ライフサイエンスコーパス: keratin-6

1 of myoepithelial cells and cells expressing keratin 6.

2 ed from its presumed polymerization partner, keratin 6.

3 als independently regulate the expression of keratin 6.

4 ed hyperkeratosis and aberrant expression of keratin 6.

5 al surface; the expression of involucrin and keratins 6, 13, 14, and 19; and the absence of keratin 1

6 ifferentiate, as demonstrated by the lack of keratin 6, a marker of the periderm.

7 al cells expressing progenitor cell markers, keratin 6 and Sca-1; subsequent tumors express these mar

8 The type II keratin 6 and type I keratins 16 and 17 are induced well

9 of the epithelial hyper-proliferative marker Keratin-6 and sustained activation of MAPK.

10 maturation is delayed, and wound-associated keratins 6 and 16 are induced, in both involved and clin

11 rmis is hyperproliferative and overexpresses keratins 6 and 16, indicating abnormal differentiation.

12 2 and 3: EGF, FGF-2, IFNalpha2, IL-1RA, HSA, keratin-6, and involucrin; cortisol was significantly hi

13 Also, abnormal expression of keratin 6 associated with the hyperproliferative phenoty

14 ed in actual healing skin wounds, HB-EGF and keratin 6 being the most prominent.

15 maintained periderm-like cells that express keratin 6, but we observed abnormal expression of GRHL3.

16 ority of CD34+ cells (98%) were positive for keratin 6, establishing this population as basal keratin

17 as ectopic localization of, and increase in, keratin-6 expressing cells.

18 The onset of keratin 6 expression also begins around day 12; because

19 ilaggrin/filaggrin along with focal areas of keratin 6 expression in the interfollicular epidermis.

20 cytoskeleton in the form of the induction of keratin 6 expression.

21 the promoter/regulatory region of the bovine keratin 6 gene was used to target ODC transgene expressi

22 ling proceeds, in part, by repression of the keratin 6 gene.

23 elial alterations associated with defects in keratin 6 genes.

24 n culture treated with interleukin-1 express keratin 6 in all suprabasal layers of the epidermis, thr

25 t also by inducing directly the synthesis of keratin 6 in epidermal keratinocytes, and thus changing

26 in 16 along with its type II keratin partner keratin 6 in the companion layer of the outer root sheat

27 suprabasal cell layers and by expression of keratin 6 in the interfollicular epidermis.

28 yzed the molecular mechanisms regulating the keratin 6 induction by interleukin-1, and found that the

29 Keratin 6 is a marker of hyperproliferative, activated k

30 ed epidermal keratinocytes, the induction of keratin 6 is time and concentration dependent.

31 Keratin 6 (K6) expression in the epidermis has two compo

32 The type II keratin 6 (K6) features a complex expression pattern, wi

33 The murine genome is known to have two keratin 6 (K6) genes, mouse K6 (MK6)a and MK6b.

34 ature multiple genes encoding highly related keratin 6 (K6) isoforms.

35 nogenesis, we used bovine keratin 5 (K5) and keratin 6 (K6) promoter elements to direct the expressio

36 sed ODC in the skin of Ptch1+/- mice using a keratin 6 (K6) promoter that directs constitutive ODC ex

37 rapid induction of several genes, including keratin 6 (K6).

38 ified epithelia causes a strong induction of keratins 6 (K6) and 16 (K16) in post-mitotic keratinocyt

39 known as K6hf) is one of the isoforms of the keratin 6 (KRT6) family located within the type II cytok

40 I keratin 16 (Krt16) and its partner type II keratin 6 (Krt6a, Krt6b) cause pachyonychia congenita (P

41 ssion of differentiation markers, keratin 1, keratin 6, loricrin, and filaggrin in ML.myc2 transgenic

42 ncreased expression of interleukin-1beta and keratin 6, markers of keratinocyte activation seen in wo

43 in genes on mouse chromosome 15, between the keratin 6 (mK6alpha/mK6beta) and hair keratin genes.

44 were p63 negative, keratin 17 positive, and keratin 6 positive and present at sites of adhesion, alt

45 interleukin-1 responsive DNA element in the keratin 6 promoter, and determined that it contains a co

46 Vascular permeability factor and keratin 6 transcripts were also strongly induced, albeit

47 follicular differentiation markers including keratin 6, transglutaminase, and the hair keratins mHa2

48 , we evaluate the association between common keratin 6 variants and severity of atopic dermatitis ove

49 keratinocyte differentiation, mouse-specific keratin 6 was overexpressed in the suprabasilar, hyperpl