ライフサイエンスコーパス: kill

1 der the LLINs (bite reduction and mosquitoes killed).

2 ingococcal resistance to complement-mediated killing.

3 processes such as bacterial phagocytosis and killing.

4 vectors encoding CAR that direct tumor cell killing.

5 utrophil NADPH oxidase activity and conidial killing.

6 f newborn cells to mediate Ab-dependent cell killing.

7 gen species for proopiomelanocortin neuronal killing.

8 cells (CARB19) that are resistant to CART19 killing.

9 trafficking to the tumor and mediating cell killing.

10 ntrol of tumor progression, but limited cell killing.

11 variants to antibody-dependent bactericidal killing.

12 migration toward tumor cells, and tumor cell killing.

13 ng feature of CD4+ T cells that survived CTL killing.

14 al essential steps in PGRP-induced bacterial killing.

15 tially explaining one mechanism of bacterial killing.

16 resistance to neutrophil-mediated bacterial killing.

17 ed SMAP component that contributed to target killing.

18 rtially restored cell couple maintenance and killing.

19 cells and macrophages, to induce tumor cell killing.

20 pharmacokinetics and radiation-induced cell killing.

21 sistance of reservoir-harboring cells to CTL killing.

22 r survival and protection against neutrophil killing.

23 ogocytosis and phagocytosis, as well as cell killing.

24 cytotoxicity has not been linked to parasite killing.

25 flammatory cytokines, leading to target cell killing.

26 ersistent natural killer (NK) cell cytolytic killing.

27 oduction and high resistance to PGRP-induced killing.

28 re also observed for different cytokines and killing.

29 serve as reagents for bacterial imaging and killing.

30 ealed that, on average, each strike directly kills 3.5 trees (> 10 cm diameter) and damages 11.4 more

31 PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer

32 together increased the likelihood of wolves killing a bull instead of a cow.

33 This peptide kills a subset of cancer cells in a manner that does not

34 ecific pathways and mechanisms in macrophage killing ability, explored how pathogens subvert these re

35 ove those considered adequate for redirected killing activity against Env-expressing target cells but

36 uplexes and R loops and showed a potent cell killing activity associated with the formation of micron

37 Here we show that the cell killing activity of PAF26 is dependent on extracellular

38 (+) T cell responses with S protein-specific killing activity were detected.

39 are necessary for the import of PyoG and its killing activity.

40 SM-164 did not kill adriamycin-resistant BC cells, while adriamycin inh

41 y effects in which human melanoma cells were killed after 5 min of light exposure.

42 utonomous release of the chemoattractant and killing agents result in long-range chemotactic attracti

43 nhance the activities of multiple "shock-and-kill" agents, which in turn may inform ongoing LRA combi

44 We observed that Spiroplasma killed all strains of wasp.

45 ococcus neoformans is a fungal pathogen that kills almost 200,000 people each year and is distinguish

46 lable therapeutic regimen cannot effectively kill and eliminate ERPC cells.

47 ed in 88hIgG1, recapitulated the direct cell killing and avidity of 88mIgG3.

48 during T-starvation, while both the dramatic killing and chromosomal DNA loss in the ECA-deficient th

49 of cell competition could induce cancer cell killing and form the basis for novel anticancer therapie

50 CD2 signaling as key for mediating cytotoxic killing and granule polarization in freshly isolated CD8

51 d killing, and formate enhanced PGRP-induced killing and H(2)O(2) production in an FDH-dependent mann

52 er monocyte recruitment, increased bacterial killing and improved healing upon a secondary infection.

53 ion in tissues, resulting in high tumor cell killing and low toxicity to surrounding tissues.

54 ctions since both direct microbial pathogens killing and matrix stabilization can occur simultaneousl

55 ith FcgammaR, maintains the opsonophagocytic killing and protective attributes of the antibody.

56 er growth that is based on both direct tumor killing and the triggering of protective immunity.

57 on and achieved both efficient in vitro cell killing and tumor regression in Mcl-1 dependent cancer m

58 n and the highest resistance to PGRP-induced killing, and formate enhanced PGRP-induced killing and H

59 mount robust T cell responses, enhance tumor killing, and provide clinical benefit.

60 direct complement-dependent killing but was killed approximately 70% by 2C7-Ximab-E430G in the prese

61 mechanisms of anti-proliferation and/or cell-killing are consistent with the published mechanisms for

62 HIVconsv-prime and MVA.HIVconsv-boost (the kill; ART + V + V; intervention).

63 formation correlated with competency in prey killing, as well as with the phylogeny of A. oligospora

64 es are identified as fast-acting agents that kill asexual blood-stage parasites at the trophozoite ph

65 A time-kill assay revealed that auranofin exhibited rapid bacte

66 ther show that cocultured allogeneic T cells kill Atg16L1-mutant intestinal organoids from mice, whic

67 However, how histones kill bacteria has remained elusive.

68 indicate that nanopatterned surfaces do not kill bacteria predominantly by rupture in between protru

69 CATH-2 can kill bacteria through a diverse range of antibacterial p

70 uld therefore be promoted therapeutically to kill bacteria.

71 mmonly accepted that nanoparticles (NPs) can kill bacteria; however, the mechanism of antimicrobial a

72 lso abolished IL-8 secretion induced by heat-killed bacteria, TNF, or latrunculin A.

73 By using phages to both kill bacterial cells and 'steer' survivors towards resis

74 honey appearing to be the most bactericidal, killing bacterial concentrations as high as 8 x 10(7) CF

75 nsulinemic hyperglycemia, highly selectively killing beta-cells by receptor-targeted photodynamic the

76 one of the most devastating human diseases, killed between 300 million and 500 million people in the

77 n contrast, Dae2 has no intrinsic ability to kill Borrelia burgdorferi, the tick-borne Lyme disease b

78 applied to the leaves of plants and crops to kill broadleaf plants and grasses.

79 10-tritriacontene and the traditional freeze-killed brood assay for selection of hygienic honey bee s

80 elk abundance, increased the odds of wolves killing bulls relative to cows.

81 actose) resisted direct complement-dependent killing but was killed approximately 70% by 2C7-Ximab-E4

82 sure enhances resistance to human neutrophil killing, but this increase in pathogenicity was not due

83 hypothetical cases in which a pedestrian was killed by a car operated under shared control of a prima

84 that myeloid leukemia cell lines are readily killed by CD83 CAR T cells.

85 n a 3-dimensional collagen gel, however, are killed by cryopreserved NK cells at a 5.6-fold lower rat

86 sis, and immune functions are reported to be killed by developmental alcohol exposure because of acti

87 wo distinct types of adult stem cells, cells killed by freezing and thawing or a chemical inducer of

88 observed that cSCC cells can be selectively killed by small-molecule inhibitors of USP8 (DUBs-IN-3/c

89 bility of roe deer Capreolus capreolus being killed by two predators with contrasting hunting tactics

90 al antiserum modestly increased phagocytosis/killing by an oxidative burst of murine neutrophils in v

91 ocuses on three different mechanisms of cell killing by checkpoint kinase I inhibitors (CHK1i).

92 agy control cancer-cell-intrinsic evasion of killing by CTLs and we highlight the importance of these

93 te to phenotypes associated with escape from killing by CTLs.

94 tibility class I (MHC-I) expression to evade killing by cytotoxic T lymphocytes (CTLs).

95 ulation plays a critical role in target cell killing by freshly isolated human CD8(+) T cells, which

96 ich were found to be important for resisting killing by H(2)O(2) Finally, DeltamumR exhibited reduced

97 e the ability of S. aureus biofilms to evade killing by neutrophils.

98 not cytotoxic) dramatically increased their killing by proteasome inhibitors and inhibitors of ubiqu

99 r the first time that platelets can directly kill C. albicans through release of their granular conte

100 elk population increased the odds of wolves killing calves relative to cows, whereas low SWE and poo

101 e fatty acid desaturase SCD1 may selectively kill cancer cells based on our discovery of spatial sepa

102 he allele retained in tumors can selectively kill cancer cells but not somatic cells, which retain bo

103 dinate with the functional groups of HD, and kill cancer cells by pro-oxidant effects.

104 s of metal complexes have been reported that kill cancer cells via ER stress induction, and many of t

105 late the host immune system to recognize and kill cancer cells.

106 irections in exploiting toxic metabolites to kill cancer cells.

107 uces PDE3A-SLFN12 complex formation, thereby killing cancer cells with high levels of PDE3A and SLFN1

108 stingly, our data show that NVS-CECR2-1 also kills cancer cells by CECR2-independent mechanism.

109 i-cancer agent in phase III clinical trials, kills cancer cells by destabilizing microtubules.

110 n-3(2H)-one (DNMDP) is a small molecule that kills cancer cells by generation of novel activity.

111 le target for an inhibitor-based approach to kill cancers with defects in homologous recombination (H

112 inflamed peritoneum and to phagocytose heat-killed Candida particles.

113 roliferation, cytokine production, and tumor killing capacity.

114 + T cell clones isolated from healthy donors killed CBFB-MYH11+ HLA-B*40:01+ AML cell lines and prima

115 eater ex vivo expansion than CAR T cells and killed CD19+ leukemic cells more effectively in long-ter

116 phosphate pools (e.g., 8-oxodGTP), which may kill cells if incorporated into DNA.

117 Killed cells release a resistance-enhancing factor that

118 This work shows that TAT-RasGAP(317-326) kills cells via a form of necrosis that relies on the ph

119 nslocation of CD107a to the cell surface and kill cellular targets, while NKG7 also had a major impac

120 extracellular traps (NETs) that confine and kill circulating pathogens.

121 or delivery into bacteria, we show that they kill clinical isolates of several multidrug-resistant ba

122 Neutrophils isolated from mouse brain tumors kill cocultured tumor cells.

123 DT2) by CDT2 knockdown can be more potent in killing cSCC cells than targeting CRLs or CRL4s in gener

124 at [Formula: see text], somewhat beyond the "kill distance" that would have precipitated a full mass

125 er to identify effective drug molecules that kill drug-tolerant borrelia we have tested two antibioti

126 LogCD147-CAR selectively kills dual antigen (GPC3(+)CD147(+)), but not single ant

127 BCH070 preferentially kills early ring-form trophozoites, and, importantly, eq

128 225)Ac-L1, to evaluate their safety and cell kill effect in PSMA-positive (+) xenograft models.

129 stored chemical energy may enhance the cell-killing effect and boost the therapeutic effect.

130 Mechanistically, the cell killing effects of PP were a result of inhibition of lip

131 sensitizers is an effective way to boost the killing efficacy of radiotherapy while drastically limit

132 s, and active GrB influenced its target cell-killing efficiency.

133 of wolf space use, the distribution of wolf-killed elk and vegetation openness.

134 as indicated by per cent marrow fat) of wolf-killed elk varied markedly with summer plant productivit

135 e, we show that UV-B irradiation selectively kills epidermal and niche cells in the shoot apex.

136 t the identified antibodies have utility for killing epithelial cell adhesion molecule-positive cells

137 sue rejection through individual target cell-killing events in vivo.

138 00 and 200 new HTLV-1 clones are created and killed every day.

139 human CD8+ T cells reduced direct tumor cell killing ex vivo.

140 umor spheroid microenvironment, whereas heat-killed F. nucleatum is internalized and sequestered in t

141 nificant temporal trends in rates of illegal killing for Southern, Central and Western Africa.

142 ts activation, recruitment, phagocytosis and killing functions of neutrophils, causing susceptibility

143 ant strains had a greatly reduced ability to kill Galleria mellonella larvae, could not replicate in

144 orally a bacterial lysate consisting of heat-killed Gram-negative Escherichia coli Symbio and Gram-po

145 The salt-functionalized filters quickly killed Gram-positive and Gram-negative bacteria aerosols

146 Mosquitoes transmit pathogens that kill >700,000 people annually.

147 anism(s) driving this sex bias in neutrophil killing have not been reported.

148 in vivo under ART.IMPORTANCE The "shock and kill" HIV cure strategy attempts to reverse and eliminat

149 Entamoeba histolytica kills human cells by ingesting fragments of live cells u

150 The "shock-and-kill" human immunodeficiency virus type 1 (HIV-1) cure s

151 us 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highli

152 sease 2019 (COVID-19) has sickened millions, killed hundreds of thousands, and utterly disrupted the

153 dly around the globe, infecting millions and killing hundreds of thousands.

154 zes tumor cells to cytotoxic T cell-mediated killing, improving CAR T cell therapy.

155 at azlocillin and cefotaxime can effectively kill in vitro doxycycline-tolerant B. burgdorferi.

156 nd PGE2 receptor blockade enhanced bacterial killing in Mphis.

157 This serum also induced bacterial killing in opsonophagocytosis assays, suggesting that HN

158 oduction and that defective L. monocytogenes killing in P2X5-deficient BMMs is substantially rescued

159 d and demonstrated potent and specific tumor killing in vitro and in vivo against both epithelioid an

160 ignificantly enhanced tumor cell binding and killing in vitro without harming healthy B cells.

161 For effective lymphoma cell killing in vivo, we further functionalized CD22 ligand-m

162 ells play a key role in adaptive immunity by killing infected or cancerous cells.

163 lium and accumulate to high enough levels to kill intracellular bacteria.

164 ia nanotubes to extravillous trophoblasts to kill intracellular Listeria monocytogenes (Lm) without k

165 Neutrophils kill invading microbes and therefore represent the first

166 icantly improved peptide function and distal killing, it also reduced surfactant spreading.

167 Critically, neutrophils were able to kill larvae in vitro, which was enhanced by neutralizing

168 e mechanism exerted by gammadelta T cells to kill late-stage blood-residing P. falciparum.

169 omponent pore-forming toxins that target and kill leukocytes, known collectively as the leukocidins.

170 embly, charged with doxorubicin, selectively kills liver cancer cells in culture, as the selectivity

171 relearn how to live with apex predators that kill livestock, compete for game species, and occasional

172 in cells overlying the LRP or by physically killing LRP-overlying cells by ablation with optical twe

173 o 129hIgG1, converting it into a direct cell killing mAb with enhanced avidity and significant in viv

174 We used observations of 2,960 kills made by 49 leopards Panthera pardus in the Sabi Sa

175 hypotheses have been proposed: liberalizing killing may decrease poaching incidence ('tolerance hunt

176 nanoparticle design that enables a "lure and kill" mechanism designed for PLA2 inhibition (denoted "L

177 ance is complicated by uncertainty regarding kill mechanisms and the relative timing of volcanogenic

178 lcanism and the Chicxulub asteroid impact as kill mechanisms for this event.

179 everaging on several synergistic cancer cell killing mechanisms.

180 d pathways that enable cancer cells to evade killing mediated by cytotoxic T lymphocytes (CTLs), we p

181 nd establishing how the NADPH oxidase (NOX2) kills microbes has proven elusive.

182 e would approve of using a nuclear weapon to kill millions of enemy civilians in the hope of ending a

183 Outbreaks have killed millions of swine around the world, and there is

184 One clinical isolate was killed more effectively in azithromycin-treated neutroph

185 d p53 activity and allowed tumor cells to be killed more efficiently.

186 4%) in disappearances reflects that poachers killed more wolves and concealed more evidence when the

187 as metastasis cancer cells, and efficiently kill most of them.

188 (R)-N-(piperidin-3-yl) linker (P2-6R), which killed NCI-H460 and A549 lung cancer cells 100 times mor

189 ogenic bacteria, and for repurposing CDCs to kill new cellular targets.

190 either LCK to enhance the kinetics of tumor killing of 4-1BB CAR-T cells or SHP1 to tune down cytoki

191 c fibrosis neutrophils, wortmannin inhibited killing of a rough clinical isolate and not a smooth iso

192 e induction of optimal antifungal neutrophil killing of A. fumigatus spores.

193 TCR transfer to T cells of patients enabled killing of autologous and nonautologous melanoma.

194 )-roscovitine and M3 significantly increased killing of B. cenocepacia and P. aeruginosa in CF MDMs i

195 ism of membrane-tension-induced (mechanical) killing of bacterial cells by non-translocating NPs.

196 umor fibrosis, and unleashed T cell-mediated killing of cancer cells.

197 apsidCas13a(s), capable of sequence-specific killing of carbapenem-resistant Escherichia coli and met

198 NHE mediates killing of cells from multiple lineages and hosts, highl

199 ved D-lactate promotes Kupffer-cell-mediated killing of circulating pathogens.

200 imetics were highly synergistic in restoring killing of CLL cells.

201 ests have been happening for weeks since the killing of George Floyd in Minneapolis.

202 CD3+ T cells to GPRC5D+ MM cells and induces killing of GPRC5D+ cells.

203 AdRGD-PG-hIFNbeta vector provides extensive killing of human melanoma cells in vitro and a potent an

204 gger the clearance of viruses and subsequent killing of infected cells(1-4).

205 nd contribute to protecting the host through killing of infected, foreign, stressed or transformed ce

206 crophages (BMMs) exhibit defective cytosolic killing of L. monocytogenes We further showed that P2X5

207 binding mode; consequently, the direct cell killing of mouse IgG3 mAb is lost upon chimerization or

208 cubation of linezolid significantly improved killing of MRSA by dysfunctional neutrophils, which was

209 covitine's impact on macrophage function and killing of multi-drug resistant bacteria.

210 the intestinal epithelium and the effective killing of penetrant microorganisms, while suppressing t

211 ompared to wild-type cells, showed increased killing of phagocytosed E. coli and M. smegmatis Polypho

212 DNA cleavage in vitro impair P2 OLD-mediated killing of recBC-Escherichia coli hosts, indicating that

213 white blood cells showed defective in vitro killing of Staphylococcus aureus, consistent with a spec

214 tains epitopes that promote opsonophagocytic killing of streptococci.

215 pansion that causes, but also relies on, the killing of surrounding cells.

216 ression of FHbp ID 896 resulted in augmented killing of the clade by LL-37.

217 essing the ability to elicit T cell-mediated killing of tumor cells and prevent disease recurrence.

218 The killing of tumor cells by CD8(+) T cells is suppressed b

219 effect of ART-only versus ART plus kick and kill on markers of the HIV reservoir.

220 ured surfaces and bacteria lead to bacterial killing or prevention of bacterial attachment and subseq

221 y (TBI) is largely non-preventable and often kills or permanently disables its victims.

222 The compounds did not kill other bacteria, indicating selectivity for Chlamydi

223 ndemic that has infected over 36 million and killed over 1 million people.

224 ldwide infecting nearly 6 million people and killing over 350,000.

225 t affects over 216 million people worldwide, killing over 445,000 patients annually.

226 uel continuity and prevent future fires from killing overstorey trees.

227 DOX concentrations > 5 uM kill parasites with first-cycle activity but are thought

228 nge, and we show that engineered S. alvi can kill parasitic Varroa mites by triggering the mite RNAi

229 in different cells and may be ineffective in killing particular clones.

230 that AB569 is a safe and effective means to kill pathogenic bacteria, suggesting that simple strateg

231 epithelia to produce antimicrobial peptides, killing pathogenic competitors, while S. epidermidis its

232 The natural antibiotic teixobactin kills pathogenic bacteria without detectable resistance.

233 for game species, and occasionally injure or kill people.

234 hat macrophages not only fail to efficiently kill phagocytosed S. aureus, but also induce tolerance t

235 Functional assays (killing, phagocytosis, transmigration, and respiratory b

236 The "shock-and-kill" pharmacological ap-proach aims to reactivate provi

237 Meanwhile, OOPC acts as inhibitor that "kills" PLA2 upon enzymatic attack.

238 (DOX) is a key antimalarial drug thought to kill Plasmodium parasites by blocking protein translatio

239 st VRE, 40 mM DAU for 120 min showed a > 94% kill rate, p < 0.001.

240 st MRSA, 40 mM SMG at 120 min showed a > 95% kill rate, p < 0.02.

241 ring high concentrations (100 mM) to achieve kill rates greater than 50%.

242 candinavia, the home-range establishment and kill rates of gray wolves (Canis lupus) are affected by

243 phate barriers achieved significantly higher killing rates than bednets alone.

244 ROCK-myosin II ablation specifically kills resistant cells via intrinsic lethal reactive oxyg

245 Conversely linezolid impaired killing responses in healthy neutrophils.

246 t toxins in commercially available corn that kill rootworms.

247 Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the

248 into identifying compounds that selectively kill senescent cells (termed senolytics).

249 ic proteins BCL-2 and BCL-xL and selectively kills senescent cells.

250 hibitors of glucose transporters selectively kill SLC7A11(high) cancer cells and suppress SLC7A11(hig

251 gated phanorods could selectively target and kill specific bacterial cells using photothermal ablatio

252 We previously showed that formalin-killed spherules (FKS) stimulate mouse macrophages to se

253 ed with decreased capacity of neutrophils to kill Staphylococcus aureus and worse clinical outcomes.

254 ntingtin (HTT) fragments that preferentially kill striatal neurons.

255 gold(I) complexes, we used a series of time-kill studies, cytotoxicity and hemolysis assays, as well

256 akinra to whole blood reduced staphylococcal killing, supporting an IL-1beta functional significance

257 activity against various human cancer cells, killing SW48 colon cancer cells in particular with a sub

258 Cytotoxic CD8(+) T cells can effectively kill target cells by producing cytokines, chemokines, an

259 ys, locally generating heat that efficiently kills targeted bacterial cells.

260 Opioid use kills tens of thousands of Americans each year, devastat

261 ctrum antibiotics geneticin and puromycin to kill the non-rescued sex.

262 en loaded with drugs, the MIPs could locally kill the tumor cells, making them efficient therapeutic

263 y bind HIV and trigger various leukocytes to kill the virus and restrict viral spread.

264 In only 4 hours, this compound killed the juvenile form of F. hepatica with an IC(50) o

265 pped tube across the bacterial cell surface, killing the bacterium.

266 cellular Listeria monocytogenes (Lm) without killing the trophoblast.

267 to release the virus, which then infects and kills the pest.

268 cells, which overwhelmingly use perforin to kill their targets.

269 certain bacterial pathogens in circulation, kill them through oxidative stress, and present them to

270 an of the prey bacterium, which leads to its killing, thereby providing a growth advantage for P. aer

271 Rai, Virtuous Violence: Hurting and Killing to Create, Sustain, End, and Honor Social Relati

272 the way for the proinflammatory direct cell killing to promote antibody-dependent cellular cytotoxic

273 Reovirus preferentially kills transformed cells and is in clinical trials to ass

274 An attract-and-kill trap based on psyllid behavior would fill a niche f

275 These fires kill trees at rates varying from < 10 to c.

276 By killing trophozoite-infected erythrocytes, PfGARP could

277 Cancer therapies aim to kill tumor cells directly or engage the immune system to

278 which tenovins are able to activate p53 and kill tumor cells in culture.

279 powering the ability of cytotoxic T cells to kill tumor cells or the reframing of their receptor to e

280 TCR/CD3 bispecifics can redirect T cells to kill tumor cells with target HLA/peptide on their surfac

281 nhancing the ability of cytotoxic T cells to kill tumor cells.

282 On the other hand, the ROS not only directly kills tumor cells by photodynamic therapy but stimulates

283 itro and in vivo have shown an improved cell kill/tumor response, that could be attributed to an addi

284 unique granule proteins that can potentially kill tumour cells.

285 sensitivity of S. epidermidis to antibiotic killing under biofilm-forming conditions.

286 The assembly does not kill untransformed cells that the aptamer does not bind.

287 atus, high-risk leukemic cells could only be killed using RAS-inhibitor or PTPN11-inhibitor, but not

288 Complement-dependent killing using the modified Ham test is blocked by either

289 D147, also known as Basigin, can effectively kill various malignant HCC cell lines in vitro, and HCC

290 arget cell interface, the immune synapse, to kill virus-infected and tumorigenic target cells.

291 However, cell killing was immediate upon re-polarization.

292 To investigate whether killing was mediated through surface components or relea

293 nse occurred in p53-defective cells and cell killing was not blocked by a pan-caspase inhibitor.

294 stars whole, whereas third and fourth instar kills were first gutted, then processed and carried away

295 Calves were most likely to get killed when elk abundance was high and when the forage p

296 cell density, revealing more effective cell killing when more cancer cells are present.

297 gardens, most second to fourth instars were killed, whereas most fifth instars escaped by thrashing

298 sing mutant superoxide dismutase-1 (mutSOD1) kill wild-type motor neurons (MNs) by an unknown mechani

299 reactivate the latent virus (e.g., shock and kill) would be detrimental to astrocyte function and pos

300 organism containing numerous gamete (spore)-killing wtf drivers, offers a tractable system to test t