ライフサイエンスコーパス: kinase complex

1 utophagy-initiating TBK1 kinase and the ULK1 kinase complex.

2 parasites by interference with the virulent kinase complex.

3 promotes Wts phosphorylation by the Hpo-Sav kinase complex.

4 f the exocyst by a specific cyclin-dependent kinase complex.

5 subunits actually mediate(s) docking of this kinase complex.

6 ibitors, a process controlled by the IkappaB kinase complex.

7 ppaB (NF-kappaB) is activated by the IkappaB kinase complex.

8 tion of the human ITS2 pre-rRNA endonuclease-kinase complex.

9 rging on the Autophagy-Related1 (ATG1)/ATG13 kinase complex.

10 A, to activation of the ATR-ATRIP checkpoint kinase complex.

11 and Ku80 components in DNA-dependent protein kinase complex.

12 R-1 activation to stimulation of the IkappaB kinase complex.

13 ch activates the TAK1 (also known as MAP3K7) kinase complex.

14 ation of the Ret/GFRalpha3 receptor tyrosine kinase complex.

15 activity regulate a cyclin/cyclin-dependent kinase complex.

16 the catalytic subunit of the CDK-activating kinase complex.

17 gamma, the regulatory subunit of the IkappaB kinase complex.

18 plex, which in turn activates the Warts/Mats kinase complex.

19 ubstrates compared with another Pho85-cyclin kinase complex.

20 the inhibitor of nuclear factor (NF)- kappaB kinase complex.

21 4 signal pathway was proximal to the IkappaB kinase complex.

22 IKKalpha, one of the subunits of the IkappaB kinase complex.

23 nd the IKKalpha/beta subunits of the IkappaB kinase complex.

24 This condensation depends on the aurora B kinase complex.

25 ion of the kinase and cyclin subunits of the kinase complex.

26 tion of the IRS-1/p85 phosphatidylinositol 3-kinase complex.

27 US28 stimulates the production of a FAK.Src kinase complex.

28 kinase stimulation in the assembled receptor-kinase complex.

29 between Bcl10 and activation of the IkappaB kinase complex.

30 of an open, uninhibited conformation of the kinase complex.

31 osphatidylinositol 3-kinase complex I) lipid kinase complex.

32 that mediates the degradation of the IkappaB kinase complex.

33 ly suppressing the activation of the IkappaB kinase complex.

34 gamma, encoding the gamma subunit of the AMP Kinase complex.

35 the action of the Atg14-containing Vps34 PI3 kinase complex.

36 one signaling pathway regulated by the TAK1 kinase complex.

37 s do not inhibit or associate with the Hippo kinase complex.

38 microscopy structure of the Hsp90-Cdc37-Cdk4 kinase complex.

39 her components of the phosphatidylinositol 3-kinase complex.

40 ved the activation of the BECN1/PIK3C3 lipid kinase complex.

41 but independent of the ULK and VPS34-beclin kinase complexes.

42 oteins), and mitogen-activated protein (MAP) kinase complexes.

43 nding of cell cycle inhibitor p27Kip1 to the kinase complexes.

44 ough inhibition of target of rapamycin (TOR) kinase complex 1 (TORC1) activity.

45 The rapamycin-sensitive Tor kinase complex 1 (TORC1) has a major role in regulating

46 In nutrient-rich conditions, Tor kinase complex 1 (TORC1) is activated to inhibit autopha

47 The target of rapamycin kinase complex 1 (TORC1) regulates cell growth and metab

48 Target of rapamycin kinase complex 1 (TORC1) regulates Pol III activity, and

49 The rapamycin-sensitive Tor kinase complex 1 is a major regulator of autophagy.

50 We report here that mTOR kinase complexes 1 and 2 (mTORC1 and mTORC2) are essenti

51 permeable peptide inhibitor of the I kappa B-kinase complex, a crucial component of signal transducti

52 tivated through phosphorylation by the TORC1 kinase complex, a sensor of nutrient availability.

53 or-associated kinase, IkappaB-alpha, IkappaB kinase complex-alpha/beta, and phospholipase-gamma1 and

54 The Aurora kinase complex, also called the chromosomal passenger co

55 osphatidylethanolamine, as well as a protein kinase complex and a phosphatidylinositol 3-kinase compl

56 ere associated with the reduction of IkappaB kinase complex and c-Jun NH(2)-terminal kinase activatio

57 (positive transcription elongation factor b) kinase complex and for its recruitment to chromatin.

58 tment resulted in degradation of the IkappaB kinase complex and inhibition of NF-kappaB through stabi

59 of the Ku70, Ku80, and DNA-dependent protein kinase complex and is conveyed to the recipient cell by

60 ough the catalytic components of the IkappaB kinase complex and leads to IkappaB phosphorylation, deg

61 le inhibitor 2c blocks assembly of the multi-kinase complex and represses HIV-1-mediated MHC-I down-r

62 paB signaling via its effects on the IkappaB kinase complex and resulting in reduced IL2 gene express

63 ed by a rapid phosphorylation of the IkappaB kinase complex and subsequent degradation of the NF-kapp

64 Chiffon to form a functional Dbf4-dependent kinase complex and that Cdc7 is necessary for DNA replic

65 , absent from previous structures, a protein kinase complex and the Mediator-activator interaction re

66 At lysosomes and endosomes, the Fab1 lipid kinase complex and the nutrient-regulated target of rapa

67 -like autophagy activating kinase 1) protein kinase complex and the PI3KC3-C1 (class III phosphatidyl

68 hrough the inactivation of the Cdk1-cyclin B kinase complex and the reversal of its phosphorylation e

69 so requires the Uvrag-containing Vps34 lipid kinase complex and the v-ATPase proton pump, whereas Atg

70 rotein signaling complexes, such as the ULK1 kinase complex and the Vps34 lipid kinase complex, which

71 -cell lymphomas: inhibition of the Jak1/Jak3 kinase complex and, given the known strong immunostimula

72 ically its role in the activation of protein kinase complexes and in coordination of cell survival an

73 chains act as scaffolds to assemble protein kinase complexes and mediate their activation through pr

74 IFREDA was used in eight protein kinase complexes and was able to find the correct ligand

75 p21 can interact both with cyclin-dependent kinase complexes and with proliferating cell nuclear ant

76 L)-VPS34 (a class III phosphatidylinositol 3-kinase) complex and its product phosphatidylinositol 3-p

77 [ataxia-telangiectasia mutated]-Rad3-related kinase) complex and the Rad9-Hus1-Rad1 (9-1-1) clamp.

78 Balpha (IkappaBalpha), activation of IkappaB kinase complex, and c-Jun NH(2)-terminal kinase and, sub

79 Rad1-Hus1 clamp, the Rad3(ATR) -Rad26(ATRIP) kinase complex, and the Crb2(53BP1) mediator.

80 composed of NEMO, a component of the IkappaB kinase complex, and the death domain of RIP (NEMO-DD) ca

81 n ligase complex, components of the PtdIns 3-kinase complex, and the ESCRT machinery.

82 purified proteins, including TRAF6, the TAK1 kinase complex, and Ub-conjugating enzyme complex Ubc13-

83 roviding viral decoy substrates for cellular kinase complexes, and through direct blocking of the IFN

84 kinase complex and a phosphatidylinositol 3-kinase complex are also required for macroautophagy in y

85 c;2 and cyct1;5 mutants, indicating that the kinase complexes are important for transcription from th

86 ycles that regulate the activity of receptor-kinase complexes are ultrasensitive because they operate

87 of the striatin interaction phosphatases and kinases complex, are multidomain scaffolding proteins th

88 These results establish Arabidopsis CDKC kinase complexes as important host targets of CaMV for t

89 he cyclin E/cyclin-dependent kinase 2 (CDK2) kinase complex, as a key coactivator to enhance histone

90 heterodimer, nominally considered a mitotic kinase complex, as a novel binding partner of 53BP1.

91 ranscription at a point distal to the Ikappa kinase complex, as only ectopic expression of the NFkapp

92 tization occurs well upstream of the IkappaB kinase complex, as protein kinase C translocation to the

93 F-regulated scaffold that modulates receptor kinase complex assembly.

94 However, in the absence of S-phase kinases complex assembly is inhibited, which is unexpect

95 20 and a corresponding reduction in ikappaB kinase complex associated protein (IKAP) levels.

96 ponding reduction of the inhibitor of kappaB kinase complex-associated protein (IKAP), also known as

97 of its encoded protein, inhibitor of kappaB kinase complex-associated protein (IKAP).

98 a mutation in the gene inhibitor of kappa B kinase complex-associated protein (IKBKAP).

99 dysautonomia patients with IKBKAP (I-kappa-B kinase complex-associated protein) mutation compared to

100 s point mutation in IKBKAP, encoding IkappaB kinase complex-associated protein.

101 machinery immediately downstream of the Atg1 kinase complex at phagophore assembly sites.

102 s the mammalian target of rapamycin (mTORC1) kinase complex at the lysosomal surface.

103 g1/Unc-51-like autophagy activating kinase 1 kinase complex, autophagic receptor proteins, and mammal

104 The Ctk1 kinase complex binds RNA in vitro, consistent with direc

105 (cryo-EM) reconstruction of a human SMG1-8-9 kinase complex bound to a UPF1 phosphorylation site at a

106 ompromises the recruitment of Cdc37 to Hsp90-kinase complexes but has only modest effects on its basa

107 unction for activation of the IKK kinase (or kinase complex), but none form a stable complex with IKK

108 mplex), linked to the inhibitor of NF-kappaB kinase complex, but signal transduction is not fully und

109 ccurs via sequestration of the active P-TEFb kinase complex (CDK 9 and Cyclin T1/T2a/b or K) that is

110 Another Ser2 kinase complex, CDK-12/cyclin K, which requires upstream

111 nance energy transfer that active LKB1/STRAD kinase complex colocalizes with E-cadherin at AJs.

112 two phosphatidylinositol 3-kinase (PtdIns 3-kinase) complexes: complex I is required for autophagy,

113 d chemical and mechanical insults activate a kinase complex composed of IkappaB kinase beta (IKK-beta

114 ally upstream of the noncanonical regulatory kinase complex composed of NIK.IKKalpha subunits.

115 ation showed altered interactions with Hsp90-kinase complexes consistent with compromised Cdc37 modul

116 on of NF-kappaB and IKK requires an upstream kinase complex consisting of TAK1 and adaptor proteins s

117 ion factor NF-kappaB is activated by the IKK kinase complex containing two kinases (IKKalpha and IKKb

118 ways by functioning as a scaffold to recruit kinase complexes containing ubiquitin-binding domains.

119 We show that the CapAB tyrosine kinase complex controls multiple enzymatic checkpoints t

120 cyclin-dependent kinase (CDK) 2-cyclin E, a kinase complex critical for the initiation of centrosome

121 with Ctk2 and Ctk3 to form an active protein kinase complex, CTDK-I.

122 ase II carboxyl terminal domain (RNAPII CTD) kinase complex (CTK complex) is known as a positive elon

123 ophila melanogaster cyclin-dependent protein kinase complex CycD/Cdk4 stimulates both cell cycle prog

124 The Drosophila cyclin-dependent protein kinase complex Cyclin D/Cdk4 induces cell growth (accumu

125 -docking site on Nud1, to which the effector kinase complex Dbf2-Mob1 bound through a phosphoserine-t

126 resses RIP3-RIP1 (also known as RIPK3-RIPK1) kinase complex-dependent necroptosis that follows death

127 egulation by Hippo and to associate with the kinase complex directly correlate with their capacity to

128 us was associated with increased DNA protein kinase complex (DNA-PK) activity.

129 ase beta, a catalytic subunit of the IkappaB kinase complex essential for NF-kappaB activation, fails

130 Inhibition of the IkappaB kinase complex essentially ablated all cytokine inductio

131 ed transient insolubilization of the IkappaB kinase complex following its dissociation from Hsp90 rep

132 ity, which occurred by inhibition of IkappaB kinase complex formation rather than by a direct effect

133 y, we showed that Hh signaling inhibits Cos2-kinase complex formation.

134 18BIOder preferentially inhibits this novel kinase complex from infected cells at nanomolar concentr

135 ally available crystal structures of protein kinases complexes have motivated structural bioinformati

136 entration of ATP above 1.2 mM and makes this kinase complex highly sensitive to ATP depletion.

137 ssociate with C9ORF72 or with a C9ORF72-ULK1 kinase complex holo-assembly, which function in maturati

138 ct myotubularin binding to the type III PI 3-kinase complex hVps34/hVps15 leads to phosphatase inacti

139 autophagic class III phosphatidylinositol-3 kinase complex I (PI3KC3-C1) and conjugation of ATG8/LC3

140 The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) is central to autophagy ini

141 The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) is required for the initiat

142 The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) that functions in early aut

143 of the class III phosphatidylinositol (PI) 3-kinase complex I (PI3KC3-C1).

144 ell is controlled by the target of rapamycin kinase complex I (TORC1) and cAMP-dependent protein kina

145 PI3KC3-C1 (class III phosphatidylinositol 3-kinase complex I) lipid kinase complex.

146 ed protein kinases Atg1, target of rapamycin kinase complex I, and protein kinase A (PKA) regulate au

147 The class III phosphatidylinositol (PI)3-kinase complexes I and II (PI3KC3-C1 and -C2) are essent

148 (PI(3)P) produced by the phosphoinositide 3-kinase complex II.

149 the NF-kappaB-activating inhibitor of kappaB kinase complex IKK-alpha/beta and active transcription f

150 or is demonstrated to signal through IkappaB kinase complex (IKK) 2 > IkappaB > nuclear factor kappaB

151 ation and degradation, inhibition of IkappaB kinase complex (IKK) activation, suppression of p65 phos

152 ay components functioned upstream of IkappaB kinase complex (IKK) activation.

153 , which subsequently activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP)

154 s required for the activation of the IkappaB kinase complex (IKK) by inflammatory stimuli such as tum

155 Inhibition of the IkappaB kinase complex (IKK) has been implicated in the therapy

156 hat both TNF and LPS activated the I-kappa B kinase complex (IKK) in DPSCs to induce the phosphorylat

157 The IkappaB kinase complex (IKK) is a key regulator of immune respon

158 The IkappaB kinase complex (IKK) is central to the activation of NF-

159 A multisubunit IkappaB kinase complex (IKK) phosphorylates IkappaB proteins and

160 The IkappaB kinase complex (IKK) that phosphorylates IkappaB contain

161 genic mice, mutant Htt activates the IkappaB kinase complex (IKK), a key regulator of NF-kappaB.

162 1, TNFR2, NF-kappaB-inducing kinase, IkappaB kinase complex (IKK), and the p65 subunit of NF-kappaB.

163 panied by enhanced activation of the IkappaB kinase complex (IKK), which is responsible for targeting

164 of NF-kappaBeta (IkappaBeta), and IkappaBeta kinase complex (IKK).

165 of NEMO, a regulatory subunit of the IkappaB kinase complex (IKK).

166 actor-kappaB (NF-kappaB) through the IkappaB kinase complex (IKK).

167 The IkappaB kinase complex (IKK)/NF-kappaB and JNK/AP-1 pathways are

168 ses and is tightly controlled by the IkappaB kinase complex (IKK-alpha/beta/gamma).

169 and activation of a key NF-kappaB activating kinase complex, IKK.

170 the gamma subunit of the inhibitor of kappaB kinase complex (IKKgamma; commonly referred to as the NF

171 The structure captures the kinase-kinase complex in a precatalytic state where the activat

172 Here, we describe a role for the Hippo (Hpo) kinase complex in promoting Partner of Inscuteable (Pins

173 he involvement of a GP Ibalpha/14-3-3xi/PI-3 kinase complex in regulating thrombopoietin-mediated res

174 and degradation upon activation of the TORC1 kinase complex in response to an increase in internal am

175 and the formation of a novel focal adhesion kinase complex in response to ErbB2 activation in mammar

176 defined an essential role for the Dbf4-Cdc7 kinase complex in the initiation of DNA replication pres

177 ells only, by sequestering a cytosolic Hippo kinase complex in which LATS kinase is inhibited.

178 raction, binds LIT-1 and thereby generates a kinase complex in which LIT-1 molecules are situated in

179 , exists in two essential, yet distinct, TOR kinase complexes in the budding yeast Saccharomyces cere

180 nteractions with activated receptor tyrosine kinase complexes including the CD19 subunit of the B-cel

181 ession and increased cyclin/cyclin-dependent kinase complex inhibitor p27kipl expression.

182 scopy, we investigated whether this cellular kinase complex interacts with IE62.

183 converts the transient noncovalent substrate-kinase complex into a covalently cross-linked product by

184 gy in S. cerevisiae, and that the Atg1/Atg13 kinase complex is a key site of signal integration withi

185 a-induced activation of p38, ERK, or IkappaB kinase complex is affected by the loss of Miz1.

186 The Sid2p-Mob1p kinase complex is an important component of the septatio

187 This kinase complex is assembled by mTOR and its essential co

188 ted)-ATRIP (ATR-interacting protein) protein kinase complex is central to the cellular response to re

189 ted)-ATRIP (ATR-interacting protein) protein kinase complex is crucial for the cellular response to r

190 In its absence, activation of the TAK1-IKK kinase complex is defective, greatly reducing signal tra

191 e, we report that the NF-kappaB inducing IKK kinase complex is localized at the postsynaptic density

192 sites on ATR and ATRIP to understand how the kinase complex is regulated by post-translational modifi

193 The Snf1 protein kinase complex is required for activation of their downs

194 Furthermore, the Snf1 protein kinase complex is required to adapt cellular metabolism

195 The multiprotein mTORC1 protein kinase complex is the central component of a pathway tha

196 e phosphorylation by Src/FAK (focal adhesion kinase) complex is essential for F-actin binding of ACF7

197 a possible target of the PAR-4-STRD-1-MOP-25 kinase complex, is also required for cell shedding.

198 mycin complex-2 (TORC2), a conserved protein kinase complex, is an indispensable regulator of plasma

199 , generated exclusively by the PIKfyve lipid kinase complex, is key for lysosomal biology.

200 be a kinase that acts as part of a receptor kinase complex, is likely to be a pseudokinase and not a

201 ngements in the alpha(v)beta(3) integrin-Lyn kinase complex leading to disruption of Lyn kinase-media

202 motes phosphorylation of AMPK by an upstream kinase complex, LKB1/Mo25/STRAD (liver kinase B 1, mouse

203 ta, and gamma) of the positively acting Snf1 kinase complex localize to the nuclear periphery, result

204 The serine and threonine kinase complex, mammalian target of rapamycin complex 1

205 For Pah1 phosphorylated by the Pho85-Pho80 kinase complex, maximum Nem1-Spo7 phosphatase activity r

206 The kinase complex mechanistic target of rapamycin 1 (mTORC1

207 e class III PtdIns3 (phosphatidylinositol 3) kinase complexes, mediates the production of PtdIns3P, a

208 ere we present evidence that the MEN protein kinase complex Mob1p-Dbf2p localizes to mitotic nuclei a

209 ed but functionally distinct multi-component kinase complexes, mTOR complex 1 (mTORC1) and mTORC2.

210 kinase) and Akt and the metabolic checkpoint kinase complex mTORC1 (mammalian target of rapamycin) an

211 ucine for activation of the serine-threonine kinase complex mTORC1 and for expression of the transcri

212 At present, inhibitors of the kinase complex mTORC1 are undergoing clinical trials.

213 We also identify signalling via the kinase complex mTORC1 as a central regulator of T(H)17-c

214 ls had more activity of the serine-threonine kinase complex mTORC1 but less mTORC2 activity, and acti

215 nine kinase Akt and the metabolic checkpoint kinase complex mTORC1 induces both expression of the glu

216 tophagy and mitophagy markers, even when the kinase complex mTORC1, an inhibitor of the autophagy, is

217 Dual inhibition of the mTOR kinase complexes mTORC1 and mTORC2 decreases tumor xenog

218 The PI3K-dependent signaling kinase complex mTORC2 (mammalian target of rapamycin com

219 gulates activity of the metabolic checkpoint kinase complex mTORC2 and the serine-threonine kinase Ak

220 manner dependent on the metabolic checkpoint kinase complex mTORC2.

221 s physically with Sid2p and Mob1p, a protein kinase complex of the septation initiation network, and

222 mAbs capable of disabling heterodimeric kinase complexes of the epidermal growth factor receptor

223 Retention of these receptor-kinase complexes on the cell surface was dependent on th

224 effect of different cyclin-cyclin-dependent kinase complexes on ubiquitination of p27 in a reconstit

225 egatively regulated by the phosphate-sensing kinase complex Pho80p/Pho85p and by the nitrogen-sensing

226 lates focal class III phosphatidylinositol 3-kinase complex (PI3KC3) activity, which is required to i

227 of the endolysosomal phosphatidylinositol 3-kinase complex (PI3KC3-C2)-which contains beclin 1 and U

228 post-translational modifications and cyclin-kinase complexes play roles at the heart of the cell div

229 ective autophagic degradation of the IkappaB kinase complex prevents constitutive activation of the i

230 determined if disruption of the Hsp90-eEF-2 kinase complex promoted degradation of the kinase.

231 ator of the class III phosphatidylinositol 3-kinase complex, promotes membrane tethering of protein-f

232 of erythropoietin (EPO) receptor (EPOR) JAK2 kinase complexes propagates signals within erythroid pro

233 istance exercise act to regulate the protein kinase complex referred to as mechanistic target of rapa

234 The ATR-ATRIP kinase complex regulates cellular responses to DNA damag

235 The Drosophila PAN GU (PNG) kinase complex regulates the developmental translation o

236 pathways, the key inputs and outputs of this kinase complex remain unknown.

237 t, IkappaB kinase (IKK)gamma, of the central kinase complex required for NF-kappaB activation, IKK, o

238 rain, we found the Cl(-)-sensitive WNK3-SPAK kinase complex, required for cell shrinkage-induced regu

239 of the autophagy-initiating ULK and the TBK1 kinase complex, respectively.

240 are the regulatory subunits of IKK and TAK1 kinase complexes, respectively.

241 omponent of class III phosphatidylinositol-3-kinase complexes responsible for autophagosome nucleatio

242 A crystal structure of the PF-06463922-ROS1 kinase complex revealed favorable interactions contribut

243 Crystal structures of inhibitor-kinase complexes showed that the inhibitor stabilizes a

244 of the striatin-interacting phosphatase and kinase complex (STRIPAK).

245 function by recruiting the ULK1/2 initiation kinase complex subunit ATG13 to nascent autophagosomes.

246 gliomagenesis by stabilizing cyclin D1-cdk4 kinase complexes, suggesting that cyclin D1 and cdk4 may

247 ) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2.

248 Here we report that removal of the kinase complex TFIIK from TFIIH shifts the TSS in a yeas

249 F2p is the catalytic subunit of a regulatory kinase complex that controls flagellar length and flagel

250 INCENP), a subunit of the conserved Aurora B kinase complex that forms part of the proposed chromosom

251 he phosphoinositide 3-kinase class III lipid-kinase complex that induces autophagy, as an interacting

252 the PI(3) kinase class III (PI(3)KC3) lipid-kinase complex that induces autophagy.

253 tial component of the Beclin1-PI(3)KC3 lipid kinase complex that is an important signalling checkpoin

254 se kinase (ASK), a component of the Cdc7/ASK kinase complex that is crucial for cell proliferation, b

255 atory subunits of a cyclin-dependent protein kinase complex that is essential for normal growth and h

256 kinase alpha (IKKalpha), a component of the kinase complex that leads to NF-kappaB activation, plays

257 of rapamycin complex 1 (mTORC1) is a protein kinase complex that localizes to lysosomes to up-regulat

258 Here, we characterize a new K(+) channel-kinase complex that operates in the metazoan Caenorhabdi

259 n target of rapamycin) complex 2 (mTORC2), a kinase complex that phosphorylates Akt at Ser473 upon ac

260 arget of rapamycin complex 1 (mTORC1), a key kinase complex that regulates cell size and growth, is o

261 PNG, PLU, and GNU constitute a novel protein kinase complex that specifically regulates S-M cell cycl

262 ng with the formation of Ci-Sufu and Ci-Cos2-kinase complexes that normally inhibit Ci activity and p

263 accharomyces cerevisiae Mec1-Ddc2 checkpoint kinase complex (the ortholog to human ATR-ATRIP) is an e

264 ; and (3) a membrane-protein phosphatase and kinase complex, the STRIPAK complex, bridges the cis-Gol

265 Tat binds to this kinase complex through a direct protein-protein interact

266 PDK1 associates with the core Hippo pathway-kinase complex through the scaffold protein Salvador.

267 or kappaB (IkappaB) proteins and the IkappaB kinase complex through two major pathways: the canonical

268 lates the IKKbeta subunit within the IkappaB kinase complex to activate NF-kappaB-regulated genes.

269 ul3 ubiquitin complex acted on the wnk4-wnk1 kinase complex to regulate Na(+)/Cl(-) cotransporter (NC

270 essential for the translocation of the LIT-1 kinase complex to the nucleus, the site of its TCF subst

271 induction, and recruitment of the Atg1-Atg13 kinase complex to the pre-autophagosomal structure by st

272 ection, Nef assembles the 2c-sensitive multi-kinase complex to trigger down-regulation of cell-surfac

273 pseudokinases that regulate multiple active kinase complexes to synergistically thwart innate immuni

274 a-arrestin, which is activated via the TORC1 kinase complex upon arginine uptake.

275 e cyclin D1/cyclin-dependent kinase 4 (CDK4) kinase complex, used as a surrogate for cyclin D1 degrad

276 ectivities, and X-ray structures of the drug-kinase complexes using a VEGFR2 TK construct inclusive o

277 ivators Gal4 and VP16 target the Snf1 (AMPK) kinase complex via direct interactions with both the cor

278 tituted kinase assay, in which an active PKR kinase complex was captured from a normal cell extract,

279 The phosphorylation site(s) of K-cyclin/Cdk9 kinase complexes was mapped in the transactivation domai

280 imilar analysis of several constructs of the kinase complex, we propose that assembly is characterize

281 upon overexpression of A1PiZ, both PtdIns 3-kinase complexes were required for delivery of the exces

282 the TNF-alpha-induced pronecrotic RIP1-RIP3 kinase complex, whereas the IkappaB Kinase (IKK) subunit

283 s occurred through activation of the IkappaB kinase complex, which also led to activation of NF-kappa

284 lated by the AUTOPHAGY-RELATED1/13 (ATG1/13) kinase complex, which connects metabolic and environment

285 ine stimulation is controlled by the IkappaB kinase complex, which contains IKKalpha and IKKbeta.

286 the ULK1 kinase complex and the Vps34 lipid kinase complex, which generates phosphatidylinositol 3-p

287 control the activation of the Hippo/Salvador kinase complex, which in turn activates the Warts/Mats k

288 autophagy depends on the autophagy-related 1 kinase complex, which is also essential for TORC1-regula

289 Both proteins are connected to the Atg1 kinase complex, which is involved in autophagy initiatio

290 m through the kinase activity of the IkappaB kinase complex, which leads to translocation of NF-kappa

291 lates the kinase activity of DNA-PK (protein kinase) complexes, which leads to increased phosphorylat

292 nslation, regulated in Drosophila by the PNG kinase complex whose activity we show here to be under p

293 small interfering RNA, blocking the IkappaB kinase complex with BMS-345541, or using the proteasome

294 association of alpha(v)beta(3) integrin-Lyn kinase complex with ionotropic glutamate receptor subuni

295 ps30, are scaffold proteins bound in a lipid kinase complex with multiple cellular functions, includi

296 the TANK-binding kinase 1-inducible IkappaB kinase complex with upstream signaling molecules in mult

297 Cyclin B3 forms active kinase complexes with CDK1, and meiotic progression requ

298 performing energy minimizations of inhibitor-kinase complexes with the molecular mechanics code GROMA

299 DFG motif as compared to that seen in other kinase complexes with VX-680.

300 two novel regulatory components of the Stt4 kinase complex, Ypp1 and Efr3.