ライフサイエンスコーパス: lacto-N-neotetraose

1 Gal(beta1-4)GlcNac(beta1-3)Gal(beta1-4)Glc (lacto-N-neotetraose).

2 with both UDP:Mg(2+) and a glycan acceptor, lacto-N-neotetraose.

3 were much lower than the strains expressing lacto-N-neotetraose.

4 that recognizes the terminal disaccharide of lacto-N-neotetraose.

5 In contrast, replacement of the lacto-N-neotetraose alpha-chain (Galbeta1-4GlcNAcbeta1-3

6 major structural differences are seen in the lacto-N-neotetraose alpha-chain.

7 Strain F62 (Opa-Pil+), expressing the lacto-N-neotetraose and the galNac-lacto-N-neotetraose L

8 b even when the glycose chain from HepI bore lacto-N-neotetraose at the terminus.

9 ons; a trend toward higher concentrations of lacto-N-neotetraose being associated with reduced transm

10 against RBCs can be blocked with the glycan lacto-N-neotetraose by inhibiting binding to the cell su

11 tor (ASGP-R) and the terminal lactosamine of lacto-N-neotetraose-expressing gonococcal lipooligosacch

12 s administered daily with or without the HMO lacto-N-neotetraose for 28 days.

13 ominantly ester C4b-LOS bonds were seen when lacto-N-neotetraose formed the terminus of the glycose c

14 trated that F62, but not the strains lacking lacto-N-neotetraose, formed extensive and intimate assoc

15 ed ions consistent with known LOS which have lacto-N-neotetraose (Galbeta1-->4GlcNAcbeta1-->3Galbeta1

16 Inhibition studies showed that lacto-N-neotetraose (Galbeta1-4GlcNAcbeta1-3Galbeta1-4Gl

17 dies (mAbs) 1B2(+) and 06B4(+)) and GalNAc-->lacto-N-neotetraose (gangliosyl; mAb 1-1-M+) oligosaccha

18 sult indicated that the inability to add the lacto-N-neotetraose group to the 559 LOS is not due to a

19 LOS produced by mutant 559 revealed that the lacto-N-neotetraose group which is attached to heptose I

20 dherence of F62, but not the strains lacking lacto-N-neotetraose, induced the rearrangement of actin

21 An antigen that is dependent on the glycose lacto-N-neotetraose induces IgG in humans that is bacter

22 failed to bind to immobilized sialic acid or lacto-N-neotetraose, known pneumococcal ligands on eukar

23 were observed for the abundant, neutral HMO lacto-N-neotetraose (LNnT) [RD -0.273 (95% confidence in

24 ce of bacteria to epithelial cells in vitro--lacto-N-neotetraose (LNnT) and its alpha2-3- and alpha2-

25 erogroup C meningococcal strains bearing the lacto-N-neotetraose (LNnT) structure on lipooligosacchar

26 (HMO), such as 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT), enhance iron absorption in i

27 the combination of higher concentrations of lacto-N-neotetraose (LNnT), lacto-N-tetraose (LNT), lact

28 he lipooligosaccharide sialic acid acceptor, lacto-N-neotetraose (LNnT), of nine meningococcal strain

29 inth parasites, lacto-N-fucopentaose III and lacto-N-neotetraose (LNnT).

30 topes consisting of both core structures and lacto-N-neotetraose (LNnT).

31 The sialylatable lacto-N-neotetraose (LNnT; Gal-GlcNAc-Gal-Glc) moiety fr

32 and Neisseria meningitidis both express the lacto-N-neotetraose (LNT) lipooligosaccharide (LOS) mole

33 ely; the other (termed 398079) expressed the lacto-N-neotetraose (LNT; Galbeta1 --> 4GlcNAcbeta1 -->

34 isogenic derivative that expressed only the lacto-N-neotetraose LOS (F62 Delta lgtD), adhered to, an

35 Lacto-N-neotetraose LOS capped with Kdn and Kdn7N(3) bou

36 n the absence of detectable Opa protein, the lacto-N-neotetraose LOS promotes gonococcal invasion int

37 ssing the lacto-N-neotetraose and the galNac-lacto-N-neotetraose LOS, and its isogenic derivative tha

38 e terminal Galbeta1-->4GlcNAc epitope in the lacto-N-neotetraose moiety of the wild-type LOS structur

39 These strains share a lacto-N-neotetraose (nLc4) LOS alpha chain.

40 ed no binding to its nonfucosylated homolog, lacto-N-neotetraose, or to oligosaccharides present on k

41 rains that express LOS molecules lacking the lacto-N-neotetraose structure were similar to that seen

42 tudies indicated that an interaction between lacto-N-neotetraose-terminal LOS and ASGP-R allows gonoc

43 a unique immune evasion strategy wherein the lacto-N-neotetraose termini of lipooligosaccharide (LOS)

44 1Hep2KDO2lipid A but without the addition of lacto-N-neotetraose to HepI or glucose to HepII.

45 ease in fucosyl-disialyl-lacto-N-hexaose and lacto-N-neotetraose was associated with 0.04% higher (P