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1 e decarboxylase (MDD) catalyzes formation of isopentenyl 5-diphosphate in an ATP-dependent irreversib
3 ressed leaves enhanced the abundance of CKs (isopentenyl adenine and its precursor) by > 200%, signif
5 ve found that discadenine and its precursor, isopentenyl adenine, not only maintain spore dormancy bu
7 Other cytokinins, including N(6)-(delta(2)-isopentenyl)adenine, trans-zeatin, benzyladenine, kineti
8 , is a tRNA modifying enzyme that adds an N6-isopentenyl adenosine modification at position 37 on a s
9 Also, increased levels (10- to 20-fold) of isopentenyl adenosine, the product of the reaction catal
11 (-SCH(3)) group at the C2 position of N(6)-(isopentenyl)adenosine (i(6)A) in the final step of the b
13 B attaches a methylthio group at C2 of N(6)-(isopentenyl)adenosine, found at nucleotide 37 in several
15 ins to produce adenine and the corresponding isopentenyl aldehyde, play a major role in regulating cy
18 ate (MEP, 5) pathway for the biosynthesis of isopentenyl diphosphate (1) and dimethylallyl diphosphat
19 e (MEP) pathway leads to the biosynthesis of isopentenyl diphosphate (IDP) and dimethylallyl diphosph
20 They are derived from the 5C building blocks isopentenyl diphosphate (IDP) and its isomer dimethylall
21 oducts dimethylallyl diphosphate (DMADP) and isopentenyl diphosphate (IDP) was postulated, but the ex
22 s an isopentenyl phosphate kinase that forms isopentenyl diphosphate (in a reaction analogous to that
23 creased protein levels by 9-fold and reduced isopentenyl diphosphate (IPP) accumulation by 4-fold.
24 erase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosph
26 erase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosph
27 ve-carbon building blocks of all terpenoids, isopentenyl diphosphate (IPP) and dimethylallyl diphosph
28 e synthesized from the isoprenoid precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosph
29 l 2-phosphate (MEP) pathway for synthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosph
30 point at which the pathway branches to form isopentenyl diphosphate (IPP) and dimethylallyl diphosph
31 e isomerase catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosph
32 equential chain elongation reactions between isopentenyl diphosphate (IPP) and dimethylallyl diphosph
33 s D-glyceraldehyde phosphate and pyruvate to isopentenyl diphosphate (IPP) and dimethylallyl diphosph
34 (HMBPP) into the two isoprenoid precursors: isopentenyl diphosphate (IPP) and dimethylallyl diphosph
35 C(15) and C(20) isoprenoid diphosphates from isopentenyl diphosphate (IPP) and dimethylallyl diphosph
36 erase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosph
40 ginate from the five-carbon building blocks, isopentenyl diphosphate (IPP) and its isomer dimethylall
41 ntenyl diphosphate isomerase (IDI) activates isopentenyl diphosphate (IPP) for polymerization by conv
42 ondensation of dimethylallyl diphosphate and isopentenyl diphosphate (IPP) in a reaction catalyzed by
43 sphate isomerase (IDI) catalyzed reaction of isopentenyl diphosphate (IPP) in D(2)O gives a 66% yield
44 actions of allylic diphosphate acceptor with isopentenyl diphosphate (IPP) in the cis (Z) configurati
45 osphates to the carbon-carbon double bond in isopentenyl diphosphate (IPP) in the primary building re
50 rase, catalyzes the addition of thousands of isopentenyl diphosphate (IPP) molecules to an allylic di
51 ne of two possible isomeric products, either isopentenyl diphosphate (IPP) or dimethylallyl diphospha
53 enoid farnesyl diphosphate (FPP) by coupling isopentenyl diphosphate (IPP) to dimethylallyl diphospha
54 (IDI) catalyzes the essential conversion of isopentenyl diphosphate (IPP) to dimethylallyl diphospha
57 lta2 T cells: pyrophosphomonoesters, such as isopentenyl diphosphate (IPP), nitrogen-containing bisph
58 mevalonate-5-diphosphate (MVAPP) to produce isopentenyl diphosphate (IPP), which is essential in bot
59 ynthesized by the successive condensation of isopentenyl diphosphate (IPP), with farnesyl diphosphate
66 he consecutive head-to-tail condensations of isopentenyl diphosphate (IPP, C5) with dimethylallyl dip
67 on of the two isoprenoid universal C5 units, isopentenyl diphosphate and dimethylally diphosphate, to
68 iene synthesis, we amplified the flux toward isopentenyl diphosphate and dimethylallyl diphosphate pr
69 h a mevalonate-dependent biosynthesis of the isopentenyl diphosphate and dimethylallyl diphosphate pr
70 thetic origin in the initial condensation of isopentenyl diphosphate and dimethylallyl diphosphate to
71 synthase (FDPS) catalyzes the conversion of isopentenyl diphosphate and dimethylallyl diphosphate to
72 hly dependent on the ratio of the substrates isopentenyl diphosphate and dimethylallyl diphosphate us
73 I-2), which catalyzes the interconversion of isopentenyl diphosphate and dimethylallyl diphosphate, c
75 hways operate in plants for the synthesis of isopentenyl diphosphate and dimethylallyl diphosphate, t
76 esis of their two universal building blocks, isopentenyl diphosphate and dimethylallyl diphosphate, w
77 alloenzyme that catalyzes interconversion of isopentenyl diphosphate and dimethylallyl diphosphate, w
78 yzes the formation of neryl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate.
79 he biosynthesis of the isoprenoid precursors isopentenyl diphosphate and dimethylallyl diphosphate.
80 ene geranyl diphosphate, when incubated with isopentenyl diphosphate and dimethylallyl diphosphate.
81 ate on the mevalonate-independent pathway to isopentenyl diphosphate and dimethylallyl diphosphate.
82 s the synthesis of farnesyl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate.
83 sis of the universal terpene building blocks isopentenyl diphosphate and dimethylallyl diphosphate.
84 oducing the essential isoprenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate.
85 l diphosphate (HMBPP) into the two products, isopentenyl diphosphate and dimethylallyl diphosphate.
86 ducing the universal precursors of terpenes: isopentenyl diphosphate and dimethylallyl diphosphate.
88 early pathway genes known to be involved in isopentenyl diphosphate and farnesyl diphosphate biosynt
89 se enzymes represented upstream pathways for isopentenyl diphosphate and geranylgeranyl diphosphate s
90 cript levels of paralogs encoding isoprenoid isopentenyl diphosphate and geranylgeranyl diphosphate-p
91 ylerythritol phosphate pathway to synthesize isopentenyl diphosphate and its allyl isomer dimethylall
92 renoids are constructed from two precursors, isopentenyl diphosphate and its isomer dimethylallyl dip
93 phosphate (MEP) pathway for biosynthesis of isopentenyl diphosphate and its isomer, dimethylallyl di
94 the conversion of radiolabeled mevalonate to isopentenyl diphosphate and other downstream products, i
96 hiolo-dimethylallyl diphosphate and S-thiolo-isopentenyl diphosphate bind intact to S2, but are cleav
97 coding enzymes of the mevalonate pathway for isopentenyl diphosphate biosynthesis in the gram-positiv
98 committed step in the mevalonate-independent isopentenyl diphosphate biosynthetic pathway and is a po
99 e mevalonate-independent pathway is the sole isopentenyl diphosphate biosynthetic pathway in this org
100 structures of Rv2361c in the apo form, with isopentenyl diphosphate bound and with a substrate analo
102 hydrogens of a vinyl thiomethyl analogue of isopentenyl diphosphate exchanged with solvent when the
103 wever, based on in vivo feeding experiments, isopentenyl diphosphate formation in several eubacteria,
104 l three enzymes responsible for synthesis of isopentenyl diphosphate from mevalonate (mevalonate kina
106 for metabolism of mevalonate 5-phosphate to isopentenyl diphosphate in Haloferax volcanii, two open
107 and co-locate with the homoallylic substrate isopentenyl diphosphate in other prenyltransferases.
109 hosphate showed a 10-fold increase of [(14)C]isopentenyl diphosphate incorporation into decaprenyl di
110 phosphate showed a 5-fold increase of [(14)C]isopentenyl diphosphate incorporation into farnesyl diph
111 recombinant strains were assayed for [(14)C]isopentenyl diphosphate incorporation into isoprenyl dip
120 psis thaliana cDNAs (IPP1 and IPP2) encoding isopentenyl diphosphate isomerase (IPP isomerase) were i
124 ntly described the identification of a novel isopentenyl diphosphate isomerase, IDI2 in humans and mi
127 ne, orf177, is a member of a large family of isopentenyl diphosphate isomerases, while sequence homol
128 respectively, the addition of two and three isopentenyl diphosphate molecules to dimethylallyl dipho
129 ntenol utilization pathway (IUP) can produce isopentenyl diphosphate or dimethylallyl diphosphate, th
131 ting carbon flow from cytosolic or plastidic isopentenyl diphosphate through overexpression in either
132 ondensation of dimethylallyl diphosphate and isopentenyl diphosphate to form geranyl diphosphate.
134 ondensation of dimethylallyl diphosphate and isopentenyl diphosphate to geranyl diphosphate, the key
135 phosphate synthase catalyzed the addition of isopentenyl diphosphate to omega,E-geranyl diphosphate o
136 es, responsible for converting mevalonate to isopentenyl diphosphate under the control of an arabinos
139 product of mevalonate metabolism proximal to isopentenyl diphosphate was responsible for the suppress
140 ases catalyze the sequential condensation of isopentenyl diphosphate with allylic diphosphates to syn
141 ead-to-tail condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate.
142 f 7-8, and K(m) values of 124 micrometer for isopentenyl diphosphate, 38 micrometer for geranyl dipho
143 cteria, green algae, and plant chloroplasts, isopentenyl diphosphate, a key intermediate in the biosy
144 ylallyl diphosphate and three equivalents of isopentenyl diphosphate, and a cyclase domain that conve
145 d arenarone bound solely to the homoallylic (isopentenyl diphosphate, IPP) site, not to the allosteri
146 Biosynthesis of the isoprenoid precursor, isopentenyl diphosphate, is a critical function in all i
150 y the nonmevalonate pathway for synthesis of isopentenyl diphosphate, the monomer unit for isoprenoid
157 nzymes farnesyl diphosphate synthase (FPPS), isopentenyl diphosphate/dimethylallyl diphosphate isomer
159 DP-galactopyranose mutase (UGM), and type II isopentenyl diphosphate:dimethylallyl diphosphate isomer
162 ive pathway for carbon flux amplification to isopentenyl-diphosphate (IPP) and dimethylallyl-diphosph
163 hosphate (FPP) synthase (geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase, EC 2.5.
164 abolites via the condensation of geranyl- or isopentenyl-diphosphate moieties by geranyltranstransfer
166 l, as well as the diphosphate derivatives of isopentenyl, geranyl, farnesyl, geranylgeranyl, and pres
167 , and Caenorhabditis elegans GRO-1 that adds isopentenyl groups to adenosine 37 (i6A37) of substrate
168 predicted ORF4 product is closely related to isopentenyl isomerase (IDI) enzymes, whereas the predict
171 kinase that catalyzes the phosphorylation of isopentenyl monophosphate as the last step of this biosy
172 terpenes and sesquiterpenes, confirming that isopentenyl monophosphate is the physiologically relevan
173 ted from peppermint glandular trichomes with isopentenyl monophosphate resulted in the rapid producti
175 A pathway where PM is decarboxylated to give isopentenyl phosphate (IP), which is phosphorylated to p
177 discovery of an alternative MVA pathway with isopentenyl phosphate kinase (IPK) catalyzing the final
178 ese missing elements led to the discovery of isopentenyl phosphate kinase (IPK), one of two activitie
179 biosynthesis, Methanocaldococcus jannaschii isopentenyl phosphate kinase is predicted to be a member
180 both the phosphomevalonate decarboxylase and isopentenyl phosphate kinase reactions that are required
181 ese proteins indicated that one enzyme is an isopentenyl phosphate kinase that forms isopentenyl diph
182 0044 gene product was found to phosphorylate isopentenyl phosphate, generating isopentenyl diphosphat
184 rbamoyl phosphate, UDP-glucose, and Delta(2)-isopentenyl-PP play similar roles in using group transfe
186 zation of the two ubiquitous isoprene units, isopentenyl pyrophosphate (IPP) and dimethylallyl pyroph
187 ginates from two five-carbon (C(5)) isomers, isopentenyl pyrophosphate (IPP) and dimethylallyl pyroph
188 e all derived from the 5-carbon diphosphates isopentenyl pyrophosphate (IPP) and dimethylallyl pyroph
192 amma-dimethylallyl pyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) to all of the known terp
193 the recombinant truncated AaIPPI1 isomerized isopentenyl pyrophosphate (IPP) to dimethyl allyl pyroph
194 at catalyzes the reversible isomerization of isopentenyl pyrophosphate (IPP) to dimethylallyl pyropho
195 e synthesised via sequential condensation of isopentenyl pyrophosphate (IPP) to dimethylallyl pyropho
196 required for haem biosynthesis-doubles as an isopentenyl pyrophosphate (IPP) transporter in Saccharom
198 nsecutive condensation of eight molecules of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosph
201 ol-4-phosphate pathway used by microbes, and isopentenyl pyrophosphate (IPP), an intermediate in the
202 encoding early steps in the biosynthesis of isopentenyl pyrophosphate (IPP), the precursor of all is
204 present only a subset of the phosphoantigen {isopentenyl pyrophosphate [IPP] and (E)-4-hydroxy-3-meth
206 ylerythritol-phosphate (MEP) pathway forming isopentenyl pyrophosphate and a heterologous downstream
207 , pulsing of BZ-(C)-C(5)-OPP is inhibited by isopentenyl pyrophosphate and an inactive analog, sugges
209 mulation with prenyl pyrophosphate antigens (isopentenyl pyrophosphate and monomethyl phosphate).
210 madelta T cells have been shown to recognize isopentenyl pyrophosphate and related structures and hum
211 ed reactivity to the prenyl pyrophosphate Ag isopentenyl pyrophosphate and to its synthetic analogue
212 ood gamma delta T cells to the nonpeptide Ag isopentenyl pyrophosphate and to its synthetic analogue
213 s Ag-nonreactive TCR destroyed reactivity to isopentenyl pyrophosphate and to the mycobacterial super
214 inity of 1.1 muM, whereas the endogenous pAg isopentenyl pyrophosphate binds with an affinity of 627
217 onophosphate kinase superfamily, and between isopentenyl pyrophosphate isomerases and MutT pyrophosph
218 by nonpeptidic monoalkyl phosphates such as isopentenyl pyrophosphate leads to the up-regulation of
219 ay, catalyzes the successive condensation of isopentenyl pyrophosphate with dimethylallyl pyrophospha
220 ethylerythritol phosphate pathway to produce isopentenyl pyrophosphate with more favorable thermodyna
221 the biosynthesis of the isoprenoid precursor isopentenyl pyrophosphate, 1-deoxy-D-xylulose-5-phosphat
222 on of mevalonate 5-diphosphate (MDP) to form isopentenyl pyrophosphate, a ubiquitous precursor for is
223 P), a microbial isoprenoid intermediate, and isopentenyl pyrophosphate, an endogenous isoprenoid inte
224 genesis in the first cycle and is rescued by isopentenyl pyrophosphate, an essential apicoplast produ
225 nic lines showed a three-fold enhancement of isopentenyl pyrophosphate, and targeting AACPR, DBR2, an
226 mportant accessory cells that provide the Ag isopentenyl pyrophosphate, CD56(bright)CD11c(+) NK cells
227 of TRPA1, being inhibited by ruthenium red, isopentenyl pyrophosphate, HC-030031, A967079 or TRPA1 k
228 -2-enyl pyrophosphate, HMBPP] or endogenous (isopentenyl pyrophosphate, IPP) and PAg sensing depends
230 levels > or =30 microM profoundly inhibited isopentenyl pyrophosphate-induced release of the chemoki
241 rget HCC cell lines sensitised to accumulate isopentenyl-pyrophosphate by the aminobisphosphonate Zol
242 thesis pathway responsible for production of isopentenyl-pyrophosphate, a short-chain phospholipid th
245 Five compounds, dimethylallyl phosphate, isopentenyl thiolophosphate, 1-butyl phosphate, 3-buten-
246 butylammonium) salt was then used to convert isopentenyl tosylate to (S)-isopentenyl thiodiphosphate
247 DR genes tested, the strategic expression of isopentenyl transferase (ipt) driven by the ESR1 promote
248 Expression from the cytokinin-synthesizing isopentenyl transferase (IPT) enzyme under the control o
251 directly activates the CK biosynthesis gene ISOPENTENYL TRANSFERASE 7 (IPT7), thus promoting cell di
252 plished by employing Omega-mutated virD2 and isopentenyl transferase cytokinin genes to impair T-DNA
253 Expression of the cytokinin-synthesizing isopentenyl transferase enzyme under the control of the
254 ipt, the bacterial gene encoding the enzyme isopentenyl transferase from Agrobacterium tumefaciens,
255 on which may arise from higher expression of isopentenyl transferase gene, concomitant with lower exp
257 ved in the crown region of nonconnated SAG12-isopentenyl transferase kernels, suggesting that cytokin
261 ne, the product of the reaction catalyzed by isopentenyl transferase, were detected in ros mutant str
266 ression of an Moniliophthora perniciosa tRNA-ISOPENTENYL-TRANSFERASE suggests the production of isope
267 ho, which encodes a protein with homology to isopentenyl transferases (IPTs), also causes CK-specific
268 be complemented by the plant and human tRNA isopentenyl transferases, but not the bacterial enzymes,