ライフサイエンスコーパス: kidney

1 redominantly in the distal intestine and the kidney.

2 e fate of monocytes recruited to the injured kidney.

3 ian rhythms, especially within the liver and kidney.

4 n the vascular endothelial cells of lung and kidney.

5 to characterize complex organs, such as the kidney.

6 es of the nephron, the filtering unit of the kidney.

7 of porcine donation after circulatory death kidneys.

8 find that TRPM7 expression increases in UUO kidneys.

9 late contrast enhancement, especially of the kidneys.

10 eogenic cells, and 0.17 +/- 0.15 cGy/MBq for kidneys.

11 of PSMA radiotracers in salivary glands and kidneys.

12 d amyloid deposits in the spleen, liver, and kidneys.

13 ment prevented the development of IRI in the kidneys.

14 vity were the adrenals (0.1835 mSv/MBq), the kidneys (0.1722 mSv/MBq), the submandibular glands (0.14

15 buffered saline (SCI + PBS), human embryonic kidney 293 (HEK293) cells, and hAFSCs transplantation.

16 eceptor isoform 2-expressing human embryonic kidney 293 cells) cells, biochemistry, dual Ca(2+)/volta

17 We identified 110 kidney, 67 liver, 85 pancreas, 68 heart, and 43 lung TRR

18 abnormal cardiolipin remodeling in diabetic kidneys, a cardinal sign of disrupted mitochondrial arch

19 activation of TFEB is the main driver of the kidney abnormalities and mTORC1 hyperactivity in a mouse

20 zed albumin binders to maximize the tumor-to-kidney absorbed dose ratio.

21 eceptor blocker telmisartan affected lung or kidney ACE2 or TMPRSS2, except for a small increase in k

22 2 or TMPRSS2, except for a small increase in kidney ACE2 protein with ramipril.

23 dy identifies compounds that shield ears and kidneys against an anticancer drug.

24 ze the available literature on the causes of kidney allograft failure, both early and late, both noni

25 recipients enrolled in the Deterioration of Kidney Allograft Function (DeKAF) study were evaluated:

26 Five-year liver and kidney allograft survivals were 67% and 64% in the T-cel

27 Western blot detected several specific uEV kidney and EV markers (>=4.5 mL urine per lane).

28 mIBG is eliminated by the kidney and extensively accumulates in several tissues kn

29 n about Gdf15 activity and effects in normal kidney and in AKI.

30 are among the leading cause of mortality in kidney and liver transplant recipients.

31 arity with native intestinal ECs relative to kidney and lung.

32 one marrow transplantation, rarely occurs in kidney and pancreas transplant recipients.

33 entral and peripheral nervous system, liver, kidney and skeletal muscle.

34 revealed off-target radiotoxicity, mainly in kidneys and liver.

35 -nuclei mRNA sequencing of dissociated mouse kidneys and of dissected cortex, outer, and inner medull

36 rvived the first 3 months with a functioning kidney, and categorized as: deceased-donor kidney transp

37 , vital statistics, outpatient prescription, kidney, and HIV databases.

38 cycles based on BED(max) for red marrow and kidneys, and a treatment having 4 cycles with optimized

39 involvement (80%-95%), as well as the hairy kidney appearance on computed tomography scan (63%), the

40 ther exploring metabolomic profiles of human kidneys as a function of age, sex, and race.

41 Using pMRI, we found that in pig kidney, ATP was rapidly generated in presence of oxygen

42 of NS8593, a known TRPM7 inhibitor, prevents kidney atrophy in UUO kidneys, retains tubular formation

43 Initial uptake in kidney averaged 2.4% +/- 2.0% and cleared with a biologi

44 n=581): Patients undergoing first for cause kidney biopsy (KTxBx) 1.7+/-1.4 (mean +/-SD) years postt

45 aradigm from patient stratification based on kidney biopsy findings towards personalized management b

46 ic marker for active SARS-CoV-2 infection in kidney biopsy or autopsy specimens.

47 ntegrative, multi-omics approaches since the kidney biopsy, blood and urine samples used to generate

48 es of renal lymphangiectasia in transplanted kidneys, both from pediatric donors.

49 h makes more efficient use of deceased donor kidneys but reduces access to transplantation for older

50 95% Confidence Interval [CI] 3.50-7.61) and kidney cancer (OR 2.50; 95% CI 1.69-3.72).

51 In 2017, kidney cancer accounted for 393.0 thousand (95% UI: 371.

52 This pathway-dependent targeting of kidney cancer arises from the fact that the secretion pa

53 hose with a history of malignancy (excluding kidney cancer).

54 ind of EpCAM negative cancer cell line (293T kidney cancer).

55 ereas it might function as an oncoprotein in kidney cancer, for example, by targeting phosphatase and

56 ce in, and potential for, addressing gaps in kidney care; and outlines avenues for conducting researc

57 Basal autophagy in kidney cells is essential for the maintenance of kidney

58 isolated nuclear envelope lipids from human kidney cells, analyzed their composition and determined

59 lticellular monolayers of Madin-Darby canine kidney cells, highlighting its acuity in reconstructing

60 enge led to robust eGFP-L10a upregulation in kidney, confirming Mac(TRAP) responsiveness in vivo.

61 aracterized by benign skin tumours, lung and kidney cysts and renal cell carcinoma(6,7).

62 elayed myeloperoxidase inhibition suppressed kidney damage without augmenting adaptive immune respons

63 ere we report a chemoproteomic analysis of a kidney-derived HLRCC cell line.

64 identify candidate pathways dysregulated in kidneys destined to form cysts.

65 es in generating and maintaining NPCs during kidney development, but little is known about the molecu

66 (ROBO2) plays an important role during early kidney development.

67 About 45% of 1103 United States kidneys discarded because of histologic findings could b

68 r filtration rate and lowest rate of chronic kidney disease (>=stage 3) from year 1 onwards until stu

69 eteriorates in autosomal dominant polycystic kidney disease (ADPKD).

70 tin 2 leads to autosomal dominant polycystic kidney disease (ADPKD).

71 ), hypertension, hyperlipidemia, and chronic kidney disease (all p < 0.001).

72 s been associated with lower risk of chronic kidney disease (CKD) progression, implicating mechanisms

73 The increasing prevalence of chronic kidney disease (CKD) seriously is threatening human heal

74 hatemia as in tumoral calcinosis and chronic kidney disease (CKD).

75 Diabetic kidney disease (DKD) is a major complication of diabetes

76 r liver disease; 2.04 (95% CI 1.30-3.20) for kidney disease and 8.15 (95% CI 3.59-18.5) for lung absc

77 human cohorts: the African American Study of Kidney Disease and Hypertension and the Atherosclerosis

78 randomly assigned 777 patients with advanced kidney disease and moderate or severe ischemia on stress

79 tional sample of 1000 patients with advanced kidney disease between 2004 and 2014 who were followed u

80 lated by Dnmt3a and Dnmt3b were enriched for kidney disease genetic risk loci.

81 d risk of cardiovascular disease and chronic kidney disease in those with gout, novel associations of

82 of CG in a kidney transplant recipient with kidney disease of unknown cause.

83 ctive for the treatment of anemia in chronic kidney disease patients and may also be beneficial for t

84 End-stage kidney disease patients presented frequently severe comp

85 national transplant registry for 35 849 T2DM kidney disease patients who received transplant between

86 nt GSTM1 deletion variant is associated with kidney disease progression in human cohorts: the African

87 .67; 95% CI, 1.02, 2.72, P = .04), perceived kidney disease risk following donation (aOR, 1.68; 95% C

88 hin human BSND significantly associates with kidney disease severity in a patient cohort with CEP290

89 aimed to assess whether adding biomarkers of kidney disease to conventional risk factors improved 10-

90 to assess and address patient activation in kidney disease to facilitate best practices for supporti

91 obesity, hypertension, diabetes, and chronic kidney disease) and yielded additional insights into the

92 ole in hypertension, cardiovascular disease, kidney disease, and fluid homeostasis.

93 , albuminuria, autosomal dominant polycystic kidney disease, and ischemia/reperfusion-induced acute k

94 hen evaluated autoimmune disease parameters, kidney disease, and response to in vivo TLR7/9 pathogeni

95 ein PKD2 cause autosomal dominant polycystic kidney disease, but the function of PKD2 in cilia remain

96 2,8-DHA nephropathy, leading to progressive kidney disease, characterized by crystal deposits, tubul

97 coronary artery disease, stroke and chronic kidney disease, complemented by a systematic review of r

98 f LTBI testing (e.g., HIV, diabetes, chronic kidney disease, etc.) were identified from physician cla

99 s, and iii) altered ER Ca(2+) homeostasis in kidney disease, including podocytopathy, diabetic nephro

100 the most common being hypertension, chronic kidney disease, obstructive sleep apnoea, and metabolic

101 induce apoptosis and glomerular dysfunction kidney disease.

102 tissue, combine to accelerate progression of kidney disease.

103 ir can also lead to fibrosis and progressive kidney disease.

104 ery of mechanisms that trigger and propagate kidney disease.

105 mportant clinical questions in patients with kidney disease.

106 n, stroke), CV death/HHF, and progression of kidney disease.

107 y and rheumatoid arthritis, and 2 on chronic kidney disease.

108 odocalyxin (PODXL) are associated with human kidney disease.

109 of cardiovascular disease and progression of kidney disease.

110 Podocytopathies are kidney diseases in which direct or indirect podocyte inj

111 implantation genetic diagnosis for heritable kidney diseases.

112 is, and ischemia/reperfusion, and in chronic kidney diseases.

113 butes to the pathogenesis and progression of kidney diseases.

114 ge contributes to the progression of chronic kidney diseases.

115 ,5-trisphosphate receptor channel in various kidney diseases.

116 role in the pathogenesis and progression of kidney diseases.

117 have therapeutic benefit in the treatment of kidney disorders.

118 Many kidneys donated for transplant in the United States are

119 Long-term safety of living kidney donation (LKD), especially for young donors, has

120 opulation-level characteristics and expected kidney donation rates by Gulf States location.

121 is a key aspect in the evaluation of living kidney donor candidates; however, data on performance of

122 ttle data on how kidney quality, measured by kidney donor profile index (KDPI), impacts KALT survival

123 recipients were allocated kidneys with lower Kidney Donor Profile Index (median 30% versus 35%, P < 0

124 MV prevention strategy via matching deceased kidney donors and recipients by CMV serostatus.

125 SAs were associated with 3.52 fewer expected kidney donors per 100 eligible deaths than non-Gulf Stat

126 Kidney dysfunction (hazard ratio, 2.28 [95% credible int

127 3(hu/hu) mice display elevated biomarkers of kidney dysfunction, glomerulosclerosis, C3/C5b-9 deposit

128 rities in metformin prescription in moderate kidney dysfunction.

129 ent to induce detectable HIF activity in the kidney endothelium, in vitro experiments implicated a hu

130 y mimic the branch geometry of the embryonic kidney epithelial network.

131 ar gene transcripts as those observed in ECD kidneys, except that tumor necrosis factor alpha and mon

132 y significant difference in the incidence of kidney failure (31.7% with intervention vs 27.3% with pl

133 ge volumes of fluid removal in patients with kidney failure who are treated with intermittent haemodi

134 564 of the 3,478 participants progressed to kidney failure, and 803 died.

135 risk factor for the progression to end-stage kidney failure, cardiovascular morbidity, and premature

136 s that underlie the many different causes of kidney failure.

137 isodes of ureteral obstruction with eventual kidney failure.

138 PH patients and not applicable in those with kidney failure.

139 We identified focal kidney fibrin thrombi in 6 of 42 (14%) autopsies.

140 condition and the subsequent development of kidney fibrosis.

141 ess, this remains uncertain when receiving a kidney from a donor >=80 years old.

142 s after transplantation in recipients with a kidney from donors >=80 years was 0.54 (95% confidence i

143 t of adults (>=18 years of age) with reduced kidney function (>=2 measures of estimated glomerular fi

144 0.007) and, in the tertile with both normal kidney function (eGFR 84 +/- 11.7 ml/min/1.73m(2)) and n

145 03 is safe, and that it effectively promotes kidney function following IRI and survival of renal tran

146 Kidney function was assessed by measurement of glomerula

147 phenol A (BPA) and phthalates on measures of kidney function, tubular injury, and oxidative stress ov

148 ease acid excretion but lead to a decline in kidney function.

149 etabolites among 1,627 patients with reduced kidney function.

150 antihypertensive medications, and had lower kidney function.

151 red erythropoiesis in the setting of reduced kidney function.

152 k will define the role of pMRI in predicting kidney graft and patient's survival.

153 ional arm died with functioning pancreas and kidney grafts.

154 hypoxic injury compared to controls and the kidneys have reduced expression of the hypoxia-inducible

155 tients in the successful management of their kidney health.

156 Kidney homeostasis is critically determined by the coord

157 ey cells is essential for the maintenance of kidney homeostasis, structure and function.

158 Hemodynamic study of the target kidney in combination with the histological analysis rev

159 elopment of inflammation and fibrosis of the kidney in salt-sensitive hypertension.

160 tations in NOTCH2 are associated with cystic kidneys in Hajdu-Cheney syndrome patients.

161 s complicates the transplantation of TKO pig kidneys in OWMs.

162 ession from gills, in marine vertebrates, to kidneys in terrestrial vertebrates.

163 s isolates associated with severe UTI, i.e., kidney infection (pyelonephritis) or urinary-source bact

164 mplications during admission included: acute kidney injury (63%), transaminitis (31%), shock (31%), a

165 d with mortality in patients with both acute kidney injury (adjusted relative risk, 2.38; 95% CI, 1.7

166 SAID) administration and postoperative acute kidney injury (AKI) and anastomotic leak.

167 alnutrition is common in patients with acute kidney injury (AKI) and the risk of mortality is high, e

168 Recent evidence suggests that acute kidney injury (AKI) is the main predictor of postparacen

169 likely to discard deceased donors with acute kidney injury (AKI) versus without AKI (30% versus 18%).

170 patients with ACLF diagnosed with HRS acute kidney injury (AKI) were randomized to albumin with infu

171 r process can result in recovery after acute kidney injury (AKI) with adaptive proliferation of tubul

172 Ischemic acute kidney injury (AKI), a complication that frequently occu

173 s for prophylaxis against postcontrast acute kidney injury (PC-AKI) in 2018 (ESUR 10.0).

174 ere associated with the development of acute kidney injury and decreased survival.

175 ischemia-reperfusion, an event that induces kidney injury and fibrosis.

176 n about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to

177 omplement activation and acute post-ischemic kidney injury are prevented, with additional protection

178 orrelates with increased mortality and acute kidney injury early after transcatheter aortic valve rep

179 48 of 116 patients (41.4%) and severe acute kidney injury in 32 of 116 (27.6%) patients, which was m

180 The occurrence rate of acute kidney injury in acute ischemic stroke patients was low

181 as a therapeutic strategy to attenuate acute kidney injury in transgenic mice receiving contrast mate

182 Acute kidney injury is common, with a major effect on morbidit

183 of crucial injury response factors-including kidney injury molecule-1 (Kim1), lipocalin 2 (Lcn2), and

184 Any-stage acute kidney injury occurred in 48 of 116 patients (41.4%) and

185 here was a trend toward higher risk of acute kidney injury requiring renal replacement therapy in SOT

186 Acute kidney injury requiring renal replacement therapy occurr

187 rate (GFR) and urine albumin excretion, and kidney injury was evaluated by histopathology and gene e

188 The risk of acute kidney injury was lower between those who either underwe

189 raft dysfunction (EAD), L-GrAFT score, acute kidney injury, and comprehensive complication index were

190 Autophagy has been implicated in acute kidney injury, which can arise in response to nephrotoxi

191 .6; males: 113 [58.2%]); 163 (84%) had acute kidney injury, which was associated variously with dehyd

192 ease, and ischemia/reperfusion-induced acute kidney injury.

193 critically ill patients with oliguric acute kidney injury.

194 fficacy of transplantation of 30 HCV-viremic kidneys into HCV-negative recipients, followed by early

195 The kidney is comprised of highly complex structures that re

196 We review the impact of obesity on kidney, liver, and cardiothoracic transplant candidates

197 on levels in blood, brain, heart, intestine, kidney, liver, lung, muscle and spleen were determined o

198 different organs including the heart, liver, kidney, lungs, immune system, gastro-intestinal system,

199 RB was independently associated with altered kidney markers with an increased risk of +25 to +31% per

200 Previously, we showed that rat kidney mesangial cells dividing during hyperglycemic str

201 a further dose saturation study in a porcine kidney model.

202 n transplant recipients (heart, lung, liver, kidney, multiorgan) at The Hospital for Sick Children (2

203 Pig kidneys (n = 5) were procured after 30 minutes of warm i

204 in a panel of primary ADPKD and normal human kidney (NHK) epithelial cells.

205 ristics of blood vessels, the heart, and the kidney of giraffes and how these functional and structur

206 HIF-1alpha and erythropoietin levels in the kidneys of KS-tg/OVE mice.

207 of senescent cells in the lungs, heart, and kidneys of mice that were intraperitoneally injected wit

208 ACE2 was similarly upregulated in the kidneys of mice with comorbid diabetes compared with age

209 r risk of the cardiovascular outcome and the kidney outcome, but not with all-cause mortality.

210 6 vs. 57.5 mL/min/1.73m for ideal comparator kidneys; p < 0.001).

211 ns have been associated with severe advanced kidney pathologies, such as cystitis and pyelonephritis,

212 rl3, and Col18a1) not previously examined in kidney pathologies.

213 f circulating plasma cells, which alleviated kidney pathology and improved survival.

214 ith the number of kidneys procured up to 549 kidneys per year and then increase.

215 In situ kidney perfusion can be performed at either 4 degrees C

216 Regulated primarily by the kidneys, phosphate reaches abnormally high blood levels

217 kidney tended to decline with the number of kidneys procured up to 549 kidneys per year and then inc

218 en the reassuring information from the first kidney provided by EVNP, the second kidney was not perfu

219 There is little data on how kidney quality, measured by kidney donor profile index (

220 The mean 12-month eGFR for AKI kidney recipients was lower, but differences were not cl

221 Failure to achieve kidney recovery after immune checkpoint inhibitor-associ

222 as the metabolic substrate for the heart and kidneys, reduced oxidative stress, lowered serum uric ac

223 The National Kidney Registry (NKR) Advanced Donation Program enables

224 which is associated with new-onset, adverse kidney-related outcomes.Study registered with Australian

225 tically ill patients treated with continuous kidney replacement therapy.

226 tor Award, MSK's Ludwig Center, Weiss Family Kidney Research Fund, Novartis, The Sidney Kimmel Center

227 Kidney research is entering an era of 'big data' and mol

228 M7 inhibitor, prevents kidney atrophy in UUO kidneys, retains tubular formation, and reduces TRPM7 ex

229 However, the clinical significance of the kidney's clearance of tubular secretory solutes is uncer

230 y isolated from some lung, brain, liver, and kidney samples that were ZsG and/or PCR positive, and on

231 Kidney-specific knockout (KO) of Gpr116 caused a signifi

232 In simultaneous pancreas-kidney (SPK) transplant recipients, the majority of comp

233 rapulmonary manifestations included hepatic, kidney, splenic, and bone marrow involvement, and microv

234 Any future kidney stone classification system should be aimed at di

235 communities and early-onset calcium oxalate kidney stone disease is unknown.

236 MED score category, the risk of developing a kidney stone was between 13% and 41% lower compared with

237 However, the diagnosis of 'kidney stone' can range from an incidental asymptomatic

238 Kidney stones and ureteral stents can cause ureteral col

239 linical importance in the absence of gout or kidney stones.

240 of erythropoietin synthesis, after which the kidney takes over.

241 ed a near-infrared fluorophore with inherent kidney-targeting ability.

242 The cost of a viable kidney tended to decline with the number of kidneys proc

243 antation candidates who were offered a DCD50 kidney that was eventually accepted for transplantation.

244 could be accurately matched to very similar kidneys that had been transplanted in France; these disc

245 In the ageing kidney there is nephron loss and lesions of focal glomer

246 sible pathological changes in blood flow and kidney tissue, and provides retention of 20.5 +/- 3% of

247 ese effects, along with acid accumulation in kidney tissue, combine to accelerate progression of kidn

248 using multiphoton live cell imaging in mouse kidney tissue, FIB-SEM, and other complementary techniqu

249 ransporter while being retained in cancerous kidney tissues with low P-glycoprotein expression.

250 Kidney transplant (KT) outcomes for HIV-infected (HIV+)

251 g kidney, and categorized as: deceased-donor kidney transplant alone (DD-KA, 68%), living-donor kidne

252 transplant alone (DD-KA, 68%), living-donor kidney transplant alone (LD-KA, 30%), or SPK (2%).

253 roving knowledge among African American (AA) kidney transplant candidates compared to other races.

254 c AMR identifies patients at higher risk for kidney transplant failure.

255 failure in patients (n = 181) who received a kidney transplant in Olmsted County, MN (January 1, 1998

256 We are reporting the first case of CG in a kidney transplant recipient with kidney disease of unkno

257 b (anti-PD-1) for ~9 months to a 57-year-old kidney transplant recipient with metastatic cutaneous sq

258 rug-resistant Cytomegalovirus retinitis in a kidney transplant recipient.

259 o study the MDSC effects on the evolution of kidney transplant recipients (KTRs).

260 2014-December 2018) comprising 4 transgender kidney transplant recipients and 2 transgender living do

261 clinical and histologic phenotyping from 224 kidney transplant recipients between 2011 and 2017.

262 hould not be used in high-immunological risk kidney transplant recipients due to a perceived increase

263 Two cohorts of kidney transplant recipients enrolled in the Deteriorati

264 evaluated 296 807 adult (age > 17) solitary kidney transplant recipients from the Scientific Registr

265 ation-09 study in which we randomized stable kidney transplant recipients to Tac withdrawal or mainte

266 is is an uncommon opportunistic infection in kidney transplant recipients.

267 Similarly, deceased donor kidney transplant volume dropped from 367 to 202 (-45%),

268 against autoantigens and alloantigens after kidney transplant.

269 in end-stage renal disease patients awaiting kidney transplant.

270 with end-stage renal disease is longer after kidney transplantation (KT) compared with those remainin

271 ion immunosuppression for simultaneous liver/kidney transplantation (SLKT).

272 We enrolled patients who underwent kidney transplantation and were actively followed up in

273 ipients (SRTR) data to identify 92 081 adult kidney transplantation candidates who were offered a DCD

274 d racial and sex disparities in living donor kidney transplantation do not appear to be related to ne

275 are new trials in autoimmunity and heart and kidney transplantation to determine effectiveness of inh

276 mulative percentage of patients referred for kidney transplantation within 1 year of dialysis at the

277 ction of a dnDSA, 65.3 months (median) after kidney transplantation.

278 ht induce cross-dressing following liver and kidney transplantation.

279 ling solution to improve equity in access to kidney transplantation.

280 DGF is a relevant problem after kidney transplantation; sufficient microperfusion of the

281 tive complications (UOC) affect up to 15% of kidney transplants (KTX).

282 rtality, and living-donor and deceased-donor kidney transplants (LDKT/DDKT) March 15-April 30, 2020 t

283 Whether donor leukocytes persist within kidney transplants or play any role in rejection is unkn

284 Conditional kidney tubule-specific ENaC gamma-subunit knockout mice

285 nism of sodium retention and its location in kidney tubules may vary with time in nephrotic syndrome

286 cords, intraoperative physiological signals, kidney ultrasound imaging, and digitized biopsy specimen

287 We recently demonstrated that removal of one kidney (uninephrectomy [UniNx]) in mice reduced high-fat

288 he first kidney provided by EVNP, the second kidney was not perfused with EVNP and was directly impla

289 rize the survival benefit of accepting DCD50 kidneys, we used 2010-2018 Scientific Registry for Trans

290 Porcine kidneys were exposed to 30 minutes of warm ischemia and

291 Kidneys were randomly allocated to receive MAPC treatmen

292 Thus, recipients of LD, DCD, and AKI kidneys were studied to provide a more complete understa

293 pressed genes (DEGs) in Pkd2 single-knockout kidneys, which were used to identify candidate pathways

294 biopsy data when available to differentiate kidneys with AKI from those with chronic injury.

295 Compared with kidneys with KDPIs <85%, kidneys with KDPIs >=85% had very similar gene transcrip

296 ic protein 1 expression was only elevated in kidneys with KDPIs >=85%.

297 Compared with kidneys with KDPIs <85%, kidneys with KDPIs >=85% had ve

298 cipients, post-KAS recipients were allocated kidneys with lower Kidney Donor Profile Index (median 30

299 is the dominant RAS peptide in healthy human kidneys with NEP rather than ACE2 being essential for it

300 been transplanted in France; these discarded kidneys would be expected to have allograft survival of