ライフサイエンスコーパス: join

1 that adjacent inorganic tablets structurally join.

2 t the frequency of translocations with exact joins.

3 Some additional nonrecruited hospitals also joined.

4 utionary loss of classical nonhomologous end joining.

5 ication and DSB repair by non-homologous end joining.

6 DSBs occurs predominantly via reciprocal end joining.

7 ed by DNA Ligase IV during Nonhomologous end-joining.

8 ations in genes related to nonhomologous end joining.

9 represses HRR and favors non-homologous end joining.

10 psis coupled to classical non-homologous end joining.

11 n the DSB repair pathway, non-homologous end joining.

12 trand breaks, facilitating nonhomologous end-joining.

13 and DNA breaks (DSBs) via non-homologous end joining.

14 ndent repair and classical nonhomologous end-joining.

15 recombination and microhomology-mediated end-joining.

16 ted HDR, and promoted error-prone distal end-joining.

17 the extreme C-terminus are required for end joining.

18 ination (HR) or mutagenic non-homologous end-joining(1).

19 routinely participate in such deletional CSR joining(11).

20 ndred twenty-seven candidates and recipients joined 23 focus groups.

21 s work, an international collaborative study joined 23 partners to assess the transferability and the

22 DNA ligases join 3'-OH and 5'-PO(4) ends via a series of three nucle

23 behavior suggest that people's decisions to join a group and their subsequent behavior are influence

24 have also included catalyzed reactions that join a heteroatomic electrophile with an in situ generat

25 nergy barrier a filament has to overcome for joining a bundle.

26 Thereafter, he is approached about joining a digital smartwatch study to help monitor his h

27 eer as a PA in ophthalmology (87.5%), and in joining a specialty organization for PAs in ophthalmolog

28 An enclosed interface that joins a direct analysis in real time (DART) probe, solid

29 y mediated by alternative non-homologous end-joining activity that may employ either DNA ligase 3 or

30 hibitor sensitivity of BRCA1-null cells, end-joining activity, and immunoglobulin class switching tha

31 Inteins are protein segments capable of joining adjacent residues via a peptide bond.

32 ntal top connectors, which are fibrous links joining adjacent stereocilia, and the TM-attachment crow

33 ingle predominant microhomology-mediated end joining allele (PreMA) repair outcome.

34 gous end joining (cNHEJ) and alternative end joining (Alt EJ).

35 h the microhomology-mediated alternative-end-joining (Alt-EJ) pathway during class switch recombinati

36 f CSR can be achieved by the alternative end-joining (Alt-EJ) pathway that preferentially uses microh

37 ed a role for macroH2A1.1 in alternative end joining (alt-EJ), which accounts for Xi anaphase defects

38 s mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including chromosomal translo

39 XPF-dependent alternative nonhomologous end joining (alt-NHEJ), which did not generate fragile telom

40 Cholera therefore joins amebic dysentery and Clostridioides difficile coli

41 mature Sup35p such that it does not readily join amyloid filaments.

42 lding of nascent Sup35p, thus preventing its joining amyloid fibers.

43 ity of Cambridge students were randomised to join an 8-week mindfulness course (N = 27), or to mental

44 Principal Component, ADMIXTURE, and neighbor joining analyses of the nuclear genomes identified two m

45 We joined analytical techniques, based on stable isotopes a

46 They were subsequently joined and largely displaced around 1,000 years ago by a

47 dividuals include impaired ribosomal subunit joining and attenuated global protein translation as a c

48 combined with the lack of nonhomologous end joining and markers for positive selection, has stalled

49 logous recombination over non-homologous end joining and potentially other mutagenic pathways of DSB

50 reviously shown to suppress pathological end joining and promote homologous recombination.

51 repair efficiency, but not nonhomologous end-joining, and decreased the formation of Rad51 foci.

52 otoredox catalysis and electrochemistry have joined approaches which utilize thermal cleavage or the

53 preferentially repaired via error-prone end joining as depletion of EXO1 diverts repair away from er

54 to the NOTCH3 N terminus at the peptide bond joining Asp(80) and Pro(81) Cleavage at this site was pr

55 ned twins who are classified as craniopagus (joined at the cranium) have a rare congenital anomaly.

56 two distinct lipid-sugar precursors and are joined at the extracellular side of the cytoplasmic memb

57 ess decreases and microhomology-mediated end joining becomes active, generating deletions in the targ

58 How this joined binding allows RUNX1 to antagonize AML1-ETO-media

59 Forty-two hospitals joined BPCI for PCI and 46 for CABG.

60 Attendees joined breakout groups, to identify factors influencing

61 sists of a cytoplasmic and a membrane domain joined by a 33-residue flexible linker.

62 ade of 2-pyrimidinecarbonitrile and cysteine joined by a benzyl linker was applied to design fluoresc

63 ase I of partners that have failed to become joined by a crossover.

64 These cells proliferate and are joined by a few neural crest-derived cells.

65 molecule that consists of two benzene rings joined by a four-membered ring at its core.

66 its second (N2) and third (N3) NEAT domains joined by a helical linker, called IsdH(N2N3).

67 hreonine-binding Forkhead-associated domains joined by an intrinsically disordered linker with multip

68 and monocytes/macrophages, these actors are joined by bone marrow-derived cells, such as eosinophils

69 om pentagon-centered {Mo(8)} building blocks joined by equal number of {Mo(1)} units as loin, and {Mo

70 tes in these zones, abundant mtDNA molecules joined by four-way junctions, and species consistent wit

71 An AD half and a BC half were joined by Knoevenagel condensation at room temperature,

72 ured, functionally well-characterized motifs joined by less understood linker regions.

73 s open cubic connectivity of Zn(4)O clusters joined by two-dimensional, terephthalate linkers, is the

74 (generally 3-5) of a small domain, CcmM(S), joined by unstructured linkers.

75 repeats (CRISPR)/Cas9 and non-homologous end-joining by deleting the repeat region, with the risk of

76 NHEJ repair intermediates compromise the end joining by DNA ligase I or the DNA ligase IV/XRCC4 compl

77 found that the canonical non-homologous end joining (C-NHEJ) factor XLF promotes these rearrangement

78 RNAP II) and the classical nonhomologous end-joining (C-NHEJ) proteins, including PNKP, along with na

79 ent mediated by canonical non-homologous end joining (C-NHEJ).

80 ination (HR) and classical nonhomologous end joining (C-NHEJ).

81 Current methods cannot join ceramics in proximity to temperature-sensitive mate

82 rameric, and pentameric IgA-Fc linked by the joining chain (JC) and in complex with the secretory com

83 from IgG1, IgG2/3, IgG4, IgA1, IgA2, and the joining chain from dimeric IgA.

84 ing two copies of IgA that assemble with one joining-chain (JC) to form dimeric (d) IgA that is bound

85 wever, restrict the available materials, and joining chemically dissimilar components remains a chall

86 d inhibitors of classical non-homologous end joining (cNHEJ) and alternative end joining (Alt EJ).

87 DNA-PKcs), is a classical non-homologous end-joining (cNHEJ) factor(1).

88 (DNA-PKcs), is a classical nonhomologous end-joining (cNHEJ) factor.

89 mediated by the classical nonhomologous end-joining (cNHEJ) pathway.

90 required for the canonical nonhomologous end joining (cNHEJ).

91 esent favored substrates for MH-mediated end-joining contributing to the robustness and resection ind

92 se, we explore the full elemental diversity, joining different areas across the whole periodic table,

93 Joining dissimilar materials such as plastics and metals

94 h, impact- and crush-resistant materials for joining dissimilar materials.

95 he formation of molecule aggregates that can join distant regulatory elements, such as gene promoters

96 e ligase complex) are similarly deficient in joining DNA double-stranded breaks (DSBs) with hairpinne

97 rather than the canonical non-homologous end joining DNA repair pathway.

98 aki fragments are synthesized, processed and joined during replication of the human genome.

99 s initiated by coiled-coil adaptors that (a) join dynein and its cofactor dynactin into a motile comp

100 Our findings demonstrate that the join effects of the regulatory and coding variants large

101 ing method, combined with non-homologous end joining, enabling permanent chromosomal integration of a

102 by the contraction of myriads of sarcomeres joined end to end by the Z-bands.

103 Mycobacterial MCM thus joins enzymes in the glyoxylate shunt and the methylcitr

104 This result suggests that non-homologous end-joining, even in haploid cells where homologous chromoso

105 CMG removal results in fork breakage and end joining events involving deletions and templated inserti

106 log of XRCC4 and XLF, PAXX nonhomologous end joining factor (PAXX).

107 hors demonstrate that the non-homologous end-joining factor XLF promotes the stability of replication

108 n is particularly likely to thrive if people join forces to curb free riding and punish their non-con

109 itute for Bioengineering of Catalonia (IBEC) joined forces to unite researchers from all over the glo

110 In 2017, CaT joined forces with the Typhoid Vaccine Acceleration Cons

111 Joining forces of allergists, manufacturers and authorit

112 Variable-joining gene segment usage was not associated with aGvHD

113 pairings of T-cell receptor beta variable or joining genes, specific clonotypes or obvious "public" T

114 nism might also contribute to pathogenic DSB joining genome-wide.

115 esponsibility as a another key motivation to join groups helps understand behaviours with societal im

116 When individuals can choose to join groups precommitted to charity, such groups sustain

117 The complex Cussac mortuary pattern joins growing evidence from other Gravettian sites of va

118 Cancer has joined heart disease as the leading source of mortality

119 The homology-mediated end joining (HMEJ) approach has been shown to improve knock-

120 reporter cassettes by homology-mediated end joining (HMEJ) at high frequency at a double strand brea

121 ies of practice, seek education mentors, and join in scholarship activities.

122 tain the C-terminal kinase domain of the RTK joined in cis to various N-terminal, nonkinase fusion pa

123 n remain in active use today, they have been joined in recent years by a new array of radical generat

124 ing cnLOH, suggesting that POLQ promotes end joining in cis, which limits breaks available for recomb

125 d LigI that is critical for Okazaki fragment joining in vitro.

126 nt DNA ligase dedicated to nonhomologous end joining, in complexes with ATP that highlight large move

127 r reecombination centre-located DQ52-to-J(H) joining, in which synapsis occurs by diffusion(2).

128 Joined inhibition of Haspin and Bub1 activities fully ab

129 potential microhomology or nonhomologous end joining integration mechanism at the single-nucleotide l

130 mologous recombination and nonhomologous end joining is critical for maintaining genome integrity and

131 mology-directed repair and nonhomologous end joining is important for neuronal cells.

132 hat complete Okazaki fragment processing and joining, it is not known how the activities of these enz

133 mbination of variable (V), diversity (D) and joining (J) genes.

134 h joins the variable (V), diversity (D), and joining (J) germline genes.

135 Meanwhile, many hospitals are joining larger health systems with the stated goal of im

136 Ligase 3-mediated end-joining maintains genome stability of human embryonic st

137 roken ends, among them the nonhomologous end-joining mechanism that utilizes a DNA ligase.

138 rsue professional development opportunities, join medical education communities of practice, seek edu

139 arious mutations, microhomology-mediated end joining (MMEJ) creates precise deletions based on the al

140 ein that promotes microhomology-mediated end-joining (MMEJ) of DNA double-strand breaks (DSBs).

141 s mediated by the microhomology-mediated end joining (MMEJ) pathway.

142 repaired through microhomology-mediated end joining (MMEJ) rather than the canonical non-homologous

143 y, we developed a microhomology-mediated end-joining (MMEJ) reporter and showed that Fen1 participate

144 a third pathway, microhomology-mediated end-joining (MMEJ).

145 pathway known as microhomology-mediated end-joining (MMEJ).

146 the mechanism of microhomology-mediated end joining mostly, since microhomologies between human and

147 Here we develop inversion-induced joined neoantigen (NINJA), using RNA splicing, DNA recom

148 used to resolve DSBs are Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR).

149 by promoting Ku-dependent nonhomologous end-joining (NHEJ) at the expense of homologous recombinatio

150 ous recombination (HR) and nonhomologous end joining (NHEJ) at the same chromosomal site, we report t

151 DNA damage signaling and non-homologous end joining (NHEJ) at unprotected telomeres.

152 Finally, I find that all non-homologous end joining (NHEJ) defective cells (whether deficient in com

153 the competing error-prone non-homologous end-joining (NHEJ) DNA repair pathway.

154 integral component of the non-homologous end-joining (NHEJ) DSB repair pathway.

155 and ICF2 patients affects nonhomologous end-joining (NHEJ) during immunoglobulin class-switch recomb

156 plementary DNA ends during nonhomologous end joining (NHEJ) for the repair of double-strand breaks (D

157 mologous recombination and nonhomologous end-joining (NHEJ) genes.

158 n the BRCT domain impairs non-homologous end joining (NHEJ) in cell.

159 ell-based assay shows that nonhomologous end joining (NHEJ) is compromised in cells with ablated MEK5

160 Although non-homologous end joining (NHEJ) is the most used DSBs repair pathway in t

161 Non-homologous end joining (NHEJ) is the predominant pathway that repairs D

162 Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of an

163 erminal components of the non-homologous end-joining (NHEJ) machinery or of the BRCA1-A complex speci

164 rgo DNA repair either via non-homologous end joining (NHEJ) or, in the presence of a template, homolo

165 etions are products of the nonhomologous end-joining (NHEJ) pathway and require Top1cc removal from D

166 ion-deletions (INDELs) by non-homologous end-joining (NHEJ) pathway underlies the mechanistic basis o

167 ates in DSB repair via the nonhomologous end-joining (NHEJ) pathway, by filling small sequence gaps i

168 ant components for the nonhomologous DNA end-joining (NHEJ) pathway.

169 e participation of various nonhomologous end-joining (NHEJ) pathways.

170 Non-homologous end-joining (NHEJ) plays an important role in double-strand

171 ied the impairment of the non-homologous end joining (NHEJ) repair pathway and DNA damage in alveolar

172 ys a critical role in the non-homologous end joining (NHEJ) repair pathway and the DNA damage respons

173 While non-homologous end joining (NHEJ) repair results in various mutations, micr

174 lity (HF) and error-prone non-homologous end-joining (NHEJ), as well as between proximal and distal N

175 During non-homologous DNA end joining (NHEJ), bringing two broken dsDNA ends into prox

176 directed repair (HDR) and non-homologous end joining (NHEJ), respectively.

177 repaired predominantly by non-homologous end joining (NHEJ), which directly ligates DNA ends.

178 critical component of the nonhomologous end joining (NHEJ)-mediated DNA double-strand break (DSB) re

179 e liver is mainly through non-homologous end joining (NHEJ)-mediated knock-in.

180 us recombination (HR) and non-homologous end-joining (NHEJ)-mediated repair.

181 DNA-PK) in the process of non-homologous end joining (NHEJ).

182 predominantly repaired by non-homologous end joining (NHEJ).

183 -directed repair (HDR) or non-homologous end joining (NHEJ).

184 -NO(2) inhibits HR and not nonhomologous end joining (NHEJ).

185 ection, and DSB repair by non-homologous end-joining (NHEJ).

186 tic subunit (DNA-PKcs) and nonhomologous end joining (NHEJ).

187 le-strand break repair by non-homologous end joining (NHEJ).

188 1's ability to facilitate non-homologous end joining (NHEJ). We characterized LINP1 structure and fle

189 Despite Rps2 joining nuclear pre-40S particles, Tsr4 appears to be re

190 opens the exciting possibility that Fur may join numerous well-studied bacterial, fungal, and mammal

191 The joining of a durable PD-1 blockage significantly boosted

192 activation chemistry could have enabled the joining of building blocks in aqueous solution from a co

193 DNA ligases catalyze the joining of DNA strands to complete DNA replication, reco

194 that polymerize into filaments by end-to-end joining of hetero-oligomeric complexes.

195 tor 5B (eIF5B) on the 80S ribosome after the joining of individual ribosomal subunits-a process that

196 e ligation step plays a critical role in the joining of noncomplementary DNA ends during nonhomologou

197 on of the GTPase activity of eIF5B after the joining of ribosomal subunits prevented the dissociation

198 These properties may enable joining of single domains into multidomain proteins, lip

199 l translation involves the tightly regulated joining of the 50S ribosomal subunit to an initiator tra

200 shock momentum is important for rupture and joining of the LMNPs, providing much better control than

201 ble-strand break repair, and likely promotes joining of the strands of the convergent replication for

202 imic a DNA DSB, enabling us to study the end-joining of two fluorescently labeled DNA with the T4 DNA

203 interactions with, and robust V(H)-to-DJ(H) joining of, distal V(H)s, with patterns similar to those

204 Joining oligonucleotides together (ligation) is a powerf

205 gh either the error-prone non-homologous end joining or the homology directed repair pathways.

206 DNA polymerase theta mediates an end joining pathway (TMEJ) that repairs chromosome breaks.

207 me) codes for a canonical non-homologous end-joining pathway factor, that the RNA polymerase II compo

208 ted an impaired ability of the canonical end-joining pathway in Lsh-deficient B cells.

209 ouble-strand breaks by the nonhomologous end joining pathway is central for proper development of the

210 equence that depend on the nonhomologous end-joining pathway of DSB repair.

211 through disruption of the non-homologous end-joining pathway, with three individual evolutionary path

212 crohomology-all signs of the alternative end-joining pathway.

213 ologous recombination and non-homologous end joining pathways.

214 Neighbour-joining phylogenetic trees and direct sequence compariso

215 Join-point regression was used to model annual rates and

216 SBs) are preferentially repaired through end-joining processes that generally lead to mixtures of ins

217 , MassIVE and jPOST), two new resources have joined PX: iProX (China) and Panorama Public (USA).

218 d helps to facilitate the non-homologous end-joining reaction.

219 AXX and XLF in both variable, diversity, and joining recombination and immunoglobulin class switch re

220 XX interplay during variable, diversity, and joining recombination in vivo but not during class switc

221 A JPH2 with induced mutations in the joining region (mut(PG1)JPH2) caused T-tubule remodeling

222 The idea that this joining region directly interacts with LTCCs and contrib

223 The interaction between LTCC and the joining region in JPH2 facilitates dyad assembly and mai

224 -protein interaction studies showed that the joining region in JPH2 interacts with LTCC-alpha1C subun

225 JPH2 has a so-called joining region that is located near domains that interac

226 s CRISPR/Cas9 and microhomology-mediated end joining repair for efficient tagging.

227 sion of DSB initiating and nonhomologous end joining repair machinery in newborn neurons in the devel

228 We show that although end-joining repair mechanisms may cause the system to break

229 Resistance alleles that form by end-joining repair typically disrupt the haplolethal target

230 ous compared with microhomology-mediated end joining repair.

231 in the basal state and set to bind SMAD4 and join SMAD3:FOXH1 at target promoters in response to Noda

232 We then joined stream temperature predictions to 44,396 spatial

233 l)pyrene (TFPPy), organic building units are joined substoichiometrically by imine linkages to produc

234 gy and reveal general patterns of broken end joining that can provide insights into DNA repair mechan

235 Additionally, we suggest DDX6 join the DExD/H-box genes DDX3X and DHX30 in an emerging

236 of the intrinsically disordered linkers that join the enzyme and substrate but that the scaling diffe

237 Thus I was lucky to join the field of T cell biology almost at its beginning

238 Scleractinian corals thus join the group of marine organisms capable of forming bi

239 that Dictyostelium loners-cells that do not join the multicellular life stage-arise from a dynamic p

240 Finally we ask endemic countries to join the OIE/FAO supported regional networks and take ad

241 ake place before the younger surface cohorts join the older deeper ones.

242 fied through multiple sources and invited to join the workgroup and submit outcome measures.

243 bers separated from the vagus trajectory and joined the trigeminal spinal nucleus (Sp5) and the sp5.

244 Participants joined the UK Biobank study from 2006 to 2010 and were f

245 We progress through its joining the aquaporin family as a water channel in its o

246 pments of 2D polymers by those interested in joining the effort with this fascinating and emerging cl

247 with either a double-sided surface (e.g. by joining the ends of a mesh as a tape) or a single-sided

248 rotein, called Topanga reagent, generated by joining the extra-cellular domain of a CAR-target in fra

249 gh the lacrimal caruncle and an oblique line joining the lateral canthus and the subnasal point would

250 gh the lacrimal caruncle and an oblique line joining the lateral canthus and the subnasal point.

251 e, PTPN11, the last tier of the MAPK cascade joins the group of genes mutated in RASopathies.

252 This Protocol Extension joins the ranks of other comparable methods for generati

253 re formed through V(D)J recombination, which joins the variable (V), diversity (D), and joining (J) g

254 relationships that include reward, thereby "joining-the-dots" between events that have not been obse

255 , social workers, and child life specialists joined their PICU physician colleagues to care for these

256 ibose and the canonical nucleobases and then joining them together or by building both the conjoined

257 able, and label-free optical biosensors that join these photonic crystals with dedicated bioanalytica

258 When joining thicker layered crystals, the arising structural

259 As more and more researchers join this endeavour, there is a rapidly growing demand f

260 ions resulting in the same RNA sequence when joined through RNA splicing.

261 strand ends of the grid can subsequently be joined through within-grid alkene metathesis reactions t

262 and ultimately serves to coordinate subunit joining through the release of late-stage mtLSU assembly

263 Joining time-scaled patches to backbones results in spec

264 ess, the highly mutagenic theta-mediated end-joining (TMEJ) pathway, which requires DNA polymerase th

265 d intimately integrated hydrophobic networks joining TnT1 and the tropomyosin N-/C-terminal overlappi

266 oach that captures DSBs via their ability to join to specific genomic Cas9/single-guide RNA-generated

267 Lumen and vessel boundaries are joined to create the coronary wall.

268 data sets and active surveillance data were joined to estimate influenza-associated hospitalization

269 ctional units and whether these units can be joined to form a larger composition with dual function h

270 sfer complex with transposon ends covalently joined to target DNA, at resolutions of 3.0-4.6 angstrom

271 s two molecules of protocadherin 15 (PCDH15) joined to two of cadherin 23 (CDH23).

272 SU assembly that minimizes premature subunit joining to ensure the assembly of the mature 55S monosom

273 ransformation relies on a combination of end joining to insert foreign DNA and HDR to repair collater

274 ase 4-dependent classical non-homologous end-joining to long-range inter-chromosomal telomere fusions

275 the discovery of cell-cell fusion, how cells join together to form zygotes and multinucleated syncyti

276 The structure resolves SsbA tetramers joined together by a ssDNA "bridge" and identifies an in

277 l 1,3,5-tris(p-formylphenyl)benzene were all joined together by imine linkages to yield a 2D porous c

278 the 18- most promising epitopes, which were joined together using molecular linkers to create a mult

279 ree synthetic steps: first, a CuAAC reaction joins together one end of each overhand knot.

280 , and boronic acid chemistries to reversibly join two [3-(1-acylpiperidin-4-yl)phenyl]methanamine cor

281 boron reagent serves as a useful linchpin to join two distinct carbonyl compounds to provide syntheti

282 Chemical reactions that reliably join two molecular fragments together (cross-couplings)

283 nerate antibodies with different isotypes by joining two DNA double-strand breaks at different switch

284 However, when joining two semi-infinite ballistic parts, such as the X

285 gase 1 in replication and non-homologous end-joining uniquely position and capacitate this ligase for

286 alth is the first step towards encouraging a joined-up approach to dealing with entrenched social, se

287 We invite others to join us in calling for more AS training opportunities du

288 esearch as an invitation to the community to join us in this exploration of new MPMI frontiers.

289 The intervals are then joined using a combination of graph and greedy algorithm

290 receptor (AgR) loci by variable (diversity) joining (V[D]J) recombination.

291 rp edges of the Co(3)O(4) nanocube core that join via disclinations.

292 d in which the bulky hydrocarbon fragment is joined via a quaternary carbon to the highly hindered co

293 e 12/23 compatibility, inversional D-to-J(H) joining via upstream D-12RSSs is rare(7,8).

294 In addition to non-homologous end joining, we detect signatures of replication-associated

295 hese species represents a form of anatomical joining, which is otherwise unknown in nature.

296 repair outcome is microhomology-mediated end joining, which occurs during the first cell cycle in the

297 ns about harassment that prevent people from joining while also influencing the behavior of those who

298 Parabiotic mice were generated by surgically joining wild type (WT) mice expressing green fluorescent

299 number of periodontists in the practice, and joining with other specialists or GPs to create group pr

300 ing both this deletion rearrangement and end joining without insertion/deletion mutations.