ライフサイエンスコーパス: kink

1 ion mode has been indicated by a dispersion "kink".

2 n has an extended shape with a small central kink.

3 behavior as one long helical peptide with a kink.

4 were the CE turn, the EF loop, and the H-H' kink.

5 onsistent with the introduction of a dynamic kink.

6 ed Z-DNA structures with a single-step sharp kink.

7 sequence of the energy of the main prominent kink.

8 of two turns of helix separated by a proline kink.

9 ine substitutions and evolutionary origin of kinks.

10 ernating handedness, accompanied by periodic kinks.

11 ess (perversions), accompanied by correlated kinks.

12 ility of DNA through the introduction of DNA kinks.

13 re of DNA that prompts the appearance of the kinks.

14 pulsive by optically introducing dislocation kinks.

15 es three beta-strands connected by two short kinks.

16 ched fibers, resulting in formation of fiber kinks.

17 tent account of our data set on the multiple kinks.

18 Here, we show a new landscape of dispersion kinks.

19 below the headgroups, is tilted, and may be kinked.

20 strong enough to prevent the flux rope from kinking.

21 f these vacuoles in zebrafish leads to spine kinking.

22 olecular contours that lack obvious signs of kinking.

23 geneous curving (~ 10 layers) and finally to kinking (20 or more layers), depending on the competitio

24 ere, we report the characterization of Knk1 (kink), a previously unidentified member of the superfami

25 can also be optically manipulated to induce kinks, allowing one to lock them into the desired config

26 tional main kink and a rise of another sharp kink, along with substantial energy shifts of both.

27 ld-type Cx43 revealed that it folded in to a kinked alpha-helical structure.

28 unfavourable non-ideal features--for example kinked alpha-helices, bulged beta-strands, strained loop

29 ins, a beta-barrel domain and a long, mildly kinked alpha-helix tail.

30 esults in a decline of the conventional main kink and a rise of another sharp kink, along with substa

31 Melting of the bent crystal starts at the kink and often appears as splitting of the respective en

32 pathway of globular collapse proceeds by a "kink and slide" mechanism, whereby a bend near the end o

33 f CO2 at 20 Torr and above, producing active kink and step sites.

34 The kink and the agonist do not interact directly.

35 tacts but introduces torsional stresses that kink and undertwist the promoter, stabilizing an A-form

36 , thylakoids inside the cleavage furrow were kinked and severed.

37 the membrane surface and alternates between kinked and straight-helix conformations.

38 periments, reveals that the SRP RNA adopts a kinked and untwisted conformation to allow repositioning

39 TAT-CBD3 caused a transient episode of tail kinking and body contortion.

40 wing the general connection between cumulene kinking and CC bond-breaking reactions that split off CO

41 formation mode, alongside mechanisms such as kinking and shear banding.

42 binding and dissociation, accompanied by DNA kinking and straightening, respectively.

43 recombination, appears to enforce the sharp kinks and additional inter-segment twisting in target DN

44 fibers and revealed a torsional stiffness of kinks and cross-links of ~100-200 pN.nm/rad.

45 he heterotrimer, the homotrimer easily forms kinks and freely rotates with angles much larger than he

46 PIC kinks and locks substrate DNA, creating negative superco

47 of static curvature in S[PSI(+)] fibers and kinks and self-cross-linking in W[PSI(+)] fibers.

48 It is initiated at kinks and steps edges, but the reconstruction also takes

49 by the Mid and PAZ domains and makes several kinks and turns along the binding groove.

50 ak corrections, 1 open repair for prosthetic kink, and 10 distal extensions of the graft to the thora

51 ve site, its sulfonyl group adopting a sharp kink, and its N-CF(3)-phenyl substituted piperazine grou

52 lear preference for trans-like over cis-like kinks, and (iv) the extreme sensitivity of kinking with

53 trans crystal conformations between adjacent kinks, and the nanoFET was localized through modulation

54 y considered surface defects, such as steps, kinks, and vacancies, but are now just beginning to be u

55 ar to that of wild type but with a shallower kink angle of approximately 150 degrees .

56 ansition is triggered by the rotation of the kink angles of transmembrane helices 2 and 7 and is medi

57 compression, and arise from buckling-induced kink-antikink bands that provide domain separation barri

58 titute the first experimental observation of kink-antikink solitary wave propagation in nonlinear fib

59 on; sugar repuckering, major-groove directed kinking ( approximately 9 degrees ); and local melting o

60 emained unclear whether HMGB binding and DNA kinking are simultaneous and whether the induced kink is

61 In membrane proteins, proline-mediated helix kinks are indispensable for the tight packing of transme

62 ur results clarify the notion of dislocation kinks as meaningful only for orientations within the pla

63 inear interband contributions separated by a kink at 0.2 eV.

64 efined NMR and MD structures reveal a slight kink at G13 that delineates two helical segments charact

65 trinsic tertiary interactions, and molecular kink at the active site.

66 This is accompanied by an increase in kink at the central step from 22 degrees to 51 degrees ,

67 posed energy-minimized model suggests that a kink at the interface between l- and d-blocks leads to t

68 of transmembrane helix 6 and induces a sharp kink at the middle of this helix to allow the receptor t

69 ally characterized by a sharp 70 degrees DNA kink at the position of the lesion.

70 erial homolog, LeuT, presumably because of a kink at TM12 preventing favorable monomer packing.

71 energy by undergoing sequential, cooperative kinking at two sites that are located about 180 degrees

72 experimental observations where the peptide kinks at Phe(697) to facilitate Arg(694) snorkeling.

73 Remarkably, the kink, at the end of a G(X)4G motif highly conserved amon

74 -shaped hexamers are staggered, leading to a kinked axial channel.

75 of the propagation direction, mimicking the kink behaviour of the Crab jet.

76 can reorient, via cogwheeling (rotation) and kinking (bending), to effect changes in PHK activities t

77 A conserved proline in M1 causes a kink between alpha and pi helical segments.

78 3B requires the release of a proline-induced kink between the NC and subsequent coiled-coil 1 segment

79 We demonstrate that kink blockers reduce the line tension of step edges, whi

80 ct mechanisms of haematin growth inhibition, kink blocking and step pinning(12,13), exhibit both syne

81 Detailed experimental evidence of kink blocking validates classical theory and demonstrate

82 hree distinct modes of action: step pinning, kink blocking, and step bunch induction.

83 on adjacent layers, the latter resulting in kink boundaries.

84 A kinked bridge-helix sterically blocks the RNAP active si

85 The RNA kinks by an association of the two minor grooves, stabil

86 Notably, the latter kink can be ascribed only to an oxygen-breathing phonon.

87 ta, we find that the experimentally observed kinks cannot be explained by a simple crossover between

88 peptide structural motif is a prominent "GG kink," centered at two glycines dividing the TM helix.

89 d amino-terminal domain interactions, form a kinked central channel.

90 ristics, such as rigid rods, semiflexible or kinked chains, and thermally responsive hydrogel network

91 rsus protein concentration can show signs of kinks: clear changes in scaling exponent, indicating cha

92 cal defect characterized by the formation of kinks close to cell tips.

93 ing with kinked nanowire structures, but the kink configuration and device design places limits on th

94 sented new geometric parameters defining the kink conformation.

95 The uniquely kinked conformation of the CD3gamma G-strand is crucial

96 cts a fraction of RNA that is already in the kinked conformation, thereby drawing the equilibrium int

97 -dynamics simulations) and to adopt multiple kinked conformations (by solid-state NMR).

98 II, we found that biasing simulations toward kinked conformations enables generating low-root mean sq

99 Remarkably, the propensity to kink correlated with the thermodynamic destabilization o

100 Loop binding in which the phosphate backbone kink created by the loop E motif causes the Specifier Se

101 rate that cellulose nanofibrils tend to form kink defects in response to bending stress, and that the

102 alth of non-canonical DNA structures such as kinks, denaturation bubbles and wrinkled conformations t

103 Suzuki polymerization of kinked disubstituted 1,4-dimethoxycyclohexadienylene mon

104 d by cytosines (5'CalphaAC-3') resulted in a kinked DNA duplex with an enlarged minor groove.

105 This leads to a sharply kinked DNA molecule that may fray the DNA four base pair

106 It is known, that XPA binds kinked DNA structures and that it interacts also with DN

107 Although the 1,2-GG lesion stabilizes the kink due to the covalent fixation of the crosslinked dG

108 nt length of about 70 bp when sharp bends or kinks emerge in essentially every molecule.

109 tinct structural differences: the chains are kinked, enabling non-covalent cross-linking of fibrils a

110 It changes from a double-kink excitation below the matching field to pinning-pote

111 es mostly helical conformations but adopts a kinked, extended structure when bound by antibody 2F5.

112 The protein trimer forms kinked fibers comprised of an amino-terminal tail-attach

113 (amino acids [aa] 179 to 181) included in a "kink" followed by an extra beta strand.

114 m opposite faces and induce four significant kinks from the -35 element to the -10 element of the pro

115 L7Ae family can induce the formation of the kinked geometry, raising the question of whether this oc

116 We find that all bound RNA is in the kinked geometry, with no evidence for transitions to an

117 , we propose a local seeding model where the kinked GGA motifs in the stem region of TGGAA repeat DNA

118 current at the inner lacerating surface of a kinked guidewire.

119 he structures of three types reveal similar 'kinked hairpin' folds, in which the second and third rep

120 eoretical analysis shows that sharp bends or kinks have to facilitate strong bending of the double he

121 A kinked helical beam and anchor domain link the Piezo rep

122 nsists of two elongated antiparallel proline-kinked helices (five AB tandem repeats).

123 holds a string of water molecules centred at kinked helices in two inverted-repeat triple-helix bundl

124 f the complete 2F5 epitope within continuous kinked helices.

125 thin the neck, moves by straightening of the kinked helix h28 at the point of contact with the mRNA.

126 We therefore predict that the kinked helix is the most fusogenic of these three confor

127 largely via hydrophobic interactions and the kinked helix of SCP bridges over neighboring MCPs to for

128 However, the kinked helix promotes lipid tail protrusion in our simul

129 more, a G2V variant peptide of Cx43 showed a kinked helix that now included V2 interactions with W4,

130 t SCP forms a crown on each hexon and uses a kinked helix to cross-link neighboring MCP subunits.

131 ion peptide structure in membranes include a kinked helix, a straight helix, and a helical hairpin.

132 on patterns in the magnitude or direction of kinking, (ii) the nonexistence of O = C horizontal lineC

133 However, a kink in H16 that makes specific contacts with the S4 N-t

134 In particular, the proline/glycine kink in helical peptides was reported to both increase a

135 and fluorescence experiments to show that a kink in helices affects the formation of membrane pores

136 conformation is accompanied by a 60 degrees kink in helix 6 and a large outward movement of the intr

137 water molecules, which are responsible for a kink in helix P in the apo structure.

138 lative to the membrane-water interface and a kink in its backbone that enables bending of its C-termi

139 of amino acids that are located at a proline kink in M1 that separates pi and alpha helices, in both

140 at much of the VSD, including the pronounced kink in S3 and the S3-S4 paddle, is relatively rigid on

141 In contrast, the kink in S3 is mobile on the microsecond-to-millisecond t

142 Gt CsoR reveals that Cu(I) binding induces a kink in the alpha2-helix between two conserved copper-li

143 ility was observed also in the vicinity of a kink in the beta-subunit helical region near residue bet

144 proline between V319C and E321 introduces a kink in the BK S6 inner helix sharper than that observed

145 oline, a known beta-sheet breaker, creates a kink in the center of the pore and prevents conductance

146 mmunoglobulin-like domains to induce a sharp kink in the DNA, exposing the damaged nucleobase to acti

147 e expansion, we show that obstacles create a kink in the front that persists over large distances and

148 The resulting kink in the inner transmembrane domain swings the aromat

149 n the transmembrane domain result in a sharp kink in the middle of transmembrane helix 6, which pivot

150 shape with flexibility and a characteristic kink in the middle.

151 romatic substitutions provide evidence for a kink in the peptide backbone.

152 mplate base is accommodated by a distinctive kink in the polymerase O helix, resulting in a partially

153 work must be done on the pore to reduce the kink in the pore-lining (S6) alpha-helices, thereby form

154 chored HpHbR, and a approximately 50 degrees kink in the receptor, allows two receptors to simultaneo

155 the dsDNA, which was best accounted for by a kink in the region of highest curvature.

156 plex other properties such as rigidity and a kink in the rod-like structure.

157 ular modeling indicates that L529I induces a kink in the S4 voltage-sensor helix, altering a salt-bri

158 t of mutating the PVPV motif that causes the kink in the S6 helix.

159 The position of the proline/glycine kink in the sequence further controls the specific struc

160 ta3-integrin cytoplasmic tail and inducing a kink in the transmembrane domain of beta3-integrin.

161 ectrum of fatty acyl-CoAs suggested that the kink in the unsaturated acyl chain is a key determinant

162 lly conserved AsnI:18 (1.50) stabilizing the kink in trans-membrane VII.

163 there are multiple distinctions, including a kink in transmembrane helix 12 halfway across the membra

164 the nucleosome, nucleosome formation causes kinking in a secondary repeat tract in the htt gene, com

165 one is sufficient to induce the formation of kinks in circles containing only 65 bp, but we did not o

166 f biologically relevant underwinding-induced kinks in DNA on the overall shape of DNA minicircles.

167 lambda-DNA in a U-turn by creating two sharp kinks in DNA.

168 quent occurrence of Ser or Thr based helical kinks in membrane proteins suggests that a similar mecha

169 on to understand the introduction of proline kinks in membrane proteins.

170 hat is based on introducing variable dynamic kinks in terminal helices.

171 The Csm3 thumb elements introduce periodic kinks in the crRNA-target RNA duplex, facilitating cleav

172 Kinks in the development of the superfluid fraction (at

173 thering of the intima, resulting in multiple kinks in the luminal contour that resolved after the adm

174 Finally, we show that bends and kinks in the notochord can lead to aberrant apposition o

175 e observed to change character from pairs of kinks in the ordered phase to spin-flips in the paramagn

176 r most of the simulation, whereas occasional kinks in the proline-rich linker region cause an overall

177 in a DPC surfactant micelle possesses a "GG kink," in the TM domain near the dynamic hinge located a

178 ch, which is generally unstable to the m = 1 kink instability.

179 n, which includes two helices connected by a kink, interacts with the adjacent minor groove of DNA in

180 h instability of a hemispherical membrane to kink internal tubes and operates with binary high/low in

181 ing structural motif that introduces a tight kink into duplex RNA.

182 conformations not seen previously, including kinking into the DNA major groove.

183 mmonly-occurring motifs that introduce sharp kinks into duplex RNA, thereby facilitating tertiary con

184 However, kinks invariably affect numerous interhelical interactio

185 The flexibility of the GG kink is important in the processing of C99 by gamma-secr

186 Such a kink is not observed in C99(15-55) in a POPC lipid bilay

187 ing are simultaneous and whether the induced kink is rigid (static) or flexible.

188 In related receptors, the kink is straighter and more stable in O vs. C structures

189 The kink is under greater tension in the resting versus acti

190 cture dissipates the impact energy via layer kinking, layer compression, extreme chain conformational

191 nstrate that two helical peptides can form a kink-like connection with similar behavior as one long h

192 rameter that governs the appearance of these kink-like interfacial structures, which drive the collap

193 twinned copper are inherently defective with kink-like steps and curvature, and that these imperfecti

194 ted by surface tension, a 3-dimensional (3D) kink-like structure develops in the neck, causing [Formu

195 the H bonding, the HBs being stronger when a kinked-like structure is generated by formation of the q

196 ically-protected high-frequency kink modes - kink magnetoplasmons (KMPs) - in a GaAs/AlGaAs two-dimen

197 included mesh exposure (8% vs 0%), ureteral kinking managed intraoperatively (0% vs 7%), granulation

198 These local kinks may explain the larger lateral distance between co

199 l data and theoretical analysis suggest that kinks may represent openings of isolated base pairs, whi

200 flexion, 23 CIA and 116 EIA stenoses showed kinking (mean amplitude, 76 degrees +/- 23 and 76 degree

201 ew and the M111 orientations, both moving by kink mechanism.

202 on of topologically-protected high-frequency kink modes - kink magnetoplasmons (KMPs) - in a GaAs/AlG

203 still permits a unique form of edge modes - kink modes - residing at the domain boundaries of magnet

204 stacking faults and using a vacancy-mediated kink motion, and also to understand the nature of the sw

205 None of the AChR kink mutations had a measureable effect on agonist affin

206 The DnFimA structure reveals an extended kinked N-terminal alpha-helix, an unusual centrally loca

207 inaceous nanopores of comparable dimensions, kinked nanopores exhibit up to fivefold reduction in tra

208 cale connections are made by the arms of the kinked nanostructure, and remote multilayer interconnect

209 rated FET-based intracellular recording with kinked nanowire structures, but the kink configuration a

210 to-nanoscale metal pillars, transistor-based kinked nanowires and nanotube devices.

211 growth site is found to be rate-limiting for kink nucleation, with this process having a lower activa

212 plexes of genuine transposases, where severe kinks occur at the integration sites of target DNA and t

213 e resolution of our experiments, this static kink occurs at the instant the protein binds to the DNA,

214 beta(3)(Pro 711) introduced a TMD kink of 30 +/- 1 degrees precisely at the border of the

215 f helix M2 (as in locally closed form) and a kink of helix M1, both helices no longer interacting acr

216 the recognition step for IHF is spontaneous kinking of cognate DNA to adopt a partially prebent conf

217 rically, causing vertebral malformations and kinking of the axis.

218 nd increased in diameter in association with kinking of the optic nerve sheath.

219 Significantly, kinking of TM6 in the post-ATP hydrolysis state stabiliz

220 revealed a NB-shaped Au structure with many kinks on its surface, which allow local electric field e

221 developed at the anastomosis, within a bend/kink or distally.

222 we show that Li whiskers can yield, buckle, kink or stop growing under certain elastic constraints.

223 a change in the magnetic topology, as in the kink or torus instability; and coronal jets from a resis

224 ition (for example, when a base pair step is kinked or a region of the minor groove is narrow).

225 implicated in HU's high-affinity binding to kinked or cruciform DNA, leads to less dramatically alte

226 Although n-alkanes have no branches, the "kinks" (or "protobranches") in their chains (defined as

227 cally (bubbles), sustains large-angle bends (kinks), or can locally transform into an alternative (S-

228 rins, domains EC2' and EC3' are joined in a "kinked" orientation by a previously uncharacterized Ca(2

229 i) Thr175, Tyr177, Leu179, and Asp180 at the kink overlapping the integrin-binding site; (ii) Arg153

230 otion proceeds via the thermal nucleation of kink pairs.

231 t to a single Ca(2+) entry site close to the kinked part of the first transmembrane helix, in a regio

232 n, diameter, growth direction, branching and kinking, periodic twinning, and crystal structure.

233 he temporal transfer of oxygen ions near the kink positions of the two different-diameter portions of

234 eviously shown that sequence nonspecific DNA kinking proteins, such as Escherichia coli heat unstable

235 utotransporter proteins, possesses a central kink revealing a distinctly curved structure.

236 n growths, including the formation of nodes, kinks, scale-like interfaces, and curved backbones.

237 t enhance DNA flexibility at the site of the kinks show 3- to 4-fold increase in DNA bending rates th

238 Here we report the formation of 'kinked' silica nanopores, using evaporation-induced self

239 fabricating free-standing probes in which a kinked silicon nanowire with an encoded field-effect tra

240 nanoFET) device at the tip of an acute-angle kinked silicon nanowire, where nanoscale connections are

241 large number of palladium atoms on ledge and kink sites of hollow nanocages are advantageous to enhan

242 , while sequence modifications away from the kink sites, as well as mutations in IHF designed to dest

243 ionalized by considering additive binding to kink sites, which is consistent with crystal growth by a

244 he activity is greatly enhanced at strained (kinked) sites and regions modified by oxidation.

245 information in the form of a sharp magnetic kink soliton to be unidirectionally pumped (or 'shifted'

246 cidate the electronic origin of the curious "kinked'" spine geometries that are common in such specie

247 ly complementary strand, suggesting that the kinked state is locally melted.

248 elasticity, without the need to invoke any 'kinked' states.

249 ng studies indicate that NS1643 binds to the kinked structure induced by the mutation with a higher a

250 modeling of the SAXS data results in a long kinked structure of the ternary complex, showing an angl

251 ther this occurs by passive selection of the kinked structure, or a more active process in which the

252 ntercalates into the duplex to stabilize the kinked structure.

253 in an extended form, or by folding into the kinked structure.

254 are Ba-O layer terminated, and two kinds of kink structures at the Ruddlesden-Popper faults with dif

255 ucture, and that Cu(751) has a heterogeneous kinked surface with (110) terraces that is closely relat

256 In some kinked systems, however, the justification from the Clar

257 king of a primary structural unit based on a kinked Ta-O-Ta backbone.

258 ine-valine-proline motif, which introduces a kink that allows for electromechanical coupling with vol

259 uch as a climbing plant tendril, refers to a kink that connects two helices with opposite chiralities

260 consistent with formation of a single static kink that is short lived (lifetimes of a few seconds) un

261 Between nucleotides 6 and 7, there is a kink that may function in microRNA target recognition or

262 undamaged fibrils-were first created within kinks that developed at discrete, repeating locations al

263 nts in RNA that mediate tertiary contacts by kinking the helical axis.

264 played along a single, peripheral, regularly kinked topoisomerase II/cohesin/condensin II axis.

265 onal target), which contains two >80 degrees kinks towards the minor groove, only 3 bp apart.

266 NMR studies of MMP23-PD reveal a single, kinked trans-membrane alpha-helix, joined by a short lin

267 onella pneumophila Cu(+)-ATPase shows that a kinked transmembrane segment forms a "platform" exposed

268 suggest that straightening of the M1 proline kink triggers AChR desensitization.

269 d FAs, which are instead accommodated by the kinked tunnel within the FakB2 protein.

270 sing a three-way helical junction based upon kink turn (k-turn) architecture.

271 -23 from Thelohania solenopsae is a rare RNA kink turn (k-turn) where an adenine replaces the normal

272 s including L7Ae, which is known to bind the kink-turn (K-turn), an RNA structural element that cause

273 ticodon loop and is flanked on one side by a kink-turn (K-turn), or GA, sequence motif.

274 e identify in the Mma RNase P RNA a putative kink-turn (K-turn), the structural motif recognized by L

275 for kink-turn, C-loop, sarcin-ricin, reverse kink-turn and E-loop motifs against a 23S rRNA (PDBid: 1

276 rent RNA 3D motifs (such as sarcin-ricin and kink-turn internal loops or T- and GNRA hairpin loops) i

277 tool has been demonstrated by rediscovering kink-turn motif instances, conserved domains in group II

278 nsistent predictions for a new stem P0 and a kink-turn motif.

279 NAMotifScan is demonstrated by searching for kink-turn, C-loop, sarcin-ricin, reverse kink-turn and E

280 many known motifs including GNRA tetraloop, kink-turn, C-loop, sarcin-ricin, reverse kink-turn, hook

281 op, kink-turn, C-loop, sarcin-ricin, reverse kink-turn, hook-turn, E-loop and tandem-sheared motifs,

282 potential novel instances of GNRA tetraloop, kink-turn, sarcin-ricin and tandem-sheared motifs.

283 Kink turns (k-turns) are widespread elements in RNA that

284 Kink turns (k-turns) are widespread structural elements

285 Kink turns are widely occurring motifs in RNA, located i

286 equence and distinct secondary structures of kink-turns (k-turn) suggest computational folding rules

287 These results support the presence of two kink-turns, the structural motifs recognized by L7Ae, in

288 N-terminus and (B) to the lack of a helical kink upon ligand binding.

289 There, collagen denaturation within the kinks was concentrated within certain subfibrils.

290 t (f-I) curves that exhibit a suitably sized kink where the slope of the curve decreases more abruptl

291 ween these two processes can account for the kinks which we observe in our and others' experimental d

292 phipathic alpha helices separated by a rigid kink, which prevents intramolecular association and pres

293 The kink, which reduces the tilt of the C-terminal helical d

294 hape, with proline or serine residues at the kinks, which functions as a lever-arm, coupling the subs

295 thus prevent the reverse reaction, the sharp kink with RAG is 1 bp away from the integration site.

296 t: Fz7(-/-) mice exhibit tail truncation and kinking with 100% penetrance and ventricular septal defe

297 e kinks, and (iv) the extreme sensitivity of kinking with respect to weak perturbations, such as cage

298 These growth directions can change at kinks with no observable crystallographic defect.

299 s into the active site cleft imposes a sharp kink within the central GlcNS-GlcA/IdoA-GlcNS trisacchar

300 at bending strain can localize hyperflexible kinks within the DNA template, which in turn reduces the