ライフサイエンスコーパス: kilobase

1 dividual and a density of 1.1 variations per kilobase.

2 rage 3.2 single-nucleotide polymorphisms per kilobase.

3 nvasive variant detection across hundreds of kilobases.

4 elic gene conversion events spanning tens of kilobases.

5 etween direct and tethered GBSs over tens of kilobases.

6 ve multivalent interactions over hundreds of kilobases.

7 ypically within several kilobases to tens of kilobases.

8 h the smallest genome currently known at 112 kilobases.

9 ng nearly all genes that are longer than 200 kilobases.

10 raction patterns at length scales of several kilobases.

11 s, wild-type Yan-bound regions span multiple kilobases.

12 tational hot and cold spots spanning several kilobases.

13 slate to ~40 ribonucleotides inserted per 10 kilobases.

14 tivation from as far away as several hundred kilobases.

15 ically relevant level of tens to hundreds of kilobases.

16 gions of recombination extended over several kilobases.

17 recovered by another binding event within 10 kilobases.

18 equence variants (PSVs) separated by several kilobases.

19 accuracy and genomic resolution reaching two kilobases.

20 with mate-pair libraries extending up to 20 kilobases.

21 ging from several hundred base pairs to many kilobases.

22 served RNA structural domains that span many kilobases.

23 A, a protein-binding module in its first two kilobases (2kb), to repress transcription.

24 so identified a highly conserved sequence 21 kilobase 5' of BP4 that we called BE5.2, which contains

25 ss Igh domains that span tens to hundreds of kilobases, a phenomenon not observed in simple eukaryote

26 urther measure a ribosome density of 1.3 per kilobase and an elongation rate of 13-18 amino acids per

27 ly, imaging of tagged genomic loci, with <=1 kilobase and ~20-nanometer precision, in live cells, rev

28 les per parS site (~20) can spread over many kilobases and suggests a mechanism by which ParB protein

29 mpirical p = .04 for duplications of 100-200 kilobase) and a particular deletion region spanning gene

30 ll count input, we profile both small-scale (kilobase) and large-scale (megabase) changes in chromati

31 the opportunity to phase mutations multiple kilobases apart directly from sequencing reads.

32 ranging from a few hundred base pairs to 100 kilobases, are created upstream of the target site.

33 uently associated with cis variants within 5 kilobases, as were intron retention alternative splicing

34 e heterozygous for deletions of at least 593 kilobases at 16p11.2 and whose ascertainment included co

35 tion of discrete target fragments of several kilobases at 37 degrees C from both double- and single-s

36 lexes traveling an average distance of >/=10 kilobases at a velocity of 60 base pairs per second.

37 This compaction is processive over tens of kilobases at an average rate of 0.5 kilobases per second

38 henomenon-duplication of tens or hundreds of kilobases at the breakpoint junction, so that the same s

39 is bound across domains spanning 10 or more kilobases at the DAFC rather than at a specific site.

40 and marker-free DNA integration of up to 10 kilobases at ~100% efficiency in bacteria.

41 ments, most endemic events occur hundreds of kilobases away from Myc.

42 e crossover rate of flanking markers tens of kilobases away from the sequence polymorphisms was affec

43 nhancers may be located tens or thousands of kilobases away from their promoters.

44 ge genomic distances and can be located many kilobases away from their target promoters.

45 variants in the same gene up to hundreds of kilobases away that cannot be obtained from DNA sequenci

46 al upstream CpG island (CGI) located several kilobases away that functions as an alternative promoter

47 good indicator of eQTL targets for genes 150 kilobases away, but insulators, TF co-occurrence, open c

48 ter gene located at distances of hundreds of kilobases away, suggesting that both proximal and distal

49 heir target genes, often located hundreds of kilobases away.

50 lements in 3D proximity to genes hundreds of kilobases away.

51 8641 (P=2.8 x 10(-8)), the nearest gene (306 kilobases) being OPRM1.

52 restricted interactions spanning hundreds of kilobases between promoters and distal loci.

53 ologies can produce long-reads up to tens of kilobases, but with high error rates.

54 or schizophrenia is conferred by large (>500-kilobase) CNVs at several loci, including microdeletions

55 dy data set, we identified a significant 202-kilobase consensus region on Chr15q24.1 (empirical P val

56 3 Mb (P = .02), as well as a significant 114-kilobase consensus region on chr4q31.3 (empirical P valu

57 PCR products in the range of 700 bases to 2 kilobases could be amplified without addition of cosolve

58 ed proteins encoded in the approximately 100 kilobase crAssphage genome showed no significant similar

59 presses wild-type mtDNA and mtDNA with a 3.1-kilobase deletion (mtDNA) lacking four essential genes.

60 iver and that arises as the result of a ~400-kilobase deletion on chromosome 19.

61 sequencing revealed a novel, heterozygous 3-kilobase deletion removing exons 7-9 of TP53 in the pati

62 tions of nucleosome density over hundreds of kilobases, delineating chromosomal domains within IgH, i

63 s, we observe the redistribution of XPD onto kilobase DNA strands containing a single base mismatch,

64 s of constant region exons (CHs) lie 100-200 kilobases downstream in the same transcriptional orienta

65 l elongation, even at operators located many kilobases downstream of the transcription start site and

66 s an E-protein-dependent enhancer located 41 kilobases downstream of the transcription start site of

67 increased gene expression, extending tens of kilobases downstream of transcription start sites.

68 in size (approximately 4 and approximately 6 kilobases) due to alternative 3' untranslated regions (U

69 es by individually testing 55 segments of 50 kilobases each.

70 th an average of 1.44 heterozygous sites per kilobase for each individual.

71 Transgenic mice where a 3.6-kilobase fragment of the collagen type 1 alpha1 promoter

72 tagenic synthesis is limited to within a few kilobases from the break by Mus81 endonuclease and a con

73 damage and could extend up to a range of few kilobases from the lesion.

74 th modification footprints extending several kilobases from the site of dsRNA homology and with locus

75 ransformed cells for mutations as far as 1.3 kilobases from the ZFN cleavage site.

76 scriptional enhancers can be located tens of kilobases from their target genes, but display character

77 Often located tens of kilobases from their target promoters and functioning in

78 uture gene targeting efforts involving multi-kilobase gene segments, particularly in human iPSC.

79 ent 'knock-in' targeted replacement of multi-kilobase genes in human induced pluripotent stem cells (

80 The 235-kilobase genome of human cytomegalovirus (HCMV) is by fa

81 apable of efficiently packaging either its 8 kilobase genome or non-viral DNA.

82 A five kilobase genomic window scan showed differences in genom

83 A 240 kilobase haplotype encompassing the ALX1 gene that encod

84 Reads exceeding 150 kilobases have been achieved, as have in-field detection

85 Highly reduced genomes of 144-416 kilobases have been described from nutrient-provisioning

86 e 5'-guanosine modifies the function of a ~9-kilobase HIV-1 transcript.

87 n site, and can be recapitulated using a 2.8-kilobase HSPA1A gene fragment.

88 We found that the 4.2-kilobase HXT13-DSF1 region sharing divergent homology wi

89 humanized gene, hmTert, by knocking-in a 47-kilobase hybrid fragment containing these human non-codi

90 predominantly induce deletions longer than a kilobase in A. thaliana.

91 omes to a low of 0.57 heterozygous sites per kilobase in segments inferred to have diploid Native Ame

92 The majority of SVs are less than 1 kilobase in size and 98% are deletions or insertions.

93 rom minicircles, which are approximately one kilobase in size, and encode between three and four gRNA

94 ged from a high of one heterozygous site per kilobase in west African genomes to a low of 0.57 hetero

95 d to adjacent non-specific DNA over multiple kilobases in a phenomenon called spreading.

96 covery and 23 for fine-mapping) spanning 300 kilobases in and around COL5A1 were genotyped and tested

97 zed noncoding RNAs that are 10's to 100's of kilobases in length and low in abundance due to efficien

98 ility to generate reads tens to thousands of kilobases in length with an accuracy approaching that of

99 generate short tandem repeats, often several kilobases in length, embedded within (G+C)-rich genomic

100 pe-resolved, sequence motif maps hundreds of kilobases in length, resulting in a median coverage of 1

101 hages belonging to a clade with genomes >540 kilobases in length, the largest yet reported in the hum

102 that practically works for reads of averaged kilobases in length.

103 hromatin folding for sequences up to tens of kilobases in length.

104 ess double-stranded DNA genomes of 65 to 100 kilobases in size that encode a structural module charac

105 In contrast to hotspots, which are a few kilobases in size, and widely scattered throughout the g

106 ng domains (TADs), typically several hundred kilobases in size, form an intermediate level of organiz

107 sensitivity occurring for events less than 5 kilobases in size.

108 human today are usually less than a hundred kilobases in size.

109 CRISPR RNA generated large deletions (7-424 kilobases) in Pseudomonas aeruginosa with near-100% effi

110 own diabetes risk factors, odds ratios per 1-kilobase increment were 1.00 (95% CI 0.90-1.11) in white

111 This variation includes multi-kilobase indels containing entire genes, and orthologs f

112 stant hotspots, has been mapped within a 181-kilobase interval, three of whose genes can be eliminate

113 up to ~50 fluorescent Cy3-labeled dNTPs per kilobase into a ssDNA chain.

114 ging in length from tens of bases to tens of kilobases, involved in all biological processes and alte

115 at continued processive unwinding of several kilobases involves multiple monomers at the DNA unwindin

116 Nested 0.5- and 1.0-kilobase (kb) deletion fragments of the ITPR3 promoter w

117 family-based analysis, an approximately 200 kilobase (kb) deletion in the first intron of the MAGI1

118 e rs1619661 variant is on chromosome 10, 132 kilobase (kb) downstream from <em>CXCL12</em>, which enc

119 A 2.7 kilobase (kb) homozygous gene replacement was achieved i

120 Sequence polymorphisms in a 58-kilobase (kb) interval on chromosome 9p21 confer a marke

121 uclear injection of a construct carrying a 3-kilobase (kb) region of the Rlbp1 gene and 5'-flanking s

122 method, we utilized sequence data from a 200-kilobase (kb) region on chromosome 9p21 of the human gen

123 hree-dimensional (3D) genome structure at 20-kilobase (kb) resolution, achieved by applying our recen

124 , and specific segments at megabase (Mb) and kilobase (kb) resolutions of single average and ensemble

125 omes, 22 (18 are complete), ranging from 159 kilobase (kb) to 527 kb in length, were found to encode

126 ese studies were done with plasmid DNA (~2.6 kilobase (kb)) in JM109 E. coli cells.

127 3D chromosome models at high resolution (<=5 Kilobase (KB)).

128 ation was characterized as a deletion of 112 kilobase (kb), encompassing over 90% of PRPF31 and five

129 ned, with inter-sister connections every ~35 kilobase (kb).

130 An enhancer 32 kilobases (kb) downstream of the Irf8 transcriptional st

131 ith uniformly repeating sequences to over 20 kilobases (kb) in length.

132 By functionally interrogating >500 kilobases (kb) of mouse and human sequence in mouse embr

133 Megabases (Mb) resolution to the current 10 Kilobases (Kb) or even 1 Kb resolution.

134 TL was approximately 0.5 kilobases (kb) shorter in leukocytes from patients with

135 The lymphocyte promoter maps 13 kilobases (kb) upstream of the monocyte promoter; its us

136 ractions, even at genomic distances below 25 kilobases (kb) where both tend to be high.

137 te genes near the breakpoints of large (>100 kilobases (kb)) inversions but not smaller events.

138 phage genomes with lengths of more than 200 kilobases (kb), including a genome of 735 kb, which is-t

139 ll rare exonic CNV in the size range of 1-30 kilobases (kb), making use of the eXome Hidden Markov Mo

140 a lower size limit for detection of about 30 kilobases (kb).

141 ithin a C(H) locus that span several hundred kilobases (kb).

142 (HiFi) reads with an average length of 13.5 kilobases (kb).

143 romosome conformations at a resolution of 50 kilobases (kb).

144 However, the size of the genome (5.2 kilobases [kb]) surpasses the optimal packaging capacity

145 SNPs) into long haplotype blocks (N50 of 386 kilobases (kbp)).

146 to gene deserts, regions of several hundred kilobases lacking protein-coding genes.

147 s inflated with short repeats and is tens of kilobases larger than the ptDNAs of its closest known ph

148 in a negatively supercoiled DNA molecule of kilobase length and specified base sequence.

149 sequence-dependent structural transitions in kilobase length superhelical DNA molecules.

150 uclease 1 (EXO1) and DNA2 nucleases catalyze kilobase-length DNA resection on nucleosome-coated DNA.

151 d base-pair level models (BPLMs) to simulate kilobase-length dsDNAs and dsRNAs under external forces

152 hree-dimensional (3D) genome organization at kilobase level.

153 Here we show that a 3.7-kilobase lncRNA, terminal differentiation-induced ncRNA

154 of dozens of viral RdRp elongation traces on kilobases long templates, and this has shown that RdRp n

155 hnologies capable of producing reads tens of kilobases long.

156 SMS sequencing produces reads up to tens of kilobases long.

157 estructive, preserving DNA fragments over 10 kilobases long.

158 ve been shown to be partitioned into several-kilobase-long chromosomal domains that are topologically

159 Schwann cells and harbored a homozygous 10.7-kilobase-long deletion encompassing a myelin-specific en

160 pre-mRNA) that is initiated within a several-kilobase-long region, called the transcription start sit

161 much more active, being capable of digesting kilobase-long stretches of DNA.

162 Several kilobase-long tracts of genome sequence can be replaced.

163 population-specific selective signals to 55 kilobases (median), identifying known and novel causal v

164 Small, approximately 10-kilobase microhomology-mediated tandem duplications are

165 IsoEM2 estimates fragments per kilobase million (FPKM) and transcript per million (TPM)

166 d robustness, we synthesized the entire 16.3-kilobase mouse mitochondrial genome from 600 overlapping

167 at Ars2 binds a specific region within the 6-kilobase NSC enhancer of Sox2.

168 ectral abundance factor (NSAF) and reads per kilobase of exon model per million mapped reads (RPKM) a

169 ssion quantification matrices (Fragments Per Kilobase Of Exon Per Million Fragments Mapped, Transcrip

170 model per million mapped reads and reads per kilobase of gene model per million mapped reads, for qua

171 dated a 2-fold cutoff and 10 RPKM (reads per kilobase of mappable length per million mapped reads) (~

172 cts and introduced new strategies, reads per kilobase of splice junction model per million mapped rea

173 ly 28,900 transcripts was >/=2 fragments per kilobase of transcript per million mapped fragments, and

174 in both groups, but also clustered within 1 kilobase of transcription start sites.

175 ch to measure the effects of a total of >450 kilobases of 3' UTR sequences from >2,000 human genes on

176 otable in that rs910652 is located within 78 kilobases of ADAM33, which is one of the most well studi

177 , Bayesian and parsimony analyses of over 41 kilobases of aligned DNA sequence from 62 single-copy nu

178 Factor) genes showed that 97% were within 50 kilobases of an inducible CBP peak, and 70% of these req

179 We found that Slx4 is recruited within a few kilobases of an irreparable DSB, through the interaction

180 verted repeats that are separated by several kilobases of DNA and share >20 base pairs of homology.

181 he sloppy paired (slp) locus, we analyzed 30 kilobases of DNA encompassing the tandem, coordinately r

182 wed by replication that can copy hundreds of kilobases of DNA from a donor molecule all the way throu

183 In the deletion experiments we excised ~ 15 kilobases of DNA that contained a fragment of the integr

184 lymerase II (Pol II) transcribes hundreds of kilobases of DNA, limiting the production of mRNAs and l

185 s a processive helicase capable of unwinding kilobases of dsDNA in length.

186 genesis and integration of up to more than 3 kilobases of exogenous DNA in the genome of hMSCs derive

187 art sites, potentially bypassing hundreds of kilobases of interspersed sequence on the linear genome.

188 omosomes (BACs) containing approximately 200 kilobases of mammalian genomic DNA tagged with lac opera

189 after RNA polymerase II transcribes several kilobases of pre-mRNA, suggesting that metazoan splicing

190 er windows of two to three nucleotides after kilobases of RNA synthesis.

191 We applied this strategy to 115 kilobases of the human genome encompassing 47 genes impl

192 sion of a transgene comprising the first two kilobases of Xist (Xist-2kb) causes transcriptional read

193 er second) unwinding extensive tracts (~8-10 kilobases) of double-stranded DNA (dsDNA).

194 he following biomarkers were associated with kilobase pair differences in LTL: BMI -0.00478 (95% CI -

195 ates, all exhibiting tandem copies of a 37.6-kilobase pair region with identical breakpoints.

196 lete chemical synthesis to minimize the 1079-kilobase pair synthetic genome of Mycoplasma mycoides JC

197 The method provides kilobase pair-scale genomic methylation patterns compara

198 that displayed ESBL activity possessed a 140-kilobase-pair plasmid that produced the TEM-63 beta-lact

199 ion of Sir proteins over a region of several kilobase pairs compared to the telomeric repeat, even th

200 shared a rare haplotype of approximately 644 kilobase pairs containing the c.828+3A>T mutation, which

201 es with knots for DNA molecules of up to 166 kilobase pairs in length and find that the knotting occu

202 bulk methods and circular molecules below 10 kilobase pairs in length.

203 ccur over separations of tens to hundreds of kilobase pairs in vivo.

204 uences, encoding a total of approximately 35 kilobase pairs of DNA.

205 otide window after transcription of multiple kilobase pairs of DNA.

206 Enhancers act over many kilobase pairs to activate target promoters, but their a

207 i-essential genes, produced JCVI-syn3.0 (531 kilobase pairs, 473 genes), which has a genome smaller t

208 copy number for duplications as small as 1.9 kilobase pairs, ranging from 0 to 48 copies.

209 Ps have few clonal matches longer than a few kilobase pairs.

210 mposed of DNA molecules spanning hundreds of kilobase pairs.

211 DNA brushes, a few kilobase-pairs long, undergo a striking transition into

212 ding reporting the read counts and reads per kilobase per million mapped reads (RPKM) for genes selec

213 Defining a gene with more than one read per kilobase per million mapped reads as expressed, we ident

214 734 were transcriptionally active (reads per kilobase per million reads >/= 3), representing approxim

215 It automatically computes the reads per kilobase per million reads mapped expression-level summa

216 a genome browser, calculate RPKMs (reads per kilobase per million) and identify peaks.

217 AX after DNA damage propagated more than 100 kilobases per minute, reaching up to 30 megabases.

218 to the terminus (>2 megabases) at rates >50 kilobases per minute.

219 tens of kilobases at an average rate of 0.5 kilobases per second.

220 rity ssDNA with lengths up to at least seven kilobases. Polymerase chain reaction (PCR) with a forwar

221 cates on single-stranded DNA (ssDNA), it has kilobase processivity; yet, it is unable to processively

222 ids, composed of up to five DNA parts in the kilobase range with efficiencies of between 75 and 100%.

223 Large (>500 kilobases), rare (<1%) deletions were significantly enri

224 mediated by nonhomologous end-joining using kilobase, rather than megabase, fragments of DNA, which

225 l-time sequencing, which generates long (>16 kilobases) reads with random errors, we assembled 99% (2

226 h variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 (0.35%)

227 cleotide polymorphism genotype data in a 216 kilobase region of human 6p21.3 from which three shorter

228 tically mapped the carbonaria morph to a 200-kilobase region orthologous to a segment of silkworm chr

229 vo 16p11.2 deletion, extending through a 593-kilobase region previously associated with autism and me

230 ed for association signals in the entire 100-kilobase region that includes MAPT.

231 a locus has been coarsely localized to a 200-kilobase region, but the specific identity and nature of

232 Red individuals have a 30-kilobase region, encoding a single carotenoid desaturase

233 11 global populations, and sequenced ten 100-kilobase regions in 692 of these individuals.

234 ven with analysis window sizes as small as 1 kilobase, reliable profiles can be generated with as lit

235 eletions of an integral number of tandem 3.3 kilobase repeats, termed D4Z4, located on chromosome 4q3

236 g development, primarily in units of 400-800 kilobases ('replication domains'), whose positions are p

237 ly inferred copy number at equivalent to 100-kilobase resolution genome-wide from a platform targetin

238 hod for genome-wide identification of COs at kilobase resolution in pooled recombinants.

239 actions, and applied it to generate a map at kilobase resolution of the haploid genome of Saccharomyc

240 dentify >25,000 discrete origin sites at sub-kilobase resolution on the human genome, with high conco

241 r identifying and mapping large deletions at kilobase resolution, suggesting that data generated from

242 g methods, enabling micro-CNV detection with kilobase resolution.

243 We recently used in situ Hi-C to create kilobase-resolution 3D maps of mammalian genomes.

244 7 individual hybrid mouse sperm, providing a kilobase-resolution genome-wide map of crossovers.

245 MUSTACHE is scalable to kilobase-resolution maps and reports loops that are high

246 cherichia coli chromosome ( approximately 10 kilobases) reveal large-scale conformational transitions

247 rocco were homozygous for the recurrent 7.36-kilobase RLBP1 deletion of exons 7 through 9.

248 been demonstrated previously with a multiple-kilobase 'scaffold strand' that is folded into a flat ar

249 The SVs were of kilobase scale and complex, consisting of deletion(s) an

250 f guide RNAs (gRNAs) to program thousands of kilobase-scale deletions that deeply scan across a targe

251 TEGRATE as a versatile tool for multiplexed, kilobase-scale genome engineering.

252 Copy number variation of kilobase-scale genomic DNA segments, beyond presence/abs

253 Gene silencing showed that genes in a 31-kilobase segment at rhg1-b, encoding an amino acid trans

254 ion of a cytogenetically cryptic event: a 77-kilobase segment from chromosome 15 was inserted en bloc

255 There is one copy of the 31-kilobase segment per haploid genome in susceptible varie

256 h some vendors are beginning to supply multi-kilobase sequence-verified constructs, synthesis workflo

257 to those of SpCas9, while being more than 1 kilobase shorter.

258 Scalable production of kilobase single-stranded DNA (ssDNA) with sequence contr

259 y virus 1 (HIV-1) is a retrovirus with a ten-kilobase single-stranded RNA genome.

260 echnologies for site-specific integration of kilobase-sized DNA sequences in bacteria are limited by

261 hundred nucleotides apart are clustered over kilobase-sized regions, often associated with sites of D

262 ingle proteins moving on laterally stretched kilobase-sized ssDNA.

263 a mouse lacking the entire approximately 400-kilobase Slam locus, which encodes all six SFRs and CD48

264 SNAPCAR enabled scalable isolation of multi-kilobase ssDNA with high purity and 50-70 % yield.

265 ch share 99.92% identity with XMRV over >3.2-kilobase stretches of their genomes.

266 ediated H3K9me3 methylation over hundreds of kilobases surrounding HBB and on G9a-mediated H3K9me2 me

267 ing ~18,000 single guide RNAs targeting >700 kilobases surrounding the genes NF1, NF2, and CUL3, whic

268 across large genomic regions (more than 100 kilobases) surrounding two key autoimmunity risk loci, C

269 construction, and characterization of a 770-kilobase synthetic yeast chromosome II (synII).

270 inactivation is strongly associated with 10 kilobase tandem duplications in ovarian cancer.

271 e MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tiss

272 re located in a "gene desert," a few hundred kilobases telomeric to the Myc gene.

273 ribe chromatin domains on the order of 10-60 kilobases that, only in quiescent cells, are formed by c

274 tion signals, frequently in introns near (<5 kilobases) the start of the transcript.

275 tural variants including medium size (from 1 kilobase to 1 megabase) deletions and duplications, and

276 f differentially methylated regions from the kilobase to the megabase scale.

277 sely sequenced long fragments ranging from 5 kilobases to > 1 megabase.

278 hromosomal DSBs separated by several hundred kilobases to be frequently joined together and discuss t

279 We used sequencing reads of 20-160 kilobases to generate a whole-genome single-molecule map

280 olor imaging of regions ranging from tens of kilobases to megabases with the same basic protocol.

281 At the intermediate scale of kilobases to megabases, which encompasses the sizes of g

282 uires sequence elements beyond its first two kilobases to robustly silence transcription, and the 5'

283 point localization, typically within several kilobases to tens of kilobases.

284 revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions

285 der genomic segments that range in size from kilobases to whole chromosomes(1-7).

286 aging for different epigenetic states at the kilobase-to-megabase scale, a length scale that is direc

287 s, whereas regional centromeres span several kilobases up to megabases and do not seem to have DNA se

288 ressed genes and in promoter regions up to 5 kilobases upstream of all protein-coding genes.

289 This SNP is located 8.2 kilobases upstream of COMMD7, a gene highly expressed in

290 consensus RA-responsive element located 6.6 kilobases upstream of the coding region.

291 ucleotide polymorphism (SNP) rs11674786 (2.7 kilobases upstream of the family with sequence similarit

292 This region is located a few dozen kilobases upstream of the GATA binding protein 2 (GATA2)

293 ingle nucleotide polymorphism (rs12979860) 3 kilobases upstream of the IL28B gene, which encodes the

294 ions with elements located approximately 120 kilobases upstream of the TSS.

295 cations overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide

296 ponses (P = 0.0007), and SNP rs16983422 (2.8 kilobases upstream of the visinin-like 1 gene (VSNL1)) w

297 e integrated HPV-18 genome approximately 500 kilobases upstream, and enabled global analyses of the r

298 richodesmium, when normalized per intergenic kilobase, was comparable and twofold higher than that fo

299 Over kilobases, we find core recombination hotspots of up to

300 on extends beyond the promoter, over tens of kilobases; we term such patterns of histone modification