ライフサイエンスコーパス: isotype switching

1 are able to transduce signals that result in isotype switching.

2 years increased antibody titers and elicited isotype switching.

3 haride/interleukin-4-mediated immunoglobulin isotype switching.

4 cts of immune responses including Ig H chain isotype switching.

5 terleukin-4 (IL-4)-induced immunoglobulin G1 isotype switching.

6 optimal proliferation, differentiation, and isotype switching.

7 C found 4-7 days after KLH facilitates IgG2a isotype switching.

8 jectory distinct from classical mediators of isotype switching.

9 s in antibody production, amplification, and isotype switching.

10 of memory B cells, affinity maturation, and isotype switching.

11 6 directly provide help to B cells to induce isotype switching.

12 typical T-cell-dependent response involving isotype switching.

13 o cells that undergo affinity maturation and isotype switching.

14 and retained until mature B cells undergo Ig isotype switching.

15 ates DNA DSB repair, V(D)J recombination and isotype switching.

16 an respond to T-dependent Ags and support Ig isotype switching.

17 synthesis at a stage distal to Tfh-mediated isotype switching.

18 CL3 plays a part in B cell proliferation and isotype switching.

19 l mechanism of regulating the specificity of isotype switching.

20 ed by trans-chromosomal recombination during isotype switching.

21 on plays a critical role in T cell-dependent isotype switching.

22 rmal specific Ab responses with Ag-driven Ig isotype switching.

23 ctivated mature B cell, secretion of Ig, and isotype switching.

24 -cell survival, growth, differentiation, and isotype switching.

25 ndent intracellular signals that lead to IgE isotype switching.

26 R) that includes an enhancer which regulates isotype switching.

27 lper cell differentiation and immunoglobulin isotype switching.

28 eration, differentiation, and immunoglobulin isotype switching.

29 cell proliferation, survival, memory, and Ig isotype switching.

30 n and immunoglobulin affinity maturation and isotype switching.

31 ceptor-driven activation, proliferation, and isotype switching.

32 t acute infections, and T-bet promotes IgG2a isotype switching.

33 ly impaired, possibly at the stage of B cell isotype switching.

34 d resisted apoptosis, but was independent of isotype switching.

35 te of immunoglobulin affinity maturation and isotype switching.

36 ainst C. burnetii and contribute to antibody isotype switching.

37 ognate T- and B-cell interactions and normal isotype switching.

38 I ligand APRIL, probably reflecting impaired isotype switching.

39 2) responses, germinal center formation, and isotype switching.

40 y reports of changes in Ab Id structure with isotype switching.

41 losely related to aberrant hypermutation and isotype switching activity in these B cells.

42 icited an antibody response featuring normal isotype switching, affinity maturation, and germinal cen

43 cell dependent immune responses that lead to isotype switching, affinity maturation, and the inductio

44 In addition to their role in isotype switching, AID-induced lesions promote Igh-cMyc

45 Ab class (isotype) switching allows the humoral immune system to a

46 characterize migration, differentiation, and isotype switching along B cell phylogenetic trees.

47 n extension, in targeting Cgamma regions for isotype switching, an IgM+ Burkitt lymphoma cell line (R

48 ) vaccine resulted in improved IgG1-to-IgG2a isotype switching, an increase in neutralizing antibodie

49 or TRAF3 but not TRAF6 is essential for CD40 isotype switching and activation in B cells.

50 -) mice provide a novel model for separating isotype switching and affinity maturation during acute (

51 ase (AID) has been shown to be essential for isotype switching and affinity maturation of antibody ge

52 er and memory B cell formation, and antibody isotype switching and affinity maturation.

53 rmed the known role of AID in immunoglobulin isotype switching and also demonstrated few other effect

54 CD28-deficient mice exhibit defects in isotype switching and are more susceptible to pathogens

55 g heavy chain loci precede the occurrence of isotype switching and are thought to play an important t

56 o, as well as inhibition of Th1 cell-induced isotype switching and attenuation of experimental allerg

57 -derived CD154 alone is sufficient to induce isotype switching and augment T lymphocyte function duri

58 oliferate and induced splenomegaly; however, isotype switching and autoantibody production were dimin

59 These B cells demonstrate Ig heavy chain isotype switching and autoimmune reactivity, suggesting

60 As BAFF mediates T-cell-independent isotype switching and B-cell survival, our data implicat

61 ignificant fraction of naive B cells undergo isotype switching and differentiate into plasmacytes.

62 ts interactions with IL-21R are required for isotype switching and differentiation of B cells into Ab

63 B cell Ig isotype switching and differentiation toward IgA product

64 nous Ig genes, Ab H chain transgenes undergo isotype switching and gene conversion-like sequence tran

65 , in the transgenic mice both immunoglobulin isotype switching and germinal center formation were als

66 ion; and a pattern of anti-collagen antibody isotype switching and glycosylation that corresponded wi

67 in switch regions of the H chain locus cause isotype switching and have been extensively characterize

68 such primed T cells fail to provide help for isotype switching and IgG production in B cells.

69 made an about face with the emergence of Ig isotype switching and IgG-like structure/function.

70 activation-induced deaminase (AID) that lack isotype switching and immunoglobulin hypermutation.

71 4(+) T cells are required to induce antibody isotype switching and long-term memory responses.

72 B-1b cell expansion and the frequency of IgG isotype switching and plasmablast/plasma cell differenti

73 ay haploinsufficiency both in the context of isotype switching and plasmacytomagenesis.

74 s characterized by failure of immunoglobulin isotype switching and severe defects of cell-mediated im

75 Since isotype switching and somatic hypermutation occur in ger

76 Interestingly, although isotype switching and somatic hypermutation show many pa

77 help shapes the Ab response by facilitating isotype switching and somatic hypermutation, and promoti

78 ptor and communication with T cells, inhibit isotype switching and somatic hypermutation, downregulat

79 d cytidine deaminase, an enzyme required for isotype switching and somatic hypermutation, was also in

80 ndergone comparable levels of immunoglobulin isotype switching and somatic hypermutation, while neith

81 e remodeling, including V(D)J recombination, isotype switching and somatic hypermutation.

82 y B cells, suggesting a reduced frequency of isotype switching and somatic mutation in RV VP6-specifi

83 ination defect in A-T cells affected both Ig isotype switching and TCR rearrangeme

84 T-cell-dependent B-cell isotype switching and the consequent production of IgG a

85 Isotype switching and the initial LCMV-specific IgG resp

86 response in plasma cells that have undergone isotype switching and those resulting from secondary imm

87 response, which was demonstrated by Th2-type isotype-switching and the induction of cellular immune r

88 clonal B-cell activation/expansion, antibody isotype switching, and affinity maturation remain normal

89 TACI-driven proliferation, isotype switching, and antibody responses were measured

90 54, induce dendritic cell maturation, B cell isotype switching, and augment CD8(+) T cell responses b

91 critical signals for B cell differentiation, isotype switching, and B cell memory.

92 were present: significant somatic mutation, isotype switching, and codon insertion/deletion.

93 lls in XLA patients can proliferate, undergo isotype switching, and differentiate into specific Ab-pr

94 In addition, germinal center (GC) formation, isotype switching, and generation of memory B cells, inc

95 B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are

96 iciently induce antibody avidity maturation, isotype switching, and immunological memory in immunized

97 nct B cell subsets play in clonal expansion, isotype switching, and memory B cell differentiation in

98 Ag-specific B-1b cell activation, expansion, isotype switching, and plasmablast/plasma cell different

99 g spontaneous formation of germinal centers, isotype switching, and production of autoreactive antibo

100 es, subsequent differentiation of Th1 cells, isotype switching, and stimulation of cross-priming.

101 ired for the generation of germinal centers, isotype switching, and sustained Ab production, even whe

102 events such as proliferation, Ig secretion, isotype switching, and up-regulation of cell surface mol

103 B cell proliferation, Ig and IL-6 secretion, isotype switching, and up-regulation of surface molecule

104 tial for CD40-mediated B-cell proliferation, isotype switching, and upregulation of CD23, ICAM-1, CD8

105 D40 stimulation on B-cell proliferation, IgE isotype switching, and upregulation of surface expressio

106 ms and significance of the effect of BSAP on isotype switching are discussed.

107 autoantibody responses with some changes in isotype switching as compared with untreated animals.

108 ll activation, germinal center formation, Ig isotype switching as well as plasma cell differentiation

109 ion of ICOS to germinal center formation and isotype switching, as well as its relevance to the fate

110 aged animals was not due to a deficiency in isotype switching because the number of total IgG1 splen

111 IL-4 pathway did not suffice to trigger IgE isotype switching, but promoted IgG1 production and inhi

112 The reduction in isotype switching by Atm-/- B cells occurs at the level

113 y be involved in the mechanism that leads to isotype switching by B cells.

114 ide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and so

115 D86 expression, Ig secretion and heavy chain isotype switching by neonatal B cells.

116 some instances terminal differentiation and isotype switching can occur.

117 can influence fine specificity suggests that isotype switching contributes to the generation of Ab di

118 l activation, we investigated whether B-cell isotype switching could predict acute cellular rejection

119 This would predict isotype-switching deficiency but normal affinity maturat

120 MR-deficient mice show a 35-75% reduction in isotype switching, depending on the isotype and on the p

121 gglutinin+ germinal centers and a failure in isotype switching despite normal B cell signaling in vit

122 antidonor CD8(+) T effector cells and for Ab isotype switching, despite DST/anti-CD40L.

123 lls (Tfh) as the key T cell subset in B cell isotype switching, due to their physical location at the

124 in class switch recombination (CSR) mediates isotype switching during B cell development.

125 n IgG1 and IgE occurs independently from the isotype switching event.

126 onoclonal antibody was generated followed by isotype switching for improved antibody-dependent, cell-

127 We also find that these inferred isotype switching frequencies are similar in healthy and

128 fer patterns of cellular differentiation and isotype switching from high throughput BCR sequence data

129 onstrated increased total IgG production and isotype switching from IgG1 to IgG2a and IgG2b in sE2(44

130 or modified recipient class II antigens; (c) isotype switching from IgM to IgG alloantibody requires

131 recent years several groups have shown that isotype switching from IgM to IgG to IgA can affect the

132 aracterized by (i) more rapid kinetics, (ii) isotype switching from immunoglobulin M (IgM) to IgG, an

133 ch circular DNA representing in vitro driven isotype switching from mu to alpha.

134 B cell model, we found that Ag presentation, isotype switching, GC formation and zonation, somatic hy

135 tes, including V(D)J gene rearrangements and isotype switching, generally occur in cis, i.e., intrach

136 -germ line-encoded residues, and intraclonal isotype switching generated a surprising degree of parat

137 helper cell subset that contributes to IgG4 isotype switching have both been defined by multiple gro

138 MAb can be converted to a protective MAb by isotype switching, (ii) indicate that the efficacy of pr

139 The phospho-mimetic variants fail to mediate isotype switching in activated mouse splenic B lymphocyt

140 nduces Cepsilon germline transcripts and IgE isotype switching in B cells from patients with gammac c

141 helper cell, type 2 (Th2) phenotype and IgE isotype switching in B cells, its role in other IL-4-med

142 on to parental sE2 treatment and facilitated isotype switching in B cells, leading to the generation

143 h2 differentiation of CD4(+) T cells and IgE isotype switching in B cells, we hypothesized that basop

144 the role of TRAF proteins in CD40-dependent isotype switching in B cells, we introduced wild-type (W

145 ses to protein Ags and is responsible for Ig isotype switching in B cells.

146 of Id3 in cytokine production in T cells and isotype switching in B cells.

147 and cyclophilin ligand interactor) mediates isotype switching in B cells.

148 Ig heavy chain isotype switching in B lymphocytes is known to be preced

149 s receptor CD40 induces proliferation of and isotype switching in B lymphocytes.

150 APRIL by itself induced IgA as well as IgG1 isotype switching in CD40-deficient IgM(+)IgD(+) sorted

151 ducing Cepsilon germline transcripts and IgE isotype switching in human B cells.

152 ctor family members BAFF and APRIL induce Ig isotype switching in human B cells.

153 Activation-induced deaminase initiates isotype switching in mature B cells of secondary lymphoi

154 restricted almost entirely to IgA, although isotype switching in mediastinal continued to be skewed

155 tandem repeat (SmuTR) sequences each reduce isotype switching in mice by about 2- to 3-fold.

156 yzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and Ig

157 4 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells f

158 exhibit decreased Ab production and impaired isotype switching in response to immunization with a thy

159 - mice, suggesting that IRF9 plays a role in isotype switching in response to self antigens.

160 cells and mice) as well as a restoration of isotype switching in SMUG-transgenic msh2-/- ung-/- mice

161 pable of proliferating, differentiating, and isotype switching in the absence of CD40-CD40L interacti

162 causes mouse B cells to undergo IgE and IgG1 isotype switching in the presence of IL-4.

163 his can be explained by impaired RA-mediated isotype switching in TLR9/RP105-stimulated CVID-derived

164 Ig, express germ-line CHRNA, and undergo Ig isotype switching in vitro in response to a number of di

165 e, accumulate V genes mutations, and undergo isotype switching in vivo.

166 d clonal amplification, somatic mutation and isotype switching, indicating a local antigen-driven B-c

167 Isotype switching involves a region-specific, nonhomolog

168 Immunoglobulin (Ig) isotype switching is a recombination event that changes

169 This study implies that isotype switching is another mechanism for generating di

170 How the magnitude of immunoglobulin isotype switching is controlled is still poorly understo

171 Isotype switching is the DNA recombination mechanism by

172 , characterized by failure of immunoglobulin isotype switching, is caused by mutations of the CD40 li

173 rom RIP(-/-) mice proliferated and underwent isotype switching normally in response to anti-CD40-IL-4

174 Isotype switching occurs by intrachromosomal DNA recombi

175 These results indicate that isotype switching occurs in lpr/lpr mice deficient in CD

176 The isotype switching of anti-MUC1 Ab was CD4 dependent.

177 r the survival, growth, differentiation, and isotype switching of B lymphocytes.

178 blasts increases, correlating with potential isotype switching of GM-CSF- and IL-3-producing IgM(+) B

179 tch recombination (CSR)--a process mediating isotype switching of immunoglobulin--and somatic hypermu

180 We found evidence that secondary isotype switching of mutated IgG1-expressing B cells is

181 al center reactions after Ag stimulation and isotype switching of naive B cells to IgA production hav

182 ted to a subset of B cell lines that support isotype switching on their endogenous loci and to mitoge

183 t local environments and thus affects either isotype switching or homing of IgA-expressing cells.

184 p-1 expression in Irf4(-/-) B cells promoted isotype switching or secretion, respectively.

185 creted Abs, but no deficiencies in survival, isotype switching, or expression of germinal center (GC)

186 ired for the generation of germinal centers, isotype switching, or sustained Ab production.

187 B cell isotype switching plays an important role in modulating

188 pansion of IgG but not IgA isotypes, and IgG isotype switching positively associated with survival ou

189 This defect is not due to a failure of the isotype switching process, but rather to reduced levels

190 CD40-mediated isotype switching, proliferation, and activation of p38,

191 ration in that significant somatic mutation, isotype switching, receptor revision, codon insertion/de

192 rocesses, we have analyzed H chain transgene isotype switching, sequence transfer, and somatic hyperm

193 specific B cells that have not yet undergone isotype switching showed a relatively higher expression

194 MHC-I and MHC-II affect antibody isotype switching, since both PIV-vaccinated B2m KO and

195 T cell-dependent B cell responses, including isotype switching, somatic hypermutation, and limited af

196 In order to probe the isotype switching status of HCL, RNA transcripts of V(H)

197 ontribute to the activation of Ab secretion, isotype switching, T cell costimulation, and immunologic

198 rotection of an IgG1 MAb can be increased by isotype switching to another subclass, (iii) show that p

199 ith a SphK1 inhibitor or in SphK1(-/-) mice, isotype switching to antigen-specific IgE was decreased

200 cytokine environment was adequate to support isotype switching to cytophilic IgGs, the isotypes that

201 The ability of GE2 to block human isotype switching to epsilon, in addition to its already

202 onists with remarkable antitumor activity by isotype switching to hIgG2.

203 surface GARP/latent TGF-beta1 complexes with isotype switching to IgA production.

204 We evaluate models for isotype switching to IgE in human subjects using immunog

205 t deficiencies in eosinophil recruitment and isotype switching to IgE production may be at least part

206 lon germline transcript, reflecting antibody isotype switching to IgE, measured at 6 years of age.

207 transcripts, an essential step preceding Ig isotype switching to IgE, requires activation of transcr

208 believed to be a necessary prerequisite for isotype switching to IgG1 and IgE, respectively.

209 on and are normally required for T-dependent isotype switching to IgG1 and IgE.

210 g both p50 and p65 secreted Ig and underwent isotype switching to IgG1 as efficiently as B cells lack

211 Frequencies of isotype switching to IgG1, IgG2b, IgG2c, and IgG3 were t

212 uble NTB-A-Fc fusion protein inhibits B cell isotype switching to IgG2a and IgG3, commonly induced by

213 er increase their IgM production nor undergo isotype switching to IgG2a in response to the infection.

214 HC region regulate autoantigen selection and isotype switching to IgG3 but have minimal effect on end

215 Isotype switching to IgG4 in an autoimmune response ther

216 mmune imprinting for the ancestral spike and isotype switching to IgG4 responses following bivalent m

217 Although no isotype switching to IgY or IgA occurred, the IgM repert

218 Isotype switching to immunoglobulin G (IgG) was abrogate

219 lar to that in the controls, including rapid isotype switching to immunoglobulin G antibody.

220 ody (NAb) responses against XBB variants and isotype switching to immunoglobulin G4 (IgG4) responses

221 e previously showed that IgW VDJ can perform isotype switching to mu C regions; in this study, we fou

222 gens, causes stronger antibody responses and isotype switching to the IgG isotypes.

223 the Ag 85B epitope and consistently induced isotype switching to the IgG2c subclass.

224 cell encounters with antigen, how they favor isotype switching to the secretory IgA isotype, and how

225 served increased IgE diversity and increased isotype-switching to IgE, suggesting that B-cell develop

226 y reported, we observed a defect in antibody isotype switching toward the IgG1 isotype in ICOS-/- mic

227 CD40 signaling is crucial for Ab production, isotype switching, up-regulation of surface molecules, d

228 s induces immunoglobulin (Ig)M-to-IgG B-cell isotype switching via costimulatory regulatory pathways.

229 c expression in B cells is linked with IgG2c isotype switching, virus-specific immune responses, and

230 The reduction in isotype switching was demonstrated to be at the level of

231 lpha to stimulate the Ab response and induce isotype switching was markedly reduced in mice in which

232 B cell Ig isotype switching was measured by enzyme-linked immunosp

233 To determine the role of these receptors in isotype switching, we examined B cells from mice deficie

234 irect effect on any of the steps involved in isotype switching, we generated a transgenic mouse that

235 To directly examine the effects of BSAP on isotype switching, we use a tetracycline-regulated expre

236 I antigens for >30 days and the lack of IgG isotype switching were associated with protection agains

237 were present, but NK cell number and B cell isotype switching were reduced.

238 immune responses, including induction of IgG isotype switching, were characterized in calves immunize

239 udy demonstrates that peptides can induce TI isotype switching when antigen and TLR ligand are assemb

240 m viral infections depends on immunoglobulin isotype switching, which endows antibodies with effector

241 s, but their TI variants, that initiate sIgE isotype switching, while both canonical and TI variants

242 ar mechanisms underlying the coordination of isotype switching with plasma cell differentiation are p

243 ression of IRF-4 developmentally coordinates isotype switching with plasma cell differentiation.

244 y reactive T cells from SLE patients induced isotype switching, with a striking increase in IgG produ