ライフサイエンスコーパス: isomerase

1 around the block of stromal triose phosphate isomerase.

2 on of a hydrophobic clamp in triosephosphate isomerase.

3 metabolism by inhibition of triose-phosphate isomerase.

4 e ER lumen is prevented by protein disulfide isomerase.

5 D) is a mitochondrial matrix peptidyl-prolyl isomerase.

6 by serving as an IKK scaffold as well as an isomerase.

7 enzymatic function of a spliceosomal proline isomerase.

8 s and proteins and is present in other thiol isomerases.

9 nderstanding of the mechanisms guiding lyase isomerases.

10 al module homologous to enoyl-CoA hydratases/isomerases.

11 for an interaction with the peptidyl prolyl isomerase 1 (Pin1), a critical component of PDPK-mediate

12 TASE (SBPase), the PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 20-3 (CYP20-3), and ENOLASE2 (ENO2).

13 the endomembrane proteins protein disulfide isomerase 5 (PDI5) and NAI2, with the PDI5 interaction b

14 des encoded by the peptidyl-prolyl cis-trans isomerase A (PPIA) gene whose abundance was increased in

15 n A, also known as peptidylprolyl cis-/trans-isomerase A (PPIA), as a foldase is beneficial intracell

16 n A, also known as peptidylprolyl cis-/trans-isomerase A (PPIA), is a mediator of the neuroinflammato

17 proteins were identified as triosephosphate isomerase A and Protein FAM45A.

18 serve that the dual-substrate phosphoribosyl isomerase A or priA gene, at which these pathways conver

19 (encoding 3beta-hydroxysteroid-Delta8,Delta7-isomerase), a key enzyme in the cholesterol biosynthesis

20 Catalysis is achieved by peptidylprolyl isomerases, a superfamily of molecular chaperones.

21 In B cells, protein disulfide isomerase A1 (PDIA1/P4HB), the most abundant ER oxidored

22 ick protein, I. scapularis protein disulfide isomerase A3 (IsPDIA3), enhances B. burgdorferi coloniza

23 ng calnexin, calreticulin, protein disulfide isomerase A3, tapasin, TAP1, and TAP2.

24 Protein disulfide isomerase A6 (PDIA6) interacts with protein kinase RNA-l

25 an essential gene encoding protein disulfide isomerase A6 (PDIA6), an oxidoreductase that functions i

26 The retinol-isomerase activities of Rpe65 and Des1 are inhibited by

27 that in addition to its known histone prolyl isomerase activities, the Fpr4 FKBP domain binds to nucl

28 The compounds inhibited peptidyl-prolyl isomerase activity (half maximal inhibitory concentratio

29 R) and phenylpyruvate tautomerase/dopachrome isomerase activity (MIF and DDT genes).

30 ding of type III collagen through its prolyl isomerase activity and acted as a molecular chaperone fo

31 sis studies on specific residues abolish the isomerase activity and decrease the multidrug binding ca

32 d tested them against CypD using binding and isomerase activity assays.

33 itor of ACSLs, also potently inhibited RPE65 isomerase activity in cellulo.

34 n unfolding, inhibition of PDI reductase and isomerase activity in vitro and in vivo, and subsequent

35 the enzymatic center, and affected disulfide isomerase activity in vitro.

36 ase-substrate interaction, but we found that isomerase activity is not critical for function.

37 ding to 11-cis-retinoid, CRALBP augments the isomerase activity of retinoid isomerohydrolase RPE65 (R

38 and influences its peptidyl-prolyl cis/trans isomerase activity on residue Pro(314) of NS5A-D2.

39 The effect of beta-galactosidase to glucose isomerase activity ratio and glutaraldehyde to protein m

40 EBI2 signaling activated Pin1 isomerase activity through a cascade that was sensitive

41 zation/transmission, and exhibits disulphide isomerase activity which is up-regulated post-gamete act

42 ne-rich repeat containing 15 [LRRC15]), and "isomerase activity" (FKBP8).

43 layed restored RPE65 expression and retinoid isomerase activity, and near-normal levels of retinal an

44 or contributes to, trans-to-cis violaxanthin isomerase activity, producing both cis-xanthophyll precu

45 to have an additional, unexpected oxidative isomerase activity, thus making it a trifunctional enzym

46 ectly phosphorylated by MLK3 to increase its isomerase activity.

47 ophosphorylase, fumarase, and phosphoglucose isomerase activity.

48 r- and substrate-binding mutase domains with isomerase activity.

49 This activates CypD's isomerase activity.

50 thase FATP2/SLCA27A2 to test their effect on isomerase activity.

51 PE65 is not dependent on O2 for its cleavage/isomerase activity.

52 itivity with other reported triose-phosphate isomerase allergens.

53 Vascular thiol isomerases also act as redox sensors.

54 a competitive inhibitor of triose phosphate isomerase, an enzyme in the Calvin-Benson cycle that con

55 ion of the BCO-related outlier RPE65 retinol isomerase, an enzyme that does not utilize carotenoids a

56 and kinase (Escherichia coli) followed by an isomerase and aldolase sequentially function to salvage

57 fied as a secreted peptidyl-prolyl cis/trans isomerase and chaperone that is dispensable for bacteria

58 hPDI) is an endoplasmic reticulum (ER) based isomerase and folding chaperone.

59 ially reduced in mice deficient in the Rpe65 isomerase and in mice deficient in cellular retinaldehyd

60 This has led to the hypothesis that the isomerase and lyase activities performed by the MST enzy

61 two key glycolytic enzymes, triosephosphate isomerase and phosphofructokinase.

62 le isozyme, beta-enolase and triosephosphate isomerase and phosphoglucomutase-1.

63 by this algorithm, genes (ribose 5-phosphate isomerase and ribulose 5-phosphate 3-epimerase) in the p

64 Calvin-Benson cycle enzymes triose-phosphate isomerase and sedoheptulose 1,7-bisphosphate phosphatase

65 synuclein reverses the action of the proline isomerase and turns it into a potent molecular chaperone

66 m enabled through the introduction of xylose isomerase and xylulokinase.

67 on requires help from other proteins such as isomerases and chaperones.

68 mechanism of dual functionality in cis/trans isomerases and define its molecular determinants acting

69 protein structure via their oxidoreductase, isomerase, and chaperone activities.

70 by two proteins with homology to ketosteroid isomerases, and assisted by two proteins with homology t

71 ional change in catalysis by triosephosphate isomerase are presented.

72 Thiol isomerases are multifunctional enzymes that influence pr

73 These vascular thiol isomerases are released following vessel injury and part

74 on of biological catalysis using ketosteroid isomerase as a prototypic example.

75 the yeast glycolytic enzyme triose phosphate isomerase as being aggregation-prone in response to cadm

76 antigen A and the peptidyl-prolyl cis-trans isomerase, as well as the Enterococcus faecalis polysacc

77 We further characterized triose-phosphate isomerase (Asp t 36), one of the dominant IgE (IgE)-reac

78 ses, and some of these enzymes, called lyase isomerases, attach phycoerythrobilin and simultaneously

79 e Escherichia coli peptidyl-prolyl cis/trans-isomerase B following mutation of two phenylalanine resi

80 novel morbid gene TXNDC15, encoding a thiol isomerase, based on independent loss of function mutatio

81 bridge leading to loss of protein disulfide isomerase binding and lipid transfer activities; however

82 arrier for alpha-synuclein misfolding, while isomerase-binding to a separate, disease-associated prot

83 ct types (racemases/epimerases and cis-trans isomerases), but reactions entailing structural isomeris

84 xidoreductin 1 (Ero1), and protein disulfide-isomerase can be inactivated by a feedback inhibition me

85 However, thiol isomerases can escape endoplasmic retention and be secre

86 RPE65 is the isomerase catalyzing conversion of all-trans-retinyl est

87 retoglobin family 1D and glucose-6-phosphate isomerase characterized the LF phenotype.

88 ibute to the terrestrial plants and chalcone isomerase (CHI)-catalyzed intramolecular and stereospeci

89 -3' HYDROXYLASE (F3'H) gene, nco in CHALCONE ISOMERASE (CHI).

90 reatment with 17l in the glucose-6-phosphate isomerase chronic in vivo mouse model of arthritis yield

91 derstanding of the mechanisms by which thiol isomerases control vascular function, the clinical utili

92 Phosphomannose isomerase controls response of LPS-activated macrophages

93 he cytosol, where cytosolic triose phosphate isomerase could convert it to dihydroxyacetone phosphate

94 tene isomers in the fruit due to a defective isomerase (CRTISO) and the old gold crimson (og(c) ) tom

95 s of PHYTOENE SYNTHASE (PSY1) and CAROTENOID ISOMERASE (CRTISO) as well as the strigolactone apocarot

96 Pseudomonas spp. possess a cis-trans isomerase (Cti) an enzyme that converts the cis-unsatura

97 nce, whose interaction with the human prolyl isomerase cyclophilin A (CypA) is essential for viral RN

98 raction between ANT3 and the peptidyl-prolyl isomerase cyclophilin D (CypD), mortalin decreased mitoc

99 silencing the mitochondrial peptidyl prolyl isomerase cyclophilin-D (Cyp-D) reduces Vo(2).

100 The peptidylprolyl isomerase, cyclophilin D (CypD, PPIF), is a positive reg

101 ontrol) and mice deficient in peptidylprolyl isomerase D (cyclophilin D, encoded by Ppid) by administ

102 ked genes, we nominated Ppid (peptidylprolyl isomerase D, a member of the tetratricopeptide repeat (T

103 Ls promote complement- and protein disulfide isomerase-dependent TF-integrin beta1 trafficking that t

104 A putative alternative retinoid isomerase, dihydroceramide desaturase-1 (DES1), is expre

105 tion was located in the C-terminal disulfide isomerase domain of PDI, sterically close to the enzymat

106 omain and a C-terminal FKBP peptidyl-proline isomerase domain.

107 mprises a core domain and two peptidylprolyl isomerase domains (P1 and P2), but its mechanisms of cli

108 onversely, over-expression of the disulphide isomerase DsbA increases the colistin MIC of laboratory

109 Another thiol isomerase, endoplasmic reticulum protein 5 (ERp5), is in

110 nism whereby binding of a substrate to thiol isomerases enhances catalytic activity of remote domains

111 In bacteria and fungi one desaturase/isomerase enzyme completes the same series of reactions.

112 An isomerase enzyme is thought to be responsible for the tr

113 etinyl esters to 11-cis-retinol, is also the isomerase enzyme responsible for the production of meso-

114 Thus, a subclass of FKBP prolyl isomerase enzymes is recruited to linker regions of chro

115 The isomerase enzymes release isochorismate or aminodeoxycho

116 thiol isomerases including protein disulfide isomerase, ERp57, and ERp5 are secreted by and localize

117 synergized with inhibitors of PIN1, a prolyl isomerase essential for IRAK1 activation in response to

118 Here we describe a protein disulphide isomerase essential for malarial transmission (PDI-Trans

119 Cyclophilin D (CypD) is a peptidyl-prolyl isomerase expressed in the nucleus and transported into

120 nd knockout mice deficient in peptidylprolyl isomerase F (Ppif) or deficient in both Ppif and Mlkl.

121 e five TMX proteins of the protein disulfide isomerase family, hitherto not linked to human developme

122 d inhibition of the 12-kDa cis-trans proline isomerase FK506-binding protein (FKBP12).

123 mbi-CLEAs) of beta-galactosidase and glucose isomerase for catalyzing the cascade reactions of lactos

124 erium tuberculosis (Mtb) DprE1, an essential isomerase for the biosynthesis of the mycobacterial cell

125 protein model of AMF, namely phosphoglucose isomerase from rabbit muscle (RmPGI).

126 udies of the IGPS-phosphoribosylanthranilate isomerase fusion protein from Escherichia coli Here, we

127 hared mutations: amplification of the xylose isomerase gene and inactivation of ISU1, a gene encoding

128 The glucose isomerase GICA from Caldicoprobacter algeriensis was imm

129 Here we show that the bacterial heptose isomerase GmhA displays homotropic positive and negative

130 vivo efficacy in a mouse glucose-6-phosphate isomerase (GPI)-induced paw swelling model comparable to

131 y of the glycolytic enzyme glucose phosphate isomerase (Gpi1) selectively eliminates inflammatory enc

132 c disulfide bonds that are modified by thiol isomerases have been described in substrates such as alp

133 ines to leucines abolished protein disulfide isomerase heterodimerization, lipid transfer, and apoB s

134 by the cyclophilin family of peptidyl-prolyl isomerases, highlighting the potential for regulation of

135 Human protein disulphide isomerase (hPDI) is an endoplasmic reticulum (ER) based

136 reduced a domain of human protein disulfide isomerase (hPDI) with atomistic resolution.

137 The human protein disulfide isomerase (hPDI), is an essential four-domain multifunct

138 ent oncogenic event and a biomarker for Topo-isomerase I inhibitor based therapy.

139 Correspondingly, Topo-isomerase I inhibitors effectively and preferentially el

140 mic instability and hypersensitivity to Topo-isomerase I inhibitors.

141 events replication-dependent removal of Topo-isomerase I-DNA adducts at the step of strand cleavage,

142 The enzyme IDP isomerase (IDI) catalyzes the interconversion between ID

143 desaturase-1, the putative all-trans retinol isomerase in Muller cells, appears to be 9-cis retinol.

144 ductase reactions can be employed to replace isomerases in vitro for biotransformation.

145 Several thiol isomerases including protein disulfide isomerase, ERp57,

146 The peptidyl-prolyl isomerase inhibitor Cyclosporine A (CsA) selectively kil

147 (ii) the DHAP analogue and triose-phosphate isomerase inhibitor phosphoglycolohydroxamate (PGH).

148 adient-2 (AGR2), a soluble protein-disulfide isomerase involved in ER protein folding and quality con

149 ERp57 is a disulfide isomerase involved in the folding of a subset of glycopr

150 tudy, we cloned an isopentenyl pyrophosphate isomerase (IPPI) cDNA, AaIPPI1, from Artemisia annua (Aa

151 e cis/trans equilibrium, catalyzed by prolyl isomerases, is shifted towards trans, while steady-state

152 3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase, known as Emopamil-Binding Protein (EBP), is a

153 e active site base of the enzyme ketosteriod isomerase (KSI) allows efficient and saturable base resc

154 of an aspartate general base in ketosteroid isomerase (KSI) by exogenous rescue.

155 aphy data for Pseudomonas putida ketosteroid isomerase (KSI), and we obtained conformational ensemble

156 in the active site of the enzyme ketosteroid isomerase (KSI).

157 r the naturally occurring enzyme ketosteroid isomerase (KSI).

158 tric field in the active site of ketosteroid isomerase (KSI).

159 de the active site of the enzyme ketosteroid isomerase (KSI).

160 g the spliceosome components Peptidyl-Prolyl Isomerase Like-1 (PPIL1) or Pre-RNA Processing-17 (PRP17

161 or in maize indicated that protein disulfide isomerase-like and phosphoglycerate kinase were required

162 tinct modules: an N-terminal sugar phosphate isomerase-like domain associated with DSD activity and a

163 rk, we study Lactobacillus sakei L-arabinose isomerase (LsLAI) for D-galactose to D-tagatose isomeriz

164 thermodynamic, kinetic, or stability issues (isomerases, lyases, transglycosidases).

165 sly unappreciated role for Mannose phosphate isomerase (MPI) as a metabolic enzyme required to mainta

166 children with mutations in mannose phosphate isomerase (MPI) develop liver fibrosis led us to explore

167 The mannose-6-phosphate isomerase (Mpi) locus in Semibalanus balanoides has been

168 ase (MtnP), 5-(methylthio)ribose-1-phosphate isomerase (MtnA), and an annotated class II aldolase-lik

169 pistatic interaction between a zeta-carotene isomerase mutant (ziso-155) and ccr2 blocked the biosynt

170 n centre for aldoxime dehydratase, cis-trans isomerase, N-N bond formation, hydrazine formation and S

171 ssociated retinal pigment epithelium (RPE)65 isomerase necessary for recycling 11-cis-retinal, the li

172 with binding of a peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) to p53-RS, but not t

173 ere, we describe a peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)-dependent mechanism

174 ng carotenoid isomerase (yofi), a carotenoid-isomerase nonsense mutant, which arrests the turnover of

175 This study provides an overview of which isomerases occur in nature, how we should describe and c

176 pigment epithelium (RPE), is a key retinoid isomerase of the visual cycle necessary for generating 1

177 we evaluate the role of a candidate retinol isomerase of this pathway, sphingolipid delta4 desaturas

178 ave shown that the peptidyl-prolyl cis/trans isomerase parvulin 17 (Par17) interacts with tubulin in

179 correct DSB errors through protein-disulfide isomerase (PDI) activity.

180 Protein disulfide isomerase (PDI) and endoplasmic reticulum protein 57 (ER

181 his model was dependent on protein disulfide isomerase (PDI) and TF expression by myeloid cells, but

182 gest that the catalysis by protein disulfide isomerase (PDI) and thiol-disulfide exchange is mostly e

183 e therapeutic potential of protein disulfide isomerase (PDI) as a target to overcome resistance to ch

184 an MTPalpha subunit and a protein disulfide isomerase (PDI) beta-subunit.

185 Thiol isomerases such as protein-disulfide isomerase (PDI) direct disulfide rearrangements required

186 doxin, oxidoreductase, and protein disulfide isomerase (PDI) families, among others.

187 a protein belonging to the protein disulfide isomerase (PDI) family, is overexpressed in multiple can

188 (AGR2) is a member of the protein disulfide isomerase (PDI) family, which plays a role in the regula

189 Protein disulfide isomerase (PDI) has two distinct CGHC redox-active sites

190 we describe a new class of protein disulfide isomerase (PDI) inhibitors that significantly and synerg

191 Protein disulfide isomerase (PDI) interacts with these early intermediates

192 Protein disulfide isomerase (PDI) is a chaperone protein in the endoplasmi

193 Protein-disulfide isomerase (PDI) is a ubiquitous dithiol-disulfide oxidor

194 Protein disulfide isomerase (PDI) is an oxidoreductase essential for foldi

195 Protein disulfide isomerase (PDI) is responsible for nascent protein foldi

196 increase in the levels of protein-disulfide isomerase (PDI), a multifaceted endoplasmic reticulum re

197 his enzyme cooperates with protein disulfide isomerase (PDI), a redox chaperone previously implicated

198 ule and lysosome cargo and protein disulfide isomerase (PDI), all of which serve to stabilize thrombu

199 e protein A (NusA), human protein disulphide isomerase (PDI), and the b'a' domain of PDI (PDIb'a').

200 Protein disulfide isomerase (PDI), secreted by platelets and endothelial c

201 Surprisingly, we find that protein disulfide isomerase (PDI), the major protein oxidase of the ER lum

202 s]), the gene that encodes protein disulfide isomerase (PDI).

203 ted protein 94 (GRP94) and protein disulfide isomerase (PDI).

204 ization of Tom20/Nur77 and Protein Disulfide Isomerase (PDI)/Nur77.

205 Thus, inhibition of protein disulfide isomerases (PDI) required for protein folding in the end

206 mannosidase Htm1p and the protein disulfide isomerase Pdi1p (Htm1p-Pdi1p) acts as a folding-sensitiv

207 interaction of VWF and the protein disulfide isomerase PDIA1, which has previously been used to visua

208 ticulum and is mediated by protein disulfide isomerase (PDIA1).

209 Protein disulfide isomerases (PDIs) areERfoldases identified as possibleAL

210 Protein disulfide isomerases (PDIs) play a central role in this process.

211 Protein disulfide isomerases (PDIs) support endoplasmic reticulum redox pr

212 Isomerases perform biotransformations without cofactors

213 concentration is dependent on phosphoglucose isomerase (PGI) activity.

214 conate, a potent inhibitor of phosphoglucose isomerase (PGI).

215 ycolysis cascade: hexokinase, phosphoglucose isomerase, phosphofructokinase and aldolase.

216 The prolyl isomerase Pin1 enhanced p53-dependent BAX activation by

217 s of BRD4 are positively regulated by prolyl isomerase PIN1 in gastric cancer cells.

218 identify a homologue of the peptidyl-prolyl isomerase PIN1 in T. annulata (TaPIN1) that is secreted

219 and a unique therapeutic target, the prolyl isomerase Pin1 is overexpressed in a majority of HCCs, w

220 n was suppressed by inhibitors of the prolyl isomerase Pin1 or extracellular signal-regulated kinases

221 The prolyl isomerase PIN1, a critical modifier of multiple signalli

222 K, conformation of XPO5 is altered by prolyl isomerase Pin1, resulting in reduction of pre-miRNA load

223 tch3 is a novel target protein of the prolyl-isomerase Pin1, which is able to regulate Notch3 protein

224 iated by the phosphorylation-directed prolyl isomerase PIN1.

225 h is further regulated by the unique proline isomerase Pin1.

226 ia analysis of fission yeast peptidyl-prolyl isomerase Pin1.

227 catalyzed by the peptidyl-prolyl cis-/trans isomerase Pin1.

228 al recognition sites for the peptidyl-prolyl isomerase Pin1.

229 catalyzed by the peptidyl-prolyl cis-/trans isomerase Pin1.

230 orylation-specific peptidyl-prolyl cis/trans isomerase Pin1.

231 double-strand breaks is regulated by prolyl isomerase Pin1.

232 We also show that a peptidyl-prolyl isomerase PINN-1 antagonizes SYDN-1 in the spatiotempora

233 not exposed to VCs, plastidic phosphoglucose isomerase (pPGI) acts as an important determinant of pho

234 n mesophyll cells (plastidial phosphoglucose isomerase [pPGI]).

235 f MLK3 down-regulates expression of a prolyl-isomerase, Ppia, which is directly phosphorylated by MLK

236 Here, we postulated that peptidyl prolyl isomerase (PPIase) activity of FKBP65 positively modulat

237 nomeric functional peptidyl-prolyl cis-trans isomerase (PPIase) activity.

238 Hsp90 binding and peptidyl-prolyl cis-trans isomerase (PPIase) activity.

239 n A is a conserved peptidyl-prolyl cis-trans isomerase (PPIase) best known as the cellular receptor o

240 dy, we demonstrate that the prolyl cis-trans isomerase (PPIase) cyclophilin A (CypA) is hijacked by L

241 omain flexibly tethered to a peptidyl-prolyl isomerase (PPIase) domain, resulting in interdomain inte

242 urA has a core domain and two peptidylprolyl isomerase (PPIase) domains, the role(s) of which remain

243 , a superfamily of peptidyl-prolyl cis-trans isomerase (PPIase) enzymes have been shown to be importa

244 roxylase (LH) 2 or peptidyl-prolyl cis-trans isomerase (PPIase) FKBP65.

245 Human peptidyl-prolyl isomerase (PPIase) Pin1 plays key roles in developmental

246 ed Dwarf1 (TWD1), a peptidylprolyl cis-trans isomerase (PPIase), but all attempts to demonstrate such

247 Peptidyl-proline isomerases (PPIases) are a chaperone superfamily compris

248 Peptidylprolyl isomerases (PPIases) catalyze cis/trans isomerization of

249 , the rER-resident peptidyl prolyl cis/trans isomerases (PPIases) play an important role in the zippe

250 es is regulated by cis/trans peptidyl-prolyl isomerases (PPIases).

251 drogenase (PGHDH), peptidyl-prolyl cis-trans isomerase (PPIF), solute carrier 15 (SLC15), solute carr

252 CypA (Cyclophilin A) is a peptidyl-prolyl isomerase previously shown to be required for chondrogen

253 ith close similarity to the triose-phosphate isomerase protein sequence from Dermatophagoides farinae

254 This study shows that protein disulphide isomerase provides a key component of these barriers, me

255 nACO) but similar to the vertebrate retinoid isomerase RPE65.

256 ion: one involving the well-studied retinoid isomerase (RPE65) and a second photoisomerase reaction m

257 Mutations in retinoid isomerase (RPE65) or lecithin-retinol acyltransferase (L

258 ters for activation of yeast triosephosphate isomerase (ScTIM), yeast orotidine monophosphate decarbo

259 ER protein 57 (ERp57), a thiol isomerase secreted from vascular cells, is essential for

260 BvnE was revealed to be an essential isomerase/semi-pinacolase that specifies selective produ

261 Current inhibitors of peptidylprolyl isomerases show no selectivity between the tightly conse

262 se, pyruvate kinase, and glucose-6-phosphate isomerase showed IgE-binding for 6%-13% of patients.

263 PPIL1 and PRP17 form an active isomerase-substrate interaction, but we found that isome

264 e more comprehensive identification of thiol isomerase substrates and better elucidation of their cel

265 y the ubiquitous presence of peptidyl prolyl isomerases such as cyclophilins that accelerate the intr

266 mmalian cells but had little effect on other isomerases such as Pin4, FKBP12, or cyclophilin A.

267 Thiol isomerases such as protein-disulfide isomerase (PDI) dir

268 PIN1 is a peptidyl-prolyl isomerase that catalyzes the cis/trans isomerization of

269 Our results show that MpeV is the lyase isomerase that covalently attaches a doubly linked phyco

270 PPIF or CypD) is a peptidyl-prolyl cis-trans isomerase that regulates mPTP opening in the inner mitoc

271 D) is a mitochondrial matrix peptidyl-prolyl isomerase that regulates the MPTP and is a drug target f

272 ugh most of the activities of vascular thiol isomerases that contribute to thrombus formation are yet

273 our results with those of protein disulfide-isomerase, the eukaryotic counterpart of DsbA, allowing

274 nt four case studies, focused on ketosteroid isomerase, the SH3 domain, dihydrofolate reductase, and

275 Here we show that an ER protein disulfide isomerase, thioredoxin domain containing 5 (TXNDC5), is

276 he toxin is transferred to protein disulfide isomerase; this ER redox chaperone is known to unfold CT

277 Triosephosphate isomerase (TIM) barrel proteins have not only a conserve

278 tmU3 adopts an unprecedented triosephosphate isomerase (TIM) barrel structural fold for this class of

279 lase 1 family (alpha/beta)8 triose-phosphate isomerase (TIM) barrel structure with a highly conserved

280 end of the HydG (betaalpha)8 triosephosphate isomerase (TIM) barrel, a canonical [4Fe-4S] cluster bin

281 active site cavity via the triose-phosphate isomerase (TIM) barrel.

282 Y208 and S211 from loop 7 of triosephosphate isomerase (TIM) form hydrogen bonds to backbone amides a

283 Triosephosphate isomerase (TIM) is a proficient catalyst of the reversib

284 The tunnel region at triosephosphate isomerase (TIM)'s dimer interface, distant from its cata

285 Triosephosphate isomerase (TIM), an enzyme of the glycolytic pathway, ha

286 ate (GAP) bound to wild-type triosephosphate isomerase (TIM), as well as to the K12G, E97A, E97D, E97

287 12 identified), including a triosephosphate isomerase (TIM)-barrel protein that likely derived from

288 hat the drug interferes with triosephosphate isomerase (TPI) causing release of methylglyoxal (MG).

289 Of the proteins identified, triosephosphate isomerase (TPI) exhibited a strong affinity to the CuNPs

290 ion of the glycolytic enzyme triosephosphate isomerase (TPI) through demalonylation of Lys56.

291 acity (10%-49%), followed by triosephosphate isomerase (TPI; 19%-34%) in raw and tropomyosin (6%-32%)

292 d, namely cystatin B (CSTB), triosephosphate isomerase (TPI1), and deleted in malignant brain tumors

293 17, it was unable to bind protein disulfide isomerase, transfer lipids, and support apoB secretion.

294 Glucose isomerase was chemically aminated to increase its reacti

295 In the glycolysis pathway, triosephosphate isomerase was up-regulated, whereas pyruvate kinase was

296 ibitor of the FKBP family of peptidyl prolyl isomerases, was shown to increase survival in animal mod

297 ts with the oxidoreductase protein-disulfide isomerase, we hypothesized that thioredoxin-1 (Trx1), a

298 n-dependent interaction with Pin1, a proline isomerase, which mediates cis-trans isomerization of the

299 MpeV is a putative lyase isomerase whose role in PEI and PEII biosynthesis is not

300 ies with double mutants including carotenoid isomerase (yofi), a carotenoid-isomerase nonsense mutant