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1 unique mechanism of action for lysozyme and lactoferrin.
2 tion, causing decreased peptide release from lactoferrin.
3 elations with levels of the glandular marker lactoferrin.
4 tract iron from hemoglobin, transferrin, and lactoferrin.
5 secretion of bactericidal concentrations of lactoferrin.
6 with the ferric iron within transferrin and lactoferrin.
7 uch as Magainin II amide, hNP1-3, LL-37, and lactoferrin.
8 partially iron-saturated transferrin but not lactoferrin.
9 the highly cationic lactoferricin moiety of lactoferrin.
10 epresent major associations between PspA and lactoferrin.
11 identified the proteins as fibronectin-1 and lactoferrin.
12 -treated, and 10 subjects received untreated lactoferrin.
13 properties and its propensity to bind human lactoferrin.
14 human serum transferrin, ovotransferrin, and lactoferrin.
15 Antibody to PspA enhanced killing by lactoferrin.
16 gatively regulated the myeloid-specific gene lactoferrin.
17 y be the cause of the differential action of lactoferrin.
18 immune pathways known to be associated with lactoferrin.
19 release of antibacterial myeloperoxidase and lactoferrin.
20 eat potential for functional foods providing lactoferrin.
21 ey, Lactalbumin, Lactoferrin, or pair-fed to lactoferrin.
22 eficial iron-scavenging molecules, including lactoferrin.
23 ody iron absorption between the groups given lactoferrin (20.4 +/- 15.3%; n = 20) or ferrous sulfate
27 s of diverse lineages synthesize and secrete lactoferrin, a pleiotropic glycoprotein with known antii
28 the human small intestine has receptors for lactoferrin, a role for it in iron absorption has been s
30 y was to assess the utility of ascitic fluid lactoferrin (AFLAC) for the diagnosis of SBP and to iden
31 esents scientific and clinical evidence that lactoferrin alleviates or prevents this life-threatening
32 eins on heat-induced changes to lactoferrin, lactoferrin alone, and lactoferrin mixed with either mil
33 cropeptide, immunoglobulin, lactoperoxidase, lactoferrin, alpha-lactalbumin and beta-lactoglobulin fr
34 n injected into the mouse peritoneal cavity, lactoferrin also caused a marked recruitment of neutroph
36 d fungal growth and were found to be rich in lactoferrin, an abundant PMN secondary granule protein.
37 e epithelial ERalpha was necessary to induce lactoferrin, an E(2)-regulated secretory protein selecti
39 ere enriched for the specific granule marker lactoferrin and 82% with the azurophil granule marker el
40 some proteins from human milk but did affect lactoferrin and alpha-lactalbumin proteolysis and emulsi
41 tory bowel disease had measurements of fecal lactoferrin and alpha1-antitrypsin and underwent pouch e
43 associated to the heat-denaturated proteins, lactoferrin and bile salt-stimulated lipase, presented d
44 markers of inflammation, specifically stool lactoferrin and calprotectin as well as small intestine
45 es identified so far, autoantibodies against lactoferrin and carbonic anhydrase II are most frequentl
47 deficient local production of antimicrobial lactoferrin and deficient functioning of the bitter tast
48 es is revealed by elevated plasma and tissue lactoferrin and ET-1 levels in patients with TNBC compar
49 for the use of iron bound by transferrin and lactoferrin and examined the importance of the Ybt syste
50 l that, in contrast to family members (human lactoferrin and hen ovotransferrin), both lobes are almo
51 showed a stronger positive correlation with lactoferrin and IL-1ra and a stronger negative correlati
52 ctoferrin (ALF) is the iron-depleted form of lactoferrin and is bactericidal against pneumococci and
53 gradation of antimicrobial proteins, such as lactoferrin and members of the beta-defensin family.
55 Markers of inflammation, including fecal lactoferrin and mucosal cytokines, have been reported as
56 he leukocyte transcriptome by downregulating lactoferrin and other genes important in the pathogenesi
57 ether iron binding proteins; apotransferrin, lactoferrin and ovotransferrin; could prevent the hydrox
60 as encapsulated by complex coacervation with lactoferrin and sodium alginate using transglutaminase a
62 n of detailed site-specific glycosylation of lactoferrin and transferrin following gel separation and
63 n use both bovine and human versions of both lactoferrin and transferrin, contrary to previous report
64 s phenomenon was mediated by transferrin and lactoferrin and was influenced by the iron-saturation st
67 toglobin, transferrin, transferrin receptor, lactoferrin, and ferritin in the bronchoalveolar lavage
69 day contained adequate amounts of lacritin, lactoferrin, and lipocalin for use in lacritin secretion
71 Target proteins fixed on the EIG (protein G, lactoferrin) are detected using antibody probes with sig
74 eactive oxygen species, myeloperoxidase, and lactoferrin, as well as the inflammatory chemokine IL-8
77 In this study, glycoproteins such as, bovine lactoferrin (b-LF) for N-glycosylation and kappa casein
78 In vivo, the intravenous administration of lactoferrin-bearing DAB dendriplex resulted in a signifi
80 rain barrier, we propose to investigate if a lactoferrin-bearing generation 3-diaminobutyric polyprop
81 and decreased adiposity, with the effects of lactoferrin being partly independent of caloric intake.
84 The crystal structure of a complex of the lactoferrin-binding domain of PspA with the N-lobe of hu
85 the best 3 peptides, peptide A, derived from lactoferrin-binding protein A, showed superior activity
87 lobed nuclei, and neutrophil granules lacked lactoferrin but showed normal levels of myeloperoxidase.
90 apolactoferrin, the iron-free form of human lactoferrin, can kill many species of bacteria, includin
92 hil granules, including neutrophil elastase, lactoferrin, cathepsin G, proteinase 3, and myeloperoxid
93 bumin produced transient hypophagia, whereas lactoferrin caused prolonged hypophagia; the hypophagia
95 infants should receive colostrum, a natural lactoferrin concentrate, immediately after birth and, id
96 Samples with SBP had a significantly higher lactoferrin concentration (median, 3744 ng/mL; 25th-75th
98 ory condition had significantly higher fecal lactoferrin concentrations (median, 176.0 microg/mL, int
99 , there were inverse associations of IgA and lactoferrin concentrations with motor skills (P = 0.018
101 cus mutans and Streptococcus mitis, however, lactoferrin containing Lys at position 29 exhibited sign
102 om subjects with this SNP, recombinant human lactoferrin containing this SNP, or an 11-mer peptide de
105 At a cutoff level of 7 microg/mL, fecal lactoferrin could distinguish patients with irritable po
106 f the type III secretory system implies that lactoferrin could provide broad cross protection against
107 gly, epithelial-specific Scrib deletion by a lactoferrin-Cre (Ltf-Cre) driver does not adversely affe
110 therapeutic ET-1 receptor-antagonist blocked lactoferrin-dependent motility and invasiveness of breas
114 peptide derived from the N terminus of human lactoferrin, displays diverse modulatory activities on m
116 erum proteins accelerated the aggregation of lactoferrin during heating through thiol/disulphide inte
117 equal proportions to the plasma membrane and lactoferrin-enriched fractions, consistent with FPRL1 si
118 lasma membrane with a minor component in the lactoferrin-enriched intracellular fractions, consistent
119 edimentation rate, C-reactive protein, fecal lactoferrin, fecal calprotectin, serologic tests for cel
121 e have evaluated the potential of camel milk lactoferrin for its ability to inhibit the proliferation
124 lpyridinium were also partially protected by lactoferrin, further supporting the view that mitochondr
125 However, molecular mechanisms of how the lactoferrin gene is regulated in the mammary gland in re
127 An 8.2 kilobase (kb) fragment of the bovine lactoferrin gene, containing 4.4 kb of 5' flanking regio
130 rest among neonatal caregivers as to whether lactoferrin given enterally may reduce the incidence of
131 linical studies in neonatal rats showed that lactoferrin given orally before enteral infection with p
134 ow-birth weight preterm infants given bovine lactoferrin had a significant reduction in late-onset se
135 actoferrin alfa, a recombinant form of human lactoferrin, has similar properties and plays an importa
136 Single-nucleotide polymorphisms (SNPs) in lactoferrin have been shown to be present in individuals
138 certain antimicrobial proteins, most notably lactoferrin, have been found in sinus secretions, wherea
140 Pro-Ile) and a casein (CasH), whey (WPH) and lactoferrin hydrolysate (LFH) generated with gastrointes
144 ecificity 0.87; 95% CI, 0.78-0.92) and fecal lactoferrin in a range of 4.0-7.25 mug/g (pooled sensiti
148 ing the microfluidic WB assay, assessment of lactoferrin in human tear fluid is demonstrated with a g
149 l, our data suggest that the accumulation of lactoferrin in PD brains might be evidence of an attempt
151 extend previous studies of the importance of lactoferrin in the innate immune defense against bacteri
152 ementation, recombinant human protein C, and lactoferrin in the prevention and treatment of neonatal
153 ects homozygous for this lysine (K) SNP have lactoferrin in their saliva that kills mutans streptococ
154 dalities, such as MRI, and biomarkers (fecal lactoferrin) in pediatric inflammatory bowel disease.
156 receptor antagonist to completely block the lactoferrin-induced motility and invasiveness of the TNB
157 ondary forms of antimicrobial defense, e.g., lactoferrin, ineffective in preventing biofilm formation
159 relevance of these catecholamine-transferrin/lactoferrin interactions to the infectious disease proce
160 we found that the iron binding capability of lactoferrin intervened in DA cell rescue only when neuro
173 ed proteomic analysis of CA/PC revealed that lactoferrin is the predominant protein component, a resu
174 ave shown that the iron-binding glycoprotein lactoferrin is upregulated in dopamine (DA) neurons resi
175 11-amino-acid peptide from the N terminus of lactoferrin, is bactericidal for Streptococcus pneumonia
176 ositions in ovotransferrin (Q-K-L) and human lactoferrin (K-N-N) as well as a triad with an interchan
179 lk serum proteins on heat-induced changes to lactoferrin, lactoferrin alone, and lactoferrin mixed wi
180 he simultaneous quantification of the minor (lactoferrin, lactoperoxidase, bovine serum albumin) and
181 ived proteins, including transferrin (TbpA), lactoferrin (LbpA), and hemoglobin (HpuB), in addition t
189 ssue of the JCI, Liu et al. demonstrate that lactoferrin (LF) converts newborn neutrophils and monocy
193 nnate defense mechanisms in the oral cavity, lactoferrin (LF) is a vital antimicrobial that can modif
195 trained panel evaluated the effect of bovine lactoferrin (LF) on NG bitterness using time-intensity a
197 sphatidylcholine (HPC) for the encapsulation lactoferrin (LF) was studied; lipid membrane of liposome
198 ins, together with human holo- and apoTF and lactoferrin (LF) were assessed as inhibitors of all cata
199 operties of a fluorescently labeled protein, lactoferrin (Lf), and its association with heparin and h
200 nists, receptor-associated protein (RAP) and lactoferrin (LF), and LRP1-specific antibody had the ent
201 estrogen-inducible uterine secretory protein lactoferrin (LF), and reduced expression of SV secretory
204 tely 0.35 mum, 20 wt.%) with a suspension of lactoferrin (LF)-coated lipid droplets (zeta=+32 mV, d(4
207 bin, haptoglobin, transferrin, ferritin, and lactoferrin, limiting the availability of free iron for
208 acteria by release of Tamm-Horsfall protein, lactoferrin, lipocalin, and constitutive and inducible b
210 teins IIb/IIIa (ITGA2B/3), lipocalin (LCN2), lactoferrin (LTF), and the thrombopoetin receptor (MPL),
211 line downregulated C/EBP-epsilon protein and lactoferrin (Ltf), cathelicidin antimicrobial protein (C
212 HMOs, and 6 bioactive proteins (lactalbumin, lactoferrin, lysozyme, antitrypsin, IgA, and osteopontin
214 Tp34 to bind zinc and the iron-sequestering lactoferrin may relate overall to the biology of T. pall
217 These results suggest that interleukin-27/lactoferrin-mediated modulations of neutrophil function
218 r ferric iron transport from transferrin and lactoferrin, might also contribute to the utilization of
219 anges to lactoferrin, lactoferrin alone, and lactoferrin mixed with either milk serum or beta-lactogl
220 in cell counts when milk contained 3.0 mg of lactoferrin/ml and markedly reduced the likelihood of fa
224 n, bovine serum albumin, beta-galactosidase, lactoferrin) on the EIG with initial capture efficiencie
227 elated in subjects when they received either lactoferrin or ferrous sulfate, which suggested that iro
229 creased fungal growth, whereas saturation of lactoferrin or PMN supernatants with iron, or testing in
230 ing inflammatory markers such as leukocytes, lactoferrin, or calprotectin, or positive stool culture
232 f these proteins, such as alpha-lactalbumin, lactoferrin, osteopontin, and milk fat globule membrane
233 Pasteurization enhanced the proteolysis of lactoferrin (P < 0.01) and reduced that of alpha-lactalb
234 globulin (P = 0.010), casein (P = 0.047) and lactoferrin (P = 0.030) during treatment than those who
236 testing [Hemoccult], fecal leukocytes, fecal lactoferrin, plasma C-reactive protein), and the numbers
238 5 min), IMF containing alpha-lactalbumin and lactoferrin preserved a higher proportion of native whey
239 insically labeled purified recombinant human lactoferrin produced in rice and to compare it with the
241 en together, our findings suggested that the lactoferrin promoter responds to infection via the NF-ka
243 We determined fecal interleukin 8 (IL-8) and lactoferrin protein concentrations by enzyme immunoassay
245 xcess of unlabeled HLE, CG, myeloperoxidase, lactoferrin, proteinase 3, phenylmethylsulfonyl fluoride
246 and this bacterium uses both transferrin and lactoferrin receptors to fulfill the essential iron requ
247 r cut between amino acids 78 and 79 of human lactoferrin, removing the N-terminal end of the molecule
248 ding domain of PspA with the N-lobe of human lactoferrin reveals direct and specific interactions bet
249 Targets of desialylation included human lactoferrin, secretory component, and IgA2 that were sho
252 , including whole blood, plasma, hemoglobin, lactoferrin, serum IgG, soil extracts and humic acid, as
253 ated and sialylated glycopeptides from human lactoferrin served as positive controls, and high-mannos
257 degree than did that with apotransferrin and lactoferrin, suggesting additional effects of these ferr
258 -1, and late differentiation markers such as lactoferrin, suggesting that this kinase induced termina
259 recorded, and mRNA expression levels of Ltf (lactoferrin), Svs4, and androgen receptor (Ar) were asse
260 dy, we show the ability of recombinant human lactoferrin (talactoferrin alfa (TLF)) to chemoattract m
262 d position 29 in the antimicrobial region of lactoferrin that acts against caries associated bacteria
264 eficial molecules, including iron-scavenging lactoferrin that may limit hematoma/iron-mediated brain
265 osition 29 in the N-terminal region of human lactoferrin that results from a single nucleotide polymo
266 e to be a novel antiinflammatory property of lactoferrin: the ability to function as a negative regul
267 histochemistry (IHC) suggested the source of lactoferrin to be prostate-infiltrating neutrophils as w
268 attribute this antiinflammatory function of lactoferrin to its effects on granulocyte signaling path
269 phils via, at least partly, the induction of lactoferrin to present a potential therapy for ICH.
270 letion, regulatory burdens required to bring lactoferrin to the bedside may limit its availability.
271 ork, we demonstrated that the conjugation of lactoferrin to the dendrimer led to an enhanced DNA upta
274 three porin-independent phenotypes, namely, lactoferrin utilization, beta-lactamase production, and
276 olamines to obtain iron from transferrin and lactoferrin via uptake pathways involving the BfrA, BfrD
278 ect of milk serum proteins on aggregation of lactoferrin was characterized, after which the effect of
280 ver clinical trial of recombinant human (rh) lactoferrin was conducted among 54 human immunodeficienc
285 To this end, a potent AMP derived from human lactoferrin was synthesized and covalently immobilized o
287 e on simulated data for adenylate kinase and lactoferrin, we show how cryo-EM data for two different
289 of alpha-lactalbumin, beta-lactoglobulin and lactoferrin were investigated between 67.5 degrees C and
292 Here, we examine two proteins, lysozyme and lactoferrin, which are observed in the organic matrix of
293 recombinant form of the human glycoprotein, lactoferrin, which has been shown to have a wide range o
294 binds the iron-free forms of transferrin and lactoferrin, which limits its ability to extract iron fr
295 c-iron-binding proteins transferrin (Tf) and lactoferrin, which then enables bacterial acquisition of
296 pounds, such as immunoglobulins, albumin and lactoferrin whilst iodine was only found as iodide.
298 hesis and suggests that a genetic variant in lactoferrin with K in position 29 when found in saliva a
299 In conclusion, heat-induced aggregation of lactoferrin with milk serum proteins affected both its d