ライフサイエンスコーパス: isomeric

1 different types of [2]catenanes that are non-isomeric.

2 ienophiles (tetrazine ligation), the new and isomeric 1,2,3,5-tetrazine displays similarly remarkable

3 t additional reactivity complementary to the isomeric 1,2,4,5-tetrazines.

4 roduced as a mixture of three compounds with isomeric 15-carbon acyl lipids, designated P-A1 (linear

5 Conjugated trienones and isomeric 2H-pyrans were found to engage in a novel cyclo

6 The nature of the bonding in isomeric 3 and 4 was probed by experimental and theoreti

7 trinsic reactivity comparable to that of the isomeric 3,6-diphenyl-1,2,4,5-tetrazine, display a singl

8 -dependent assembly between two irreversible isomeric 3D nanocages.

9 efination (70-99% yields), were converted to isomeric 5- and 6-fluorobenzo[c]phenanthrene, 5-and 6-fl

10 o their 6,13 and 7,14-positions to form four isomeric 6,13-syn-TBDT, 7,14-syn-TBDT, 6,13-anti-TBDT, a

11 ce fragmentation interferences, and discrete isomeric abundances related to biological function.

12 from an enantiomeric chiral domain to a meso-isomeric achiral domain.

13 However, differentiation of isomeric acyl-, N-, and O-glucuronide derivatives of dru

14 unmigrated 1-beta-acyl-glucuronides from the isomeric acyl-glucuronides formed upon acyl migration.

15 xanone are relatively slow but form a single isomeric adduct in >80% yield.

16 ize selectivity was observed for a series of isomeric alcohols.

17 Identification of isomeric amino acid residues in peptides and proteins is

18 Isomeric amino acid residues such as valine (Val) and no

19 Therefore, separations of isomeric analytes using a modifier can be related to the

20 lder-ene (IMAE) reaction, thus producing the isomeric and cyclic 1,4-diene (e.g., 12).

21 paration and detailed structural analysis of isomeric and epimeric HS mixtures has not been achieved.

22 ometry method that can separate and identify isomeric and epimeric structures from complex mixtures.

23 Subsequently, we demonstrate that isomeric and isobaric ions can be selectively monitored

24 The technology is demonstrated with isomeric and isobaric mixtures (e.g., 4-methoxy-1-naphth

25 Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed an

26 gical entities presenting a dense pattern of isomeric and tautomeric forms in their spectra that can

27 These isomeric and/or isostructural NCs have provided valuable

28 gNP arrays templated by two constitutionally isomeric aromatic peptide amphiphiles (APAs), K(S)C'EK(S

29 Two isomeric aryl 2-deoxy-2-fluoro-beta-glucosides react wit

30 the practically important cases that require isomeric assignments is that associated with single-nucl

31 via DAPK1, stabilizing the pro-survival cis-isomeric ATR.

32 haped Au(25) (with different ligands), quasi-isomeric Au(28) (SR)(20) with different R groups, struct

33 , the TWIM-MS technique was used to separate isomeric Au(I) metallopeptide ions that were formed by Z

34 Herein, we summarize recent work with isomeric Au(n) NCs protected by ligands and isostructura

35 ution affect aromatic character of the three isomeric azaborines?

36 Coupling of the radical sites in isomeric benzynes is known to hinder their radical react

37 In addition, the isomeric bilirubin dipyrrinone subunits were found to po

38 s all-trans-to-cis-lycopene isomerization or isomeric-bioavailability differences underlie the greate

39 Herein, we present work on two isomeric biomimetic side-on Mn(III) -peroxo intermediate

40 e consisting of a tetrasilyldisilene and its isomeric bis(silyl)silylene, the first isolable silylene

41 ficinalis, are uncommon antioxidants bearing isomeric bisphenol cores substituted with allyl function

42 e formation and stereochemistries of all six isomeric bisulfite adducts to Psi; conversion of interme

43 al features and electronic properties of the isomeric borane-functionalized products have been invest

44 ization, and computational evaluation of two isomeric borepin-containing polycyclic aromatics.

45 on and H2S release kinetics from a series of isomeric caged-carbonyl sulfide (COS) compounds, includi

46 O(2), and CH(2)-H(2)O) by narrowing down the isomeric candidate structures using the mobility domain.

47 ation of metabolite structures when isobaric/isomeric candidates were present.

48 Biological functionality of isomeric carbohydrates may differ drastically, making th

49 mparing the known relative concentrations of isomeric carbohydrates mixed in solution with the concen

50 We demonstrate that isomeric carbohydrates of any isoforms can be distinguis

51 accuracy in analysis of unknown mixtures for isomeric carbohydrates of similar complexity.

52 ver that the exchange rates are distinct for isomeric carbohydrates with even subtle structural diffe

53 experimental and theoretical studies of two isomeric carotenoporphyrin molecular dyads having differ

54 For example, isomeric cathinones give similar product ion MS(2) spect

55 Irradiation of the three isomeric chlorobenzylphophonic acids in aqueous buffer l

56 ow a marked difference in reactivity between isomeric cis- and trans-Ru catalysts suggesting that the

57 Large single crystals of a constitutionally isomeric COF (BP-COF-6), composed of rod units, were als

58 a(5)-C5H2tBu3) yields the unprecedented bond isomeric complexes [(Cp'''Fe)2(mu,eta(4:4)-As4)] (3a) an

59 es identification, new insights into the WAF isomeric complexity (e.g., [m/z; chemical formula; colli

60 ans play in many biological processes, their isomeric complexity makes their structural determination

61 The isomeric complexity of glycans make their analysis by tr

62 lar features per nominal mass due to the WAF isomeric complexity.

63 somers are chiral, which further adds to the isomeric complexity.

64 to the MS analysis the presence of numerous isomeric compounds limits the amount of information that

65 s it has the ability to discriminate between isomeric compounds or difficult to separate structurally

66 trometry (LC-MS) which enables separation of isomeric compounds that cannot be discriminated using ma

67 synthesizing ten triads of constitutionally isomeric compounds via complexity-generating photochemic

68 The LC elution order of isomeric compounds was associated with their fine struct

69 Two isomeric compounds with molecular weight of 176 u have b

70 ively identified including a large number of isomeric compounds, both aliphatics and cyclics.

71 challenge, supplemented by the occurrence of isomeric compounds, e.g., hydroperoxylated vs dihydroxyl

72 eously allowing the identification of 71 240 isomeric compounds.

73 ishing the stereochemistry of 48 challenging isomeric compounds.

74 to their hydrophobicity and dependent on the isomeric configuration, being the incorporation of the c

75 tral linker leads dendrimers to possess more isomeric conformations and thus successfully converts no

76 -frequency modes, and the access to cis-like isomeric conformations, which cannot be appropriately ca

77 e, this new strategy allows the detection of isomeric contamination.

78 s analytically challenging due to their high isomeric content (e.g., varying acyl chain positions and

79 The distribution of the isomeric content in an atactic PMMA sample is determined

80 be IMS-MS, we characterized PFAS species and isomeric content in both analytical standards and enviro

81 gorithm also gives the ability to screen for isomeric contributions and to follow homologous series o

82 ted identification of major, and some minor, isomeric contributors that are unresolved using conventi

83 ification and the relative quantification of isomeric contributors.

84 mation of a rapidly equilibrating mixture of isomeric copper(I) allyl complexes, from which Curtin-Ha

85 discernment of E. coli R-LPS structures with isomeric core structures confirmed the degree to which s

86 COS/H2S release rates and efficiencies from isomeric core structures.

87 cing result, except for two amino acids with isomeric counterparts, enabling accurate germline sequen

88 either the corresponding cyclopent-3-enes or isomeric cyclopent-2-enes having two acceptor groups at

89 and Buchwald-Hartwig coupling on a range of isomeric dichlorinated and trichlorinated arenes, substr

90 l p-quinone methide and an in situ generated isomeric diene promoted by either Lewis or Bronsted acid

91 Whereas its BN analogues, the three isomeric dihydro-azaborines, have been shown to have var

92 rgo an intramolecular rearrangement yielding isomeric diketopiperazines precluding further chemical l

93 Treatment of D with MeOH affords two isomeric dimers, MD1 and MD2, both of which incorporate

94 Herein, seven isomeric disaccharides and two isomeric tetrasaccharides

95 and mass spectrometry to identify different isomeric disaccharides of chondroitin sulfate (CS) and h

96 Time-resolved UV-vis measurements and the isomeric distributions of Z-stilbene epoxidation product

97 ites within a molecule and correctly predict isomeric distributions.

98 MS is an important alternative to study the isomeric diversity and elemental composition of complex

99 <0.5 kcal/mol) both in the energy of (Z)/(E)-isomeric ester enolates and in the alternative Zimmerman

100 We show that both 2' and 3' isomeric esters undergo mutual transformation via the cy

101 Compared to porphyrin, its isomeric, expanded, and contracted analogues are less we

102 Nevertheless, the chemistry of annulated isomeric, expanded, and contracted porphyrins started fl

103 ility to determine relative contributions of isomeric FA using multiple linear regression analysis pa

104 advantage includes differentiating cis/trans-isomeric FAMEs (e.g. oleic acid methyl ester and linolei

105 acyl sn-position and relative abundances for isomeric fatty acyl substituents.

106 osition(s) and (ii) relative quantitation of isomeric fatty acyl substituents.

107 PN1 transforms thermally into an isomeric form (PN2) with kappa(2) -O,O'-((-) OONO) coord

108 The isomeric form of carotenoids did not affect such relatio

109 cis-Lycopene is the predominating isomeric form of lycopene found in blood and tissues.

110 arge state, which reflects the fact that the isomeric form of the carbon cage in endohedral metallofu

111 mpounds allows us to identify their specific isomeric form, including the anomericity of the glycosid

112 e can separate different conformers for each isomeric form.

113 substituted alkenes in either the E or the Z isomeric forms are not known.

114 in these mixtures were separated from their isomeric forms by using differential mobility spectromet

115 Both isomeric forms of alanine play a crucial role in bacteri

116 f the structural similarity and the multiple isomeric forms of carbohydrates in solution, their analy

117 the separated isomers also distinguish these isomeric forms of cyclosporin.

118 Two isomeric forms of DEHTP primary metabolite were highly d

119 Identification of the precise isomeric forms of NPS is of significant forensic relevan

120 ochemical interconversion between transient, isomeric forms of the complexes corresponding to the ini

121 ons of the IR spectra of the Eigen and three isomeric forms of this cluster are presented.

122 ed to determine the concentration of the two isomeric forms of thujone.

123 Discriminating among these isomeric forms using mass spectrometry alone can be daun

124 enabling the simultaneous detection of both isomeric forms while retaining compatibility with shotgu

125 ecomposition to CsF+2 F2 , or to CsF3 (three isomeric forms)+F2 , or for rearrangement to a significa

126 cability due to the large number of possible isomeric forms, for example, more than 50 billion for C6

127 cal molecular weights can be present in many isomeric forms, with one form having dramatically more b

128 CCS) values to support the identification of isomeric forms.

129 including some enantiomeric and structurally isomeric forms.

130 sites of an anomeric tag, yielding specific isomeric fragment ions.

131 ther exotine-derived natural products having isomeric frameworks.

132 itation dissociation (EED) MS/MS analysis of isomeric glycan mixtures following G-TIMS separation sho

133 e in the field of glycomics to easily deduce isomeric glycan structures, especially in a high-through

134 MS) is an excellent tool for differentiating isomeric glycan structures.

135 tial mobility spectrometry (DMS) to separate isomeric glycans differing only in the linkages of siali

136 the ion mobility behavior of several sets of isomeric glycans, analyzed as their permethylated deriva

137 Although the TLC was not able to separate isomeric glycans, the DHB@MNPs generate diagnostic glyco

138 try (TIMS-MS) was used to investigate common isomeric glycerophosphocholine (PC) and diacylglycerol (

139 glycan structure information to discriminate isomeric glycoforms are well acknowledged practical prob

140 Extracted ion chromatograms of isomeric glycoforms enabled quantitative assignment of G

141 itive ion mode to determine the branching of isomeric glycopeptides and RFMS labeled glycans.

142 ful analytical method to study site-specific isomeric glycosylation.

143 Therefore, isomeric GPLs are often unresolved, representing a signi

144 The unknowns detected were classified into isomeric groups and tentatively identified using mass sp

145 The (R) isomeric guanine derivative emerged as a selectively act

146 The syntheses of isomeric helical viologens that have potential applicati

147 s to overcome this challenge and distinguish isomeric heparan sulfate tetrasaccharides that differ on

148 The isomeric heterogeneity of glycans poses a great challeng

149 rospray ionization were used to evaluate the isomeric heterogeneity of neutral oligosaccharide-aldito

150 ed for two isomeric pentasaccharides and two isomeric hexasaccharides, each studied in an underivatiz

151 set of model peptides, the method allows for isomeric identification of threonine residues in peptide

152 By harnessing three indolyne isomers, six isomeric indole trimers are accessible, none of which ha

153 spersity change in polymers derived from the isomeric initiators.

154 d the presence of several equilibria between isomeric intermediates where water, or the same alcohol

155 e product contains increasing amounts of the isomeric inverted product.

156 Numerous isomeric/isobaric ion species are successfully separated

157 Multiphase chemistry of isomeric isoprene epoxydiols (IEPOX) has been shown to b

158 Two isomeric K-shaped tetrapyridyl templates with trifluorom

159 propanal derivatives and their corresponding isomeric ketones from aromatic enol ethers.

160 their Wagner-Meerwein rearrangement afforded isomeric ketones.

161 urate quantification of sialylglycans at the isomeric level remains challenging due to their instabil

162 derived from quasi-equivalent constitutional isomeric libraries of self-assembling dendrons, dendrime

163 e with high detail (down to the position and isomeric linkage of each monosaccharide).

164 imension was effective for the separation of isomeric lipid species presenting distinct double bond l

165 are sufficient for the discrimination of the isomeric lipid species using TIMS-MS.

166 rating and identifying the many isobaric and isomeric lipids and metabolites that can complicate imag

167 alternative MS/MS strategies to distinguish isomeric lipids has become a high impact goal in shotgun

168 and liquid chromatography (LC) can separate isomeric lipids under appropriate conditions, convention

169 Complex 3 thermally transforms to its isomeric low-spin nitrato form [(P(Im))Fe(III)(NO3(-))]

170 The isomeric macrocycles incorporated with interesting optic

171 we report on the synthesis of two series of isomeric macrocyclic tetraimines based on bis-alkynylben

172 method for facile differentiation of acidic, isomeric metabolites by attaching high proton affinity,

173 roach with citrate and isocitrate, which are isomeric metabolites each containing three carboxylic ac

174 bolite signal and separate both isobaric and isomeric metabolites with different distributions within

175 is determined by the relative stabilities of isomeric metallacycles governed by steric repulsion betw

176 rsenicin A, the dimethyl analogue 2 and four isomeric methylene homologues (including the natural pro

177 A series of isomeric mixtures were qualitatively investigated with H

178 ass spectrometry to aid in the separation of isomeric mixtures.

179 ns of important but low abundance epimers in isomeric mixtures.

180 of isomers, which are generally employed as isomeric mixtures.

181 Guided by topology, two flexible isomeric MOFs, compounds 1 and 2, with a formula of In(M

182 re, a strategy is developed by designing two isomeric molecular phosphors incorporating and combining

183 tion order of Phase I metabolites, including isomeric monohydroxylated compounds.

184 We describe how IMS is able to distinguish isomeric N-glycans and glycopeptides using both intact I

185 -substituted NBA molecules and corresponding isomeric NBA-bithiophene copolymers P1 and P2, respectiv

186 ducts from one substrate can be facilitated, isomeric olefin mixtures commonly found in petroleum-der

187 of the fragment ion intensities of just two isomeric oligomer groups, GlcNAc(1)GlcN(3) and GlcNAc(2)

188 n effective tool for gas-phase separation of isomeric oligosaccharides that has been demonstrated wit

189 aration dimensions capable of resolving some isomeric oligosaccharides.

190 wheel cluster junction and a compositionally isomeric one of higher f based on a M12L24 cage.

191 library, but are indistinguishable for many isomeric organic compounds (for example, linear and bran

192 bled the identification of a large number of isomeric organic compounds, both aliphatic and aromatic,

193 Three benzimidazole-based isomeric organic dyes possessing two triphenylamine dono

194 s custom MS/MS methods to equally sample all isomeric oxidation products across their elution window,

195 (where the peptide sequence is the same but isomeric oxidation products are formed at different site

196 Isomeric oxidation products could be differentiated by m

197 tinguish between electrochemically generated isomeric oxidation products.

198 The isomeric pairs 2a and 3a are separated by crystallizatio

199 developing potential sensors for interesting isomeric pairs in the future.

200 After synthesizing isomeric pairs of ruthenium complexes featuring 2'-picol

201 The monomeric structures consist of three isomeric Pd(kappa(1)-DAF)2(OAc)2 complexes, together wit

202 3)2 produced an unprecedented single linkage-isomeric Pd8 tetrafacial molecular nanobarrel (PSMBR-1)

203 s are demonstrated through analysis of three isomeric pentasaccharide species and the small protein u

204 This is demonstrated for two isomeric pentasaccharides and two isomeric hexasaccharid

205 HRPF quantification of isomeric peptide oxidation products (where the peptide s

206 hy (ZIC-HILIC) method to ideally coelute all isomeric peptide oxidation products while separating dif

207 only partially chromatographically resolved isomeric peptide oxidation products.

208 nd peptides, enabling the differentiation of isomeric peptides (or proteins) that have the same seque

209 proteomics is demonstrated by separations of isomeric peptides with variant localization of post-tran

210 me by the differential evolution channels of isomeric peroxyl radical intermediates at the 2- versus

211 A series of isomeric phenylphenalenones in which the phenyl ring is

212 he ability to separate and uniquely identify isomeric phosphatidylcholines that differ only in their

213 It contains a large diversity of essentially isomeric polypeptides with the cationic and amphiphilic

214 ctronic structures and optical properties of isomeric porphyrins are examined by comparing the proper

215 ical properties of expanded, contracted, and isomeric porphyrins is described with an emphasis on the

216 e formula C(3)HBr(3)N(2) due to very limited isomeric possibilities.

217 Experimental studies demonstrate that both isomeric precatalysts facilitate electroreduction of CO(

218 intermediate en route to the thermodynamic, isomeric product 3(Dipp)(+).

219 ngle product, and no rotameric and keto-enol isomeric products are formed.

220 Either of two different isomeric products can be selectively obtained by photoch

221 hnique is demonstrated by characterizing the isomeric products generated during in vitro aging of a s

222 in proteomic studies, isomerization (and the isomeric products of deamidation) remain exceptionally c

223 ased approach for rapidly characterizing the isomeric products of Gln deamidation using diagnostic fr

224 eds with the formation of the mixture of two isomeric products with good yield and diastereoselectivi

225 how that MftC catalyzes the formation of two isomeric products.

226 actions and alters the relative stability of isomeric products.

227 issue lycopene pool) drove tissue and plasma isomeric profiles.

228 nteract, the gas-phase reactivity of several isomeric protonated (iso)quinoline- and acridine-based b

229 By contrast, an isomeric pyrene-based diamine was observed to undergo na

230 The formation of the cyanamides from isomeric pyrrolo[3,2-c][1,2,4]triazolo[3,4-a]isoquinolin

231 For 1,3-thiazol-2-amines the isomeric ratio depends on the reaction conditions and ki

232 the steric size (Charton parameter) and the isomeric ratio suggests that the selectivity is dominate

233 These findings permitted the isomeric separation of glycopeptides resulting from high

234 Comprehensive structural isomeric separation of glycopeptides was observed by hig

235 eir structures were further detailed through isomeric separation on porous graphitized carbon (PGC) p

236 Two isomeric series have been obtained with 4-ethynylpyridin

237 Two isomeric series of benzothieno-fused 7-deazapurine (benz

238 Two isomeric series of new thieno-fused 7-deazapurine ribonu

239 are was evaluated for its ability to bind an isomeric series of possible diradical cyclophane guests,

240 Most nucleosides (from both isomeric series) exerted low micromolar or submicromolar

241 ructures were discovered, many of which were isomeric, showcasing the need for a rapid de novo approa

242 susceptible to be contaminated with another isomeric side-product in trace levels.

243 ed to quantitate possible changes of fucosyl isomeric species associated with the pathological condit

244 hallenge due to the presence of isobaric and isomeric species, which greatly complicates data interpr

245 ted in terms of the coexistence of different isomeric species.

246 In addition to the isomeric state of the azobenzene groups, the size of the

247 Here, we have designed a system in which all isomeric states of an azobenzene moiety (trans --> cis-(

248 arily high leading to half-lives of the pure isomeric states of up to 83 years at 25 degrees C.

249 hotochromism in the visible enabling the two isomeric states to be distinguished by the naked eye.

250 release of ammonia upon cycling between its isomeric states.

251 mination of HBQ-induced ROS further supports isomeric structure and halogen substitution effects.

252 report a systematic study on the effects of isomeric structure and the type and number of halogen su

253 Strong isomeric structure effects were shown with 2,5-HBQ isome

254 Determining the exact isomeric structure of the platelet lipid remains to be u

255 mer level, with confident assignment of each isomeric structure.

256 Accurately characterizing these isomeric structures by current techniques is not straigh

257 ility mass spectrometry, we demonstrate that isomeric structures have different structural conformati

258 s resolving capabilities for the dp4 and dp6 isomeric structures makes this methodology particularly

259 us for the first time to fully elucidate the isomeric structures of the MW 212 OSs.

260 ccharides, because the lack of contaminating isomeric structures provides unambiguous structural assi

261 d the characterization of closely related or isomeric structures through the generation of glycan col

262 -N-hexaose and lacto-N-neohexaose showed the isomeric structures to be baseline resolved, and a new c

263 ty features previously thought to arise from isomeric structures were conformers of a single structur

264 ion was carried out by LC-MS/MS to determine isomeric structures where possible.

265 des makes their purification, including many isomeric structures, very challenging and is a bottlenec

266 f neutral glycan isomers as well as sulfated isomeric structures, where the sulfate was retained on t

267 aran sulfate (HS) by nature contain multiple isomeric structures, which are fundamental for the regul

268 anipulation of the main-chain and side-chain isomeric structures.

269 MS/MS data interpretation of closely related isomeric structures.

270 The relative stereochemistry and isomeric substitution pattern of organic molecules is ty

271 achieved in the TW SLIM IM-MS enabled, e.g., isomeric sugars (lacto-N-fucopentaose I and lacto-N-fuco

272 An initial evaluation of the isomeric sugars lacto-N-hexaose and lacto-N-neohexaose s

273 The more reactive isomeric sulfonium ion 22 was discounted as being respon

274 using both unpurified reaction products from isomeric synthetic hexasaccharides and an octasaccharide

275 We designed and synthesized two isomeric TADF emitters, 2DPyM-mDTC and 3DPyM-pDTC, based

276 6pi-electrocyclization/aromatization, while isomeric TD-syn-TBDT and TD-anti-TBDT with four decyl gr

277 Herein, seven isomeric disaccharides and two isomeric tetrasaccharides with subtle structural differe

278 The isomeric thieno[2,3-d]pyrimidine SGC-STK17B-1N (19g) was

279 nning calorimetry analysis on the reversible isomeric transformation demonstrates that the Gibbs free

280 In this work, a reversible isomeric transformation in an atomically precise nanoclu

281 on, TIMS was able to distinguish between two isomeric transformation products of the model compound m

282 nce between the putative product-determining isomeric transition states (DeltaDeltaE(double dagger))

283 sed with depth, consistent with differential isomeric transport.

284 Multistage mass spectrometry of the two isomeric triantennary glycans uncovered unique fragment

285 possibility to discriminate 13 underivatized isomeric trisaccharides were reported using electrospray

286 situ generated [Pd-H] was demonstrated using isomeric trisubstituted alpha,beta-unsaturated esters.

287 Our "isomeric tuning" approach is generalizable, yielding a f

288 The knots and their isomeric unknot macrocycles were characterized by NMR sp

289 ysis remains challenging and resolving minor isomeric variants can be difficult, in particular termin

290 id biosynthesis genes, as well as by mapping isomeric variation in the accumulation of phenylpropanoi

291 stem is consistent with the decomposition of isomeric vinylhydroperoxides to release vinoxy radical i

292 y and amyloid-incompetent oligomers that are isomeric with amyloid-competent oligomers in some cases.

293 Marbon is isomeric with Dechlorane Plus (DP).

294 e family of compounds of composition CH (and isomeric with ethyne, HC identical withCH), but it has b

295 s to CPM-74, Zn(2)(OH)(obdc), that is nearly isomeric with MOF-74-Zn.

296 designed and synthesized molecules where two isomeric, yet, different, 8pai antiaromatic subunits, a

297 rivatives were investigated giving very high isomeric yields in both switching directions, i.e. >90%

298 irm the presence and unravel the identity of isomeric z and y-NH(3) fragment ions ("twins").

299 demonstrates that the relative abundance of isomeric z and y-NH(3) ions requires consideration for a

300 cal profiles as a result of co-occurring and isomeric z and y-NH(3) ions.