ライフサイエンスコーパス: knock-out mice

1 idea in a more definitive way using genetic knock out mice.

2 -immunity, we generated T-cell-specific Atg5 knock-out mice.

3 on of these molecules was observed in ERK1/2 knock-out mice.

4 hibition of HDAC6 reduced cyst growth in PC1-knock-out mice.

5 lammasome in wild-type mice but not in SIRT3 knock-out mice.

6 ence in survival between wild-type and PRMT1 knock-out mice.

7 notype was similarly severe in each of these knock-out mice.

8 onset of learning in both FX and conditional knock-out mice.

9 F-NB1 was validated in wild-type and sigma1R knock-out mice.

10 , Rag2(-/-), and Rag2(-/-)xParp1(-/-) double knock-out mice.

11 rent was lacking in DGGCs from delta-subunit knock-out mice.

12 estine-specific and liver-specificLpcat3gene knock-out mice.

13 to lysosomes, we generated GAA/Stbd1 double knock-out mice.

14 AR by using a set of specific inhibitors and knock-out mice.

15 in Trpv4 keratinocyte-specific and inducible knock-out mice.

16 Recovery was also delayed in IL-10 knock-out mice.

17 ced direct propriospinal excitation in EphA4 knock-out mice.

18 ed with conventional (whole body) Coronin 1a knock-out mice.

19 and apoA-IV expression in liver-specific MTP knock-out mice.

20 inimal radiotracer uptake was present in sEH knock-out mice.

21 vesicles after depletion recover normally in knock-out mice.

22 sent from hippocampal slices of CB2 receptor knock-out mice.

23 expression were also increased in the double knock-out mice.

24 expressed at high levels in testes from Mtdh knock-out mice.

25 ne expression were markedly reduced in these knock-out mice.

26 igomerization-deficient mutant in arrestin-1 knock-out mice.

27 not Fcgamma-receptor or neonatal Fc-receptor knock-out mice.

28 evealed significant CST regeneration in NgR1 knock-out mice.

29 ers from wild-type mice but not in p47(phox) knock-out mice.

30 reported to exert its effect also in PKMzeta knock-out mice.

31 on with small inhibitory RNA, and cells from knock-out mice.

32 vascular permeability/inflammation in sdc-1 knock-out mice.

33 in neurons cultured from mu-opioid receptor knock-out mice.

34 gene to produce the first conditional EAAT2 knock-out mice.

35 ferator-activated receptor alpha (PPARalpha) knock-out mice.

36 pocampal neurons and brain tissue from Fbxo2 knock-out mice.

37 ChR agonist), and was absent in alpha7 nAChR knock-out mice.

38 re potentiated by VU0238429 and absent in M5 knock-out mice.

39 n erythrocytes from pannexin 1 wild type and knock-out mice.

40 in lung was subsequently studied using LCAD knock-out mice.

41 using conditional, tamoxifen-inducible Hif1a knock-out mice.

42 er, most studies were performed using single knock-out mice.

43 characteristics in adult male, GnRH receptor knock-out mice.

44 e able to protect neurons derived from HDAC8 knock-out mice.

45 D in the CA1 hippocampus of Grf1/Grf2 double knock-out mice.

46 n levels were decreased in livers from KLF14 knock-out mice.

47 n a variety of tissues and ubqln conditional knock-out mice.

48 nd memory, in contrast with heterozygous NGF knock-out mice.

49 ontrol experiments showed no labeling of TG2 knock-out mice.

50 ce neutrophil apoptosis was impaired in AnxA-knock-out mice.

51 triggered a vigorous immune response in ZnT8 knock-out mice.

52 tes to the infection susceptibility in PRMT1 knock-out mice.

53 erebellum internal feedback pathway in EphA4 knock-out mice.

54 Cdc42, we generated myeloid-restricted Cdc42 knock-out mice.

55 ct against cholesterol lipotoxicity in Sort1 knock-out mice.

56 that have previously been reported in VGLUT3 knock-out mice.

57 manifestations of EAE disappeared in miR-142 knock-out mice.

58 at the organism level, we generated Slc30a10 knock-out mice.

59 wild-type and Ca(v)3.1(-/-); 3.2(-/-) double knock-out mice.

60 nutrient deprivation in wild-type and SIRT3 knock-out mice.

61 d spread of labels were greater in alphaENaC knock-out mice.

62 Here, we tested this hypothesis using triple-knock-out mice.

63 ocampal-dependent memory in male conditional knock-out mice.

64 BLT1 and TRPV1 as shown using the respective knock-out mice.

65 sh mutants, and photoreceptor-specific Exoc5 knock-out mice.

66 ake values wild-type versus apolipoprotein E knock out mice, 0.05 +/- 0.01 versus 0.17 +/- 0.01, P<0.

67 uced microglia counts in the brains of MECP2 knock-out mice; (2) proliferation of mitochondria and en

68 fferentiated from neural progenitors of Fmr1 knock-out mice, a mouse model for FXS, and that tPA is i

69 Prx2 was detected in erythrocytes from Grx1 knock-out mice after peroxide challenge.

70 Using both transgenic and knock-out mice along with in vitro assays, our data show

71 6Ala-Gpx4(+/-)) and crossed them with Alox15 knock-out mice (Alox15(-/-)).

72 Tau was required, as crossing with tau knock-out mice also prevented both Kv4.2 depletion and d

73 The knock-out mice also show decrease in both basal and xeno

74 Fmr1 knock-out mice also show reduced functional connectivity

75 ng of ryanodine receptors using synaptopodin-knock-out mice ameliorates AD symptoms at the behavioral

76 Using these vectors, we vaccinated STAT-1 knock-out mice, an animal model for CCHFV.

77 ges isolated from myeloid cell-specific LKB1 knock out mice and their wild type littermate control mi

78 m stellate cells in triple NL123 conditional knock-out mice and analyzed synaptic responses by acute

79 radiopharmaceutical, was evaluated in alpha4 knock-out mice and by competitive blocking in wild-type

80 Recently, we generated Ada3 knock-out mice and demonstrated that deletion of Ada3 le

81 the physiologic/metabolic profile of cavin-1 knock-out mice and determined that they were lean becaus

82 in microtubule assembly and bundling, using knock-out mice and expression of WT and mutant Dcx in no

83 t using either specific inhibitors or PDE10A knock-out mice and has been suggested as a promising tar

84 thionine biosynthesis by constructing LanCL1 knock-out mice and measuring LK concentrations in their

85 ondria of alpha-, beta-, and gamma-synuclein knock-out mice and monomeric alpha-synuclein, this curre

86 t the late stage of membrane fusion in Ophn1 knock-out mice and OPHN1-silenced bovine chromaffin cell

87 ding specificity was assayed in CD-1 and sEH knock-out mice and Papio anubis (baboon) through pretrea

88 Using knock-out mice and primary brain cells, we connect a key

89 ells of Cplx3/4 wild-type and Cplx3/4 double knock-out mice and quantified synaptic vesicle number at

90 -200 was decreased in kidneys from HNF-1beta knock-out mice and renal epithelial cells expressing dom

91 In the present study we generated IP6K3 knock-out mice and show that IP6K3 is highly expressed i

92 nfirm recent data obtained in the hypocretin knock-out mice and suggest that the absence of hypothala

93 ype previously reported in alphaB-crystallin knock-out mice and suggests that the elevated chaperone

94 ct on somatic inhibition was absent in TRPV1 knock-out mice and was also eliminated by two different

95 ssed and compared with responses in p75(NTR) knock-out mice and wild-type animals.

96 of spinal and supraspinal A3AR, lost in A3AR knock-out mice, and independent of opioid and endocannab

97 ralgesia, an effect that was absent in TRPV1 knock-out mice, and was blocked by the TRPV1 antagonist

98 gnificantly down-regulated in NSPCs from APP knock-out mice (APPKO) and increased in APP transgenic (

99 recordings from hippocampal neurons of KCTD knock-out mice are consistent with these findings and in

100 at the phenotypical changes in collagen XIII knock-out mice are milder than symptoms in human patient

101 s, several neurological phenotypes of R7-RGS knock-out mice are not readily explained by dysregulated

102 Furthermore, adipose-specific Dnmt3a knock-out mice are protected from diet-induced insulin r

103 Although separase is essential, securin knock-out mice are surprisingly viable and fertile.

104 ondria of alpha-, beta-, and gamma-synuclein knock-out mice are uncoupled, as characterized by increa

105 Homozygous Mtdh knock-out mice are viable, but males are infertile.

106 nese-induced disease and identifies Slc30a10 knock-out mice as a new model for studying thyroid biolo

107 d expression of piRNAs in the testes of Mtdh knock-out mice as compared with wild type mice.

108 This project identified Fam151b homozygous knock-out mice as having retinal degeneration.

109 sosomal glycogen content to the level of GAA knock-out mice, as did a mutant lacking the Atg8 family

110 ogenesis were downregulated in the testes of knock-out mice, as well as Hsd17b3, which encodes a key

111 LTD was absent in CB1 knock-out mice but preserved in heterozygous littermates

112 erations in dendritic spine density in Fbxo2 knock-out mice, but result instead in increased axo-dend

113 In Capn3 knock-out mice (C3KO), Ca(2+) release and Ca(2+)/calmodu

114 Exercise of 3-month-old laforin knock-out mice caused a similar depletion of glycogen bu

115 of RLC phosphorylation in conditional cMLCK knock-out mice caused cardiac dilation and loss of cardi

116 occurs in rod arrestin and rhodopsin kinase knock-out mice, caused a rapid and specific induction of

117 CBE1DeltaCollagen mice fully phenocopy CCBE1 knock-out mice, CCBE1DeltaEGF knock-in embryos still for

118 is enhanced in the muscle and liver of Sco2 knock-out mice, clearly suggesting that cell death is a

119 In GluN3A knock-out mice, cocaine did not alter SK channel functio

120 ST were up to 2.7 times greater in alphaENaC knock-out mice compared with the respective field volume

121 protocol, LID severity was decreased in Narp knock-out mice compared with their wild-type littermates

122 ession and protein levels in bone from Sirt1 knock-out mice compared with wild type mice.

123 ests, glucose disposal was enhanced in SIRT2 knock-out mice, compared with wild type controls, withou

124 In Rarb(-/-) knock-out mice, concomitant reduction of Gad65, dopamine

125 mma-H2AX in spermatocytes of homozygous Mtdh knock-out mice confirms an increase in unrepaired DNA br

126 hibited adipose tissue expansion observed in knock-out mice correlated with lower expression of genes

127 s or a control vector into the CeA of orexin knock-out mice crossed with vGAT-Cre mice, resulting in

128 In Cx26 conditional knock-out mice (Cx26(Sox10-Cre)), the maturation of IHCs

129 t-specific protein-1 driven conditional Cx43 knock-out mice (Cx43fsp1KO).

130 e hypermethylation in the brain, we used Ddo knock-out mice (Ddo(-/-)), which show constitutively sup

131 We showed that myeloid-specific PRMT1 knock-out mice demonstrate higher proinflammatory cytoki

132 e experiments on kisspeptin-specific ERalpha knock-out mice demonstrate that ERalpha in kisspeptin ce

133 Analyses of Tulp1 knock-out mice demonstrate that Tulp1 is essential to ke

134 Selective antagonists and neurons from knock-out mice demonstrated a BLT1-dependent sensitizati

135 -derived macrophages from wild-type and GILZ knock-out mice demonstrated that curcumin inhibits the a

136 ped similarly in wild-type, GluK1, and GluK2 knock-out mice, demonstrating that GluK1 kainate recepto

137 Conditional DCC knock-out mice develop balance and coordination deficits

138 ely 800-1000-fold), indicating that Slc30a10 knock-out mice develop hypothyroidism.

139 uPA-knock-out mice developed fewer and smaller TSC2-null lun

140 demonstrated that knockdown of Stbd1 in GAA knock-out mice did not alter lysosomal glycogen storage

141 The Dlx1/Dlx2 double knock-out mice die at birth with abnormal cortical devel

142 The protein is essential for development as knock-out mice die in utero due to placental defects cau

143 In dectin-1-null mutant (knock-out) mice, dieback of corticospinal tract axons al

144 Ric-8b conditional knock-out mice display impaired olfactory guided behavio

145 We found that EphA4 knock-out (-/-) mice displayed impaired goal-directed re

146 es CerS3 activity, whereas cytosol from ACBP knock-out mice does not.

147 Cys(259) were identical to those of p75(NTR) knock-out mice even though the Cys(259) mutant differed

148 In vivo, EC-specific ATG7 knock-out mice exhibit a basal reduction in endothelial-

149 Pcmt1 knock-out mice exhibit a profound neuropathology and die

150 avioral analyses show that PRMT8 conditional knock-out mice exhibit impaired hippocampal-dependent fe

151 hearing in young adult mice, IHCs from Cx30 knock-out mice exhibited a comprehensive brake in their

152 OEBFs prepared from OPG-knock-out mice exhibited a similar effect, indicating OP

153 Cell culture and knock-out mice experiments demonstrated that M1 muscarin

154 Pcsk9 knock-out mice expressing a human bacterial artificial c

155 Axons that reach the GP in Frizzled3 knock-out mice fail to enter this structure.

156 ozotocin administration, the retina of REDD1 knock-out mice failed to do so.

157 r, after weaning and compared with controls, knock-out mice failed to gain weight, were smaller, and

158 L-6, IL-1beta, and ccl5 in the skin of IFNAR knock out mice following subcutaneous administration.

159 (PcTx1) and the absence of these currents in knock-out mice for ASIC-1a subunit (ASIC1a(-/-)) suggest

160 We generated knock-out mice for ELKS1 and found that its constitutive

161 c1, we analyzed bones from OB-specific BMP-2 knock-out mice for NFATc1 expression by immunohistochemi

162 rated inducible and skeletal muscle-specific knock-out mice for Rheb (iRhebKO) and TSC2 (iTSC2KO) and

163 both inducible and skeletal muscle-specific knock-out mice for Rheb and iTSC2KO mice.

164 Unfortunately, the available P2RX7 knock-out mice generated by pharmaceutical companies pos

165 ysis of the retinal microvasculature in ORP2 knock-out mice generated during this study demonstrates

166 In fasted double knock-out mice, glycogen accumulation in skeletal and ca

167 We used male and female heterozygous Gnal knock-out mice (Gnal(+/-)) to study how GNAL haplodefici

168 Here we show that thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after bi

169 Similarly, knock-out mice had delayed leptin resistance development

170 lowing AKAP siRNA transfection and from AKAP-knock-out mice had less PKA activity, GRK2 Ser-685 phosp

171 PTH2R knock-out mice had significantly reduced c-Fos activatio

172 uring the CP, but not the pre-CP or in GAD65 knock-out mice, had larger synapses and increased docked

173 required for endogenous CPC response as Pin1 knock-out mice have a reduced number of proliferating CP

174 ndings are complicated by the fact that ApoE knock-out mice have highly elevated plasma lipid levels,

175 VGF knock-out mice have impaired fear and spatial memory.

176 Caspase-3 knock-out mice have increased spine density and altered

177 Although Cdkl5 constitutive knock-out mice have recapitulated key aspects of human s

178 Studies analyzing complete Coronin 1a knock-out mice have shown that this molecule is an impor

179 nducible astrocyte-specific Fmr1 conditional knock-out mice (i-astro-Fmr1-cKO) and restoration mice (

180 Using conditional knock-out mice in which Bcl-xL is deleted in neural prog

181 In apolipoprotein E knock out mice, increased (18)F-FLT signal was observed

182 r studies performed on P2X7 or P2Y2 receptor knock-out mice indicate P2Y2 receptors are involved in t

183 ease was similar in wild-type and kisspeptin knock-out mice indicating that this release is independe

184 er did not increase the infarct size of Rag1 knock-out mice, indicating antigen-dependent activation

185 and by 60% at 13 months as compared with GAA knock-out mice, indicating that the transport of glycoge

186 on of YAP rescues cardiac defects in Xinbeta knock-out mice-indicating a functional and genetic inter

187 rferon-gamma knock-out but not from perforin knock-out mice induced neuronal cell death in vitro.

188 from perforin knock-out or interferon-gamma knock-out mice into Rag1 knock-out mice revealed that CT

189 Accordingly, the neuroretina of PrP-knock-out mice is iron-deficient.

190 s in R1a subunit expression are seen in Fmr1 knock-out mice (KO) mice, a widely used animal model of

191 SMCs derived from LPA receptor 1 (LPA1) knock-out mice lack the ability of Cyr61 induction and c

192 yltransferase (LCAT) and LDL receptor double knock-out mice (Ldlr(-/-)xLcat(-/-) or DKO) spontaneousl

193 combinant TRX in wild-type mice, but not TG2 knock-out mice, led to a rapid rise in intestinal transg

194 In studies with both alpha6 integrin knock-out mice lenses and primary lens cell cultures fol

195 al cerebral ischemia we used TNF conditional knock out mice (LysMcreTNF(fl/fl)) in which the TNF gene

196 ng eosinophil-derived granule protein double knock-out mice (major basic protein-1/eosinophil peroxid

197 In vivo, cerebella in Mef2d knock-out mice manifest increased susceptibility to DNA

198 d adducin whose altered disposition in IP6K3 knock-out mice may mediate phenotypic features of the mu

199 In Frizzled3 knock-out mice, MSN axons fail to extend along the anter

200 20 controls in normal sinus rythm) and nNos-knock-out mice (n=28 compared with 27 wild-type litterma

201 Improvements in myelin regeneration in PAR1 knock-out mice occurred in tandem with a skewing of reac

202 rom compound-transgenic wild-type and Chrna5 knock-out mice of both sexes.

203 We found that olfactory-specific Ric-8b knock-out mice of mixed sex do not express the Galphaolf

204 Using a combination of PAR1 knock-out mice, oligodendrocyte monocultures and oligode

205 induced in almost all neuron-specific SOCS3 knock-out mice on this diet.

206 toxin receptor signaling were analyzed using knock-out mice or specific inhibitors.

207 Dorsal root ganglia in Zfp36l2 knock-out mice, or wild-type ganglia expressing ZFP36L2

208 ressed with fluorouracil in apolipoprotein E knock out mice (P<0.05).

209 rior low gradient in the striatum, and Wnt5a knock-out mice phenocopy striatal anterior-posterior def

210 cardiac fibroblasts isolated from PI3Kgamma knock-out mice (PI3KgammaKO) showed decreased insulin-st

211 for the PON1 human transgene [PON1Tg], PON1 knock-out mice [PON1KO], and wild type littermate contro

212 tive deletion of BLA KORs in KOR conditional knock-out mice prevented foot-shock-induced CPP reinstat

213 by using anti-murine Abeta antibodies or APP knock-out mice, prevents the cGMP-dependent enhancement

214 Adiponectin knock-out mice receiving dextran sulfate sodium exhibite

215 ongly suggest that the hearing loss of BACE1 knock-out mice represents a developmental phenotype.SIGN

216 Given that the receptor double knock-out mice resemble reeler mutants, we infer that Re

217 xogenous expression of human Stbd1 in double knock-out mice restored the liver lysosomal glycogen con

218 preoptic nucleus of fever-refractive mPGES-1 knock-out mice, resulted in a temperature elevation in r

219 of the vertebrate P3H family, P3h3 and Sc65 knock-out mice revealed a common lysine under-hydroxylat

220 in the corneal surface of Piezo2 conditional knock-out mice revealed a reduced number of mechano-sens

221 or interferon-gamma knock-out mice into Rag1 knock-out mice revealed that CTL neurotoxicity was media

222 r earlier findings with retina-specific Rce1 knock-out mice, rod PDE6 in Icmt-deficient mice traffick

223 In NG2 knock-out mice, sensory axons in the dorsal columns dieb

224 Romk knock-out mice show a similar phenotype to Bartter syndr

225 ts showed that the olfactory-specific Ric-8b knock-out mice show an impaired sense of smell, even tho

226 Furthermore, we report that aged APLP1 knock-out mice show impaired basal transmission and a re

227 Similarly, alpha-synuclein knock-out mice show increased neuronal DSBs that can be

228 miR-155 knock-out mice show reversal of LPS-induced neurogenic d

229 Among other phenotypical differences, knock-out mice showed a significantly impaired glucose t

230 GECs from iPLA2gamma knock-out mice showed blunted ATF6 activation and chaper

231 Castration of conditional Pten knock-out mice showed increased Akt, phosphorylated Akt,

232 holesterol atherogenic diet-challenged Sort1 knock-out mice showed less hepatic free cholesterol accu

233 of cultured neurons from wild-type and SUMO1 knock-out mice showed that anti-SUMO1 immunolabelling at

234 sma analyses of single-proprotein convertase-knock-out mice showed that loss of the convertase furin

235 Conversely, cochleae from Sema5b knock-out mice showed type I SGNs with more numerous, bu

236 was observed in Neto1, but not Neto2, single knock-out mice, specifically implicating Neto1 in regula

237 sensitivity was not evident in delta-subunit knock-out mice subjected to a similar withdrawal paradig

238 mbryonic, postnatal, and adult brain of Fmr1 knock-out mice suggest an important role for tPA in the

239 yte-specific furin, PC5/6, or complete PACE4 knock-out mice suggested that the cleavage of overexpres

240 ype mice, the depression was slower in cpg15 knock-out mice, suggesting impairment in short-term depr

241 aptophysin expression were abolished in Apoe-knock-out mice, suggesting the importance of daidzein-in

242 ene is unknown, embryonic lethality in Mrpl3 knock-out mice suggests it is critical for early develop

243 We used novel trypsinogen-7 knock-out mice (T(-/-)), which lack intra-acinar trypsin

244 ound a lower generation of DYT1 knock-in/p58 knock-out mice than expected from this cross, suggesting

245 not gain rate, remains higher in adult Lynx1 knock-out mice than in control wild-type mice, revealing

246 Furthermore, knock-out mice that lack PLK2 (the predominant kinase th

247 Generation of knock-out mice that lacked PEMT showed that they were pr

248 amined Leydig cell-specific TSPO conditional knock-out mice that suggested TSPO was not required for

249 In astrocyte-specific Cx43 knock-out mice the magnitude of heart rate responses to

250 In beta2-microglobulin knock out mice, the D76N beta2-microglobulin/ Nb24 pre-f

251 rrel cortex activity in young and adult Fmr1 knock-out mice, the mouse model of fragile X syndrome (F

252 In Exoc5 photoreceptor-specific knock-out mice, the photoreceptor outer segment structur

253 Taking advantage of the conditional Oxtr knock-out mice, the present study highlights the importa

254 in the corpus callosum and cortex of Cav1.2 knock-out mice through demyelination.

255 generated ERK1 and conditional ERK2 compound knock-out mice to determine the role of ERK signaling du

256 We then use conditional knock-out mice to eliminate FMRP only in the PFC alone o

257 We used neuron-specific SOCS3 knock-out mice to elucidate this and the effects on regi

258 exposed to O3 Additionally, exposure of LXR knock-out mice to O3 enhanced pro-inflammatory cytokine

259 logical roles of the PRLs, we generated PRL2 knock-out mice to study the effects of PRL deletion in a

260 d potent inhibitors of PI4KA and conditional knock-out mice to study the importance of this enzyme in

261 fied mice (germline Npy, Y1, and Y2 receptor knock-out mice) to assess pulsatile GH secretion under b

262 We then used VU0238429, along with M5 knock-out mice, to elucidate the role of this receptor i

263 In contrast to the knock-out mice, transgenic mice overexpressing a human m

264 reducing lysosomal storage in the CNS of ASA-knock-out mice treated by ERT.

265 ssion, but prior microarray studies in Mecp2 knock-out mice using brain tissue homogenates have revea

266 Here, we produced Dgcr8 conditional knock-out mice using progesterone receptor (PR)-Cre (Dgc

267 itotic forebrain-specific Cited2 conditional knock-out mice, using the Emx1-Cre and NEX-Cre mouse lin

268 uncover these mechanisms, we generated Mtdh knock-out mice via a targeted disruption of exon 3.

269 Paradoxically, excitability in kisspeptin knock-out mice was similar to the maximum observed in co

270 hippocampal cultures from Arp2/3 conditional knock-out mice, we analyze the roles of the Arp2/3 compl

271 as wild-type and dopamine transporter (DAT) knock-out mice, we demonstrate that dopamine uptake thro

272 rocessing in cellular models and in specific knock-out mice, we demonstrate that the membrane-bound s

273 Using transfected cells and knock-out mice, we demonstrated that R7-binding protein

274 Furthermore, using knock-out mice, we determined that the zeta isoform of D

275 Using conditional Gdnf knock-out mice, we found that endogenous GDNF affects st

276 ased models and F-box Only Protein 2 (Fbxo2) knock-out mice, we found that the ubiquitin ligase subst

277 NS-1 beta-cells and beta-cell-specific Txnip knock-out mice, we now found that TXNIP regulates IAPP e

278 Here, using conditional knock-out mice, we show that hippocampal-dependent learn

279 Using connexin knock-out mice, we show that IHCs fire spontaneous actio

280 Using muscle-specific PGC-1alpha knock-out mice, we show that PGC-1alpha is necessary for

281 By using Piezo2 conditional knock-out mice, we show that Piezo2 channels, present in

282 By using SCF conditionally knocked out mice, we demonstrated that keratinocytes' au

283 selective inhibitor TP-10, and global PDE10A knock out mice were used.

284 n 1a Furthermore, T cell-specific Coronin 1a knock-out mice were largely resistant to the induction o

285 Adiponectin knock-out mice were orally administered dextran sulfate

286 ected, male and female neuron-specific SOCS3 knock-out mice were protected from HCD-induced obesity.

287 The knock-out mice were resistant to diet-induced obesity an

288 Immunodeficient RAG2 knock-out mice were unable to control infection with TDP

289 AR potentials in slices from serine racemase knock-out mice, which are devoid of D-serine, indicating

290 stin expression through use of the SOST gene knock-out mice, which are resistant to Pb-induced trabec

291 f water and electrolytes was higher in VAMP3 knock-out mice, which produced more diluted urine.

292 Here, we subjected knock-out mice, which suffer from impaired intrinsic pla

293 t, will become a bilateral movement in EphA4 knock-out mice with a bilateral CST.

294 We have generated Thap1 knock-out mice with a view to understanding its transcri

295 Daily treatment of adult male fmr1 C57Bl6 knock-out mice with BPN14770 for 14 days reduced hyperar

296 Finally, we crossed EP3R conditional knock-out mice with either VGluT2-IRES-cre or Vgat-IRES-

297 Knock-out mice without functional mGluR5 exhibit severe

298 in prion diseases, we tested whether mGlur5 knock-out mice would be susceptible to prion infection.

299 from both wild type (WT) and Bax/Bak double knock-out mice (WT MEF and DKO MEF that were responsive

300 in both constitutive and conditional PKMzeta knock-out mice, yet both are still impaired by ZIP appli