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1 -speaking movements of the tongue, lips, and jaw.
2  those involving the brain, eye, digits, and jaw.
3 ptional outcomes that pattern the developing jaw.
4 previously unexpressed inputs from the lower jaw.
5 lled medication-related osteonecrosis of the jaw.
6 from medication-related osteonecrosis of the jaw.
7 eferring to feed using the right side of the jaw.
8 apy to the jaws or metastatic disease to the jaws.
9 ent stem cells, expressing the chloride pump Jaws.
10 bone development between the upper and lower jaws.
11 (FPDs) in posterior mandibular and maxillary jaws.
12 acterize type I and type III bones in murine jaws.
13 ns of tooth wear in a large sample of intact jaws.
14 tween different groups of osseous lesions of jaws.
15 , adjudicated events of osteonecrosis of the jaw (1 event each in the romosozumab-to-alendronate and
16 ants are solitary hunters with powerful trap jaws [10].
17 s; the most common were osteonecrosis of the jaw (17 [3%]), anaemia (6 [1%]), bone giant cell tumour
18  [5%] of 526 patients), osteonecrosis of the jaw (17 [3%], pain in extremity (12 [2%]), and anaemia (
19                  When a whale kept its upper jaw above the sea surface, many anchovies in the targete
20 cs, forming the jaw joint and supporting the jaw adductor muscles.
21 ture with a unique pulley system redirecting jaw adductor musculature.
22  use a versican-rich matrix to stabilise the jaw against the cranial base.
23 erian molar morphologies and musculoskeletal jaw anatomies evolved concurrently with increased yaw ro
24                         Osteonecrosis of the jaw and atypical femur fractures have been reported with
25 ls and the changing relationship between the jaw and ear.
26                       We find that while the jaw and hyoid arch skeleton derive from neural crest, an
27 cteristics, including scales and specialized jaw and neck joints.
28 shapen, and underdeveloped eyes and abnormal jaw and pectoral fin development.
29        Risk factors for osteonecrosis of the jaw and renal impairment should be assessed, and any pen
30 econstruct due to the complex anatomy of the jaw and the limited availability of appropriate tissue f
31 f cooking possibly affected the evolution of jaw and tooth morphology.
32  regulation evolved before the divergence of jawed and jawless vertebrates.
33 point of classic hypotheses on the origin of jaws and paired appendages.
34 sented by only a single cranium and isolated jaws and teeth(1-5).
35 he Miocene epoch, largely comprises isolated jaws and teeth, and little is known about ape cranial ev
36 9 million years ago) is known primarily from jaws and teeth, whereas younger species (dated to 3.5-2.
37  facial growth with severe disarrangement of jaws and teeth.
38 ascular adverse events, osteonecrosis of the jaw, and atypical femoral fractures were adjudicated.
39 nclude striking neurodevelopmental, digital, jaw, and eye anomalies, and in one individual, features
40 s were harvested from discarded 6-mo-old pig jaws, and decellularized by successive sodium dodecyl su
41                           We describe a trap-jaw ant from 99 million-year-old Burmese amber with head
42 est ant lineage [9], and together these trap-jaw ants suggest that at least some of the earliest Form
43 olution in the deepest branching lineages of jawed arthropods, the mandibulates.
44 lature in lizards, whereas those forming the jaw articulation evolve faster in snakes.
45 ith the highest correlations in the occiput, jaw articulation, and palate.
46 The biomechanical capability of S. melilutra jaws as related to their large size is unknown but cruci
47 ically constrained [9-12] with the origin of jaws as the key innovation that precipitated the ecologi
48                           Although the lower jaw barrel subfield (LJBSF) is a likely source of the in
49 r impressions created by the upper and lower jaws, bearing some similarity to fossil traces interpret
50 reveals the transformation of the surangular jaw bone from an independent element into part of the ma
51 omplex and also as the site for endochondral jaw bone growth.
52 f osteogenic transcription factors in normal jaw bone MSCs.
53  that endogenous SMOC2 blocks injury-induced jaw bone osteonecrosis and offsets age-induced periodont
54 a vs jaw) nor pathology (healthy vs necrotic jaw bone tissue) affected the averaged spectral shape of
55 actions and integration of the root with the jaw bone, blood supply and nerve innervations.
56 MSC-driven osteogenic differentiation in the jaw bone.
57 compared with their counterparts from normal jaw bone.
58 ameleons) are symmetrically ankylosed to the jaw bone.
59 alternative hypothesis that 'core' placoderm jaw bones are premaxillae and maxillae lacking external
60 osaurian reptiles are mostly anchored to the jaw bones by pleurodont ankylosis, where the tooth is he
61             Uterine neoplasms, myometria and jaw bones of Cdc73(+/-) mice had increased proliferation
62                                    The upper jaw bones of placoderms have traditionally been consider
63 hosphonate (BP)-related osteonecrosis of the jaw (BRONJ) and dental implant failure are two negative
64  bisphosphonate-related osteonecrosis of the jaw (BRONJ), has been reported as cytotoxic for bone and
65 ual vibrissa and microvibrissae in the lower jaw but not from trident whiskers.
66      Destruction of the alveolar bone in the jaws can occur due to periodontitis, trauma or following
67 arkable dietary adaptations, using tooth and jaw characters to examine changes in dental disparity an
68 = volume of cartilage) during 10 symmetrical jaw-closing cycles with a 20-N mandibular right canine l
69  neurons that project to both left and right jaw-closing motoneurons.
70 udal fin base distance), the surface area of jaw-closing musculature scales with positive allometry (
71                                      The Mo5 jaw-closing subdivision shows the highest VGluT1+ innerv
72  3D reconstructions of developing molars and jaws, computational modeling of cusp patterning, and too
73             CBCT scans of osseous lesions of jaws confirmed with histopathological reports depicting
74 outh, (ii) opening the mouth until the lower jaw contacted the sea surface, which created a current o
75  (i.e., treatment group, time-point, gender, jaw, craniofacial growth, gingival biotype, buccal bone
76 ife-threatening progressive expansion of the jaw, craniofacial, and other intramembranous bones cause
77 ies, such as growth retardation; hypoplastic jaws crowded with multiple supernumerary, yet unerupted,
78         By CAD/CAM technique, it can correct jaw deformities simultaneously and produce stable result
79 rior cricoarytenoid), tongue (genioglossus), jaw (digastric), and respiration (diaphragm, internal in
80 idely used to correct irregular teeth and/or jaw discrepancies to improve oral function and facial ae
81                                   Pharyngeal jaw diversification is associated with the exploitation
82 ositive condition and "Blink", "Lips part", "Jaw drop", "Nose lick", and "Ears flattener" were more c
83                                              Jaw-dropping new fossil material now establishes when an
84 currently with increased yaw rotation of the jaw during chewing cycles.
85 A) leads to permanent cartilage destruction, jaw dysfunction, and compromises the quality of life.
86  or a series of short dermal bones along the jaw edges, and teeth are added lingually as is the case
87 ely homology between bilateral and chitinous jaw elements in gnathiferans and chaetognaths [5], which
88 sted that the transformation of post-dentary jaw elements into cranial ear bones occurred several tim
89                        These are sclerotized jaw elements, which generally range from 0.1-2 mm in siz
90  that larger neonates are capable of greater jaw excursions.
91 oropharyngeal swallowing exercises including jaw exercises, tongue exercises and swallowing maneuvers
92  prey's response threshold until after rapid jaw expansion.
93 nd hypoglossal (Mo12) motor nuclei innervate jaw, facial, pharynx/larynx/esophagus, and tongue muscle
94  atypical adenomas and carcinomas, ossifying jaw fibromas, renal tumours and uterine benign and malig
95 as heart malformation and deformities in the jaw, fin, and tail.
96  to characterize the evolution of fusion and jaw form throughout Mammalia.
97 lay an important role in patterning head and jaw formation, but mechanisms coupling Hox genes to neur
98 rway pressure, oral appliances that hold the jaw forward during sleep, and surgical modification of t
99  positively adjudicated osteonecrosis of the jaw, four (1%) had atypical femur fracture, and four (1%
100 the divergence between jawless (Agnatha) and jawed (Gnathostomata) vertebrates.
101 in vitro by using the microsomal fraction of JAWS II cells, followed by liquid chromatography coupled
102  appearance of intramembranous bones and the jaw in ancestral vertebrates, implying that elmo2 might
103 rate medication-related osteonecrosis of the jaw in rats.
104        This proximity between the larynx and jaw in the brain might support the coupling between voca
105 individuals to a completely toothless beaked jaw in the more mature individuals, representing the fir
106 or using the red-light-shifted halorhodopsin Jaws in primates, and developed a large-volume illuminat
107 xpected one is the change from fully toothed jaws in the hatchling and juvenile individuals to a comp
108 athy, a specialization of the second pair of jaws in the pharynx, enhances the ability of fishes to p
109 nergistic light-gated ion channels VChR1 and Jaws in the same cell to manipulate membrane polarizatio
110 igin, with a history of dental tumors of the jaws, in correspondence to original clinical diagnosis o
111        This study evaluates contributions of jaw injury and experimental pain sensitivity to risk of
112                            During follow-up, jaw injury from any of 9 types of potentially traumatic
113                                              Jaw injury was strongly associated with elevated painful
114 looked when judging prognostic importance of jaw injury.
115           The mandibular canal enables lower jaw innervation through the passage of the inferior alve
116 echanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required
117                    Development of vertebrate jaws involves patterning neural crest-derived mesenchyme
118 e localisation of mandibular canals in lower jaws is important in dental implantology, in which the i
119 f CSF1 later in lineages after the advent of Jawed/Jawless fish.
120 iated with feeding biomechanics, forming the jaw joint and supporting the jaw adductor muscles.
121 e adaptive significance of variation in this jaw joint centers on whether a bony symphysis is stronge
122 born before the bones of the novel mammalian jaw joint form.
123 ed to the formation of the dentary-squamosal jaw joint, which allows a posterior chewing movement, an
124 he co-evolution of the primary and secondary jaw joints in allotherians was an evolutionary adaptatio
125 sability), incidence of osteonecrosis of the jaw, kidney dysfunction, skeletal morbidity rate (mean n
126                                  We measured jaw kinematics during benthic feeding and cranial muscul
127  digestive tract is composed of muscularized jaws linked to the esophagus that permits food ingestion
128 fied shape variation of the lower pharyngeal jaw (LPJ) using geometric morphometrics.
129 os has been shown to contribute to heart and jaw malformation phenotypes.
130       In the mouse, teeth are located on the jaw margin while TBs and other oral papillae are located
131                                              Jaw morphogenesis is a complex event mediated by inducti
132 n coupling in the dysregulation of heart and jaw morphogenesis.
133                                              Jaw morphological data, including those derived from Mi-
134 e relies primarily on indirect evidence from jaw morphology and the dentition.
135 fractures (low SOE) and osteonecrosis of the jaw (mostly low SOE).
136 y correlated (r = 0.97), bite rate and total jaw movement rate were positively correlated but both we
137 -muscle architecture is a key determinant of jaw movements and bite force.
138      Medication-related osteonecrosis of the jaw (MRONJ) is a rare intraoral lesion that occurs in pa
139      Medication-related osteonecrosis of the jaw (MRONJ) is an infrequent but morbid and potentially
140      Medication-related osteonecrosis of the jaw (MRONJ) occurs in patients undergoing oral surgery w
141 ge fatigue via TMJ energy densities (ED) and jaw muscle duty factors (DF), which were combined to cal
142                                              Jaw-muscle architecture is a key determinant of jaw move
143 st that architectural dynamics may influence jaw-muscle performance by enabling the production of hig
144 e-locked spiking relative to the activity of jaw muscles during biting.
145 c representations between the larynx and the jaw muscles in the human primary motor cortex.
146 issa muscles, while only SpVO is premotor to jaw muscles.
147 reatest disparity in regions associated with jaw musculature in lizards, whereas those forming the ja
148 t that neither the anatomical site (tibia vs jaw) nor pathology (healthy vs necrotic jaw bone tissue)
149 levant concurrent movements of the forelimb, jaw, nose, and vibrissae.
150  Positively adjudicated osteonecrosis of the jaw occurred in 122 (5%) of 2241 patients treated with d
151 erior to middle region of the upper or lower jaw of a large, osteologically mature individual.
152 -binding segment of Pds5B is shaped like the jaw of a plier lever and inhibits the binding of Scc1 to
153 f large-scale bone regeneration in the lower jaw of adult zebrafish, we show that chondrocytes are cr
154 ree P2O5 glass-ceramic rods implanted in the jaws of beagle dogs.
155   Morphometrics and modeling analyses of the jaws of Mesozoic mammals indicate that cladotherians evo
156 r along the tooth rows of nearly one hundred jaws of the small, early Permian (289 million years ago)
157 ion complex, making direct contact with the 'jaws' of RNAPII and nucleic acids in the transcription s
158 femoral fracture (AFF), osteonecrosis of the jaw (ONJ), and esophageal cancer.
159                         Osteonecrosis of the jaws (ONJ) is a rare but severe complication of antireso
160 ower tooth-row eversion and inversion during jaw opening and closing, respectively, enacted by hemima
161 d (3) no history of radiation therapy to the jaws or metastatic disease to the jaws.
162 ave permitted greater mobility of each lower jaw, or hemimandible(6,7).
163 s that humans inherited voluntary control of jaw oscillations from ancestral species, but added volun
164 ion onto this scaffold in order to turn such jaw oscillations into vocalized syllables.
165 upport the coupling between vocalization and jaw oscillations to generate syllable structure.
166 res, performance status scores, incidence of jaw osteonecrosis, and kidney dysfunction did not differ
167                                  No cases of jaw osteonecrosis, atrial fibrillation, or non-healing f
168                                  No cases of jaw osteonecrosis, atrial fibrillation, or nonhealing fr
169 iculty eating, dry mouth, bad breath, and/or jaw pain), teeth problems (toothache; broken/missing fil
170                              Self-reports of jaw parafunction were markedly stronger predictors than
171 cuit-specific postnatal abnormalities in the jaw proprioceptive sensory neurons in the well-studied S
172                                              Jaw protrusion substantially enhances the suction feedin
173 that oscillatory lowering and raising of the jaw provided an evolutionary scaffold for the developmen
174 d teeth that are nearly perpendicular to the jaw rami, and thus completely concealed in lateral view.
175              There are three dental rows per jaw ramus, and the root lacks infoldings of the dentine
176 a raptorial feeder and possessed the largest jaws recorded in polychaetes from the fossil record, wit
177                  The in vivo zebrafish lower jaw regeneration model reveals that NHFs enhance blastem
178  on in vitro wound healing and in vivo lower jaw regeneration of zebrafish.
179        Implants placed in the lower anterior jaw region had the most favorable outcome.
180 brain area that came to be situated near the jaw region in the human motor cortex.
181 ial interdependencies between dental age and jaw relationships.
182 x9(+) progenitors within the mammalian lower jaw requires FGF signaling.
183 es that increase mechanical advantage during jaw rotation around a dorsoventrally-oriented axis (i.e.
184 while decreasing the mechanical advantage of jaw rotation around a mediolaterally-oriented axis (i.e.
185 like in other dinosaurs, its snout and lower jaw show large cranial fenestrae.
186                Most significantly, the lower jaw shows evidence for neurovasculature that is also see
187     These structures are best interpreted as jaws situated within an expanded pharyngeal complex.
188 sults in decreased proliferation and altered jaw skeletal differentiation and cleft palate.
189 the extent to which osteoporosis affects the jaw skeleton and then to evaluate possible mechanisms wh
190 ctively, these analyses demonstrate that the jaw skeleton is susceptible to the untoward effects of o
191 first demonstrated that the appendicular and jaw skeletons both develop osteoporotic phenotypes.
192              The representation of the lower jaw skin consisting of chin vibrissae and microvibrissae
193 , microelectrodes were used to map the lower jaw skin surface representation in SI, and electrolytic
194 LJBSF organization, a nomenclature for lower jaw skin surface was developed, cytochrome oxidase (CO)
195 ted tomography scans of fragile skull bones (jaws, skull roofs and braincases) and reliably associate
196 with sox9 essential functions, including the jaw/snout region, otic vesicle, eye, and brain.
197  otters in morphology and biting efficiency, jaw strength in S. melilutra far surpasses molluscivores
198           Although the mutant mice exhibited jaw structures and occlusion comparable to controls at b
199 t functions of their skeletal derivatives in jaw support and sound transduction.
200 aces of healthy volunteers and orthognathic (jaw) surgery patients, diagnoses patients with 95.5% sen
201 d; it is necessitated by a secondarily fused jaw symphysis, and permitted by the reduction of high, i
202 ependent on the 3D support of the developing jaw than other aspects of tooth shape.
203 ly 6,800 extant frog species, most have weak jaws that play only a minor role in prey capture.
204 tal domains required for formation of hinged jaws, the defining feature of gnathostomes.
205             Relative to standard length (SL; jaw tip to caudal fin base distance), the surface area o
206 vity and heightened sensitivity of the lower jaw to Sox9 expression reduction.
207 ndible measuring <9 cm from the angle of the jaw to the tip of the chin or subjectively short; positi
208 hopping heads" use a vice-like grip of their jaws to restrain and immobilize prey.
209                                         This jaw-tooth integration of a specific aspect of the tooth
210 Dynamic stereometry (MR images combined with jaw-tracking data) characterized individual-specific dat
211  global p11 knockout (KO) mice develop fewer jaw tremors in response to tacrine.
212 gene are associated with hyperparathyroidism-jaw tumor (HPT-JT) syndrome, an autosomal dominant disor
213                      The hyperparathyroidism-jaw tumour (HPT-JT) syndrome is an autosomal dominant di
214 e Element planar models of different primate jaws under different loading scenarios (incisive, canine
215                     Mammals articulate their jaws using a novel joint between the dentary and squamos
216                                              Jawed vertebrate adaptive immunity relies on the RAG1/RA
217    Paired fins are a defining feature of the jawed vertebrate body plan, but their evolutionary origi
218 esegmentation as an ancestral feature of the jawed vertebrate body plan.
219 ems circuits and behaviors in this important jawed vertebrate group, we studied the distribution of n
220 ruities in character evolution in this major jawed vertebrate group.
221 nd functional properties with the equivalent jawed vertebrate HB locus.
222 iginated together with, if not before, their jawed vertebrate hosts >450 million years ago in the Ord
223  major anatomical difference between the two jawed vertebrate lineages is the presence of a single la
224 dingly, we find BAFF orthologs in all of the jawed vertebrate representatives that we examined, altho
225 vel type of opsin-expressing cell that, like jawed vertebrate rods, encloses the ciliary membrane wit
226                               RAG2 extends a jawed vertebrate-specific loop to interact with target s
227 f agnathans, and the elephant shark, a basal jawed vertebrate.
228 n is exemplified by the antigen receptors of jawed vertebrates (B- and T-cell receptors), heterodimer
229 Ds predate the emergence of fishes and other jawed vertebrates (Gnathostomata).
230                                              Jawed vertebrates (Gnathostomes) have 4 tissue inhibitor
231                                           In jawed vertebrates (gnathostomes), Hox genes play an impo
232 rtebrates (cyclostomes), the sister group of jawed vertebrates (gnathostomes), is unknown.
233 g considered the ancestral condition for all jawed vertebrates (gnathostomes).
234 tebrates that diverged from lines leading to jawed vertebrates (including mammals) in the late Cambri
235 es; herein 'sharks') are the earliest extant jawed vertebrates and exhibit some of the greatest funct
236 r activity is evolutionarily conserved among jawed vertebrates and is able to rescue the finless phen
237 ast, the second duplication is found only in jawed vertebrates and occurred in the mid-late Ordovicia
238 t is no more stark than between the earliest jawed vertebrates and their immediate relatives, the ext
239                The enteric nervous system of jawed vertebrates arises primarily from vagal neural cre
240 at last shared a common ancestor with modern jawed vertebrates around 500 million years ago(12).
241 mplex class I molecules (MHC I) help protect jawed vertebrates by binding and presenting immunogenic
242                    Developing lymphocytes of jawed vertebrates cleave and combine distinct gene segme
243 tebrates open directly into the environment, jawed vertebrates evolved skeletal appendages that drive
244 tebrates reveals that the Tbx5 expression in jawed vertebrates is derived in having an expression dom
245           Although homology of oral teeth in jawed vertebrates is well supported, the evolutionary or
246                 Other agnathans gave rise to jawed vertebrates or gnathostomes, the group including a
247  of mouse TCRbeta chains with those of other jawed vertebrates preserved reactivity to mouse pMHC.
248            The adaptive immune system of all jawed vertebrates relies on the presence of B and T cell
249 Comparison of gene expression in jawless and jawed vertebrates reveals that the Tbx5 expression in ja
250                                       In all jawed vertebrates studied to date, one of the HB gene cl
251 ive and predatory lifestyles, culminating in jawed vertebrates that dominate modern vertebrate biodiv
252 s fishes, or chondrichthyans, are the oldest jawed vertebrates that have an adaptive immune system ba
253      Intriguingly, extant HBs of jawless and jawed vertebrates were shown to have evolved twice, and
254 eptor (GHR) and prolactin receptor (PRLR) in jawed vertebrates were thought to arise after the diverg
255 hothoracids, the most phylogenetically basal jawed vertebrates with teeth, belonging to the genera Ra
256 l component of the adaptive immune system in jawed vertebrates(3).
257 ulate multiple aspects of NCC development in jawed vertebrates(7-10).
258          The gill apparatus of gnathostomes (jawed vertebrates) is fundamental to feeding and ventila
259  principal divisions of modern gnathostomes (jawed vertebrates).
260 or HoxD genes in patterning the fin-folds of jawed vertebrates, and fuel new hypotheses about the evo
261 e animals retained plesiomorphic features of jawed vertebrates, including a well-differentiated stoma
262                                              Jawed vertebrates, or gnathostomes, have two sets of pai
263 rentiation of a novel digestive structure in jawed vertebrates, the stomach.
264 isms capable of generating this structure in jawed vertebrates, we characterised the development of t
265                       In this basal group of jawed vertebrates, we identified a third nonclassical MH
266 tetrapod novelty, or an ancestral feature of jawed vertebrates, we tested the relationship between so
267 ates-lampreys and hagfish) and gnathostomes (jawed vertebrates-cartilaginous and bony fishes), based
268  the evolutionary transition from jawless to jawed vertebrates.
269 activity, mediating homologous expression in jawed vertebrates.
270 rtilaginous fish, the oldest group of extant jawed vertebrates.
271 e evolution of the adaptive immune system of jawed vertebrates.
272 se tissues evolved in the common ancestor of jawed vertebrates.
273 r genes evolved independently in jawless and jawed vertebrates.
274 la neurons instruct predatory hunting across jawed vertebrates.
275 ry skills led to the evolutionary triumph of jawed vertebrates.
276  cells, before the divergence of jawless and jawed vertebrates.
277 l record of ontogenetic edentulism among the jawed vertebrates.
278 n and somatic hypermutation of antibodies in jawed vertebrates.
279 - and T-lymphocyte antigen receptor genes of jawed vertebrates.
280 LM orthologs are not identifiable in certain jawed vertebrates.
281 nds to the NPRL3 intron 7 MCS-R1 enhancer of jawed vertebrates.
282 current NPRL3-linked HB genes in jawless and jawed vertebrates.
283 e these characteristics as ancestral for all jawed vertebrates.
284 lar, we identify two adaptations specific to jawed-vertebrates-arginine 848 in RAG1 and an acidic reg
285  with only parts of the original sclerotized jaw walls occasionally present.
286 y, the first molar on each side of the upper jaw was extracted, and either a zirconia or a titanium i
287              Inspired by the polychaete worm jaw, we report a novel approach to generate stiffness gr
288 um stenosis, and severe osteomyelitis of the jaw were common clinical features.
289           Morphological changes to the lower jaw were detected at 96 hpf in response to 1 mug/L of pr
290          Seven cases of osteonecrosis of the jaw were reported in the long-term group and six cases i
291 herbivorous, because their derived teeth and jaws were capable of processing fibrous plant foods.
292     Twenty-one patients contributing with 26 jaws were finally included in the analysis.
293               The left and right side of the jaws were randomly assigned to either test or control gr
294 ated brainstem (BS)/spinal cord (SC) and the jaws were set to shield the BS/SC while ensuring the tar
295  amber specimen attached to a Prosaurolophus jaw, which reveals details of the contemporaneous paleof
296 were agnathans - fish-like organisms without jaws, which first appeared near the end of the Cambrian
297 find that folivores species have the weakest jaws, whilst omnivores have the strongest mandibles with
298 2.21; P < .001), and absence of Marcus Gunn (jaw-winking) syndrome (adjusted OR, 0.12; P = .01).
299 atment in posterior mandibular and maxillary jaws with NDIs was as reliable as with SDIs, although ND
300                         We show that, in the jaw, Wnt signalling is reduced specifically in regions o

 
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