ライフサイエンスコーパス: labeling

1 after experimental intervention (e.g., pulse labeling).

2 oaches and barriers to penicillin allergy de-labeling.

3 based fragment screen using selective methyl labeling.

4 sion of dCK mediates cell-selective 2'-AzCyd labeling.

5 n animal models with exogenous or transgenic labeling.

6 reduced proliferation, and increased DNA end labeling.

7 erns with spacing comparable to that of FDAA labeling.

8 is, posttranslational modifications, and DNA labeling.

9 -MS/MS) using ten-plex tandem mass tag (TMT) labeling.

10 o define conditions that enable their robust labeling.

11 ntitative imaging or freeze-fracture replica labeling.

12 istance mapping by the still unsaturated DNA-labeling.

13 ctionalization and the surface available for labeling.

14 ctron microscopies as well as stable isotope labeling.

15 laborious steps of protein purification and labeling.

16 d substrate in the first step for subsequent labeling.

17 ariant needed for site-specific fluorescence labeling.

18 e labeling cells and 1-2 weeks to test their labeling ability.

19 o the multiobjective model, a multi-criteria labeling algorithm is then proposed.

20 We show that BAcTrace-mediated labeling allows electrophysiological recording of connec

21 milarities and differences in the pattern of labeling among the human, rat, and mouse in these brain

22 erize RMs at different ages by conditionally labeling and ablating RMs populations in several transge

23 Chile's Law of Food Labeling and Advertising, implemented in 2016, was the f

24 Projection-specific labeling and calcium imaging showed that the great major

25 Using genetic labeling and calcium imaging, we show that npvf-expressi

26 f cardiomyocytes by combining stable isotope labeling and click chemistry with subsequent mass spectr

27 simple and novel strategy for site-selective labeling and control of RNAs, potentially of any length

28 re also investigated using immunofluorescent labeling and correlated to serum levels of the associate

29 cleotidyl transferase-mediated dUTP nick-end labeling and DNA fragment enzyme-linked immunosorbent as

30 tance data gathered using site-directed spin labeling and electron paramagnetic resonance spectroscop

31 fish line that allows for cell-type-specific labeling and imaging of nascent proteins in the entire a

32 ble reaction for site-selective biomolecular labeling and imaging.

33 both CO(2)RR and CORR, via combined isotopic labeling and in situ spectroscopic investigations.

34 Combined precursor isotopic labeling and isobaric tagging (cPILOT) is an enhanced mu

35 18)F-rhPSMA-7 offers the advantages of (18)F labeling and low urinary excretion compared with (68)Ga-

36 ral regulations, these findings suggest that labeling and marketing of some products which claim to p

37 Using covalent labeling and mass spectrometry, we measure the decrease

38 ant analysis, metabolic engineering, isotope labeling and metabolic profiling to capture PFCs and dem

39 Using metabolic labeling and pulse-chase analysis of HIV-1 Gag proteins,

40 ot well defined because methods for directly labeling and quantifying the CA in viral cores have been

41 yrosyl-tRNA mimic that blocks translation by labeling and releasing elongating polypeptide chains fro

42 t mostly performed with the help of isotopic labeling and site-directed mutagenesis, and complemented

43 Using domain-specific BioID proximity labeling and super-resolution imaging, we identify CEP11

44 Proximity-labeling and super-resolution microscopy show that Nup18

45 ombines it with cell type-specific chromatin labeling and superresolution microscopy.

46 By combining sparse genetic labeling and whole-mount placental alkaline phosphatase

47 g peptides, in vivo SLiM-dependent proximity labeling, and in silico modeling of motif determinants u

48 s' nutrition knowledge through education and labeling, and monitor the nutritional status of the popu

49 x3.1 reduces proliferation, enhances DNA end-labeling, and protects from DNA damage, ultimately block

50 Immunoblot, pulse labeling, and ribosome profiling analyses of mutants lac

51 rized by tandem mass spectrometry, deuterium labeling, and UV/Vis action spectroscopy.

52 se of TurboID and split-TurboID in proximity labeling applications for mapping protein-protein intera

53 Using a multiplexed isobaric labeling approach (TMT-11plex), ~77 single cells could b

54 This lentiviral-labeling approach can be deployed in any organism or in

55 fluoride-mediated desilylation (FMDS) (11)C-labeling approach is reported.

56 the sensory domain, we used a genetic sparse labeling approach to track SGNs and found no differences

57 ible mass spectrometry-based method, a pulse labeling approach using stable isotope-labeled amino aci

58 Using a metabolomic and stable-isotope labeling approach, combined with transcriptional analysi

59 Through this interaction-dependent labeling approach, intratumoral TSA-reactive CD4(+), CD8

60 Using a BioID proximity labeling approach, we show that SHCA exists in a complex

61 S analysis, through which different covalent labeling approaches "mark" the solvent accessible surfac

62 vided into direct (or one-step) and two-step labeling approaches and will start with DNA before treat

63 c plant tissues, while nonstationary isotope labeling approaches are amenable to the study of photoau

64 All of these covalent labeling approaches combine to constitute a problem-solv

65 we provide a structured overview of covalent labeling approaches for nucleic acids and highlight nota

66 applying a variety of biotin-based proximity labeling approaches in several plant systems using vario

67 chanisms, and applications of these covalent labeling approaches.

68 ing a small-molecule additive during the TMT labeling as a decoy reagent to deplete the excess amount

69 Operationalizing penicillin allergy de-labeling as an aspect of ASP has become an increasing gl

70 ise for penicillin allergy evaluation and de-labeling as an individual and public health strategy to

71 Arterial spin labeling (ASL) is a neuroimaging technique used to measu

72 y, carotid plaque imaging, and arterial spin labeling (ASL) to identify imaging parameters that best

73 Arterial spin labeling (ASL), as a non-invasive and non-contrast enhan

74 ucleotidyl transferase-mediated dUTP nickend labeling assay.

75 mediated deoxyuridine triphosphate nick end labeling assay.

76 Metabolic labeling assays, FADS3 overexpression and knockdown appr

77 developed an innovative glycosyltransferase labeling assisted mass spectrometry (GLAMS) strategy.

78 ing revealed synaptic and perisynaptic GluD1 labeling at putative axo-dendritic and axo-spinous gluta

79 se in the area and intensity of ACh receptor labeling at the neuromuscular junction (NMJ).

80 Here, we extend a modular method for labeling base modifications in DNA to recognize all four

81 antiCD81 modified magnetic particles and the labeling based on CD24 and CD340 as cancer-related bioma

82 We propose a novel sequence labeling-based biomedical relation extraction method nam

83 one of the most ideal positron emitters for labeling bioactive molecules for molecular imaging studi

84 encapsulation of cells in agarose beads and labeling breaks directly and specifically with biotinyla

85 in CGRP(+), TH(+), and Iba1(+) (macrophage) labeling, but no increase in ATF3(+) cells.

86 his protocol takes 2-3 weeks to generate the labeling cells and 1-2 weeks to test their labeling abil

87 but also quantitative information for every labeling channel and avoid the issue of ratio distortion

88 peptide backbone originating from different labeling channels are identical, the Ac-AG tag is compat

89 ER arrival sites (ERAS) can be visualized by labeling COPI vesicle tethers such as Tip20.

90 moral metabolic heterogeneity, where lactate labeling correlated with MCT1 expression and hypoxia.

91 Conversely, [(13)C(16)]-palmitic acid labeling demonstrated that GCBCs generate most of their

92 Lineage tracing using EdU-labeling demonstrates that donor-derived IA6+ Candidate

93 ation of double-stranded breaks using biotin-labeling DNA break assay, and End-seq analysis indicated

94 nsitivity and specificity were compared with labeling done by three neuroradiologists.

95 tion, the Ter119-NPs achieved remarkable RBC labeling efficiencies (>95%), resulting in marked enhanc

96 on method: immobilized direct in situ breaks labeling, enrichment on streptavidin and next-generation

97 lently tethered to genetically encoded, self-labeling enzymes.

98 Site directed spin labeling EPR and DEER (double electron-electron resonanc

99 M1 activates FAK, we used site-directed spin-labeling EPR spectroscopy-based studies coupled with bio

100 parcellated the entire brain directly in 3D, labeling every voxel with a brain structure spanning 43

101 odel of familial AD crossed with mouse lines labeling excitatory pyramidal cells (PCs) and inhibitory

102 situ whole mature tree nitrogen-15 ((15) N) labeling experiment ((15) NH(4) (+) vs (15) NO(3) (-) )

103 A continuous labeling experiment, followed by proteolytic digestion a

104 Deuterium labeling experiments and a comprehensive computational s

105 n was corroborated by intramolecular isotope labeling experiments and theoretical calculations.

106 Isotopic-labeling experiments have been valuable to monitor the f

107 electivity on model substrates and deuterium-labeling experiments imply that the m-chlorobenzoyloxy r

108 The BGC and the labeling experiments provide further insights into the b

109 (15)N-labeling experiments revealed that NH(4)(+) was oxidized

110 tion of chelate aryl substituents, deuterium labeling experiments were consistent with unimolecular C

111 n mechanism through kinetic studies, isotope-labeling experiments, (19)F NMR, electrochemical studies

112 ction pathway was further confirmed by (18)O labeling experiments, and to the best of our knowledge,

113 Using genetic labeling experiments, the authors identify resident micr

114 tructural insights and guided stable-isotope labeling experiments, which led to the assignment of the

115 -IR methodologies, as well as by (18)O(2(g)) labeling experiments.

116 tes and their isotope incorporation in (13)C-labeling experiments.

117 Using immunofluorescent labeling, flow cytometry and Cre-dependent ribosomal imm

118 , ovary and spleen) by tandem mass tag (TMT) labeling followed by mass spectrometry, providing a comp

119 tunately, they generally rely on fluorescent labeling for cellular phenotyping, an indirect measure o

120 s of segmental (or domain-specific) isotopic labeling for NMR, or deuteration for neutron scattering

121 beling in cell protrusions was distinct from labeling for the endocytic adaptor complex AP-2.

122 Besides, the sequence labeling framework enables Bio-Seq to take advantage of

123 In the method, sequence labeling framework is extended by multiple specified fea

124 The radioligand was additionally used for labeling GPR84 in native cells and tissues.

125 n the future striolar region of the utricle, labeling hair cells following EdU birthdating, and demon

126 s and use of [(11) C]carbonyl difluoride for labeling heterocycles with [(11) C]carbonyl groups in hi

127 on fluorescence microscopy based on covalent labeling highlights specific proteins and has sufficient

128 rase, "bump-and-hole" (BH)-GalNAc-T2, boosts labeling in a programmable fashion by increasing incorpo

129 stable transgenic id2b:gal4 larvae revealed labeling in a subset of neurons in optic tectum, cerebel

130 Pulsed Stable Isotope Labeling in Cell culture (SILAC) approaches allow measur

131 Further, AP-1B labeling in cell protrusions was distinct from labeling

132 Combined cfos imaging and retrograde labeling in dopamine transporter (DAT) Cre mice revealed

133 taneously preserve potent and specific NCEH1 labeling in live cells and animals, while permitting fac

134 h the goal of achieving controllable isotope-labeling in N-alkylated amines, we herein rationally des

135 ident immune cells to be visible without any labeling in the living mouse retina using near-infrared

136 gnificantly less dendritic and axon terminal labeling in TRPM1 knockout compared to wild type, despit

137 4-thiouridine (4SU) labeling in vivo enables the specific capture of such ne

138 stochemical staining following juxtacellular labeling in vivo pGABA neurons were found to be fast-fir

139 Pulse-chase fluorescent labeling indicates that Nup188 populates centrosomes wit

140 per crypts, longer villi, with increased EdU labeling, indicating increased proliferation of epitheli

141 ace at sub-milliseconds, faster than most of labeling-induced protein conformational changes, thus en

142 e as metabolic chemical reporters (MCRs) for labeling inositol-containing glycoconjugates in eukaryot

143 Operationalizing penicillin allergy de-labeling into a new arm of antimicrobial stewardship pro

144 Isobaric peptide termini labeling (IPTL) is an attractive protein quantification

145 Proximity labeling is a powerful approach for detecting protein-pr

146 We propose that pulse-chase SILAC labeling is a useful tool for studying rates of protein

147 for this approach is that the solution-phase labeling is conserved in the gas phase prior to precurso

148 Sia immunoreactivity: we report that polySia labeling is particularly dense in the dorsal tegmentum,

149 Subtissue labeling is prohibitively expensive, and only rough anno

150 ydrogen bonding, whereas one drawback is the labeling is reversible.

151 However expert labeling is time and labor intensive, and the costs rema

152 variation of the functional groups, enabling labeling kinetics and selectivity to be tuned.

153 nge, nor can we parse out the effects of the labeling, marketing, and school sales ban policies.

154 e we describe the integration of a proximity labeling method and quantitative mass spectrometry to ma

155 Sequence labeling method can be successfully used to extract docu

156 We have then used a graph labeling method for vertex ordering in our graph embeddi

157 Through development of an in vivo cell labeling method we provide direct evidence for the syste

158 cation information than traditional isobaric labeling methods (e.g., TMT and iTRAQ) by making use of

159 perimentally realistic SBRs, cell densities, labeling methods, and cell shapes.

160 he method is compared to other bioorthogonal labeling methods.

161 Here, we report use of 2-AA for labeling N-glycans on a MALDI target through nonreductiv

162 cope of the process was explored through the labeling of 6-Trp-containing peptides and proteins rangi

163 nt interaction- and light-dependent proximal labeling of a model protein-protein interaction (PPI) in

164 ptide tag CIS that allows facile N, S-double labeling of a protein of interest with >90% yield.

165 of the Ac-AG tag was demonstrated by triplex labeling of a yeast proteome spiked with bovine serum al

166 Its use is demonstrated by the fluorescent labeling of active UCHL1 both in vitro and in live cells

167 ed acyl imidazole chemistry enables covalent labeling of AMPA-type glutamate receptors in the same br

168 Here, we used direct labeling of B cells reactive with the N-acetyl-D-glucosa

169 es have numerous applications in fluorescent labeling of biomolecules.

170 odification of lysines or more site-specific labeling of cysteines, each with attendant challenges.

171 Metabolic labeling of de novo lipogenesis (DNL) using (2)H(2)O rev

172 a brain slice, RhoVR-Halos provide exquisite labeling of defined cells and can be imaged using epiflu

173 and the most reactive one was applied to the labeling of endogenous MAGL in live cells.

174 d that Cxcr4-CreER enables permanent genetic labeling of hematopoietic stem cells (HSCs) and distingu

175 to its rapid internalization and subsequent labeling of internal membranes, we redesigned it by intr

176 Double labeling of JO and ocellar afferents revealed that input

177 FM labeling of lateral cristae in tmc double mutants reveal

178 QRS duration (QRSd) >=150 ms and subjective labeling of left bundle branch block (LBBB).

179 y magnetic resonance imaging and neurotracer labeling of long-distance corticospinal axons suggest th

180 Coupling APEX2 labeling of lysosomes and metabolic labeling of protein,

181 In contrast, following labeling of MCs in the dorsal DG, the projections were m

182 of the reaction conditions and the isotopic labeling of methane by deuterium allow for an unambiguou

183 ed a lectin array and suitable protocols for labeling of microbes that could be used to probe this ar

184 rnessed for post-synthetic and site-specific labeling of nucleic acids has increased significantly.

185 labeling of PBPs with Bocillin FL, a fluorescent penicil

186 ng APEX2 labeling of lysosomes and metabolic labeling of protein, we identify that individual lysosom

187 bases during DNA synthesis, which allows for labeling of replicating or repaired DNA.

188 ciation (HCD)-based fingerprints and isotope labeling of RNA.

189 finity DNA aptamer generation, site-specific labeling of RNAs, semi-synthetic organism creation, and

190 This approach to selective labeling of sensory nerve terminal endings will help to

191 We combined rapid in vivo labeling of single CN V axons in LgDel+/- mouse embryos,

192 ice, in which low doses of tamoxifen allowed labeling of single-cell pericytes at high resolution.

193 glycoprotein on the viral surface, covalent labeling of the Cys residues using a Cys-reactive label

194 rter, confer Cre-dependent sparse and bright labeling of thousands of neurons, astrocytes, or microgl

195 Unbiased detection through proximity labeling of transient protein interactions in cell-free

196 is demonstrated by rapid and non-disruptive labeling of two enzymes.

197 We used genetic labeling of two of these proteins (PSD95 and SAP102), an

198 must be mutated to other residues to enable labeling of unique positions.

199 us glutamatergic synapses, and intracellular labeling on the surface of mitochondria.

200 proteolytic digestion, tandem mass tag (TMT) labeling, online and offline fractionation strategies, o

201 sessed in HeLa cell lysate and showed robust labeling only upon photoactivation.

202 le particle formation was not due to the ICL labeling or complement attack and was observed after inj

203 ication approaches employing mass difference labeling or isobaric tagging are incompatible with DIA.

204 After specific enzymatic labeling, oxonium ions from higher-energy C-trap dissoci

205 The magnitude of the PEDFR labeling pattern was higher than PEDF and included some

206 kly to touch on the hand, while the cortical labeling pattern was largely unchanged.

207 ze, allowing direct comparisons of molecular labeling performance across a broad range of wavelength.

208 We present an approach referred to as polar labeling (PL), to create silver standard for training ma

209 To this end, enzymatic proximity labeling platforms are broadly applied for mapping the w

210 ting," "evaluation," "effects," "label," "de-labeling," "prick or epicutaneous," and "intradermal" sk

211 urified virus for the subsequent fluorescent labeling procedure, thus enabling STED imaging.

212 Drawbacks are that the labeling process is labor intensive and time consuming.

213 and ultrasensitive screening of miRNAs using labeling processes with focusing on the future applicati

214 strategy based on the discovery that carbene labeling produces subresidue peptide isomers and the int

215 Labeling protein A with a His-tag that binds 5-nm Ni-nan

216 Here, via analysis of a proximity-labeling proteomic profile of INM-associated proteins in

217 The use of terminal residues for labeling provides a universally applicable and easily sc

218 eavy water (D(2)O) with Raman-stable isotope labeling (Raman-D(2)O), we evaluated the reliability of

219 r the newly developed 16-plex TMT, including labeling reaction, desalting, and MS conditions, and the

220 Labeling reactions may utilize close-to-stoichiometric p

221 in mutually exclusive pairs of bioorthogonal labeling reagents continues to drive the design of new c

222 Similar patterns of retrograde labeling result from tracer injections into different NT

223 Our new rate, selectivity, and isotopic labeling results from ECH reactions confirm that these a

224 Pulses of FDAA labeling revealed an arrangement of separate regularly s

225 mass spectrometry analysis combined with NEM labeling revealed that all four Ag(+) ions of Ag(4)-MT a

226 te and propionate) and (15)N-ammonia isotope labeling reveals that cells performing sulfide oxidation

227 Peptide tandem mass tag (TMT) labeling, sample multiplexing, synchronous precursor sel

228 By exploiting a number of different labeling schemes, the two halves of the molecule can be

229 Site-directed spin labeling (SDSL) ESR is a valuable tool to probe protein

230 The use of (18)O(2) labeling showed that the oxygens of both hydroxyl moieti

231 Double labeling shows that primarily separate populations of PO

232 sent study, by juxtacellularly recording and labeling single CA2/CA3 neurons in freely-moving mice, w

233 unctional groups into the reagent structure, labeling sites can be more easily identified by MS and M

234 one marrow perfusion signal changed with the labeling size, suggesting that the measured bone marrow

235 aleylation-directed isobaric peptide termini labeling (SMD-IPTL) approach for quantitative proteomics

236 oach is by reactions with fast, irreversible labeling species that are highly reactive and footprint

237 small molecule fluorescent turn-on probe for labeling sphingosine in living cells.

238 l deoxynucleotidyl transferase dUTP nick end labeling staining, and immunohistochemistry in murine ce

239 o separate T-induced changes of the chemical labeling step (k(ch)) from thermally enhanced protein fl

240 UHPLC-ELSD-ESI-MS(2) method does not require labeling steps or addition of standards, and the princip

241 Exploiting the one fluorophore per molecule labeling stoichiometry, the limit of detection (S/N > 3)

242 aling whole transcriptome dynamics, targeted labeling strategies can be used to study individual RNA

243 imilar internal standards, different isotope labeling strategies, radiolabeling, and predicted ioniza

244 s measured using pre- and postadministration labeling strategies.

245 enges, here we (1) Propose an effective auto-labeling strategy based on using an unsupervised cluster

246 Deuterium labeling studies established homolytic H(2) (or D(2)) ac

247 Deuterium labeling studies established that the key step of this c

248 Retrograde labeling studies in mice from the parabrachial nucleus (

249 ynthesis by Streptomyces bottropensis, (13)C-labeling studies previously implied extraordinary carbon

250 Deuterium labeling studies suggest that formation of the seven-mem

251 rsibility, luminescence quenching, deuterium labeling studies, and quantum yield measurements provide

252 frared spectroscopic measurements, deuterium labeling studies, natural abundance (13)C KIE studies, a

253 As revealed by our earlier labeling studies, these findings suggest modes of bindin

254 netic isotope effect experiments, deuterated labeling studies, variable-temperature (1)H NMR spectros

255 First, the antibodies used for labeling synapses are not perfectly specific to synapses

256 ets with ground truth annotation or manually labeling, SynQuant was demonstrated to outperform peer s

257 m, which can easily be converted to a direct labeling system if desired.

258 netically encoded, retrograde, transsynaptic labeling system.

259 Proximity-based in situ labeling techniques offer a unique way to capture both s

260 s specific and nonperturbative intracellular labeling techniques.

261 icals is the apparent lack of suitable (18)F-labeling technologies with proven clinical relevance.

262 Using a validated labeling technology, probes are tagged with a bulky Osmi

263 anges induced by stimuli such as fluorescent labeling, temperature change, starvation, and chemical t

264 es (VLPs), facilitated by segmental isotopic labeling, that provide information about effects of BVM

265 In addition to labeling the monoclonal antibody trastuzumab with excell

266 in645 produces intense and specific membrane labeling throughout live and fixed tissue.

267 Labeling throughout the brainstem and spinal cord were v

268 namics information extracted from one or two labeling time points approaches or exceeds the informati

269 Here we use viral labeling to characterize dendritic spine morphology spec

270 e have used Cre-recombinase-mediated genetic labeling to identify and map both mature and developing

271 ISPR-CasRx-based RNA targeting and proximity labeling to identify binding proteins of specific long n

272 l deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay and immunohistochemistry for acti

273 The superiority of the proposed approach for labeling vertebrae on three datasets was investigated: a

274 ree-dimensional approaches was achieved when labeling vertebrae on two-dimensional MIPs.

275 Env) at single-residue resolution, using Cys labeling, viral neutralization assays, and deep sequenci

276 ured interferometrically, and no fluorophore labeling was required.

277 Moreover, using single-axon transfection labeling, we demonstrate that the above differences actu

278 Using stable isotope labeling, we demonstrated that phosphocholine and phosph

279 Using anterograde and retrograde labeling, we found that a sparse and relatively evenly d

280 lectron microscopy with glutamate immunogold labeling, we identified decreased intracellular glutamat

281 ctronic structure analyses and (18)O isotope labeling, we present a mechanism comprising a coupled ac

282 Using APEX2-based proximity labeling, we reveal the protein composition of Snx14-ass

283 Here, both gas exchange and isotopic labeling were carried out on sunflower leaves, using glu

284 as well as MS methods using multiplexing by labeling, which in principle can also be used in combina

285 r TSA-seq by deliberately saturating protein-labeling while preserving distance mapping by the still

286 n oral fructose/glucose bolus using isotopic labeling with 1-(13) C(1) -acetate intravenous infusion,

287 ategy for cell- and polymerase-selective RNA labeling with 2'-azidocytidine (2'-AzCyd), a modified nu

288 different secondary structures, enabling Cys labeling with Alexa Fluor 488 for quenching analysis usi

289 Metabolic labeling with alkyne-palmitic acid (100 mum for 15 h) al

290 report here that pulse-chase stable isotope labeling with amino acids in cell culture (SILAC) is a v

291 1/IKKepsilon substrates using stable isotope labeling with amino acids in cell culture phosphoproteom

292 In situ labeling with an AZP incorporating S16 revealed a potent

293 Metabolic labeling with atom-based heavy isotopes, followed by liq

294 Baskets were characterized further by triple labeling with CGRP, nitric oxide synthase (NOS) and calr

295 Labeling with fluorescent D-amino acids (FDAA) showed th

296 neity and investigated by site-directed spin-labeling with pulse-dipolar electron-spin resonance spec

297 odified nucleoside amenable to bioorthogonal labeling with SPAAC chemistry.

298 Here, we demonstrate that RNA labeling with the modified, nontoxic uridine analog 5-et

299 Here we present complementary tools for cell labeling with transgenic mice and organic dyes that allo

300 ts of metabolic function from stable isotope labeling within individual organelles in situ.