ライフサイエンスコーパス: isometric force

1 raction at 260 mmHg and report the effect on isometric force.

2 Work and power were compromised more than isometric force.

3 nsion cost decreased throughout steady-state isometric force.

4 /s, then was constant at 3.26 +/- 0.06 times isometric force.

5 in small-vessel myographs for measurement of isometric force.

6 initial force was raised to 75-80% of steady isometric force.

7 ording intracellular electrical activity and isometric force.

8 rsal of the power stroke, thereby increasing isometric force.

9 ta-cardiac myosin but a 2-fold lower average isometric force.

10 ivated force in the range 0.3-0.8 of maximum isometric force.

11 , thereby ensuring effective transfer of OHC isometric forces.

12 PD and non-COPD fibres that produced similar isometric forces.

13 o slower components by 50%, in proportion to isometric force, (2) adding a non-relaxing component and

14 electrode, intracellular microelectrode, and isometric force (a surrogate marker for the Ca2+ transie

15 timuli elicited (1) a biphasic modulation of isometric force, a transient decrease followed by a corr

16 In five healthy adults, we recorded the isometric forces acting a hand joint and the electromyog

17 Isometric force, actomyosin ATPase activity, and unloade

18 We measured the isometric force and actin filament velocity for native p

19 le spindles, whose responses can also signal isometric force and are modulated by fusimotor input.

20 We measured isometric force and ATP utilization at different calcium

21 We measured steady-state isometric force and ATPase activity in detergent-skinned

22 on and target size dependent ability to vary isometric force and co-contraction activity concurrently

23 Steady-state isometric force and crossbridge kinetics were measured b

24 Endothelin increases isometric force and decreases actomyosin ATPase activity

25 s of BS and OM on the calcium sensitivity of isometric force and filament structural changes suggest

26 We investigated the relations between isometric force and intracellular calcium concentration

27 creases in fibre number, 20-57% increases in isometric force and no differences in specific force.

28 scle fibers developed greater than twice the isometric force and power output of young fibers, yet cr

29 ated to yield 50% maximal force, after which isometric force and rate constants (k(tr)) of force deve

30 f phosphorylation at Thr(18) on steady-state isometric force and relaxation rate were investigated in

31 ased Ca(2+) sensitivity of both steady-state isometric force and sinusoidal stiffness as well as incr

32 ss as well as increased maximum steady-state isometric force and sinusoidal stiffness.

33 microM phalloidin for 1 h, the increases in isometric force and stiffness were not sustained despite

34 s on force and fiber shortening by measuring isometric force and stiffness, the rate of tension decli

35 Isometric force and surface EMG signals were recorded fr

36 ed quadriceps and handgrip maximum voluntary isometric force and the relaxation times, force-frequenc

37 rs, as measured by their ability to generate isometric force and to hydrolyze ATP by actomyosin Mg2+

38 TP, 2-deoxy ATP (dATP), CTP, and UTP support isometric force and unloaded shortening velocity (Vu) to

39 nd normalised (to muscle size and body mass) isometric force and work loop power output (PO) were mea

40 ent activation (fractional calcium binding), isometric force, and the rate of force generation in mus

41 elocity by 58% and enhanced the myosin-based isometric force approximately 2-fold.

42 ly switched from that for motion to that for isometric force approximately 65 ms before contact (p =

43 G mouse hearts expressing ssTnI and measured isometric force at extracellular pH 7.33 and pH 6.75.

44 -10 degrees C) but much larger than that for isometric force at higher temperature (1.3 at 20-25 degr

45 The average (extrapolated) value of maximum isometric force at low kinesin density was 0.90 +/- 0.14

46 5 degrees C; this was similar to the Q10 for isometric force at low temperature (3.5 at 7-10 degrees

47 Pressurization reduced isometric force at short muscle lengths (e.g., -11.87% o

48 Three millimolar BDM decreased isometric force by 50%, velocity by 29%, maximum power b

49 lue indicates that the myosin head generates isometric force by a small sub-step of the 11 nm stroke

50 ame assay could be used to determine average isometric force by loading the actin filaments with incr

51 on, RLC phosphorylation enrichment increased isometric force by more than 3-fold and peak power outpu

52 5), the normalised tendon strain at maximum isometric force (c) (varied from 0 to 0.08), the muscle

53 acting as a lever, while the enhancement in isometric force can be directly related to enhancement o

54 ibits significantly reduced maximum specific isometric force compared with littermate controls.

55 ealthy young participants performed bimanual isometric force control tasks by extending their wrists

56 nt atrophy and impairment of specific force (isometric force/cross-sectional area) and unloaded short

57 n compliance, we show that 79.7% variance in isometric force data is explained by a simple human sarc

58 sed from 2.3 microm to 2.0 microm submaximal isometric force decreased approximately 40% in both alph

59 100 pmol/L and 10 nmol/L endothelin-1 raised isometric force, decreased actomyosin ATPase activity, a

60 Histological and functional (isometric force deficit) signs of muscle injury and tota

61 r decrease in Ca(2+) sensitivity and maximal isometric force development compared with the R141W muta

62 k(tr) measurements underestimate the rate of isometric force development during submaximal Ca2+ activ

63 The time course of isometric force development following photolytic release

64 troponin C (HCTnC), and the Ca(2+) dependent isometric force development of these troponin-replaced f

65 During isometric force development, growing cross-bridge tracti

66 ch lower specific force, and slower rates of isometric force development, slow phase relaxation, and

67 ities, which can be significant, even during isometric force development.

68 , maximal force and k(tr) and the pCa(50) of isometric force did not differ between WT and cMyBP-C(-/

69 rved a significant reduction of steady-state isometric force during Ca(2+-)activation, decreased myof

70 In the present study, we measured isometric force during EPR spectral acquisition, in orde

71 n cost (i.e. ATP hydrolysis rate per unit of isometric force) during Ca2+-induced activation of Trito

72 The tension increased to 2- to 3 x P0 (isometric force) during ramp lengthening at velocities >

73 the steady-state value of F approximated the isometric force, E was large, and eta was small.

74 The isometric force elicited by voltage pulses under whole-c

75 The average isometric force exerted by each attached myosin head at

76 ases both the unloaded sliding speed and the isometric force exerted by myosin heads on the thin fila

77 rements of the unloaded sliding speed of and isometric force exerted on single thin filaments in in v

78 as calculated as the decrease in the maximum isometric force expressed as a percentage of the maximum

79 Maximal isometric force (F(0)) decreased from 91.0 +/- 1.9 to 58

80 ere paralleled by increases of 30% to 80% in isometric force (F(max)), rate of tension redevelopment

81 t contractions (75 Hz, 330 ms s(-1), 120 s), isometric force fell during indirect (sciatic nerve) sti

82 At maximal Ca2+ activation, isometric force (Fi) was inhibited at the highest solute

83 such building blocks have been described as isometric force fields.

84 , we demonstrate a >40% increase in specific isometric force following repeated administrations.

85 Redevelopment of isometric force following shortening of skeletal muscle

86 match a target force at 2% of their maximal isometric force for 35 s with abduction of the index fin

87 of fatigue, induced by production of maximal isometric force for 60 s with four fingers, upon indices

88 er, the small rodent generates the same high isometric force for both alpha and beta isoforms.

89 egment is stretched and a deficit in maximum isometric force (force deficit) is produced, the regions

90 The active isometric force, force-velocity relationship, and force

91 Maximal isometric force generated by the big toe declined to 78.

92 The model accounts for the isometric force generated by the cell and explains the o

93 e tension-pCa relationship or in the maximum isometric force generated.

94 ized as a force field: the collection of the isometric forces generated at the ankle over different l

95 Therefore, the isometric force generating capacity of airway smooth mus

96 himpanzees does not stem from differences in isometric force-generating capabilities or maximum short

97 rformance differential have included greater isometric force-generating capabilities, faster maximum

98 on returned nearly to control levels, as did isometric force generation and rate of ATP hydrolysis.

99 ficantly decreases the magnitude and rate of isometric force generation at physiological Ca(2+)-activ

100 end of the latency relaxation (LR) preceding isometric force generation, approximately 10 ms after th

101 end of the latency relaxation (LR) preceding isometric force generation, approximately 10 ms after th

102 rrant somatosensory cortical activity during isometric force generation, which ultimately contributes

103 vement without vision, passive movement, and isometric force generation.

104 ncreasing levels of unilateral and bilateral isometric force in a sitting position.

105 a powerful inotropic peptide that increases isometric force in isolated papillary muscle and the ext

106 mi) exhibited kyphosis and decreased maximal isometric force in limb muscles compared to age-matched

107 ongly dependent on sarcomere length than was isometric force in the range 1.5-2.5 microm.

108 resting sarcomere length similar to that of isometric force in the range 2.5-4.0 microm, but was les

109 oduce force using a novel optical-trap-based isometric force in vitro motility assay.

110 lthy anesthetized rats, we measured hindlimb isometric forces in response to spinal and muscle stimul

111 actin filament velocities and higher average isometric forces (in an in vitro motility assay) when co

112 At maximum Ca(2+) (pCa 4.5), isometric force increased linearly with dATP/ATP ratio,

113 ing stroke responsible for the generation of isometric force is a larger fraction of the total myosin

114 We conclude that fibroblast isometric force is not coupled to Ca2+ arising from tran

115 ter value was normalised for the decrease in isometric force, it became 2.56 +/- 0.3 mM s(1), which i

116 The influence of Ca2+ on isometric force kinetics was studied in skinned rat vent

117 ament compliance to sarcomere compliance and isometric force kinetics, the Ca(2+)-activation dependen

118 omycin inhibits myogenic tone and K+-induced isometric force largely by blockade of L-type, dihydropy

119 The isometric force-length curve for mdx muscle was steeper

120 To test this possibility, we compared isometric force, loaded shortening velocity, and power o

121 vasive measurement of airway resistance, and isometric force measurements in isolated bronchial rings

122 Video analysis and isometric force measurements revealed higher frequency a

123 Isometric force measurements taken from control and Mybp

124 -angle X-ray diffraction simultaneously with isometric force measurements to obtain the interfilament

125 Intracellular microelectrodes and isometric force measurements were used to measure vasopr

126 ith intracellular microelectrode recordings, isometric force measurements, Kit-like immunohistochemis

127 atch clamp, intracellular microelectrode and isometric force measurements.

128 s at rest and during an ankle plantarflexion isometric force motor task.

129 at 35%, 50% and 70% of the maximal voluntary isometric force (MVIF).

130 30% of the velocity and produced 65% of the isometric force of cells reconstituted with the thiophos

131 At 0 dpi, tibialis anterior isometric force of CKO was less than CON.

132 ncreased the calcium sensitivity and maximal isometric force of demembranated human donor myocardium.

133 atin not only increases the mass and maximum isometric force of muscles, but also increases the susce

134 ded in organ chambers for the measurement of isometric force or frozen for isolation of membrane prot

135 in had no effect on Vmax during steady-state isometric force or on rMLC phosphorylation.

136 ls were reduced to approximately 70% maximal isometric force (P4.5) in cardiac myocyte preparations,

137 ontraction, but as the fibres approached the isometric force plateau they showed little IS sensitivit

138 show that the effects of both GCs on maximum isometric force (Po) were fibre-type dependent.

139 The isometric force produced by glycerinated muscle fibers w

140 uced by 27.5 +/- 5.0% (P < 0.05), whilst the isometric force produced by the EDL-TA muscle group was

141 mice were anaesthetized with isoflurane and isometric force-producing capacity was recorded from the

142 Direct measurements of isometric force production in single cardiac myocytes de

143 We evaluate five models for isometric force production of a well-studied model syste

144 rylation on Ca(2+) dependence of myofilament isometric force production, isometric ATPase rate, and t

145 of unloaded thin filament sliding speed and isometric force production.

146 mproved toe-spread reflex, EMG responses and isometric force production.

147 cquired during walking, reaching, flying, or isometric force production.

148 ntal efforts to greatly affect quasi-static, isometric, force production in muscle.

149 Elevated levels of phosphate (Pi) reduce isometric force, providing support for the notion that t

150 eshold force of units for recruitment during isometric force ramps in many different directions.

151 rteries were suspended in organ chambers for isometric force recording.

152 Isometric force recordings of single cardiac myocytes de

153 Thin-filament regulation of isometric force redevelopment (k(tr)) was examined in ra

154 ate that the stiffness to force ratio during isometric force redevelopment depends on the active shor

155 h the assumption that the linear increase in isometric force reflects a proportional increase in the

156 ted in a leftward shift of the concentration-isometric force relations for both aorta types, as expec

157 The cumulative concentration-isometric force relations for the PLB- aorta were to the

158 Contraction-isometric force relations in response to phenylephrine o

159 aorta, phenylephrine and KCl concentration- isometric force relations in the presence or absence of

160 Aortic rings were excised and isometric force responses to phenylephrine, acetylcholin

161 of P(i)/mol of LC(20)) and similar levels of isometric force revealed differences in the rates of dep

162 ogether with the increased sliding speed and isometric force seen in the presence of regulatory prote

163 measured the time course of [Ca(2+)](i) and isometric force simultaneously in an intact artery after

164 roM free Ca2+ induced sustained increases in isometric force, stiffness, and rMLC phosphorylation.

165 ous and endogenous NO on murine fundus using isometric force studies.

166 itro motility assay, or the relative average isometric force supported by F-actin.

167 V0 shortening is superimposed on the maximum isometric force T0 , n decreases progressively with the

168 electrodes and contractions were recorded by isometric force techniques.

169 thin filament sliding speed but reduced the isometric force that heavy meromyosin exerted on regulat

170 lue of the muscle force, F, approximates the isometric force, the muscle stiffness, E, is large, and

171 nt with PI(3,5)P2 increased the magnitude of isometric force, the rate of force development, and the

172 Linear first-order models can approximate isometric force time courses well at high spike rates, b

173 ; (2) rapid movement to position target; (3) isometric force to a target level; and (4) adaptation to

174 ons when comparing the measurements using an isometric force transducer and 3D-printed electrochemica

175 tone of smooth muscle strips was measured by isometric force transducers.

176 Measurements of isometric force, transmembrane potentials from impaled s

177 membranated sperm assay we estimated maximum isometric force using a laser trap-based assay.

178 of control when healthy individuals exerted isometric forces using seven grip types.

179 In the absence of Tm, isometric force was a linear function of the density of

180 Thus the isometric force was approximately proportional to the ax

181 Isometric force was directly recorded from individual hy

182 Isometric force was measured over a wide range of calciu

183 Isometric force was nearly the same at all lengths.

184 Isometric force was not different between the two groups

185 Isometric force was not improved but the resistance to e

186 rol mice, but no reduction in muscle mass or isometric force was observed in SynTgSod1(-/-) mice comp

187 Isometric force was recorded from strips of ferret aorta

188 At 10 dpi, isometric force was reduced by half in both groups.

189 09 ms (mean +/- s.e.m.) to 113 +/- 17 ms and isometric force was reduced to 63 +/- 3% of the initial

190 The Ca(2+) sensitivity of isometric force was significantly greater for V95A and E

191 5% so that its relative amplitude (amplitude/isometric force) was increased by 75%.

192 active isometric tension curve and developed isometric force were studied.

193 The isometric forces were measured upon activation.

194 at physiological temperatures, a decrease in isometric force, which mainly indicates a reduction in t

195 ng the Ca sensitivity of ATPase activity and isometric force, which were both completely restored by

196 ibly and concentration-dependently inhibited isometric force with an IC50 of 1.71 mM.