ライフサイエンスコーパス: kinetic

1 NA sites have a significant effect on search kinetics.

2 no-1,2,4-triazol-5-one following first-order kinetics.

3 tem can be applied to evaluate the enzymatic kinetics.

4 alysis framework to quantify the recruitment kinetics.

5 ication among parasites and influence growth kinetics.

6 and plasticity and synaptic vesicle release kinetics.

7 from low n to high n species with different kinetics.

8 ntial adsorption of oxygen atoms with facile kinetics.

9 rphology, viral RNA profile, and replication kinetics.

10 ve substitution, which together enable rapid kinetics.

11 ct the polymer with pH-dependent degradation kinetics.

12 uires atomic-level understanding of reaction kinetics.

13 ing, slower digestion and leucine absorption kinetics.

14 d to more accurately describe DO consumption kinetics.

15 hput analysis of grafted-from polymerization kinetics, accelerating reaction discovery, and optimizat

16 By mapping visual pigment kinetics across the central retina, high fidelity IRD pr

17 ette Na(+) had no effect on the selectivity, kinetics, amplitude, rectification or reversal potential

18 Detailed kinetic analyses across different time scales, that is,

19 Reported here are thermochemical and kinetic analyses of a new pincer-ligated rhenium complex

20 Results of steady-state kinetic analyses revealed that AsFMO exhibited negligibl

21 Enzymatic kinetic analyses revealed that EAEP generated uncompetit

22 Kinetic analyses revealed that Mg dissolution to Mg(2+)

23 expressed proteins, in vitro transcription, kinetic analyses, and in vivo cell viability assays, we

24 Using kinetic analyses, fluorescence binding, X-ray crystallog

25 Steady state isotopic transient kinetic analysis (SSITKA) of ammonia synthesis showed th

26 f the reactor and the benefits of performing kinetic analysis as a routine part of reaction optimizat

27 Single-molecule kinetic analysis demonstrates that the IUTD enters from

28 Observations from kinetic analysis in concert with in situ (19)F NMR monit

29 Application to kinetic analysis of a wide variety of transformations (a

30 This report describes the first detailed kinetic analysis of the Banert cascade proceeding by bot

31 Kinetic analysis, in situ FTIR, and in situ XAS measurem

32 rived using an arterial input function-based kinetic analysis.

33 one species to another, as measured through kinetic analysis.

34 At steady-state U release, kinetic and spectroscopic results suggest detachment of

35 This reveals multiple cellular mechanisms of kinetic and thermodynamic control that maintain the prop

36 he presence of the self-assembled capsule, a kinetic and thermodynamic modulation of the imine consti

37 ition defect is due to altered nsDNA binding kinetics and affinity for the bacterial chromosome.

38 rter enables whole-brain imaging with faster kinetics and brighter fluorescence than commonly used nu

39 led electron transfer result in sluggish OER kinetics and catalysts are required.

40 ined catalytic activity, albeit with altered kinetics and cooperativity.

41 each cell division modulates nuclear growth kinetics and dictates size scaling throughout early deve

42 e presence and absence of protons reveals ET kinetics and diffusion behavior similar to other small c

43 both sides of the lesion within 1 h; but the kinetics and distribution of modification around the DSB

44 ary alcohol follows clean pseudo-first-order kinetics and exhibits a sizable kinetic isotope effect.

45 nal cysteines (NCys) that proceeds with fast kinetics and exquisite selectivity, thereby enabling fac

46 gh seeded growth can accelerate the assembly kinetics and increase the optimal temperature by circa 4

47 aproline, features rapid amide isomerization kinetics and isoenergetic amide bond geometries influenc

48 viral interferon antagonists in shaping the kinetics and magnitude of the host response during virus

49 ence, with subcellular resolution, subsecond kinetics and nanomolar-to-submicromolar affinity.

50 is the first to measure mGlu(5) NAM binding kinetics and negative allosteric modulation of mGlu(5) r

51 c crowding nontrivially alters transcription kinetics and presents dynamic crowding within the bulk n

52 chromatin remodeling was found to define the kinetics and selectivity of gene activation in response

53 sequential infections and correlate antibody kinetics and sequence of infections with disease outcome

54 ipid compositions and quantified interaction kinetics and the affinity of HuNoV virus-like particles

55 PFA decay followed first-order kinetics and the inactivation of MNV was governed by the

56 Elevated pCO(2) was reported to affect the kinetics and thermodynamics of biochemical conversions b

57 aterial imparts significant influence on the kinetics and thermodynamics of electron transfer, and fr

58 residues reveals its contribution to enzyme kinetics and thermostability.

59 parallel platform that measures the cleavage kinetics and time-resolved cleavage products for over 10

60 applied to characterize substrate transport kinetics and to test 294 top-marketed drugs for OATP2B1

61 plet-triplet annihilation pathway, where the kinetics and yield depend sensitively on the energies of

62 Results from thermodynamic, kinetic, and computational analyses suggested that this

63 Yet, studies that address their dynamic, kinetic, and mechanistic role in target reactions are sc

64 , electrochemical redox, reaction mechanism, kinetics, and degradation.

65 lize, and be explained by simple mass action kinetics, and more likely to contain proteins with intri

66 ations of alpha-dicarbonyls, their formation kinetics, and presence of stabilizing residues in close

67 he complex, the association and dissociation kinetics, and the microviscosity, which governs translat

68 Here, we present a kinetic approach complemented by a hydrodynamic theory f

69 Here, we used quantitative kinetic approaches to determine the transient kinetics o

70 same cell revealed that PPP2R5A degradation kinetics are comparable to those of APOBEC3G with a half

71 edure requires that lipid-detergent exchange kinetics are in the fast exchange regime in order to fol

72 s obfuscated by labels, however, as reaction kinetics are inevitably perturbed.

73 and persistent mark of nucleus rupture whose kinetics are partially dictated by membrane resealing.

74 ion occurs in uls1Delta cells with wild-type kinetics, arguing that global histone depletion rather t

75 eveloping new therapeutics requires reliable kinetic assays and an analysis framework to extract kine

76 Genetic complementation studies and enzyme kinetics assays indicate that B. fragilis UroS is functi

77 RFA) on Cu(II) reduction and Cu(I) oxidation kinetics at pH 8.2.

78 olution transformation because they have few kinetic barriers apart from ionic diffusion.

79 However, we also found that kinetic barriers can be encountered in these systems and

80 calization of charge give rise to additional kinetic barriers in NCA and nonmetallic LTMOs in general

81 n by enabling simulation of protein shedding kinetics based on tumor tissue-specific characteristics.

82 the SMA-PSI complexes display a heterogenous kinetic behavior.

83 eronuclear single-quantum coherence spectra, kinetics, biochemical assays, and MS analyses, we show t

84 study, we show that Ag potency regulates the kinetics but not the magnitude of NFAT1 activation in si

85 ere we quantified Mediator-controlled Pol II kinetics by coupling rapid subunit degradation with orth

86 kinetic limitation manifests not only as the kinetic capacity loss during discharge but as a subtle b

87 e because of expeditious synthesis/secretion kinetics (CCL3/4/5) and low activation thresholds (CCL1/

88 of the N(2) molecule pose thermodynamic and kinetic challenges for promoting reactivity.

89 The metabolic kinetic changes revealed the alteration of metabolism an

90 other bacterial systems, and yields bursting kinetics characteristic of eukaryotic systems.

91 Considering its favourable kinetic characteristics, the sensor can be used for moni

92 Kinetic characterization revealed that the MpBgl3 was hi

93 ress numerous viral genes spanning all three kinetic classes, and suppress productive infection.

94 Furthermore, we find that kinetic constants of maintenance methylation are correla

95 Together, structure snapshots and kinetic constants provide glimpses of intermediate confo

96 ty for 6b, and a keto-enol tautomerism under kinetic control has been proposed as the source of diast

97 alculations in packing column demonstrated a kinetic control with highly viscous FIL/ILs, revealing h

98 PL decay kinetics corroborated by DFT calculations reveal a compl

99 Kinetic crystal growth theory is used to show that cryst

100 halcogenouronium species and comparison with kinetic data demonstrate the significance of 1,5-O...Ch

101 The combination of structural and kinetic data illustrates how different conformations of

102 The Upstream module outputs were fitted to kinetic data on cGMP activity and early membrane potenti

103 irmed the catalytic effect and the estimated kinetic data point out that the bulky diol at 1 mol L(-1

104 of initial rate determination for processing kinetic data sets, no simple and automated program exist

105 d the system parameters of the model to cell kinetics data without treatment and then validated the m

106 ial [O(2) ], QO2 ) dependency that slows VO2 kinetics, decreasing CP and VO2max , increasing the O(2)

107 This effect is attributed to a kinetic delay in which characteristic times for equilibr

108 Prospective monitoring of mutation kinetics demonstrated that TKI-resistant low-level mutat

109 h a polarity that is high, relative to their kinetic diameter.

110 r graphene electrodes displayed only a small kinetic difference with respect to SLG, suggesting that

111 his problem in mouse retina by analysing the kinetic differences between rod flash responses and rece

112 ptoRaf and optoAKT differ in their signaling kinetics during regeneration, showing a gated versus gra

113 l reflection (TIR)-we elucidate the freezing kinetics during the solidification of a droplet while it

114 y based on Dynamic FBA (DFBA), called Linear Kinetics-Dynamic Flux Balance Analysis (LK-DFBA), to sat

115 the apparent first-cycle capacity loss is a kinetic effect linked to limited Li mobility at x > 0.88

116 lved photoelectron spectroscopy, whereby the kinetic energy and angle of photoelectrons emitted from

117 ion, as predicted by solutions to the master kinetic equation.

118 nts an improvement in efficiency for typical kinetic experimentation in batch as well.

119 In particular, via a synergy between NMR and kinetic experiments, we demonstrate the presence of a mi

120 This new method allowed calculation of kinetic features of these metabolites, thus enabling a d

121 Most reactions followed second-order kinetics, first order in amine and first order in electr

122 ), critical power (CP) and speed of the VO2 kinetics following exercise onset.

123 Quantifying the exchange kinetics for analytes relative to the exchange kinetics

124 The real-time data sets revealed extraction kinetics for VOCs present in these samples.

125 They have rapid twitch kinetics (full width at half-maximal stress: 11 +/- 1 ms

126 could also open undamaged DNA, suggesting a 'kinetic gating' mechanism whereby lesion discrimination

127 ts with ECG and EGC, but not in line with FQ kinetics, highlighted possible interferences of starch-f

128 VT and HVT-DeltavNr-13 showed similar growth kinetics; however, at early time points, HVT-DeltavNr-13

129 Connections between thermodynamic and kinetic hydricity are discussed, and opportunities for u

130 Kinetic hydricity represents the rate of hydride transfe

131 o promote the transgene expression level and kinetics in both adherent and suspension cells.

132 ratio correlated with different contraction kinetics in knockout versus wild-type; (2) Aberrant acti

133 is pilot study demonstrated DPSMA uptake and kinetics in localized renal masses.

134 ms to monitor bacterial concentration, decay kinetics in the presence of various antibiotics (ciprofl

135 Inactivation kinetics in TLF and on dry SS followed the Weibull model

136 pigallocatechin (EGC) exhibited slow binding kinetics (in the order of minutes), epicatechin gallate

137 urfactant formation as well as autocatalytic kinetics; indeed, no selection is observed when all reac

138 antibacterial potential and the degradation kinetics indicated first-order reactions.

139 Enzyme kinetics indicated that this RdRp efficiently incorporat

140 is, DeepFRET consequently outputs the common kinetic information metrics.

141 ll provide researchers with lots of valuable kinetic information regarding oxidizability as a functio

142 on the assigned kinetic model and to dissect kinetic interaction parameters from single-molecule FRET

143 this has shown that RdRp nucleotide addition kinetics is stochastically interrupted by rare pauses of

144 Observations of a significant kinetic isotope effect (k(H) /k(D) =5.7) for the reactio

145 -80 degrees C); thus, the hydrogen/deuterium kinetic isotope effect (KIE) = 6, consistent with H-atom

146 RMCF analysis predicts that the H/D primary kinetic isotope effect can serve as a probe for these me

147 nt work, quantum mechanical computations and kinetic isotope effect experiments demonstrate that the

148 l of mechanistic techniques, including (13)C kinetic isotope effect experiments, deuterated labeling

149 A primary (13)C/(12)C kinetic isotope effect of 1.022(4) was measured at 23 de

150 Hammett and kinetic isotope effect studies, in combination with comp

151 -first-order kinetics and exhibits a sizable kinetic isotope effect.

152 Derivation of apparent kinetic isotope effects (AKIEs) for the reaction with oz

153 Large intramolecular (13)C kinetic isotope effects (KIEs) for the di-pai-methane re

154 titutions showed varied effects on transport kinetics (K(m) and V(max)) and substrate specificity.

155 tentiometry (OCP) to measure enzyme turnover kinetics, k(turn).

156 The kinetic limitation manifests not only as the kinetic cap

157 (7)Li NMR measurements indicate that the kinetic limitation reflects limited Li transport at x >

158 behavior of breast cancer cells via reaction kinetics may help unravel the mechanisms that underlie m

159 Real-time kinetic measurements from a single well were used to det

160 Concordance of kinetic measures with tumor-to-blood ratios provides a c

161 units and other factors modify the intrinsic kinetic mechanism to result in new molecular and cellula

162 N-oxide (CNO) has been widely used, sluggish kinetics, metabolic liabilities and potential off-target

163 ons of each FRET level based on the assigned kinetic model and to dissect kinetic interaction paramet

164 We developed a detailed kinetic model of the fatty acid synthase (FAS) of Escher

165 ed relatively noise-free input functions for kinetic modeling approaches.

166 uses erroneous parameter estimates in tracer kinetic modeling in brain PET studies.

167 Quantitative kinetic modeling shows that only a fraction of RNApII bi

168 Full kinetic modeling to quantify tau load was investigated.

169 h-speed atomic force microscopy (HS-AFM) and kinetic modeling which allowed us to determine that sept

170 ombining molecular dynamics simulations with kinetic modeling, we quantify cavitation rates on biolog

171 n, allowing further analysis by fitting with kinetic models.

172 Kinetic, molecular docking, and site-directed mutagenesi

173 from stochastic switching due to the random kinetic motion of discrete defects in the nanometer-size

174 the most widely employed tool to measure the kinetics of actin polymerization and the interaction bet

175 nal Ba(2+) than in Ca(2+); voltage-dependent kinetics of activation, inactivation, and deactivation;

176 flow (19)F NMR spectroscopic analysis of the kinetics of alkene difluorocyclopropanation and competin

177 imaging flow cytometry (iFCM) to explore the kinetics of allograft sEV release and the extent to whic

178 The kinetics of antibody-antigen association are enhanced wh

179 on on the chemically-controlled dissociation kinetics of antibody-antigen pairs by the use of water-m

180 studied the effect of glycans on the binding kinetics of antiviral drugs to the influenza neuraminida

181 The kinetics of bleb formation, its dependence on POM121, an

182 cking either phot2 or chup1 and analyzed the kinetics of both the onset and recovery of NPQ under equ

183 rapies, cancer stage specific prognosis, the kinetics of cancer recurrence, as well as the limited da

184 strategies for improving the specificity and kinetics of Cas9 as a genome engineering tool and may in

185 cell tracking could be used to determine the kinetics of cell trafficking and arrest during the earli

186 nimal models that recapitulate the long-term kinetics of clinical disease, which would provide insigh

187 eptide 1 (CSP1) failed to modulate the onset kinetics of competence development in vivo The competenc

188 Small changes in the kinetics of dendritic excitatory currents amplify when r

189 in natural environments, thermodynamics and kinetics of divalent mercury Hg(II) chemical speciation

190 anslocating DNA can be exploited to tune the kinetics of DNA translocation.

191 nd the effect of the imposed DeltaPsi on the kinetics of efflux was also studied in right-side-out me

192 that GluA3 largely determines the ultrafast kinetics of endbulb synapses glutamatergic currents by p

193 d postnatal GBS acquisition, we assessed the kinetics of GBS GI colonization, progression to invasive

194 experimental observation and transformation kinetics of GBs in an elemental metal have remained elus

195 The kinetics of glucocorticoid-induced eosinopenia and bone

196 species-specific differences in the rate and kinetics of glucose consumption and glycolysis throughou

197 o the SAR1 GTP-binding pocket and alters the kinetics of GTP exchange.

198 nuclear pore complex blockade to monitor the kinetics of HIV-1 nuclear import and define the biochemi

199 Circular dichroism measurements and kinetics of inhibition indicated that the most active C-

200 The aggregation kinetics of insulin were not significantly affected in t

201 plenishment of vitamin B-12 stores, from the kinetics of its plasma appearance in a 2-compartment mod

202 ch is attributed to genomic position and the kinetics of lineage commitment.

203 We use the kinetics of loop closure involving closely spaced (131-1

204 Thus, understanding the fundamental kinetics of MOF-based molecular catalysis of electrochem

205 In this study, the inactivation kinetics of murine norovirus (MNV) by PFA, in phosphate

206 dulate the potency, selectivity, and binding kinetics of Na(V) channel ligands.

207 Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by S

208 g peanut protein, although variations in the kinetics of passage were observed between individuals an

209 on in diversifying both antigenicity and the kinetics of peptide display.

210 In this work we directly compare the kinetics of photoreduction of six different heme protein

211 effector functions, which should affect the kinetics of plasma-virus decline.

212 the nanoscale can significantly enhance the kinetics of radical-mediated oxidation reactions-polluta

213 radiation, the block can be released and the kinetics of re-equilibration to the native conformationa

214 e subtle control over the thermodynamics and kinetics of reactions.

215 inetic approaches to determine the transient kinetics of recognition and repair of alkylated DNA by A

216 form, DropMap, to measure simultaneously the kinetics of secretion and other cellular characteristics

217 By measuring the kinetics of spread at early time points, we were able to

218 brium potential landscape topography and the kinetics of state switching.

219 The binding affinity and kinetics of target engagement are fundamental to establi

220 we investigated the urease-bound aggregation kinetics of the Au and Ag NPs which has not been explore

221 However, the kinetics of the channelrhodopsin-2 (ChR2) used for cell-

222 The kinetics of the first emission phase was mainly correlat

223 Our analyses of the kinetics of the forward and reverse reactions of photool

224 an effective way to improve selectivity and kinetics of the oxygen reduction reaction (ORR).

225 netics for analytes relative to the exchange kinetics of the standards results in greater accuracy an

226 ew new methods for future elucidation of the kinetics of their turnover in humans.

227 entions because of the specific transmission kinetics of this virus.

228 We measure the association kinetics of unlabeled L-Tym by detecting its influence o

229 at a mineralized surface zone influences the kinetics of water evaporation and the surface temperatur

230 Further, the differential kinetics on this dimerization mechanism underlie an intr

231 t, O(2) limitation may differentially impact kinetic or thermodynamic versus physicochemical C protec

232 NRA over denitrification is not explained by kinetics or thermodynamics.

233 secondary oxidative process was run and the kinetic parameters (rate constant, activation energy, an

234 The thermal sensitivity of kinetic parameters allows us to predict responses of bot

235 ly investigate the temperature effect on the kinetic parameters and rate constants representing lipid

236 The fundamental thermodynamic and kinetic parameters obtained here will advance our fundam

237 Here, we review previously reported enzyme kinetic parameters of cellular and viral DNA and RNA pol

238 ic MOFs should also consider other important kinetic parameters such as the rate of proton-associated

239 ences, and (iii) the estimation of bias-free kinetic parameters.

240 sport in Li(4+) (x) Ti(5)O(12) is enabled by kinetic pathways comprising distorted Li polyhedra in me

241 However, the kinetic pathways, following which such development occur

242 assays and an analysis framework to extract kinetic pharmacological parameters.

243 (NMR) spectroscopy to determine the reaction kinetic profile.

244 hotransfer and phosphorelay networks, T-cell kinetic proofreading, and ERK signalling.

245 nhuman primates and humans, showed excellent kinetic properties as a PET radioligand.

246 We analyze how the kinetic properties of the reversible binding interaction

247 Analysis of biomarker kinetics (PSP, routine markers) was performed on 90 pati

248 M/Fe(3)O(4)-40 following pseudo-second-order kinetics (R(2) > 0.97) and equilibrium isotherm data fit

249 ution to Mg(2+) followed mostly a zero-order kinetic rate law for both Mg anode materials, and the ra

250 organic ligands are separated to reduce the kinetic reaction rates for better control over the cryst

251 The proposed biosensor and method of native kinetic registration can be used to develop new criteria

252 an additional stereogenic center, effective kinetic resolution can be achieved.

253 rk unveils a genome-scale map of methylation kinetics, revealing highly variable and context-specific

254 s of alphabeta T cell subsets and refine the kinetic selection model of CD4(+) and CD8(+) T cell line

255 ub-angstrom precision leading to the optimal kinetic separation of all three xylene isomers at room t

256 The polymerization kinetics show a second order rate law, first order in bo

257 denosyl radical were used to investigate the kinetic significance of the hydrogen atom abstraction.

258 Kinetic simulations at physiologically-relevant substrat

259 We present the first 3D fully kinetic simulations of laser driven sheath-based ion acc

260 ether a temporal-intensity voxel clustering (kinetic spatial filtering, or KSF) improved lesion detec

261 erized, with thermodynamic reversibility and kinetic stability also demonstrated.

262 We analyzed the steady-state abundance and kinetic stability of LMO2 and its partners via Halo prot

263 he approach may be broadly applicable to the kinetic stabilization and characterization of other weak

264 oredoxin, glutathione, and ascorbate) are in kinetic steady state rather than thermodynamic equilibri

265 st intriguingly, depending on the initiation kinetics, stochastic elongation can either enhance or su

266 Kinetic studies also demonstrate the requirement for sus

267 Rapid kinetic studies and EPR measurements of rapid freeze-que

268 Kinetic studies at 22 degrees C and pH 7.1 showed that t

269 Kinetic studies carried out with TEMPO-H(D) reveal secon

270 OF was subject to steady-state and transient kinetic studies involving H/D and (13)C/(12)C exchange,

271 Comparative kinetic studies of a series of new ruthenium complexes p

272 Two examples of kinetic studies of living cells under various doses of d

273 Kinetic studies of these transformations have also been

274 Kinetic studies on methyl fluorination suggest that the

275 Kinetic studies point to the second protonation event as

276 The kinetic studies showed that enzyme molecules with no net

277 To this aim, a kinetic study of the primary and secondary oxidative pro

278 ing crystallographic, spectroscopic and fast kinetics techniques.

279 ary scalar field [Formula: see text] and its kinetic term [Formula: see text], to explore non-minimal

280 exagonal-basket type; larger and with faster kinetics than in other models.

281 can have a pronounced effect on the observed kinetics that can manifest in significant run-to-run var

282 etween fluid instability and crystallization kinetics that determines the achievable feature sizes.

283 ence between folding in NDs and SUVs was the kinetics; the rate of folding was two- to threefold slow

284 Motivated by such observations, we propose a kinetic theory that addresses the nonadiabatic evolution

285 We report here kinetic, thermodynamic, hydrodynamic and computational s

286 Effective application of signaling kinetics to developing new therapeutics requires reliabl

287 platform for measuring arrestin recruitment kinetics to GPCRs using a high quantum yield, geneticall

288 we use a general model based on biochemical kinetics to quantify the combined effects of water conte

289 ar FX activation and antithrombin inhibition kinetics to the FVIIa.sTF complex.

290 hybrid containing DHTKD1 displaying improved kinetics towards 2-oxoadipic acid.

291 ICEKAT allows users to interactively fit kinetic traces using convenient browser-based selection

292 ysis of initial rates from continuous enzyme kinetic traces.

293 and/or under conditions of slow exchange, as kinetic traps and nonequilibrium product distributions a

294 e reactions evolve with profoundly different kinetics, undergoing autoinhibition (TBAT) or quasi-stoc

295 ignificant role in mediating the association kinetics, undergoing conformational rearrangement upon i

296 The extent to which interaction kinetics vary for the same RNA element across the transc

297 r surface photovoltages to be created, which kinetics vary with the composite architecture and last b

298 Although using hydrogen-deuterium exchange kinetics with MS (HDX-MS) to interrogate the high-order

299 ET-MS to the study of heterogeneous chemical kinetics with the reaction of gas phase O(3) and aqueous

300 ipate that future studies of viral infection kinetics with this reporter system will enable basic inv