ライフサイエンスコーパス: lag time

1 -off by evolving phenotypic heterogeneity in lag time.

2 o be detected and quantified even during the lag time.

3 ratio, as well as significantly reducing the lag time.

4 ated to changes in light intensity with a 3h lag time.

5 t associated with UFP, AMP, and PM2.5 at any lag time.

6 f amyloid without significantly reducing the lag time.

7 pulation reaches a maximum at the end of the lag time.

8 r on the mean and variance of the population lag time.

9 0% conversion occurring much faster than the lag time.

10 ndependent of the cytoskeleton condition and lag time.

11 dominant molecular mechanism determining the lag time.

12 tion which always displayed a characteristic lag time.

13 load derived from pathways with significant lag times.

14 effect of kinetic inhibitors on fibrillation lag times.

15 arameters of the distribution of single cell lag times.

16 luence of neighboring cells, and diffusional lag times.

17 r source of noise that appears at very large lag times.

18 dihydrate (TMAO) and sucrose, increased the lag times.

19 We find short lag times (0-6 months) between climate anomalies and mod

20 pecies increased with precipitation at short lag times (1-1.5 years) likely due to enhanced food avai

21 fter periods of high precipitation at longer lag times (2-4 years) likely due to predation and other

22 lly appropriate settings for the (1) minimum lag time, (2) maximum lag time, and (3) averaging times

23 After a short lag-time, 4,6-dinitroguaiacol is also formed.

24 A very short lag time (5.4 s) for [(14)C]acetate labeling of PC impli

25 dienes: 485 +/- 55 micro mol/mg LDL protein; lag time: 51.7 +/- 15.9 min; and rate of oxidation: 25.4

26 In fact, a longer lag time (60 h) was observed in YlPMR1-defective mutant

27 The reduction in this lag time accounts for the relative selectivity of the ef

28 id bound cspA1/A2 dramatically increases the lag time after a cold shock before re-growth occurs.

29 ssful only do so (i) after an unusually long lag time after initial arrival, and/or (ii) after multip

30 Nucleation rates (lag time) also correlated with bead mass, but only for n

31 ove significant associations remained in the lag time analyses, applied to check for reverse causatio

32 ccurred via a dose-dependent decrease in the lag time and an increase in the fibrillization rate, con

33 Besides a significantly increased lag time and decreased RPA rate for PRP compared to WB (

34 The addition of ANS increased the lag time and decreased the apparent growth rate for insu

35 fibrillization, significantly increasing the lag time and decreasing the total amount of fibrils prod

36 fibril formation by reducing the nucleation lag time and diminished protein thermodynamic stability.

37 s formed fibrils in vitro, Wil had a shorter lag time and exhibited faster kinetics under physiologic

38 TGFbeta induced hypermotility after a 1-day lag time and growth arrest by a p16-independent mechanis

39 y are capable of increasing the fibrillation lag time and high levels of crowder hydrophobicity can f

40 ed evolved strains which exhibited a shorter lag time and improved xylose-fermenting capabilities tha

41 nes with viral E1 and template shortened the lag time and increased replication in a cell-free system

42 chemical carcinogenesis, CD151 reduces tumor lag time and increases incidence, multiplicity, size and

43 kinetics of self-association, decreasing the lag time and leading to insoluble, well-defined linear f

44 onse to collagen, they did so with prolonged lag time and lessened intensity.

45 ntrations, BbetaA68T fibrinogen had a longer lag time and lower rate of lateral aggregation, V(max),

46 Lag time and maximum growth rate were determined from co

47 correlations are calculated as a function of lag time and phase.

48 2522 and clinical characteristics, including lag time and pre-enucleation treatment status.

49 half-life of the drug and the stage-specific lag time and provides the framework for understanding th

50 ed in clotting curves with 3-9 times shorter lag time and steeper slopes with respect to H2O.

51 e and kidney stone presentation according to lag time and temperatures.

52 r interactions in defining the length of the lag time and the apparent rate of elongation of the 100-

53 t of the mean and variance of the individual lag time and the initial cell number on the mean and var

54 ase, BbetaA68T fibrinogen polymerized with a lag time and V(max) similar to normal, but reached a sig

55 otyls was induced by Cel12A after a distinct lag time and was accompanied by a large increase in wall

56 rotein state equilibria can alter nucleation lag time and, hence, fibril formation kinetics.

57 ed during amyloid fibril formation shortened lag times and caused pressure insensitivity of nucleatio

58 Shorter lag times and faster growth of fibrils were seen at acid

59 in insulin concentration resulted in shorter lag times and faster growth of fibrils.

60 ic catchment exhibited significantly shorter lag times and faster rates of net H(2) oxidation and dar

61 lin concentration and ionic strength on both lag times and fibril growth.

62 il morphologies and produce eightfold faster lag times and fourfold less stochasticity than in previo

63 treatment with SPHase resulted in shortened lag times and increased rates of oxidation in both LDL s

64 t extract (10 mg/L) was critical to diminish lag times and increased the biotransformation rate of NT

65 Sensitivity analysis using different lag times and kernel density bandwidths were tested to e

66 Proton inventories of inverse lag times and maximal slopes of blood clotting curves in

67 t isotope effects (SIEs) result from inverse lag times and maximal slopes of blood clotting plots, wh

68 rated tau nucleation as reflected by shorter lag times and modulated pre-nuclear equilibria to yield

69 The observed lag times and multiple introductions that seem a prerequ

70 n a narrower distribution of the aggregation lag times and rates.

71 assembly process is "downhill" despite clear lag times and significant concentration dependence.

72 crease in ionic strength resulted in shorter lag times and slower growth of fibrils.

73 The intestinal permeation studies showed a lag-time and apparent permeability coefficient that were

74 gs for the (1) minimum lag time, (2) maximum lag time, and (3) averaging times over which an autocorr

75 thrombin potential, the peak height, and the lag time, and replicated the main findings in 2 independ

76 posure to drug, cell death commences after a lag time, and the cell kill rate is dependent on the amo

77 nce, there is a so-called surface-associated lag time, and the organisms then enter a growth phase an

78 ons for the size of the critical capsid, the lag time, and the steady-state nucleation rate of capsid

79 rence and in any summary statistics, such as lag times, and allows interpolation with the correspondi

80 usly by using a recently developed automated lag-time apparatus (ALTA).

81 nding to a multilayer geometry; the flux and lag time are affected when the lipid transbilayer diffus

82 pendent differences in predicted aggregation lag times are in the same range as the length-dependent

83 alyte showed that the device could achieve a lag time as small as 14 s.

84 t be bounded by adequate minimum and maximum lag times as dictated by the fast and slow diffusing spe

85 uclein at low micromolar concentrations with lag times as short as 11 min and apparent first order gr

86 mineral apposition rate, and mineralization lag time, as well as higher osteoid surface, osteoblasti

87 ctivation at pH 3; however, growth rates and lag times at 43 degrees C and at pH 4.5 were not affecte

88 y decreasing the otherwise long fibrillation lag times at low pH and accelerates fibril growth rates

89 n concentration and mutations on the initial lag time before amyloid fibrils form in the protein solu

90 ns: incomplete symptom relief and 2-3 months lag time before clinically meaningful improvement.

91 undles can form prior to fusion and that the lag time before fusion occurs may include the time neede

92 ound with acid capped PLGA but with a longer lag time before release.

93 s may have low migration capacities and long lag times before colonization of new areas.

94 pores' GR-dependent germination had a longer lag time between addition of germinants and initiation o

95 The timing of commitment and the lag time between commitment and DPA release were also de

96 ll body contraction led to a decrease of the lag time between force generation and FA growth, indicat

97 el to sample injection, resulting in minimum lag time between injections.

98 en two loci can be identified by varying the lag time between locus position measurements.

99 The physical lag time between microdialysis and the analytical signal

100 characteristics--such as size of commitment, lag time between signature and first disbursement, and f

101 sporine, and XIAP overexpression reduces the lag time between the administration of an apoptotic stim

102 blots after 6 h of Al exposure, indicating a lag time between the Al-induced WAK transcription and tr

103 true equivalence flow rate FE because of the lag time between the first compositional change and its

104 apoptosis, yet resulted in a decrease in the lag time between treatment of the cells and the inductio

105 l center (GC) reactions; however, there is a lag time between vaccination and the generation of GC B

106 use brain within 72 h, dramatically reducing lag time between viral transduction and imaging, while i

107 We found that the lag times between acidification and fusion were signific

108 tions were strongest for cases with shortest lag times between blood draw and diagnosis (<3 years).

109 For spore populations, the lag times between commitment and DPA release were increa

110 the times needed for commitment, as well as lag times between commitment and DPA release.

111 lysis of the distributions of loop sizes and lag times between loops reveals that initiation of prime

112 exposure classifications to model differing lag times between NSAID exposure and cancer development.

113 f BMI with survival was stronger with longer lag times between reported BMI and cancer diagnosis.

114 d a bimodal distribution of peak correlation lag times between spiking activity and force, whereas SI

115 decades to occur, resulting in decades-long lag times between the time when a land-use activity is i

116 There are also major lag times between when these clades colonized the region

117 mplicated by nonlinearities, feedback loops, lag times, buffering and convergence among processes wit

118 of age, sex, lymphoma diagnosis-to-treatment lag time, calendar year, International Prognostic Index

119 ted in a concentration-dependent decrease in lag time consistent with each peroxide's ability to act

120 were observed, but only for polymeric beads: lag times correlated negatively with contact angle of wa

121 type I and triplex sites was shortened, the lag time decreased whilst the displacement reaction rema

122 on intracellular subdiffusion and elucidate lag-time dependence, with particular focus on the impact

123 cted as a 20- to 60-min decrease in splicing lag time depending on the pre-mRNA substrate.

124 We derived the individual lag time distribution inherent in population growth mode

125 When we quantified the lag time distribution of E. coli cells in a large dynami

126 Interestingly, the lag time distribution of persisters exhibited a long tai

127 e found that normal cells rejuvenated with a lag time distribution that is well captured by an expone

128 a mathematical model based on this biphasic lag time distribution, we quantitatively explained the c

129 allows a wide range of shapes for individual lag time distribution.

130 hrough a major adjustment in the single-cell lag-time distribution, without a change in resistance.

131 We demonstrate that individual cell lag time distributions cannot be retrieved from populati

132 model which shows that bacteria evolve wide lag time distributions when both rapid growth resumption

133 only growth phenotype observed was a longer lag time during growth on nonfermentable carbon sources

134 The factors that govern fibrillation lag times during kinetic inhibition are largely unknown,

135 sigmoidal kinetic profile and showed shorter lag times during seeding with preformed amyloid fibrils

136 ion mechanism characterized by a significant lag time, during which the peptide is monomeric, and tha

137 Better understanding of lag-time evolution as a key determinant of the survival

138 A reduction in lag time exiting stationary phase was linked to L. plant

139 oordination of copper to HTI showed a 6-8 ms lag time followed by a k(obsII) of 121 +/- 9 s(-)(1).

140 the direct sprayed dried samples revealed a lag time for 2 h in acidic media followed by rapid relea

141 rate coefficients, and introducing a 100 day lag time for acetoclastic methanogenesis for oleate and

142 or 4 (PF4) binds to bacteria and reduces the lag time for aggregation, and gray platelet syndrome alp

143 n in an ATP-dependent manner, determines the lag time for bacterial regrowth.

144 angle showed a shear-dependent occlusion and lag time for both PRP and WB.

145 rage intracellular drug concentration, and a lag time for cell killing.

146 rmancy depth," which in return regulates the lag time for cell resuscitation after removal of antibio

147 fer-acquired LOOHs significantly reduced the lag time for chain initiation relative to that observed

148 /- 50 ng/L, respectively; P = 0.028) and the lag time for copper-ion-induced LDL oxidation was longer

149 etheneotrophs exhibit significantly reduced lag time for ethene utilization when epoxyethane is adde

150 The marked increase in the lag time for fibril formation with mutations to more pol

151 ermodynamic stability and an increase in the lag time for fibril formation.

152 brillation process could be described by the lag time for formation of stable nuclei (nucleation) and

153 nt 22% lower than that to gammaA-Fn, and the lag time for initiation of Pg activation by tPA was long

154 Lag time for LDL oxidation increased 32% at 12 weeks, su

155 Lag time for oxidation of unfractionated plasma and plas

156 usion times for experimental conditions if a lag time for platelet activation is included.

157 ing inert polymers significantly reduced the lag time for protofibril formation and the conversion of

158 Under the experimental conditions, the lag time for the formation of precipitable aggregates is

159 say is transient, causing a reduction in the lag time for the translational expression of the newly s

160 Lag times for LDL oxidation were prolonged during the tr

161 including low response rates and substantial lag times for response.

162 ics, emerging antiviral resistance, and long lag times for vaccine development, raising a pressing ne

163 factors such as a decrease in the transient (lag) time for appearance of the final product of the cou

164 (vii) T(lag) times for spoVA(1) and spoVA(2) spores were longer

165 t on hIAPP fibrillogenesis: it increases the lag-time for fiber formation and decreases the rate of a

166 obes, leading to the development of a novel, lag time-free quantitative assay to evaluate the activit

167 resection data, there appears to be a 5-year lag time from IPMN adenoma (63.2 years) to invasive canc

168 methodology to better estimate fibrillation lag times from experimental curves.

169 rse the skin tissue into the receptor fluid (lag time) from 0.25 h for BDE-1 to 1.26 h for BDE-153.

170 s effect was significant for patients with a lag time >1 month and no pre-enucleation treatment (P =

171 As a consequence, cells with long lag times have no substantial effect on population growt

172 t a main effect of BRICHOS is to prolong the lag time in a concentration-dependent, quantitative, and

173 sterol in 18:0,18:1PC induced a considerable lag time in MII-G(t) formation after MII formed.

174 Study limitations include likely lag time in receipt of completed death certificates rece

175 IgG1 added to IgG-depleted PRP increased the lag time in response to 5B9.

176 Our data show that during the lag time in sedimentation kinetics, there is substantial

177 Higher cloning, reduced lag time in tissue, and the acquisition of growth factor

178 A comparison of the lag times in the approach to the steady-state rate of ab

179 After ingestion of grape juice, lag time increased by 34.5% (P=0.015).

180 hly unusual kinetics are observed, where the lag time increases with increasing peptide concentration

181 The exosomes reduce the lag time indicating that they provide catalytic environm

182 ized by concentration-dependent decreases in lag time, indicating increased nucleation rates, and sub

183 the total filament length without modulating lag time, indicating that filament extension but not nuc

184 lament mass were not associated with reduced lag times, indicating that these posttranslational modif

185 In general, this theory predicts that as the lag time interval increases, the dual-loci dynamic behav

186 survival by grouping reported BMI by 2-year lag-time intervals before diagnosis.

187 ies are present at early stages and that the lag time is defined by the primary nucleation rate only.

188 n single cells in real time to determine the lag times leading to the formation of the first function

189 itions do not permit achieving the necessary lag time limits for both of the species in a binary syst

190 y one specimen of the 231 analyzed to have a lag time longer than 6 y.

191 sensors were characterized by shorter sensor lag times (<4.2 min) in response to intravenous glucose

192 milar cholesterol levels, LDL oxidizability (lag time, malondialdehyde, and relative electrophoretic

193 Similar evolutionary lag times may occur in other organisms and habitats, but

194 the whole-genome duplication (WGD) radiation lag-time model, which postulates that increases in diver

195 nt statistical support for the WGD radiation lag-time model.

196 of chloride channel function by reducing the lag time necessary for channel activation and consequent

197 to lack of knowledge about BMP functioning, lag times, nonoptimal placement and distribution of BMPs

198 In contrast, a lag time of 1-2 h occurred before abscisic acid accumula

199 detected before RNFL thinning, with a median lag time of 15.8 months (range, 4.0-40.8 months).

200 ious estimates of epidermal turnover, with a lag time of 18 days before label appeared at the skin su

201 Munc18-c traffic was time-dependent with a lag time of 3 min compared with GLUT4.

202 rage energy and macronutrient intakes with a lag time of 3-4 d, but not 1-2 d.

203 in Arabidopsis, as in other species, after a lag time of 30 s.

204 opper-induced lipid peroxidation exhibited a lag time of 4 h, while peroxide-induced lipid peroxidati

205 saturation at 120 min, and was preceded by a lag time of 40 min.

206 We model the lag time of a single cell, inoculated into a new environ

207 t to induce apoptosis, which occurred with a lag time of about 24 h, although longer treatments produ

208 relationship between protein solubility and lag time of amyloid formation is not captured by current

209 bility in determining amyloid propensity and lag time of amyloid formation, highlighting how small di

210 ter understand the role of solubility on the lag time of amyloid formation.

211 is immediate, the action of cPLA2 requires a lag time of approximately 12-15 min, probably the time n

212 correlated with Ca(2+)i oscillations with a lag time of approximately 5-6 s.

213 After a lag time of around 10 h, a phase transition occurred in

214 Strikingly, we found that the lag time of bacteria before regrowth was optimized to ma

215 is located in the lipid layers; the flux and lag time of diffusion through a brick-and-mortar geometr

216 ormation in contrasting ways: decreasing the lag time of fibril formation in the presence of LMW-hepa

217 In the spontaneous reactions, the lag time of fibril formation was rather uniform for the

218 addition of 0.3% mucin to BHI-HS reduced the lag time of H. pylori by 48 h and enhanced the growth.

219 data lead to absolute quantification of the lag time of mRNA induction (the time it takes for extern

220 here the rate of plasmid growth includes the lag time of newly formed F(+) transconjugants and the re

221 ch velocities of order km/day, and confirm a lag time of order 5-10 days between mound formation and

222 s found to inhibit the rate and increase the lag time of oxidation to a greater extent than the forme

223 Looking at cell populations, the rate and lag time of the Bid-induced permeabilization are dose-de

224 ing enzymes for optimal kinetic response and lag time of the reporter system, based on the kinetic ch

225 Lag times of 37 days (sulfate amended) to more than 100

226 sk Assessment, it is vital to understand how lag times of individual cells are distributed over a bac

227 onential growth, and the distribution of the lag times of individual cells.

228 f CD and malondialdehyde, and lengthened the lag times of LDL, sd-LDL and lb-LDL in the order TQ>LMN.

229 Lag times of onset are short and the maximum anesthetic

230 We quantify the distribution of single-cell lag times of populations of starved Escherichia coli and

231 ial response lag times with rings exhibiting lag times of up to 4 h.

232 (iii) The long T(lag) times of gerD spores were partially due to slow com

233 cal/mol), (ii) delays onset of fibrillation (lag time on gentle agitation at 37 degrees C was prolong

234 Users with longer lag times or whose cases are never reported are excluded

235 ical absorbance capacity (P < 0.001) and LDL lag time (P < 0.001) and significantly decreased the LDL

236 ct on the early oligomerization steps in the lag time period.

237 least two mechanisms are at play during the lag time: primary nucleation and autocatalytic growth.

238 n the C-terminal charge of alpha-syn and the lag time prior to the observation of fibril formation, w

239 defect that manifested through an increased lag time, produced no detectable biofilm, and displayed

240 was positively correlated with LDL oxidation lag time (r = 0.32, P = 0.03).

241 ved include severe local outbreaks with long lag time relative to the aggregate infection curve, and

242 Probabilistic modeling of these lag times revealed that one slow and seven equally fast

243 nstrates that care is needed in interpreting lag-time scaling exponents from protein assembly data.

244 Moreover, we suggest that the "lag time" seen in these studies is not the time needed f

245 displayed a concentration-dependent apparent lag time similar to observations of protein aggregation

246 n were significantly impaired, with a longer lag time, slower rate of lateral aggregation, and decrea

247 ays respond to RET activation with different lag times, such that the balance of signal flux among th

248 pores in populations was the highly variable lag time, T(lag), between mixing spores with nutrient ge

249 s of urea: We determine how the fibrillation lag time (tau(lag)) and maximum growth rate (nu(max)) de

250 In the presence of an antioxidant, the lag time (tau) produced during free radical-induced ster

251 was nucleation-dependent, occurring after a lag time that decreased with increasing peptide concentr

252 nd serotype B cells showed a decrease in the lag time that occurred before the onset of rapid accumul

253 ons enter cells, but it has no effect on the lag time that precedes this entry flow.

254 bited growth rates, final growth yields, and lag times that were significantly reduced compared with

255 In sensitivity analysis, with longer polyp lag times the mean extension in life expectancy decrease

256 is process was inhibited and occurred with a lag time, the duration of which depended on the concentr

257 meter (Omega) calculated on the basis of the lag time, the rate of formation and concentration of the

258 For an assumed 2-min lag time, the sensor readings were well correlated with

259 e we demonstrate the concept of evolutionary lag time, the time between when a climatic regime or hab

260 In particular, the lag time--the quiescent period before aggregates are det

261 wareness in the CSE tradition, or resumption lag (time to resume an interrupted task) in the applied

262 rations too low to inactivate Ras reduce the lag time to Ag-induced Ca2+ stores release and enhance s

263 idogenesis is observed as an increase in the lag time to amyloid formation and a diminished thioflavi

264 s to enhanced turnover of SECURIN, decreased lag time to anaphase and defects in chromosome segregati

265 with antihypertensive medications, and long lag time to clinical outcomes.

266 yses of baseline consumption, with a 10-year lag time to disease follow-up (quintile 5 vs. quintile 1

267 Considering the lag time to incorporate atmospheric (14)C into plant foo

268 There was a significant reduction in mean lag time to initial symptom perception and an increase i

269 t not antibodies to p110alpha, lengthens the lag time to release of Ca2+ stores and blunts the sustai

270 , or R92E gp91(phox) along with an increased lag time to the maximal rates of superoxide production r

271 stment for significant covariates of age and lag time to therapy (odds ratio [OR] = 0.018, 95% confid

272 of the entire population due to a prolonged lag time until growth resumption and a reduced growth ra

273 s phospholipids alone extended the oxidation lag time up to 40 h.

274 mers in an inactive conformation, leading to lag times up to more than 1 h.

275 ack blood glucose with an approximate 30 min lag time, using disposable and colorless contact lenses.

276 rosomucoid, as a novel locus associated with lag time variability, reflecting the initiation process

277 The lag time varied inversely with the enzyme concentration,

278 models fail to explain detailed features of lag time versus concentration curves, suggesting that ne

279 Here we show that experimental data for lag time versus protein concentration can show signs of

280 LDL oxidation lag time was approximately 8% greater (P = 0.01) after t

281 d with platelet-rich plasma (PRP), a shorter lag time was measured in 131RR donors compared to indivi

282 rate of aggregation was increased, while the lag time was unaffected.

283 , which is based on matrix analysis of burst lag times, was evaluated using baculovirus samples that

284 ies and landscapes, and indirect effects and lag times, we see a distinct shift away from single-poin

285 relations for epinephrine, ADP, and collagen lag time were 0.24, 0.22, and 0.31, respectively (P=0.00

286 e biphasic platelet aggregation and collagen lag time were determined.

287 These lag times were also decreased dramatically by the action

288 (ii) T(lag) times were lower for upward arrowSpoVA spores than

289 ered strain, however, still exhibited a long lag time when metabolizing xylose above 10 g/l as a sole

290 paired mRNA export and also generated longer lag times when glucose or raffinose was replaced by gala

291 , all mutants displayed significantly longer lag times when switching from growth on trimethylamine t

292 The denaturant, urea, decreased the lag time, whereas the stabilizers, trimethylamine N-oxid

293 ar hospitalizations were highest for smaller lag times, whereas effect estimates for respiratory hosp

294 time to the onset of amyloid formation, (the lag time), while having modest effects on the total amou

295 An increase in lag time with decreasing ATP concentration is also obser

296 ex spectral power increase that decreased in lag time with increasing locomotion speed.

297 inhibitors, which have primarily shifted the lag time with little effect on later stages of aggregati

298 easonal variability, and an increase in peak lag times with increasing body size.

299 ug sensitivity reflect differential response lag times with rings exhibiting lag times of up to 4 h.

300 ncreases in UFP, AMP, and PM2.5 at 1 or more lag times within the previous 5 days.