ライフサイエンスコーパス: kinase family

1 ne-directed" motifs (cyclin-dependent or MAP kinase families).

2 bitor of the nuclear factor kappaB (IkappaB) kinase family.

3 e to inhibitors of the Pyk2 and Src tyrosine kinase family.

4 a Ca(2+)/calmodulin-dependent kinase-related kinase family.

5 y kinase of Akt and other members of the AGC kinase family.

6 and PKA serves as a prototype for the entire kinase family.

7 ition of these enzymes within the phosphagen kinase family.

8 e CRD is not a generic mechanosensor in this kinase family.

9 portant function of the FYF motif in the Tec kinase family.

10 hat is shared among the PI3K-related protein kinase family.

11 promotes dimerization of members of the RAF kinase family.

12 or, a member of the ephrin receptor tyrosine kinase family.

13 ppears to be mediated by a member of the Tec kinase family.

14 eceptor (EGFR/HER) or ErbB receptor tyrosine kinase family.

15 ich encodes an ortholog of the mammalian Pim kinase family.

16 pted by members of a closely related protein kinase family.

17 e structural and functional diversity of the kinase family.

18 could be c-Src, a member of the Src tyrosine kinase family.

19 t does inhibit additional members of the AGC kinase family.

20 is a member of the AGC branch of the protein kinase family.

21 ent inhibitors of the VEGF receptor tyrosine kinase family.

22 member of the membrane-associated guanylate kinase family.

23 dually targeting each member of the tyrosine kinase family.

24 if shared by all members of the DYRK protein kinase family.

25 togen-activated protein kinase (MAPK) kinase kinase family.

26 ber of the leucine-rich repeat receptor-like kinase family.

27 /2, members of the mitogen-activated protein kinase family.

28 belong to the nucleoside monophosphate (NMP) kinase family.

29 the mitogen-activated protein kinase kinase kinase family.

30 g the negative regulator Csk gene of the Src kinase family.

31 that selectively target the cyclin-dependent kinase family.

32 ng substrate specificity for each individual kinase family.

33 eptors of the two-component histidine sensor kinase family.

34 Gs signal through the ErbB receptor tyrosine kinase family.

35 (Speg) is a member of the myosin light chain kinase family.

36 is highly selective for a subset of the TEC kinase family.

37 (PID)/WAG kinases of the Arabidopsis AGCVIII kinase family.

38 s the best-characterized member of the alpha-kinase family.

39 nique among members of the receptor tyrosine kinase family.

40 RR-RLK) constitute the largest receptor-like kinases family.

41 ency against these two structurally distinct kinase families.

42 tinguishing kinase substrates from different kinase families.

43 y testing protein kinases from the different kinase families.

44 ers of the receptor, protein phosphatase and kinase families.

45 predicting phosphorylation sites of all four kinase families.

46 evealed a new fold distinct from other known kinase families.

47 e most recently identified receptor tyrosine kinase families.

48 ion substrates for each of the 12 kinases or kinase families.

49 d kinase (DYRK) and cell division cycle-like kinase families.

50 ed kinases from the DYRK and the CLK protein kinase families.

51 residue, a mechanism conserved in unrelated kinase families.

52 xplored by studying Caenorhabditis elegans D kinase family-1 (DKF-1), a PKD that governs locomotion i

53 C. elegans DKF-1 (D kinase family-1) contains tandem DAG binding (C1) module

54 gical background and significance of the TRK kinase family, (2) a compilation of known TRK inhibitors

55 ber of the Tyro3, Axl, Mer receptor tyrosine kinase family,(2-4) represents an independent prognostic

56 a novel PKD, Caenorhabditis elegans DKF-2 (D kinase family-2), addressed these topics.

57 The two members of the small new kinase family 3 (NKF3) group are considered pseudokinase

58 Members of the New Kinase Family 3 (NKF3), PEAK1/SgK269 and Pragmin/SgK223

59 reclassify the latter as a member of the new kinase family 3 group.

60 uces phosphorylation of kinases from the Src kinase family, a hallmark of integrin signaling activati

61 ghts LpxK as a distinct member of the P-loop kinase family, a notion that is also reflected through i

62 several substrates that are selective within kinase families and amenable to high-throughput screenin

63 nique to the MAP kinase and cyclin-dependent kinase families and glycogen synthase kinase 3.

64 bricine kinase is a member of the phosphagen kinase family and a homolog of creatine and arginine kin

65 similar to members of the PfkB carbohydrate kinase family and appears to catalyze heptose phosphoryl

66 ulates members of the ErbB receptor tyrosine kinase family and attenuates their signaling, leading to

67 is a member of the mitogen-activated protein kinase family and controls various physiological process

68 member of the cell surface receptor tyrosine kinase family and dimerizes upon activation.

69 ticities are prevented by inhibiting the Src kinase family and extracellular signal-regulated protein

70 MAP kinases, as well as the cyclin-dependent kinase family and glycogen synthase kinase 3beta that al

71 is a member of the death-associated protein kinase family and has been genetically linked to the dev

72 is a member of the cyclin-dependent, Ser/Thr kinase family and has been identified as one of the prin

73 are members of the mitogen-activated protein kinase family and have been implicated in tumorigenesis.

74 se mTORC2 targets are all members of the AGC kinase family and include Akt, protein kinase Calpha, an

75 TM is a member of the phosphatidylinositol 3-kinase family and is activated by IR in an NBS1-dependen

76 e 2 (Pyk2) is a member of the focal adhesion kinase family and is highly expressed in brain and hemat

77 Tyk2 belongs to the Janus protein tyrosine kinase family and is involved in signaling of immunoregu

78 TAK1 is a functional member of the Snf1/AMPK kinase family and support TAK1 as a candidate for an aut

79 aranthus roseus RLK1-like (CrRLK1L) receptor kinase family and their ligands, 5-kDa cysteine-rich pep

80 Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the S

81 onserved among the entire eukaryotic protein kinase family, and alteration of these residues in a sec

82 an atypical but essential member of the Cdk kinase family, and its dysregulation or deletion has bee

83 ers of the phosphoinositide 3-kinase-related kinase family, and only SMG-1 deficiency significantly a

84 ion through activation of members of the Src kinase family, and that these kinases exert their action

85 ses constitute the largest receptor tyrosine kinase family, and their ligands, ephrins (Efns), are al

86 Nef binds several members of the Src kinase family, and these interactions have been implicat

87 Members of the protein kinase family are amongst the most commonly mutated gene

88 Several members of the FunK1 kinase family are differentially regulated during sexual

89 as members of the mitogen-activated protein kinase family are specifically phosphorylated in respons

90 In addition, various members of this kinase family are suspected pseudokinases with no or lit

91 hotransferase IIIa (APH(2'')) aminoglycoside kinase family are unique in their ability to utilize GTP

92 ypothesis that members of the focal adhesion kinase family are upstream activators of the SFKs after

93 V2 and CORYNE (CRN), members of the receptor kinase family, are required for nematode CLE signaling.

94 blast growth factor receptor (FGFR) tyrosine kinase family as a case study.

95 ifluorophenol pyridine inhibitors of the RSK kinase family as demonstrated cellularly by the inhibiti

96 kinase kinase 2) is a central member of this kinase family as it controls the actions of a CaMK casca

97 the rice phosphatidylinositol-4-phosphate 5-kinase family, as a protein that interacts with DWT1.

98 member of the Never in Mitosis Gene A (NIMA) kinase family, as a regulator of telomere integrity.

99 is a member of the death-associated protein kinase family associated with apoptosis in nonmuscle cel

100 pected distribution, we can rank kinases and kinase families based on the likelihood that these kinas

101 CPK5 of the plant calcium-dependent protein kinase family becomes rapidly biochemically activated in

102 fering RNA or inhibiting the ATM/ATM-related kinase family by caffeine strongly reduces apoptosis.

103 ed at least one additional member of the Src kinase family by phosphorylation in a manner dependent o

104 em to identify members of the mammalian AMPK kinase family by their function as Snf1-activating kinas

105 the mitogen-activated protein kinase kinase kinase family, by forming a complex with the GTPase Rho1

106 The AGC protein kinase family (cAMP-dependent protein kinases A, cGMP-de

107 that Ryk, a member of the receptor tyrosine kinase family, can bind to Wnts.

108 The phosphoinositide 3-kinase family catalyzes the phosphorylation of phosphati

109 mine kinase (GK), a member of the phosphagen kinase family, catalyzes the Mg(2+)-dependent reversible

110 he four major serine/threonine (S/T) protein kinase families-CDK, CK2, PKA and PKC.

111 The Src kinase family comprises nine homologous members whose di

112 The receptor tyrosine kinase family consisting of Tyro3, Axl, and Mer (TAM) is

113 by reactive fibrosis and remodeling.The Rho kinase family, consisting of ROCK1 and ROCK2, has been i

114 6), the ligand for the TAM receptor tyrosine kinase family, consisting of Tyro3, Axl, and Mer, is imp

115 to simulate ligand binding stimulated an Src kinase family-dependent increase in protein phospho-tyro

116 ular cell adhesion molecule-1 also in an Src kinase family-dependent manner.

117 Netrin-4-stimulated phosphorylation of Src kinase family, effectors of endothelial cell migration,

118 NK4, members of the WNK (with no lysine [K]) kinase family, either directly or via the downstream SPA

119 ong non-receptor tyrosine kinases, different kinase families employ a diverse array of regulatory mec

120 s and of the MAP (mitogen-activated protein) kinase family [ERK (extracellular signal-regulated kinas

121 neuronal membrane rafts, NMDAR/Src tyrosine kinase family/ERK signaling, and protection of neurons f

122 osphorylation-site motifs for the entire Nek kinase family, except for Nek11.

123 report that WNK3, another member of the WNK kinase family expressed by distal tubule cells, interact

124 ), a member of the inositol hexakisphosphate kinase family, functions as a growth suppressive and apo

125 FGFR2 and other FGFR kinase family gene alterations have been found in both l

126 The two NDR kinase family genes in Drosophila are tricornered (trc)

127 target the catalytically active site of this kinase family has been a formidable challenge.

128 ll functions, the full understanding of this kinase family has been restricted by the lack of highly

129 In vertebrates, the Tec kinase family has been studied extensively for roles in

130 Thus, in Leishmania, the TOR kinase family has expanded to encompass a unique role in

131 the mitogen-activated protein kinase kinase kinase family, has emerged as a key regulator of signal

132 mber of the Snf1/AMPK (AMP-activated protein kinase) family, has important roles in metabolic control

133 Despite their different nature, these two kinase families have related origin and share very simil

134 ion requires Plk4, a member of the Polo-like kinase family; however, the mechanism linking Plk4 activ

135 ghly conserved within the eukaryotic protein kinase family, hyperphosphorylation within the kinase ac

136 n (CaM)-dependent member of the unique alpha-kinase family, impedes protein synthesis by phosphorylat

137 r of the AGCVIII subgroup of the AGC protein kinase family in Arabidopsis.

138 ultiple cellular functions, the role of this kinase family in hematopoietic stem cells (HSCs) is unkn

139 sary to understand the profound role of this kinase family in signal transduction.

140 identified a new function for the entire PIM kinase family in T lymphocytes.

141 , a member of the NIMA-like serine-threonine kinase family, in a patient with congenital heart diseas

142 of the phosphatidylinositol 3-kinase-related kinase family, in particular the ataxia-telangiectasia m

143 osphorylation sites for 12 human kinases and kinase families, including ATM, CDKs, GSK-3, MAPKs, PKA,

144 g the activity of related kinases in the AGC kinase family, including AKT, by phosphorylating a speci

145 noma development involves members of the AGC kinase family, including AKT, PKC, and, most recently, P

146 of the phosphatidylinositol 3-kinase-related kinase family, including ataxia telangiectasia mutated (

147 d by protein kinases of the phosphoinositide kinase family, including ATM, ATR or DNA-PK.

148 The phosphagen kinase family, including creatine and arginine kinases (

149 Neratinib is also a Ste20 kinase family inhibitor and in carcinoma cells, and hema

150 ment of lymphocytes with the spleen tyrosine kinase family inhibitor piceatannol reduced their abilit

151 hat Src is present in sperm and that the Src kinase family inhibitor SU6656 blocked the capacitation-

152 FIP200 (focal adhesion kinase family interacting protein of 200 kDa) has been s

153 le MyD88 and members of the IL-1R-associated kinase family (IRAK-1, 2, M and 4).

154 trates that can distinguish between tyrosine kinase families is a huge challenge.

155 he most frequently altered receptor tyrosine kinase families is the fibroblast growth factor receptor

156 Because this kinase family is absent from mammalian hosts, it represe

157 The RAF kinase family is essential in mediating signal transduct

158 The Akt serine/threonine protein kinase family is linked to maintaining latency.

159 er of the phosphatidylinositol 3 kinase-like kinase family, is a master regulator of the double stran

160 AMP-dependent, cGMP-dependent, and PKC (AGC) kinase family, is a TORC2 substrate known to participate

161 kinases and the other member of the Pyk2/FAK kinase family, is activated by HBx.

162 EphA2, a member of the receptor tyrosine kinase family, is commonly expressed by a broad range of

163 JAK3, a member of the Janus kinase family, is predominantly expressed in hemopoietic

164 ), a member of the mitogen-activated protein kinase family, is selectively expressed in the neurogeni

165 of the three members of the mammalian Aurora kinase family, is the catalytic component of the chromos

166 racterized member of the mammalian polo-like kinase family, is well regulated throughout the cell cyc

167 Small-molecule inhibitors of the Janus kinase family (JAKis) are clinically efficacious in mult

168 ecificity tyrosine phosphorylation-regulated kinase family kinase Pom1 at the cell poles.

169 PIKK (phosphatidylinositol 3-kinase-related kinase) family kinase, leading to reduced ATM-p53 signal

170 ion by phosphatidylinositol-3-kinase-related kinase family kinases whereas in cells XPA was phosphory

171 eukaryotic DMPK (Myotonic Dystrophy Protein Kinase) family kinases such as Rho-associated protein ki

172 totypic member of a serine/threonine protein kinase family known as mitogen-activated protein kinase

173 latory kinase of the distinct members of AGC kinase family known to regulate cell proliferation and s

174 aucity of in vitro biochemical data for this kinase family leave a void in our understanding of Tec k

175 identify the microtubule affinity-regulating kinase family (MARKs) as activated and insoluble in a ne

176 The Microtubule-Associated Serine/Threonine Kinase family (MAST1-4, and MAST-like) is characterised

177 ocyte cell kinase (Lck), a member of the Src kinases family, mediates PC.

178 n of microtubule associated serine/threonine kinase family member 4 (MAST4).

179 nase 5 (ERK5) is a mitogen-activated protein kinase family member activated in hypoxic, reactive oxyg

180 C-kit is a receptor tyrosine kinase family member expressed in hematopoietic stem cel

181 (JNK3alpha1) is a mitogen-activated protein kinase family member expressed primarily in the brain th

182 alpha1) is a mitogen-activated protein (MAP) kinase family member expressed primarily in the brain th

183 types and is the only AMP-activated protein kinase family member known to interact with the p97/valo

184 des, including the mitogen-activated protein kinase family member p38alpha and transcription factor N

185 tion of Dictyostelium protein kinase B (PKB) kinase family member PKBR1 and PKB substrates.

186 e-threonine mitogen-activated protein kinase kinase family member T-LAK cell-originated protein kinas

187 for a rationale to target IKBKE, an IkappaB kinase family member that activates the AKT and NF-kappa

188 kinase (JNK) is a mitogen-activated protein kinase family member that is activated by diverse stimul

189 mTOR is an evolutionarily conserved PI3-kinase family member that plays a central role in integr

190 CDK5 is an atypical cyclin-dependent kinase family member that regulates many cellular functi

191 Fyn, an Src kinase family member, acts as a negative regulator of NF

192 ver insulin receptor (IR), a closely related kinase family member.

193 er closely related mitogen-activated protein kinase family member.

194 ge 1, a MAGUK (Membrane Associated Guanylate Kinase) family member that is the highly conserved homol

195 analysis demonstrated that depletion of Src kinase family members (c-Src, Yes, and Fyn) or cav-1 cle

196 mmalian TOR complex 2 (mTORC2) regulates AGC kinase family members and is implicated in various disor

197 e knockout mice, where all 3 isoforms of Pim kinase family members are genetically deleted.

198 ty is mediated through the receptor tyrosine kinase family members Axl, Rse, and Mer, all of which ar

199 Aurora kinase family members co-ordinate a range of events asso

200 s resulting from genetic deletion of all Pim kinase family members could provide important insight ab

201 The ErbB receptor tyrosine kinase family members EGFR (epidermal growth factor rece

202 expand the repertoire of functions Polo-like kinase family members fulfill in regulating pivotal cell

203 nositol 3-kinase (PI3K) or PI3K-like protein kinase family members in cells.

204 a functional difference between these 2 Syk-kinase family members in primary NK cells.

205 to activate Stat3 such as Janus kinases, Src kinase family members or receptor tyrosine kinases.

206 py-based studies, we identified Src tyrosine kinase family members Src and Fyn as upstream kinases of

207 from IL-7 and RAG DSBs activate distinct Pim kinase family members that have context-dependent activi

208 nd localization, including three AGC protein kinase family members, Akt-1, PDK-1, and cAMP-dependent

209 (iii) To define the roles of Src kinase family members, we examined the accumulation of v

210 s driven by similar fusions of the other JAK kinase family members.

211 oop region of a number of its downstream AGC kinase family members.

212 (Src and Yes are ubiquitously expressed Src kinase family members; Src-/- and Yes-/- mice lacking ex

213 K (adenosine monophosphate-activated protein kinase) family members determines proper beta cell polar

214 se, mevalonate kinase, and phosphomevalonate kinase) family members, 14 PduX variants having changes

215 rylation of Tyr416 of the members of the Src kinase family, modestly enhanced the kinase activity of

216 natural ligand, galectin-3, activated a Src kinase family molecule, hemopoietic cell kinase (Hck), a

217 e cloning of a fifth member of the polo-like kinase family named Plk5.

218 = lysine member 4) and members of the Ste20 kinase family, namely SPAK and OSR1 (Ste20-related proli

219 ber of the NIMA (never in mitosis A)-related kinase family, Nek1, is critical for initiating the ATR

220 n by protein kinases from a diverse range of kinase families, not just the GPCR kinases, and that rec

221 hat vascular plant RPs form a unique protein kinase family now designated as the DUF 299 gene family.

222 dwich fold characteristic for the amino acid kinase family of enzymes.

223 Itk and Rlk are members of the Tec kinase family of nonreceptor protein tyrosine kinases th

224 member of the membrane-associated guanylate kinase family of proteins containing PostSynaptic Densit

225 a member of the phosphoinositide kinase-like kinase family of proteins that includes ATM, ATR, and DN

226 member of the membrane-associated guanylate kinase family of proteins, which are defined by the PSD-

227 ites in S6 that are phosphorylated by the S6 kinase family of proteins.

228 e 4 (PLK4), a unique member of the polo-like kinase family of serine-threonine kinases, is a master r

229 e the phosphatidylinositol 3'-kinase-related kinase family of serine/threonine enzymes: ataxia telang

230 The casein kinase family of serine/threonine kinases regulates both

231 terization of a receiver domain from the HWE-kinase family of two-component systems.

232 nnelid enzyme that belongs to the phosphagen kinase family of which creatine kinase and arginine kina

233 talytic domains of Trk (tropomyosin receptor kinase) family of RTKs, naturally activated by neurotrop

234 k) is a member of the Btk (Bruton's tyrosine kinase) family of tyrosine kinases.

235 icity tyrosine-(Y)-phosphorylation regulated kinase] family of protein kinases that is expressed at h

236 es of the phosphatidylinositol 3-kinase-like kinase family, originally known to act in maintaining ge

237 rly characterized member of the NIMA-related kinase family, other members of which play roles in cell

238 the receptors' abilities to activate the MAP kinase families (p42/p44, JNK, and p38), but did affect

239 Another isoform in this kinase family, Pak2, is expressed at very high levels in

240 (SIK1, 2 and 3), members of the AMPK-related kinase family, play a key role as gluconeogenic suppress

241 The Syk tyrosine kinase family plays an essential role in immunoreceptor

242 (PKD1), the founding member of a new protein kinase family, plays a critical role in intestinal epith

243 Snf1, a member of the AMP-activated protein kinase family, plays a critical role in metabolic energy

244 ivated kinase 1 (TAK1), a member of the MAPK kinase family, plays a key role in B-cell growth and dev

245 lated kinase-1), a member of the AGC protein kinase family, plays an important role in regulating ion

246 that danusertib, an inhibitor of the Aurora kinase family, preferentially inhibits bone micrometasta

247 erwise poorly defined region of the Tel1/ATM kinase family proteins that is essential for normal Tel1

248 to ROK (repressors, open reading frames, and kinases) family proteins, which bind DNA and/or sugar mo

249 The p90 ribosomal S6 kinase family (RSK1-4) is a group of highly conserved Se

250 Members of the receptor tyrosine kinase family (RTK) have been shown to be present in the

251 se (AK), which is a member of the phosphagen kinase family, serves as a model system for studying the

252 nalysis of PSTK in the context of its 'DxTN' kinase family shows that PSTK co-evolved precisely with

253 stream of gp130 involved the classical Janus kinase family-signal transducer and activator of transcr

254 Activation of the Janus kinase family/signal transducer and activator of transcr

255 We demonstrate that members of the SRC kinase family (SKF) are key mediators of IFN-gamma pathw

256 rs, in particular, receptors of the tyrosine kinase family TAM (Tyro3, Axl, and MerTK), to maintain s

257 atopoietic cells, and is a member of the Tec kinase family that also includes Btk.

258 there are two other members of the polo-like kinase family that are less well understood, Plk2 and Pl

259 a member of the dystrophia myotonica protein kinase family that functions downstream of Cdc42, contai

260 is distant relative of the cyclin-dependent kinase family that has been implicated in spermatogenesi

261 of the type I phosphatidylinositol phosphate kinase family that has been shown previously to modulate

262 Msn kinases belong to the Ste20 kinase family that has been shown to act as MAP kinase k

263 K1 and WNK4, members of WNK (with no lysine) kinase family that have previously been found mutated in

264 GalAK is a distinct member of the GHMP kinase family that includes galactokinase (G), homoserin

265 EphB4 belongs to receptor tyrosine kinase family that interacts with ephrin-B2 ligand at si

266 -inducible kinase (SGK), a member of the AGC kinase family that is closely related to Akt.

267 member of the sucrose nonfermenting-related kinase family that is down-regulated when plants are dep

268 he conserved Aurora protein serine/threonine kinase family that is implicated in the regulation of G(

269 is a member of the Tec non-receptor tyrosine kinase family that is involved in regulating B cell prol

270 osine kinase 2 (TYK2) is a member of the JAK kinase family that regulates signal transduction downstr

271 are members of the mitogen-activated protein kinase family that transduce signals from various enviro

272 native human kinases, including the Ephrin A kinase family, that are sensitive to commonly used PP in

273 conserved atypical serine/threonine protein kinase family, the RIO kinases (Rio1, Rio2 and Rio3) fun

274 While highly selective within the kinase family, the series shows similar potency for both

275 t expression of a member of the AMPK-related kinase family, the SNF1-AMPK-related kinase (SNARK, also

276 nctional Ca(2+)/calmodulin-dependent protein kinase) family; this CaMK-II is necessary for proper hea

277 ermal growth factor receptor (ErbB) tyrosine kinase family to promote intratumoral survival and growt

278 JAK (Janus family of cytoplasmic tyrosine kinases) family tyrosine kinase 2 (TYK2) participates in

279 is a universal hallmark across the eIF2alpha kinase family under various stress conditions and is ter

280 revealed kinase off-targets from nearly all kinase families underpinning the need to profile kinase

281 all catalytic domains in the human tyrosine kinase family, using all available kinase catalytic doma

282 ation of targets of the calmodulin-dependent kinase family was seen, including autophosphorylation of

283 PKcs, a member of the phosphatidylinositol 3-kinase family, was found to phosphorylate HDAC3 when the

284 the AMPK (adenosine monophosphate-activated kinase) family, was essential for cardiac metabolism in

285 is analysis to the wider plant receptor-like kinase family we find that S-acylation adjacent to recep

286 ubstrate motifs (AGC or calmodulin-sensitive kinase families), whereas the down-regulated sites were

287 l process: CDC37 provides recognition of the kinase family, whereas thermodynamic parameters determin

288 ber of the phosphoinositide 3-kinase-related kinase family, which consists of ATM, ATR, DNA-PKcs, mTO

289 s a member of the SNF1/AMP-activated protein kinase family, which is essential for metabolic control,

290 The mammalian MST kinase family, which is related to the Hippo kinase in D

291 mbers of the phosphoinositide 3-kinase (PI 3-kinase) family, which contribute to various aspects of t

292 lar basis of binding specificity for protein kinases family, which is the central problem in discover

293 nases (VRKs) comprise a branch of the casein kinase family whose members are characterized by homolog

294 TAM (Tyro3, Axl, and Mer) receptor tyrosine kinase family, whose members function as inhibitors of i

295 ZK/MAP3K13) is a member of the mixed lineage kinase family with high sequence identity to Dual Leucin

296 s a member of a conserved Alphaherpesvirinae kinase family with homology to herpes simplex virus US3

297 Tie1 and Tie2, members of the tyrosine kinase family with immunoglobulin and EGF homology domai

298 We show that the atypical secretory kinase family with sequence similarity 20, member B (Fam

299 embers of the HGF and VEGF receptor tyrosine kinase families, with additional inhibitory activity tow

300 Silencing of a receptor-like cytoplasmic kinase family XII gene, subsequently named XOPJ4 IMMUNIT