ライフサイエンスコーパス: knuckle

1 d significantly on the cut type (e.g. ham vs knuckle).

2 tead of the target EbaaagbE turn (rubredoxin knuckle).

3 d also packs against the amino-terminal zinc knuckle.

4 between the RNA binding domain and the zinc knuckle.

5 pants grasped objects or touched them with a knuckle.

6 teine-rich region, predicted to fold as a Zn knuckle.

7 rmed the finger, beta-ball, thumb, palm, and knuckle.

8 re-specific binding by NC's single CCHC zinc knuckle.

9 he hand or wrist, rather than the fingers or knuckle.

10 c finger proteins containing rubredoxin-like knuckles.

11 t and third loops, which form two rubredoxin knuckles.

12 CSD) and a pair of retroviral-type CCHC zinc knuckles.

13 f object shape were similar for grasping and knuckling.

14 These include the Mtr4 Arch and Air2 zinc knuckles 1, 2, and 3.

15 ffset by increased tRNA binding on Air2 zinc knuckles 2 and 3.

16 ins share a unique structure, with both zinc knuckle and cold shock RNA-binding domains, and were ori

17 eir side chains toward the space between the knuckle and finger domains.

18 A8 packs against the amino-terminal knuckle and forms a hydrogen bond with conserved Arg32,

19 ) helix that packs against the proximal zinc knuckle and interacts with the RNA stem.

20 (iii) Regions containing zinc knuckle and major homology region motifs, characteristic

21 at mnm encodes a conserved protein with zinc knuckle and RING finger domains.

22 The knuckle and the first turn of the helix each incorporate

23 Surprisingly, both the zinc knuckle and the RING finger are needed for RNA-binding a

24 that the linker regions between the two zinc knuckles and between the N-terminal RNA binding domains

25 e1 are a ubiquitin-like (UBL) domain, a zinc knuckle, and a RING finger domain characteristic of some

26 ins (KH and QUA2 domains) and the first zinc knuckle are important for binding to RNA.

27 rms of a more compact structure in which the knuckles are in close proximity.

28 The first and third knuckles are invariant, but the second shows some differ

29 ional correlation times, indicating that the knuckles are not tumbling as a single globular domain.

30 ef aroma over time when steaks from pre-aged knuckles are stored in retail display under high oxygen

31 milar, two of the studies indicated that the knuckles behave as independently folded, non-interacting

32 Both the human and Xenopus Zn knuckles bind to a variety of nucleic acid substrates, w

33 mily; N=A,U,G or C), and the C-terminal zinc knuckle binds to residues that flank SL-A, including res

34 he zinc ion resembles that of the rubredoxin-knuckle, but there are significant differences in hydrog

35 taining major homology region (MHR) and zinc knuckle (CCHC) motifs, separated by a pre_C2HC motif (mo

36 t CLP's C-terminus, containing two CCHC zinc knuckles, confers a binding preference for RNAs that con

37 erozygous loss of function of ZCCHC8, a zinc-knuckle containing protein, as a cause of autosomal domi

38 The N and C-terminal "zinc knuckles" (Cys-X(2)-Cys-X(4)-His-X(4)-Cys; X=variable am

39 ve orientations of the N and C-terminal zinc knuckles differ in the NC-SL2 and NC-SL3 complexes, and

40 This suggests that one finger-knuckle disulfide bond (E235C/K393C) sets the channel in

41 N relaxation data indicate that the two zinc knuckles do not interact with each other, but instead be

42 that multiple residues in the alpha subunit knuckle domain contribute to the mechanism of Na(+) self

43 Deletion of the peripheral knuckle domain of the alpha subunit in the alphabetagamm

44 tematically mutated individual alpha subunit knuckle domain residues and assessed functional properti

45 ites within either the beta or gamma subunit knuckle domain resulted in little or no change in Na(+)

46 deletion of either the beta or gamma subunit knuckle domain within the alphabetagamma trimer dramatic

47 oney murine leukemia virus nucleocapsid zinc knuckle domain.

48 though the structures of the individual zinc knuckle domains are similar, two of the studies indicate

49 nclusion that structural features of NC zinc knuckle domains can vary significantly among the differe

50 ry, glycosylated asparagines in the palm and knuckle domains of alphaENaC are important for SF sensin

51 ly their N-glycans localized in the palm and knuckle domains of alphaENaC, were identified as potenti

52 Binding is mediated by the two zinc knuckle domains of NC.

53 relaxation studies reveal that the two zinc knuckle domains possess different effective rotational c

54 sid protein (NC) contains two CCHC-type zinc knuckle domains that are essential for genome recognitio

55 with weakly interacting and non-interacting knuckle domains.

56 BMPRII binds BMP10 at the knuckle epitope, with the A-loop and beta4 strand making

57 onniere injuries, jersey finger, and boxer's knuckle), flexor pulley injuries, and skier's thumb, sho

58 r cysteines, is a distant member of the "gag-knuckle fold group" of Zn2+-binding domains and appears

59 pus fragment indeed assumes the canonical Zn knuckle fold, whereas the human sequence remains unstruc

60 The proximal zinc knuckle folds in a manner that is essentially identical

61 ell as a movement of Glu-235 relative to the knuckle helix.

62 olvement of the second highly conserved zinc knuckle in RNA binding suggests that this zinc knuckle p

63 present data supporting a role for this zinc knuckle in RNA binding.

64 The N-terminal knuckle interacts with a conserved U(217)GCG tetraloop (

65 In particular, the N-terminal zinc knuckle interacts with an A-U-A base triple platform in

66 main (CSD) and two C-terminal CCHC-type zinc knuckles interspersed with glycine-rich regions.

67 ue extra C-terminal domain containing a zinc knuckle-like motif containing 4 cysteines.

68 the central zinc ion and consists of a zinc knuckle, loop, beta-hairpin and an alpha-helix.

69 in particular sequences encompassing a zinc knuckle motif near its N terminus, modulate Trf4p activi

70 nding occurs through a highly conserved zinc-knuckle motif present in NC.

71 rved zinc-coordinating "CCHC array" or "zinc knuckle" motif common to the nucleocapsid proteins of ne

72 l Pol beta RNA polymerases, and the two zinc knuckle motifs of Air2p interact with the Trf4p central

73 with a fragment of Air2p comprising two zinc knuckle motifs.

74 s indicate that both the finger loop and the knuckle move away from the beta-ball residue Trp-233 dur

75 Chunks of knuckle muscle from pork and beef as well as of breast m

76 , including the Incoming Nucleotide Binding, Knuckles, NNRTI Adjacent, and 399 sites, located in the

77 Three of these sites (Knuckles, NNRTI Adjacent, and Incoming Nucleotide Bindin

78 either one of two different residues of the knuckle of a neighboring subunit opens the channel at ph

79 However, the distal zinc knuckle of MMTV NC exhibits a rare three-dimensional fol

80 ure was observed recently in the distal zinc knuckle of the Mason-Pfizer monkey virus nucleocapsid pr

81 The zinc knuckles of BBP are partially responsible for the enhanc

82 ains of capsid, and the N- and C-terminal Zn knuckles of nucleocapsid) have the same structures as th

83 ns of capsid, and the N- and C-terminal zinc knuckles of nucleocapsid) retain their fold and reorient

84 ect non-LTR retrotransposons with three zinc knuckles of the form: (1) CX2CX4HX4C, (2) CX2CX3HX4C, (3

85 to that observed previously for the two zinc knuckles of the human immunodeficiency virus type 1 nucl

86 amino- and carboxyl-terminal CCHC-type zinc knuckles of the NC protein and the G7 and G9 nucleotide

87 as follows: (1) touching the object with the knuckles of the right hand; (2) grasping the object with

88 T four-helix bundle contacts the hydrophobic knuckles of Vps36-NZF-N.

89 ural hearing loss, palmoplantar keratoderma, knuckle pads, and leukonychia, which show considerable p

90 ia, acral punctate keratoses, cheilitis, and knuckle pads, which we propose to be given the acronym P

91 the 1H NMR chemical shifts of isolated zinc knuckle peptides are very similar to those of the intact

92 An AF10 region consisting of a PHD finger-Zn knuckle-PHD finger (PZP) folds into a single module that

93 uckle in RNA binding suggests that this zinc knuckle plays a different role in RNA processing than en

94 QTL, LIGHT5, was identified as a tandem zinc knuckle/PLU3 domain encoding gene (At5g43630; TZP), whic

95 splicing factor because they contain a zinc knuckle, precipitate with 65% ammonium sulfate, and cros

96 ontains the poly(A) polymerase Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p.

97 taining the poly(A) polymerase Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p.

98 CCTG expansion in the gene encoding the zinc knuckle protein CNBP causes a common form of muscular dy

99 nucleotidyl transferases, Trf4p, and a zinc knuckle protein, Air2p, mediates initial substrate recog

100 r4p; a poly(A) polymerase, Trf4p; and a zinc knuckle protein, Air2p.

101 e walking and support themselves on the hind knuckles, rather than the soles.

102 gly, a previously published peptide from the knuckle region of BMP9 was found to inhibit BMP4-induced

103 Similarity is most striking in the zinc knuckle region, a region characteristic of gag genes of

104 domain and fix the orientation of the two Zn knuckles relative to one another so that the nucleocapsi

105 mmunostaining of Cx26 in lesional palmar and knuckle skin was weak or absent, although its adnexal ex

106 effect of a segment located upstream the Zn knuckle that is highly conserved and rich in positively

107 robably in parallel with the known AG target KNUCKLES to terminate floral stem cell fate.

108 weight being relevant for grasping, not for "knuckling." Using multivariate analysis showed that repr

109 ks; 3, movements in hind limbs but unable to knuckle walk; 4, no movement, drags hind limbs.

110 lized for suspension, vertical climbing, and knuckle-walking among extant African apes.

111 human bipedalism evolved from a terrestrial knuckle-walking ancestor or from a more generalized, arb

112 uggests that bipedal hominids evolved from a knuckle-walking ancestor that was already partly terrest

113 differs from that of later hominids and non-knuckle-walking anthropoid primates, suggesting that knu

114 e these data to test the hypothesis that all knuckle-walking apes share similar anatomical features a

115 probably retained from an LCA that exhibited knuckle-walking as part of its locomotor repertoire and

116 ectations, features long-assumed to indicate knuckle-walking behavior are not found in all African ap

117 ent simulations of the hominoid wrist during knuckle-walking by virtually generating fused and unfuse

118 flexible forelimb while terrestrial fist or knuckle-walking demands more rigidity of the hand and wr

119 amined variation or development of purported knuckle-walking features in apes or other primates, data

120 The presence of purported knuckle-walking features in the hominin wrist can thus b

121 on the frequency and development of putative knuckle-walking features of the wrist in apes and monkey

122 ngly suggest that the ancestor of man used a knuckle-walking form of locomotion prior to becoming bip

123 Proponents of the knuckle-walking hypothesis focused on the wrist and hand

124 walking anthropoid primates, suggesting that knuckle-walking is a derived feature of the African ape

125 An African great-ape-like ancestor using knuckle-walking is still the most parsimonious hypothesi

126 vertical climbing, forelimb suspension, and knuckle-walking that are seen in extant African apes.

127 ighly derived suspension, vertical climbing, knuckle-walking, and facultative bipedality of extant Af

128 ermits variation of locomotion: brachiation, knuckle-walking, etc., minor variations in structure det

129 specialized wrist morphology associated with knuckle-walking.

130 vements, increased pronation/supination, and knuckle-walking.

131 or the fusion as a functional adaptation for knuckle-walking.

132 ale better withstands the loads derived from knuckle-walking.

133 typical of suspension, vertical climbing, or knuckle-walking.

134 ing any morphological traits associable with knuckle-walking.

135 ndamentally different biomechanical modes of knuckle-walking: an extended wrist posture in an arborea

136 under body when walking but with ataxia; 2, knuckle walks; 3, movements in hind limbs but unable to

137 residues comprising and adjacent to the zinc knuckles were assigned by standard two-dimensional (1)H

138 ss pronounced after subintimal crossing with knuckle-wire-technique compared with CrossBoss in contro

139 ry to cross a complex CTO lesion, subintimal knuckle wiring and subintimal tracking and reentry resul

140 n with two RNA recognition motifs and a zinc knuckle (ZD7), and a DNA/RNA helicase with a DEAD box (Z

141 Deletion of the Zinc knuckle (Zn) domain in CLIP170 that mediates its interac

142 (RRM), a CCHC type zinc finger domain (Zinc Knuckle, ZnK) and a C-terminal RS domain that is rich in

143 binding proteins that contain five CCHC zinc knuckles (ZnKs).