
isoleucyl-tRNA synthetase is essential for the parasites
38 Escherichia coli
isoleucyl-tRNA synthetase is one of five closely related
39 For example,
isoleucyl-tRNA synthetase misactivates valine (to produc
40 In the absence of tRNA,
isoleucyl-tRNA synthetase misactivates valine, while val
41 Substitution of a homologous CP1 domain from
isoleucyl-tRNA synthetase or mutation within the LeuRS C
42 Here we report that a specific mutation in
isoleucyl-tRNA synthetase prevents editing by blocking t
43 Recent mutational analysis of an
isoleucyl-tRNA synthetase showed that discrimination of
44 mutations in a presumptive "hinge region" of
isoleucyl-tRNA synthetase that is situated between the t
45 Valyl-tRNA synthetase, a close homolog of
isoleucyl-tRNA synthetase, misactivates threonine, alpha
46 eukaryote-like features, and unlike E. coli
isoleucyl-tRNA synthetase, the M. tuberculosis enzyme ch
47 For
isoleucyl-tRNA synthetase, these errors are reduced by t
48 as demonstrated by its ability to complement
isoleucyl-tRNA synthetase-deficient mutants of E. coli.
49 hromosomally encoded organellar (apicoplast)
isoleucyl-tRNA synthetase.
50 parasites had a mutation in the cytoplasmic
isoleucyl-tRNA synthetase.
51 were investigated with an editing-defective
isoleucyl-tRNA synthetase.
52 yl adenylates by editing synthetases such as
isoleucyl-tRNA synthetase.
53 m with p43, as well as cross-reactivity with
isoleucyl-tRNA synthetase.
54 ase of the particle and maps the location of
isoleucyl-tRNA synthetase.
55 mary structure of Mycobacterium tuberculosis
isoleucyl-tRNA synthetase.
56 Vertebrate cytoplasmic
isoleucyl-tRNA synthetases (IARS1s) have an uncharacteri
57 by bacterial-type but not by eukaryotic-type
isoleucyl-tRNA synthetases and might also be a determina
58 Examples include
isoleucyl-tRNA synthetases whose acquisition from eukary
59 or of Escherichia coli and other eubacterial
isoleucyl-tRNA synthetases, but not of eukaryote cytopla
60 aryote cytoplasmic than to other eubacterial
isoleucyl-tRNA synthetases.