ライフサイエンスコーパス: kappa chain

1 r after rearrangements of the locus encoding kappa-chain.

2 lambda and 14 Abs more frequently expressed kappa chains.

3 23F-specific Abs had predominantly kappa chains.

4 vy (IGHG1a) together with a light (lambda or kappa) chain.

5 ozyme-specific IgM nor the secretion of free kappa-chains.

6 had amino acids infrequently found in other kappa-chains.

7 assayed in the context of the immunoglobulin kappa chain 3' enhancer and associated binding proteins,

8 bind to adjacent sites in the immunoglobulin kappa chain 3' enhancer and generate a potent transcript

9 of these proteins bind to the immunoglobulin kappa chain 3' enhancer, which is developmentally regula

10 , and Gm(21) (odds ratio 7.3, P = 0.005) and kappa-chain allotype Km(3) (odds ratio 7.3, P = 0.005) w

11 ost allelically included B cells express two kappa chains, although rare dual-lambda cells are also o

12 all part of a sequence belongs to a heavy or kappa chain and predict its precise localization in the

13 terodimers can be detected readily between a kappa-chain and a chimera consisting of a heavy chain va

14 for various fragments, from 11 to 75 in the kappa chains, and from 23 to 189 in the heavy chains.

15 ted from the 1,172 human heavy and 668 human kappa chains available in the Kabat database.

16 ombinant baculoviruses containing Fd and AP7 kappa chain cDNA.

17 ion of the locus encoding the immunoglobulin kappa-chain complex (Igk) requires expression of the pre

18 a heavy chain variable domain linked to the kappa-chain constant domain.

19 kappa-chain joining region (J(kappa)) to the kappa-chain constant region (C(kappa)).

20 ted a wider range of elbow angles than their kappa chain counterparts, and that the lambda light chai

21 cell lymphopenia by measuring immunoglobulin kappa chain-deletion recombinant excision circles and fo

22 lent reagents that bound only one of the two kappa-chains, dual kappa B cells responded suboptimally

23 Expression cloning of a mouse kappa chain fragment has been achieved from a cDNA libra

24 Each of the two H and the two kappa chain fragments encompasses, in germline configura

25 es and for the B motif of the immunoglobulin kappa chain gene enhancer.

26 n activation potential of the immunoglobulin kappa chain gene intronic enhancer.

27 , transcriptional induction of rearranged Ig kappa-chain gene in response to LPS was suppressed by PF

28 ain gene VH3-23 with or without the variable kappa-chain gene VK1-33 and often had a Y-x-R motif with

29 ination of the locus encoding immunoglobulin kappa-chain (Igk).

30 CD32B or CD32C, and IgG1 H chain (IGHG1) and kappa-chain (IGKC) polymorphisms determining allotypes d

31 s (NF-AT), nuclear factor for immunoglobulin kappa chain in B cells (NF-kappa B/Rel), activator prote

32 but not to nuclear factor for immunoglobulin kappa chain in B cells or activator protein 1 motifs.

33 e heavy (mu) chains and two light (lambda or kappa) chains in association with a heterodimer of Igalp

34 istone H3 at Lys27 (H3K27me3) throughout the kappa-chain joining region (J(kappa)) to the kappa-chain

35 ransgene consisting of murine immunoglobulin kappa-chain leader sequence coupled to sequence coding f

36 rangements in immunoglobulin heavy (IgH) and kappa chain loci, but increased sterile transcription an

37 g this TCR Tg mouse with mice expressing the kappa chain of mAb 36-71, we found that kappa-specific T

38 ppaB signaling is dispensable, predominantly kappa-chain-positive B cells are generated, which underg

39 To analyze the human kappa chain repertoire and the influences that shape it,

40 differences were found in both the heavy and kappa chain repertoires between OmniRats and humans incl

41 nd KM allotypes-genetic markers of gamma and kappa chains, respectively-are associated with immune re

42 nd KM allotypes-genetic markers of gamma and kappa chains, respectively-play in the outcome of hepati

43 e synthesized a panel of mAbs from alpha and kappa chain sequences present in the KD arterial wall an

44 th an anti-DNA heavy chain often coexpress a kappa chain that prevents DNA binding.

45 Hbs using antibody either to human IgG or to kappa chains, the anti-Hb antibody demonstrated specific

46 In contrast, in germ-line kappa chains, the codons in both CDR and FW are more pro

47 to residues 145-159 and 188-203 of human Ig kappa-chains to peptide-specific mouse T cell hybridomas

48 ed significant differences in immunoglobulin kappa-chain V-II levels in KC patients compared to contr

49 genesis of the heavy chain variable (VH) and kappa-chain variable (Vk) genes separately, then combini

50 f the normal stop codon, this portion of the kappa chain was composed of 128 amino acids (rather than

51 to the N-terminal leader sequence of the Ig kappa-chain, was transfected transiently into COS-7 cell

52 gements in the locus encoding immunoglobulin kappa-chain, we define here two distinct, consecutive ph

53 , for this infant bnAb, substitutions in the kappa chain were critical for activity, particularly in

54 we found that cells expressing two distinct kappa-chains were 1.4-3% of all B cells and that they we

55 neously replacing recombined mouse heavy and kappa chains with those of human antibodies, using a sin

56 region, which is one residue longer than in kappa chains, with glycine occurring most frequently at

57 ultaneous expression of both IgH-mu- and IgL-kappa-chains, without progressing through the stage of I