ライフサイエンスコーパス: isozyme

1 r the 11-beta hydroxysteroid dehydrogenase 2 isozyme.

2 ypeptide 1 subunit zeta, and pyruvate kinase isozyme.

3 ide Ca(2)(+) feedback to the remaining RetGC isozyme.

4 sheveled, and ZO1) ligand unique to this PKC isozyme.

5 and siRNA-induced knockdown of specific PKC isozyme.

6 from the mammalian cofactor-dependent (dPGM) isozyme.

7 a highly reactive cysteine unique to the bGP isozyme.

8 Arabidopsis contains two ProRS isozymes.

9 retina, RD3 inhibited both RetGC1 and RetGC2 isozymes.

10 otent and show selectivity toward particular isozymes.

11 ized sites and covering nine Cytochrome P450 isozymes.

12 ction against the 12 catalytically active CA isozymes.

13 n amino acid residues among the different CA isozymes.

14 discriminate among structurally similar GST isozymes.

15 b-wave amplitude and the expression of GSK3 isozymes.

16 embrane-mediated allosterism within PLC-beta isozymes.

17 ed only in cells lacking their corresponding isozymes.

18 bitor of a broad range of Gram-negative TrmD isozymes.

19 redicts the regioselectivity of the last six isozymes.

20 sibly by competing with the endogenous LPCAT isozymes.

21 poxic tumors overexpressing extracellular CA isozymes.

22 phosphorylated during the maturation of PKC isozymes.

23 es for Ca(2+) and specificities toward RetGC isozymes.

24 use of U73122 as a general inhibitor of PLC isozymes.

25 , a species that expresses three active FAD2 isozymes.

26 e 10-member family of protein kinase C (PKC) isozymes.

27 e lack of potency against gram-positive GlmU isozymes.

28 bited low off-target inhibition of other CYP isozymes.

29 istinguish between the two highly homologous isozymes.

30 y if selective against individual ppGalNAc-T isozymes.

31 umor-linked NAD(P)H: quinone oxido-reductase isozyme 1 (hNQO1) results in fast trigger group removal

32 ociated human NAD(P)H:quinone oxidoreductase isozyme 1 (hNQO1).

33 of this process, human lactate dehydrogenase isozyme 1 (LDH-1) microcrystals were separately dissolve

34 kinase (PI3K), pyruvate dehydrogenase kinase isozyme 1 (PDK1), and mammalian target of rapamycin (mTO

35 ursor (GPC) by the cellular subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P) is crucial for p

36 The proprotein convertase subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P) plays crucial ro

37 lycoprotein by the cellular subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P).

38 SD11B1 (hydroxysteroid 11-beta-dehydrogenase isozyme 1), a key glucocorticoid-activating enzyme, inde

39 gs inhibit poly-ADP ribose polymerase (PARP) isozymes 1, 3, and 16.

40 The proprotein convertase subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P) is implicated in

41 Pyruvate kinase muscle isozyme 2 (PKM2) is a key regulator of aerobic glycolysi

42 N-gamma secretion via pyruvate kinase muscle isozyme 2 (PKM2) to accelerate atherosclerosis.

43 factor-1A and reduced pyruvate kinase muscle isozyme 2 activity, both key regulators of aerobic glyco

44 ll IgG production via pyruvate kinase muscle isozyme 2.

45 ed biochemical potency against gram-negative isozymes 300-fold and afforded antimicrobial activity ag

46 Cerebrospinal fluid lactate dehydrogenase isozyme 5, beta2-microglobulin, and immunoglobulin heavy

47 mits GCAP1 access to RetGC2 and makes RetGC1 isozyme a preferential target for the disease-causing GC

48 Similar effects were observed with human GST isozymes A1-1 and M1-1.

49 haped by the sequential recruitment of RetGC isozyme activation by GCAPs according to the different G

50 is revealed few peculiar residues in the 1A3 isozyme active site.

51 he antiviral activities of noncanonical PARP isozyme activities are limited by the availability of NA

52 indel mutations of human erythroid-specific isozyme ALAS2, within a C-terminal (Ct) extension of its

53 he maximal level of activation by GCAP, this isozyme alone could provide a significantly high rate of

54 Importantly, PKC isozymes alpha/beta control alternative splicing of thes

55 Both GSK-3 isozymes (alpha/beta) were hyperactive in this model.

56 B); alkaline phosphatase, tissue-nonspecific isozyme (ALPL); and chemokine (C-X-C motif) receptor 2 (

57 n Michigan, USA, and was characterized using isozyme analysis and ribosomal and mitochondrial gene se

58 rst demonstrated link between a specific PKC isozyme and inhibitor of DNA binding factors, and it poi

59 for elucidating the biological roles of this isozyme and may ultimately be useful for treating specif

60 An isozyme and tumor-selective role of PDE10 were evident b

61 olution structure of a full-length PLC-gamma isozyme and use it to underpin a detailed model of their

62 ng strategy of dual recognition of PKCdeltaI isozymes and a caspase-3 binding site on the PKCdeltaI h

63 und was devoid of inhibitory activity on COX isozymes and blocked AKR1C3 mediated production of T and

64 lts extend understanding of the B. napusFAD2 isozymes and define the practical limit to increasing oi

65 hing novel transcriptional effectors for PKC isozymes and may have significant functional and therape

66 and KFB50 physically interact with four PAL isozymes and mediate their proteolytic turnover via the

67 /-) retinas expressed normal levels of RetGC isozymes and other phototransduction proteins, with the

68 ive stimulator of steroidogenesis, both PDE8 isozymes and PDE4 need to be simultaneously targeted.

69 s and network edges, due to the existence of isozymes and protein complexes.

70 domains, motifs originally identified in PKC isozymes and responsible for binding of phorbol esters a

71 of effectors, the phospholipase C (PLC)-beta isozymes and Rho guanine nucleotide exchange factors (Rh

72 analyzed the functional coupling between COX isozymes and terminal enzymes by developing a PGH2-divid

73 : pathological reduction of synaptogenic PKC isozymes and their downstream synaptogenic substrates, s

74 e of the signaling pathways regulated by PKC isozymes and their effectors, there is essentially no in

75 tance of diacylglycerol and protein kinase C isozymes and then on the molecular motor proteins that f

76 remaining paralogs, encoding six plastidial isozymes and two cytosolic isozymes, were expressed in s

77 e first rapid and specific inhibition of MEK isozymes, and introducing photoisomerizable linkers in t

78 are indistinguishable from other hexokinase isozymes, and which displays a 100-fold increase in cata

79 Cytochrome P450 isozymes are also increased in immune cells in irreversi

80 PLC-beta isozymes are autoinhibited, and several proteins, includ

81 tructures of isolated domains from PLC-gamma isozymes are available, these structures are insufficien

82 Phospholipase C (PLC) isozymes are important signaling molecules, but few smal

83 Protein kinase C (PKC) isozymes are key signal transducers involved in normal p

84 We conclude that PKC isozymes are not the calcium sensors that mediate PTP at

85 the biological effects of selective PLC-beta isozymes are poorly understood.

86 heparosan, the catalytic phenotypes of these isozymes are quite different.

87 Oxidative enzymes such as cytochrome P450 isozymes are rapidly upregulated in TG neurons after oro

88 Protein kinase C (PKC) isozymes are the paradigmatic effectors of lipid signali

89 Atypical protein kinase C (aPKC) isozymes are unique in the PKC superfamily in that they

90 y mediating autophagy and identify this HDAC isozyme as a druggable regulator of advanced-stage tumor

91 stem cells highlights the potential of this isozyme as a prognosis marker and drug target.

92 nst ALDH1A1 over ALDH3A1, ALDH1B1, and ALDH2 isozymes as well as other dehydrogenases such as HPGD an

93 ade for the promiscuous 2C9, 2D6 and 3A4 CYP isozymes, as well as CYPs 1A2, 2A6, 2B6, 2C8, 2C19 and 2

94 horylase muscle form, pyruvate kinase muscle isozyme, beta-enolase and triosephosphate isomerase and

95 e catalytic constants of both GCAP-activated isozymes between 12- and 19-fold higher than previously

96 Although these isozymes both generate heparosan, the catalytic phenotyp

97 mplex are defined not by a particular target isozyme but the intrinsic properties of GCAPs themselves

98 We verify inhibition of the studied isozymes by a thorough kinetic analysis.

99 are integral for the activation of PLC-beta isozymes by diverse modulators, and we propose a model d

100 displaying selectivity for cancer-associated isozymes CA IX and CA XII compared to off-target CA I an

101 o interact with the extracellular domains of isozymes CAIX and CAXII.

102 eraction of the CPOs with the cancer related isozymes CAIX and XII and thereby promoting cellular dam

103 PHLPP isozymes catalyze the dephosphorylation of a conserved r

104 lthiobutyrate, whereas the Ni(2+)-containing isozyme catalyzes an off-pathway shunt with the same sub

105 The Fe(2+)-containing isozyme catalyzes the on-pathway reaction using substrat

106 The main pyruvate kinase isozyme (Cdc19) is phosphorylated in response to environ

107 ree Arabidopsis thaliana secondary cell wall isozymes: CESA4, CESA7, and CESA8.

108 e more widely applicable, we investigated if isozyme competition influenced production of ESA.

109 Our results indicate that isozyme competition is a limiting factor in the engineer

110 erely than in the retinas lacking both RetGC isozymes, consistent with a hypothesis that the inhibito

111 Cardiac isozymes contain one catalytic alpha-subunit isoform (al

112 t structural and regulatory properties of GP isozymes contribute to the different functions of muscle

113 D1, -2, -3, -4, and -6), it is unclear which isozyme contributes to disease pathogenesis.

114 We conclude that Gln-1;2 is the main isozyme contributing to shoot GS1 activity in vegetative

115 a timer for the lifetime of conventional PKC isozymes, converting the enzymes into a species that can

116 heir distinct regulatory features, these two isozymes could confer distinct metabolic functions of gl

117 We propose that individual 3-OST isozymes create distinct modified domains or 'glycocodes

118 Despite a 97% sequence identity, both isozymes differ largely in their ability to hydrolyze AT

119 . truncatula revealed the presence of unique isozymes displaying novel regulatory properties.

120 isozymes from cytosol and mitochondria-human isozymes exist in the same subcellular compartments.

121 CR identified SULT1A1, -1A3, and -1E1 as the isozymes expressed in four human lung cell lines.

122 the voltage dependence of human cardiac NKA isozymes expressed in Xenopus oocytes, and of native NKA

123 ombined with null mutations in the other two isozymes, FAD2.C5 and FAD2.C1.

124 ompetition between endogenous and transgenic isozymes for substrates limits accumulation of unique FA

125 Plants have an isozyme form of eIF4F (eIFiso4F) with comparable subunit

126 e revealed minor kinetic differences between isozymes formed by different alpha-beta isoform combinat

127 o explains why mutant forms of the PLC-gamma isozymes found in several cancers have a wide spectrum o

128 he coexpression of triacylglycerol synthesis isozymes from castor along with the fatty acid hydroxyla

129 tructures of MTX and PTX bound to plant SHMT isozymes from cytosol and mitochondria-human isozymes ex

130 one dynamic combinatorial libraries with two isozymes from the glutathione S-transferase class of enz

131 Protein kinase C (PKC) isozymes function as tumor suppressors in increasing con

132 oli--aspC, argD, and gltA--are examined, and isozyme functions are uncovered for each to a different

133 Seven isozyme functions based on genetic and transcriptional e

134 These data establish that PKC isozymes generally function as tumor suppressors, indica

135 Somatic PLC isozymes generate inositol 1,4,5-trisphophate-mediated C

136 r BD can activate glycogen synthase kinase-3 isozymes (GSK3alpha and beta).

137 GSK3 has two mammalian isozymes, GSK3alpha and GSK3beta, whose functions remain

138 The native RetGC isozymes had different basal activity and were accelerat

139 tive small molecule modulators of individual isozymes has been a longstanding goal.

140 us complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis

141 GLS isozymes have been consistently related to cell prolifer

142 orbol ester-regulated protein kinase C (PKC) isozymes have been widely linked to tumor promotion and

143 CaMKII isozymes have complex structural and autoregulatory prop

144 hemic brain injury, but its human and rodent isozymes have different inhibitor specificities.

145 We found that cytosolic PGD1 and PGD2 isozymes have heat-stable activity, while amyloplast-loc

146 Biliverdin reductase A (BVR) and Akt isozymes have overlapping pleiotropic functions in the i

147 Protein kinase C (PKC) isozymes have remained elusive cancer targets despite th

148 inhibition of an important cancer-associated isozyme, hCA XII, with a Ki of 0.79 nM.

149 The isozyme HDAC10 contributes to chemotherapy resistance an

150 positions of the structurally characterized isozyme histone deacetylase 8 (HDAC8).

151 The yeast HMGR isozyme Hmg2 also undergoes feedback-regulated ERAD in r

152 Degradation of the yeast HMGR isozyme Hmg2 is controlled by the sterol pathway interme

153 The yeast HMG-CoA reductase isozyme Hmg2, like its mammalian counterpart, undergoes

154 Phospholipase C-beta (PLC-beta) isozymes hydrolyze the membrane lipid phosphatidylinosit

155 , eight can inhibit at least one of four hCA isozymes (I, II, IX, and XII) with submicromolar inhibit

156 or-overexpressed CA IX and XII and cytosolic isozymes, identified nanomolar-potent inhibitors against

157 en for inhibitors against carbonic anhydrase isozyme II is performed, in which known inhibitors are c

158 calization in the epidermis and mesophyll of isozymes implicated in starch and malate turnover are di

159 obvious drug targets that have no homologous isozyme in the human host have now been investigated.

160 el and rapid approach to profile various ALP isozymes in blood via a single-molecule-analysis platfor

161 These results indicate that ROD1 isozymes in canola are responsible for less than 20% of

162 s not inhibit the catalytic activity of aPKC isozymes in cells.

163 he activity of PDC is regulated by different isozymes in different tissues.

164 identified important roles for specific PKC isozymes in erlotinib resistance and EMT in lung cancer

165 Analysis of protein content of PDK isozymes in major metabolic tissues revealed that PDK1 a

166 ressed in Xenopus oocytes, and of native NKA isozymes in rat ventricular myocytes, using normal mamma

167 ac/Val animals had altered expression of PKC isozymes in RV tissue compared with PH alone.

168 nd explained substrate preferences among PAL isozymes in sorghum and other monocots, which can serve

169 e differential involvement of individual PKC isozymes in the control of gene expression, our studies

170 ular models, the relevance of individual PKC isozymes in the progression of human cancer is still a m

171 his study, we have profiled transglutaminase isozymes in the rat subtotal nephrectomy (SNx) model of

172 s a potential role of protein kinase C (PKC) isozymes in the resistance to TKIs, we used the isogenic

173 two separate assay formats with purified PLC isozymes in vitro.

174 , indicating that GCAP2 activates both RetGC isozymes in vivo.

175 e demonstrate that inhibition of various PDE isozymes, including PDE4, lead to significant increases

176 Transition states of closely related isozymes indicate that the protein's dynamic architectur

177 ere found to be selective against certain CA isozymes, indicating that it should be possible to devel

178 at the turn motif, thus converting these PKC isozymes into species that can be efficiently down-regul

179 To identify the PKC isozyme involved, we used a sod2 gene response reporter

180 anhydrases (CAs, EC 4.2.1.1) are ubiquitous isozymes involved in crucial physiological and pathologi

181 The Na,K-ATPase alpha2 isozyme is the major Na,K-ATPase of mammalian skeletal m

182 Although the expression of PKC isozymes is altered in multiple cancer types, the causal

183 ation of conventional protein kinase C (PKC) isozymes is initiated by the binding of their C2 domains

184 of GPAT4 and other LD-localized TG synthesis isozymes is required for LD growth.

185 ycogen phosphorylase, pyruvate kinase muscle isozyme, isoforms of creatine kinase.

186 s were tested against the tumor-expressed CA isozyme IX (CA IX), and the cytosolic CA I, CA II, and m

187 in the pathway, and it is provided by three isozymes known to rely upon a divalent metal.

188 on of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatoce

189 cs on the L-asparaginase structural homology isozymes L-asparaginases I (AnsA) and II (AnsB), which a

190 mes alpha-enolase (ENO1) and pyruvate kinase isozyme M2 (PKM2), were assessed for their ability to bi

191 the glycolytic enzyme pyruvate kinase muscle isozyme M2 and after KIR cross-linking have increased ph

192 ding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and up-regulation of widely expressed

193 Atypical protein kinase C (aPKC) isozymes modulate insulin signaling and cell polarity, b

194 he conclusion that PDE3A is the primary PDE3 isozyme modulating basal contractility and SR Ca(2+) con

195 MtDHDPS sequences indicated the presence of isozymes (MtDHDPS2 and MtDHDPS3) with multiple amino aci

196 r, the allosteric regulation of the three GP isozymes (muscle, liver, and brain) by metabolites and p

197 lactone with preferential affinity for novel isozymes (nPKCs) relative to classical PKCs (cPKCs).

198 tions in the gene for the tissue-nonspecific isozyme of alkaline phosphatase (TNSALP).

199 thetic pathway: ferrochelatase (HemH) and an isozyme of coproporphyrinogen III oxidase (HemF).

200 A editing factor, and cpPNP, the chloroplast isozyme of polynucleotide phosphorylase.

201 ous genes (Bn-FAE1.1 and Bn-FAE1.2) encoding isozymes of 3-keto-acylCoA synthase, a subunit of the cy

202 Two distinct isozymes of bacterial PK have been recognized, PykA and

203 enes, BnROD1.A3 and BnROD1.C3, encode active isozymes of PDCT, and these genes are strongly expressed

204 Two isozymes of plant POR, POR A and POR B from barley, whic

205 le phosphorylation governed by at least four isozymes of pyruvate dehydrogenase kinase (PDK).

206 Additional PAL isozymes of sorghum were characterized and categorized i

207 The sequences of the two isozymes only differ at six amino acid residues.

208 y grown plants, the plastidial phosphorylase isozyme participates in transitory starch degradation an

209 The role of different PDE isozymes, particularly PDE3A vs PDE3B, in the regulation

210 Maize also has two cytosolic isozymes, PGD1 and PGD2, that are not required for kerne

211 al groups of the endogenous substrate of PLC isozymes, phosphatidylinositol 4,5-bisphosphate (PIP(2))

212 the activity of the plastidial phosphorylase isozyme (PHS1) is increased.

213 eal distinct functional roles of the two PKA isozymes, PKA type I (PKA-I) and PKA-type II (PKA-II), o

214 Atypical protein kinase C (aPKC) isozymes, PKClambda/iota and PKCzeta, are now considered

215 teracts directly with pyruvate kinase muscle isozyme (PKM)2 to modulate metabolic flux in cancer cell

216 Ten protein kinase C (PKC) isozymes play divergent roles in signal transduction.

217 4-Oxalocrotonate tautomerase (4-OT) isozymes play prominent roles in the bacterial utilizati

218 ctivation of the human phospholipase C-gamma isozymes (PLC-gamma1, -gamma2) by tyrosine phosphorylati

219 a comprehensive evaluation of intracellular isozyme potency and selectivity for a collection of 46 c

220 In addition, oligomerization of OAS isozymes, potentially OAS1 and OAS2, is hypothesized to

221 orted mutations in the gene encoding PYCR2's isozyme, PYCR1, suggesting a unique and indispensable ro

222 JNK isozymes regulate cell death and survival, differentiati

223 both muscle and brain glycogen phosphorylase isozymes regulate glycogen mobilization.

224 e activity showed that PDK1 is the principal isozyme regulating hepatic PDC.

225 he specificity and substrate profile of each isozyme remains largely unknown.

226 ry in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied s

227 arotenoid enzyme, is represented by multiple isozymes residing at unknown plastid sites.

228 Yet, the phospholipase C (PLC) isozymes responsible for coupling the CXCR4-TCR heterodi

229 GGPPS11 and GGPPS1 are the major isozymes responsible for their biosynthesis.

230 either the cytosolic or mitochondrial MTHFD isozyme resulted in decreased cellular NADPH/NADP(+) and

231 an retinal membrane guanylyl cyclase (RetGC) isozyme RetGC1 cause various forms of blindness, ranging

232 nthesis by retinal membrane guanylyl cyclase isozymes (RetGC1 and RetGC2) in rod and cone photorecept

233 eceptor by retinal membrane guanylyl cyclase isozymes (RetGC1 and RetGC2) to expedite recovery, but c

234 e guanylyl cyclase (RetGC), comprised of two isozymes, RetGC1 and RetGC2.

235 ermore, elimination of RetGC1 but not RetGC2 isozyme reverses abnormal calcium sensitivity of cGMP sy

236 The sulfatase isozyme S gene constitutes a functional and positional c

237 derivative (TM-2-51) serves as a potent and isozyme-selective activator for human histone deacetylas

238 The discovery of isozyme-selective histone deacetylase (HDAC) inhibitors

239 ed approach coupled with treatment using PDE isozyme-selective inhibitors to characterize the phospho

240 es, it is particularly difficult to generate isozyme-selective small molecule inhibitors.

241 lso been suggested that HDACi with increased isozyme selectivity and potency may broaden their clinic

242 active site features that contribute to the isozyme selectivity observed in biochemical assays.

243 ed excellent activity against SIRT2 and high isozyme selectivity over SIRT1 and SIRT3.

244 GSK-3beta-isozyme selectivity was assessed to reveal OCM-51, the m

245 OS, offers compelling insight to explain its isozyme selectivity, which should guide future drug desi

246 Previous work has shown that isozyme specific residues (ISRs) distant from the active

247 e structure offers a template for developing isozyme-specific allosteric inhibitors that can be used

248 Here, we report the first PKC isozyme-specific analysis of global gene expression by m

249 By the use of isozyme-specific cAMP analog pairs, we show that both PK

250 (RS-WebPredictor) is a server that predicts isozyme-specific cytochrome P450 (CYP)-mediated sites of

251 The approach enabled us to profile isozyme-specific engagement and binding kinetics for a p

252 nds capable of differentially regulating PKC isozyme-specific function in cellular models.

253 ur study opens new avenues for defining GSK3 isozyme-specific functions in various cellular processes

254 alpha and TPA, to monitor the effects of PKC isozyme-specific inhibitors and siRNA-induced knockdown

255 ted immune diseases, in which development of isozyme-specific inhibitors may be useful for treatment.

256 a interacts with mitochondria by a novel and isozyme-specific mechanism distinct from its canonical r

257 s has been attained in the generation of PKC isozyme-specific modulators acting via the C1 domain, th

258 y, recent proteomics studies have identified isozyme-specific reactive cysteine residues in brain gly

259 dopsis contains four CEK isoforms, but their isozyme-specific roles in metabolism and development are

260 cture offers a molecular explanation for the isozyme specificity of EGCG, which is corroborated exper

261 mitochondrial SHMT2, with the mitochondrial isozyme strongly up-regulated in cancer.

262 DPH oxidase subunit, beta-myosin heavy chain isozyme switch, accumulation of AGE, fibrosis, and decre

263 aturation-resistant NB4-LR1 cells have a PKA isozyme switch: compared with the NB4 cells, they have d

264 e largely reflects the properties of the PDK isozyme that is principally responsible for the regulati

265 eveal molecular features unique to the brain isozyme that provide a deeper understanding of the diffe

266 fatty acid synthase systems, the individual isozymes that catalyze these steps are quite diverse in

267 There are three isozymes that effectively catalyze the first committed s

268 etween human bGP and the two other mammalian isozymes, the bGP structures reveal molecular features u

269 ied to develop functional substrates for PLC isozymes, thereby serving as the foundation for further

270 nity to discover selective inhibitors of Nox isozymes, through enhanced conceptual understanding of t

271 ds the hydrophobic motif of conventional PKC isozymes to catalyze the isomerization of the phospho-Th

272 ns carrying targeted mutations of individual isozymes to explore their role in regulating PDC activit

273 sine kinases, activate phospholipase C (PLC) isozymes to hydrolyze phosphatidylinositol 4,5-bisphosph

274 of the C2 domain in driving conventional PKC isozymes to the plasma membrane and reveal that not only

275 which recruits multiple protein kinase (PK)C isozymes to the synaptic membrane.

276 tial PSY locations, linked with activity and isozyme type, advances the engineering potential for mod

277 Protein kinase C (PKC) isozymes undergo down-regulation upon sustained stimulat

278 , and regulation of native RetGC1 and RetGC2 isozymes using mice lacking guanylyl cyclase activating

279 Only one major trypsin isozyme was isolated with high purity, as assessed by SD

280 ty levels of the three mammalian glutaminase isozymes was established, with GAC being the most active

281 ous alkaline phosphatase (tissue-nonspecific isozyme) was inhibitory.

282 inhibitor of human cytochrome P450 (CYP) 2C9 isozyme, was identified as a novel and leading cytoprote

283 than 250-fold selectivity versus related LOX isozymes, was a mixed inhibitor, and did not reduce the

284 used to elucidate the specific roles of each isozyme, we describe tetrazole analogs as suitable backb

285 dentify a compound targeting the ppGalNAc-T3 isozyme, we screened libraries to find compounds that ac

286 d the 11-beta hydroxysteroid dehydrogenase 2 isozyme were significantly higher in patients compared t

287 hat the characteristics of both native RetGC isozymes were considerably different from other reported

288 as unaffected when all calcium-dependent PKC isozymes were eliminated.

289 In the present study, Lox isozymes were purified to near homogeneity (107-fold).

290 Starch-related isozymes were then evolutionary conserved by constraints

291 In maize (Zea mays), the three isozymes were transiently expressed and found either in

292 ng six plastidial isozymes and two cytosolic isozymes, were expressed in specific tissues and/or at s

293 ve site distinguishes it from the liver-type isozyme, which is known to be less dependent on this ion

294 ctivity of glycogen synthase kinase 3 (GSK3) isozymes, which are proposed to contribute to both neuro

295 ns, can effectively inhibit at least one hCA isozyme with low nanomolar inhibition constants.

296 iotemporal activity of phospholipase C (PLC) isozymes with a PLC-selective sensor would dramatically

297 hiazine derivatives reactivate specific PP2A isozymes with potential benefit in cancer and other dise

298 eral, CIIIPRX genes encode a large number of isozymes with ranges of in vitro substrate specificities

299 The OAS family consists of several isozymes, with unique domain organizations to potentiall

300 ore, selective inhibition of individual GSK3 isozymes yields distinct phenotypes from gene deletion,