ライフサイエンスコーパス: karyotypic

1 cations into the IgH locus (i) are frequent (karyotypic 14q32 translocations and/or illegitimate swit

2 ronic lymphocytic leukemia with normal FISH, karyotypic aberrations by conventional cytogenetics with

3 Karyotypic aberrations contribute to the understanding o

4 We evaluated the significance of karyotypic aberrations in a learning cohort (LC; n = 64)

5 aryotyping to provide a detailed analysis of karyotypic aberrations in the diverse group of cancer ce

6 The observed karyotypic aberrations probably reflect the progressive

7 cent cytogenetic studies of HESCs have shown karyotypic aberrations.

8 ptosis is accompanied by the accumulation of karyotypic abnormalites that often typify cancer cells,

9 y of MDS patients have either clonal somatic karyotypic abnormalities and/or gene mutations that aid

10 46% of T-PLL cases, but some cases also have karyotypic abnormalities at 11q, including 11q23.

11 offers low-resolution detection of balanced karyotypic abnormalities but cannot provide the precise,

12 IDH family mutations and additional cryptic karyotypic abnormalities can occur in advanced phase CML

13 ge response pathway activation, or result in karyotypic abnormalities following multiplexed editing.

14 Although specific karyotypic abnormalities have been linked to MDS for dec

15 nal evolution was defined as the presence of karyotypic abnormalities in addition to the Philadelphia

16 f leukemia was significantly correlated with karyotypic abnormalities in addition to trisomy 21 (P =

17 Karyotypic abnormalities in cultured embryonic stem cell

18 ients with intestinal juvenile polyposis and karyotypic abnormalities involving chromosome 10q.

19 Coupled with the karyotypic abnormalities observed in CIN tumors are the

20 n situ hybridization probes, we show complex karyotypic abnormalities of the c-myc or L-myc locus in

21 were independently correlated with specific karyotypic abnormalities on the resected specimens.

22 Typically, altered gene dosage caused by karyotypic abnormalities results in embryonic lethality

23 of chromosome 6 are among the most frequent karyotypic abnormalities that appear in human malignant

24 ws concurrent tracking of both mutations and karyotypic abnormalities throughout therapy and is able

25 spect to pluripotency as well as a subset of karyotypic abnormalities whose dynamic properties were m

26 Of 20 patients with karyotypic abnormalities, 11 had at least a 50 percent r

27 ups was in the proportion of patients having karyotypic abnormalities, an observation common only in

28 eterogeneity among cases in cell morphology, karyotypic abnormalities, and clinical course.

29 ity of T-lineage ALL patients, regardless of karyotypic abnormalities, and such features do not ident

30 translocations without extensive additional karyotypic abnormalities, and those without such signatu

31 y evidence of genomic instability, including karyotypic abnormalities, gene amplification, and hypers

32 A model containing karyotypic abnormalities, hemoglobin, platelet count, an

33 essed by a targeted RT-qPCR assay for common karyotypic abnormalities, significantly affected differe

34 fic translocations, which generally have few karyotypic abnormalities, telomere lengths were similar

35 viously recognized genetic polymorphisms and karyotypic abnormalities, which collectively determine i

36 Cytogenetic analysis revealed clonal karyotypic abnormalities, which may contribute to pathog

37 rmal karyotypes, but not in those with other karyotypic abnormalities.

38 ity, promoting acquisition of structural and karyotypic abnormalities.

39 apoptosis in ESCs and is a likely source of karyotypic abnormalities.

40 normal karyotype and 12% of those with other karyotypic abnormalities.

41 intact p53 response, and an absence of gross karyotypic abnormalities.

42 oth humans and mice, occur in the absence of karyotypic abnormalities.

43 ttle is known about genes altered in complex karyotypic abnormalities.

44 at senescence before developing significant karyotypic abnormalities.

45 ere analysed by M-FISH to identify recurrent karyotypic abnormalities.

46 yotype and 12 percent among those with other karyotypic abnormalities; P=0.007) and patients with low

47 eletions of chromosome 5 are the most common karyotypic abnormality in myelodysplastic syndromes (MDS

48 her tumor cells do not, indicating that this karyotypic abnormality of c-myc occurs as a late event.

49 rimary MM tumors, some tumor cells contain a karyotypic abnormality of the c-myc locus, whereas other

50 o had de novo MDS with trisomy 8 as the sole karyotypic abnormality responded to ATG with durable rev

51 With a median follow-up of 24 months, a karyotypic abnormality that was classified as myelodyspl

52 Trisomy 12, the most frequent karyotypic abnormality, is commonly found in a subset of

53 was associated with either a 13q- or a 20q- karyotypic abnormality.

54 hromosome 1q gain (Chr1q+) was the commonest karyotypic abnormality.

55 - or int-1-risk MDS who lack the deletion 5q karyotypic abnormality.

56 fic region of chromosome 1 is thus the first karyotypic alteration that can be identified in hepatocy

57 tigate the basis of recent observations that karyotypic alterations are related to telomeric fusions,

58 A few karyotypic alterations can be directly linked to distinc

59 r could be a factor contributing to frequent karyotypic alterations observed in Chinese hamster cells

60 hibit extensive chromosomal instability, but karyotypic alterations will be significant in carcinogen

61 nses (DDRs) at the telomeres, culminating in karyotypic alterations with massive arrays of telomere f

62 ly account for the magnitude of the observed karyotypic alterations.

63 Karyotypic analyses demonstrate that reprogramming of hu

64 Karyotypic analyses of MEFs and lymphomas from DMP1-null

65 Karyotypic analyses performed in 28 patients showed clon

66 Flow cytometry and karyotypic analyses revealed increased polyploidy and an

67 Karyotypic analyses, using whole chromosome probes from

68 re below the detection limit of conventional karyotypic analyses.

69 Further research should consider sequential karyotypic analysis as a determination of risk of progre

70 Karyotypic analysis further indicated that secondary gen

71 double minute chromosomes upon conventional karyotypic analysis indicated overt amplification of DNA

72 Karyotypic analysis of the stages of rat hepatocarcinoge

73 au susceptibility locus was undertaken after karyotypic analysis revealed no abnormalities.

74 Here we confirm by spectral karyotypic analysis that MYC-induced hematopoietic tumor

75 By spectral karyotypic analysis, we found that MYC even within one c

76 nd the absence of interstitial deletions, in karyotypic analysis.

77 previously been shown to be common sites of karyotypic and allelic loss in MM, our comparative genom

78 We use sciHi-C data to separate cells by karyotypic and cell-cycle state differences and identify

79 Using karyotypic and comparative genomic hybridization (CGH) a

80 ed region was confirmed to be within 1p22 by karyotypic and fluorescence in situ hybridization analys

81 Karyotypic and phenotypic analysis of human disseminated

82 nal analysis of fused cells reveals that the karyotypic and phenotypic potential of tumors formed by

83 zed Arabidopsis allohexaploids and monitored karyotypic and phenotypic variation in this population o

84 nd two sister genera, followed by contrasted karyotypic and subgenomic evolution.

85 Comparative genomic analysis revealed karyotypic and syntenic conservation across all scleract

86 erranean rodents that present morphological, karyotypic, and evolutionary history differences and are

87 sMNs display high-risk morphological, karyotypic, and molecular features.

88 ed a 2;17 translocation in addition to other karyotypic anomalies [46,XX,t(2;17)(p23;q23),add(16)(q24

89 As the morphological, molecular and karyotypic aspects of Myomorpha rodents do not evolve at

90 distinct CIN mechanisms can lead to similar karyotypic cancer-causing outcomes.

91 Here, we investigate the role of karyotypic change in homoploid hybrid speciation by gene

92 ygous deletions identified at 9p21, the only karyotypic change was a single case in which one entire

93 tica suggest several constraints that govern karyotypic change, a key component of eukaryotic genome

94 caused by diploidisation favour accelerated karyotypic change, with each change increasing barriers

95 iated with normal karyotypes (IL3) or simple karyotypic changes (IL3R, FLT3).

96 Extensive karyotypic changes (tetrasomy) were observed in the hybr

97 Karyotypic changes accounting for these molecular alleli

98 n both preventing, and generating, oncogenic karyotypic changes are discussed.

99 the mitotic machinery senses and responds to karyotypic changes by using a series of budding yeast st

100 Important similarities were noticed between karyotypic changes in cancer cell lines and that seen in

101 However, the events that lead to these karyotypic changes in embryos after Cas9-treatment remai

102 We have observed karyotypic changes involving the gain of chromosome 17q

103 All 21 strains were diploid, although karyotypic changes were present in eight of the 21 isola

104 Karyotypic changes, especially fusions, that reduce gene

105 Karyotypic changes, however, detect only gross alteratio

106 nonreciprocal translocations and additional karyotypic changes, indicating that genomic instability

107 on of SIR2 also produces a high frequency of karyotypic changes.

108 ay initiate rapid evolution due to heritable karyotypic changes.

109 The karyotypic chaos exhibited by human epithelial cancers c

110 Clear differences between the karyotypic characteristics of B-lineage ALL and T-ALL we

111 ient co-detection and in situ phenotypic and karyotypic characterization as well as quantification of

112 at the same rate, we strategically employed karyotypic characters for the construction of chromosoma

113 the basis of these changes, we compared the karyotypic chromosomal abnormalities of primary pancreat

114 The results of karyotypic, clinical, and ERP investigations of this fam

115 derived factors as major contributors to the karyotypic complexity afflicting mammalian preimplantati

116 n of these cell lines we defined and studied karyotypic complexity and heterogeneity (metaphase-to-me

117 We have asked whether we could use karyotypic complexity and instability as determinants fo

118 This solidifies karyotypic complexity as an important prognostic factor

119 istinct therapeutic agents that target tumor karyotypic complexity has important clinical implication

120 In a multivariable analysis, increasing karyotypic complexity was an independent predictor of sh

121 Baseline karyotypic complexity, presence of del(17)(p13.1), and a

122 We sought to determine if increasing karyotypic complexity, treated as a continuous variable,

123 nifested by chromosomal reconfigurations and karyotypic complexity.

124 (snow leopard) provides further evidence for karyotypic conservation within felids, and demonstrates

125 Previous studies of DNA sequence and karyotypic data have revealed high genetic diversity in

126 tic patterns were heterogenous; a variety of karyotypic defects with numerical and structural abnorma

127 vorable prognosis than those with additional karyotypic defects, who tend to develop myeloproliferati

128 The karyotypic del(11)(q23) was a cryptic t(11;17).

129 Along with the karyotypic description of these cell lines we defined an

130 cies and progenitors primarily resulted from karyotypic differences between the species.

131 QTL analyses indicate that the karyotypic differences contribute to reproductive isolat

132 omic makeup of I. nelsonii), suggesting that karyotypic differences do not contribute substantially t

133 We suggest that the karyotypic differences probably evolved in allopatry, in

134 ies complex, suggesting an important role of karyotypic divergence in its evolutionary history and un

135 Karyotypic diversification is more prominent in Equus sp

136 f an "evolutionary trap" (ET) targeting both karyotypic diversity and fitness.

137 The phenotypic diversity resulting from karyotypic diversity endows the cell population with sup

138 ay be a facilitator of dangerous genetic and karyotypic diversity in tumorigenesis.

139 sed by molecular analysis and indicates that karyotypic diversity is associated with species radiatio

140 iple rearrangements fueled the extraordinary karyotypic diversity of therian mammals.

141 ypes reveals a propensity for tumors of less karyotypic diversity to segregate from the more pleomorp

142 The gibbon genome exhibits extensive karyotypic diversity with an increased rate of chromosom

143 mong the Gymnotiformes, having a significant karyotypic diversity.

144 Although karyotypic events in follicular lymphoma and its transfo

145 e involving LCRs plays a significant role in karyotypic evolution accompanying primate speciation.

146 gests that isolation may arise through rapid karyotypic evolution and/or ecological divergence of hyb

147 ked to ploidy states or cell types can drive karyotypic evolution in fungi.

148 ian karyotypes provides strong evidence that karyotypic evolution is driven by nonrandom segregation

149 the impact of cytogenetic abnormalities and karyotypic evolution on the outcome of 256 patients.

150 Karyotypic evolution was documented in the majority of t

151 nts with otherwise typical AA in whom clonal karyotypic evolution was observed during frequent period

152 otoroos), which exhibit recent and extensive karyotypic evolution, rearrangements involve chiefly the

153 to reveal structural mechanisms underpinning karyotypic evolution, reproductive isolation and ecologi

154 omic duplication plays a significant role in karyotypic evolution.

155 except for body size; and (3) unpredictable karyotypic evolution.

156 ineage 1, finding evidence for admixture and karyotypic evolution.

157 aps provide a powerful tool for the study of karyotypic evolution.

158 The Cerradomys genus underwent an extensive karyotypic evolutionary process, with multiple rearrange

159 with a predominant and predictably drugable karyotypic feature.

160 In general, karyotypic findings in splenic tissue (n = 92) were simi

161 pecific cell biological mechanism for Todd's karyotypic fission concept, "kinetochore reproduction th

162 The karyotypic fission idea by contrast posits that all medi

163 Karyotypic fission theory of Todd offers an explanation

164 est that environmental perturbations promote karyotypic heterogeneity and could contribute to the eme

165 hat CENP-A OE contributes to aneuploidy with karyotypic heterogeneity in human cells and xenograft mo

166 While karyotypic heterogeneity is a hallmark of cancer cells,

167 n CENP-A OE and aneuploidy, and suggest that karyotypic heterogeneity may contribute to the aggressiv

168 eny of irradiated cells also included clonal karyotypic heterogeneity.

169 f NCVs and SCVs generated massive organismal karyotypic heterogeneity.

170 ed a wide variety of chromosomal changes and karyotypic heterogeneity.

171 zed by non-recurrent genetic aberrations and karyotypic heterogeneity.

172 have shed light on the diverse effects that karyotypic imbalances have on cellular phenotypes, and s

173 om the proband was studied using microarray, karyotypic, immunohistochemical, and immunoblotting tech

174 the development of consensus in reporting of karyotypic information in clinical trials involving youn

175 Karyotypic information on multiple myeloma (MM) is less

176 Increased karyotypic instability and activation of tumor-promoting

177 ultiple myeloma is characterized by frequent karyotypic instability at the earliest stage, progressin

178 Thus, the karyotypic instability generated by aneuploidy emerges a

179 The mechanism causing this karyotypic instability is largely unknown, but recent ob

180 he horse, is a promising model for exploring karyotypic instability.

181 "gain-of-CIN" phenotype and led to profound karyotypic instability.

182 structure are linked to mitotic defects and karyotypic instability.

183 s, indicating that human selection maintains karyotypic integrity.

184 orient linkage groups relative to a standard karyotypic layout (short arms at top).

185 d that with new precise methods more cryptic karyotypic lesions can be uncovered that may show import

186 morphological and physiological traits) and karyotypic levels for around 30 generations of laborator

187 in the initial state, at both phenotypic and karyotypic levels; (2) predictable phenotypic evolution

188 ion can drive tumorigenesis through impaired karyotypic maintenance.

189 We analyzed karyotypic, mitochondrial DNA, and 3RAD genomic data to

190 have survived >168 doublings in vitro, with karyotypic normalcy and without replicative senescence.

191 d trial, we enrolled adults (>40 years) with karyotypic or clinically diagnosed Down's syndrome, with

192 em for the study of nuclear DNA replication, karyotypic plasticity and other aspects of chromosomal b

193 eckpoint) gradually trended toward a similar karyotypic profile, as determined by single-cell whole-g

194 sp. carinii infecting rats differentiated by karyotypic profiles exhibit the same low level of geneti

195 istent with the elevated rate of speciation, karyotypic rearrangement, and mitochondrial DNA evolutio

196 We suggest that karyotypic rearrangement, drug resistance and homozygosi

197 combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cel

198 KARIBIN () is a karyotypic region-based integrated information resource

199 ed valuable information about the drivers of karyotypic reorganization and evolution in the model gra

200 Both groups were balanced for age, karyotypic risk, and FLT3-internal tandem duplication an

201 wth requirements, cell-cycle checkpoints and karyotypic stability in telomerase-expressing cells are

202 pair mechanisms, cell cycle checkpoints, and karyotypic stability, and this is likely partially due t

203 tion may be necessary for the maintenance of karyotypic stability.

204 e to great apes, explaining their remarkable karyotypic stability.

205 lomere maintenance pathway incapable of full karyotypic stabilization in pleomorphic sarcomas.

206 of heterozygosity (LOH) were associated with karyotypic structural anomalies.

207 This variation in karyotypic structure affords the possibility of reconstr

208 ubflavus (CSU) and C. vivoi (CVI) shows that karyotypic variability is due to 16 fusion events, 2 fis

209 me pairing and reveal the type and extent of karyotypic variation and its immediate phenotypic manife

210 The MRS affects karyotypic variation by expanding and contracting intern

211 at sequence (MRS) is known to play a role in karyotypic variation in Candida albicans.

212 Karyotypic variation was observed within the asexual pop

213 ze sequence, stock, phenotype, genotypic and karyotypic variation, and chromosomal mapping data.

214 en rodent species, which were independent of karyotypic variation.