ライフサイエンスコーパス: laminin

1 of this receptor in relaying the effects of laminin.

2 a4-integrin along with its matrix substrate, laminin.

3 hologs (Paf, AfeA, and MntC) interacted with laminin.

4 d when mAgrin is in molar excess relative to laminin.

5 GC axons on substrates of Nogo-A-Fc, but not laminin.

6 ronectin levels with little direct effect on laminin.

7 ue sections were stained for C5b-9, C4d, and laminin.

8 collagen III, collagen IV, fibronectin, and laminin.

9 could be modulated by the adhesion molecule laminin.

10 onectin and vitronectin, but not collagen or laminin.

11 targeted multiple heparin-binding domains of laminin.

12 eta2 chain, demonstrating that they may bind laminins.

13 proteins, including perlecan, collagens, and laminins.

14 Previous studies demonstrated that laminin 1 (L1) is critical for intact salivary cell clus

15 of extracellular matrix proteins, especially laminin-1 and fibronectin, suggesting altered cytoskelet

16 We previously reported that mouse Laminin-111 (msLam-111) protein could reduce muscle path

17 LG domains from the subunit alpha chains of laminin-111 and -332, the latter isoform of which is the

18 Several studies have shown laminin-111 can serve as an effective protein-replacemen

19 investigated the extent to which trimers of laminin-111 chemically conjugated to FH (L(1p)T-FH) can

20 gether, these findings support the idea that Laminin-111 could serve as a novel protein therapy for t

21 For instance, monomers of laminin-111 peptides chemically conjugated to fibrin hyd

22 udies have demonstrated early treatment with laminin-111 protein results in an increase in life expec

23 In this study, we tested the efficacy of laminin-111 protein therapy after disease onset in a mou

24 sed after advanced disease, it is unclear if laminin-111 protein therapy at an advanced stage of the

25 Together these studies indicate laminin-111 protein therapy either early or late in the

26 Our results showed laminin-111 treatment after muscle disease onset increas

27 which in turn led to increased secretion of laminin-111.

28 drives expression of ECM components and that laminin 211 increases BP proliferation in embryonic mous

29 dy2J mice) express a nonpolymerizing form of laminin-211 (Lm211) and are a model for ambulatory-type

30 inin-alpha2 is critical for the formation of laminin-211 and -221 heterotrimers in the muscle basal l

31 e autoantibodies against the alpha3 chain of laminin 332 (LAMalpha3), a structural protein of epiderm

32 nd the keratinocyte footprint assay for anti-laminin 332 antibodies.

33 ctors, cytokine secretion, and deposition of laminin 332 for several days.

34 an essential, dynamic adhesion receptor for laminin 332 found on epithelial cells, required for form

35 en alpha6beta4 and intermediate filaments or laminin-332 results in similar phenotypical changes.

36 , a major receptor for epidermal adhesion to laminin-332, is critical for proper basement membrane or

37 ys reveal higher binding to laminin 511 than laminin 411 but faster migration across laminin 411.

38 lacking the major endothelial BM components, laminin 411 or 511, in murine experimental autoimmune en

39 than laminin 411 but faster migration across laminin 411.

40 ion between the expression of tumor vascular laminin-411 (alpha4beta1gamma1) with higher tumor grade

41 We also showed that depletion of laminin-411 alpha4 and beta1 chains with CRISPR/Cas9 in

42 etic mutations in glioblastoma.Significance: Laminin-411 expression in the glioma microenvironment co

43 ng blood-brain barrier was designed to block laminin-411 expression.

44 Laminin-411 overexpression also correlated with higher r

45 Inhibition of laminin-411 suppressed Notch pathway in normal and malig

46 Laminin-421 and -211 were identified by proximity-based

47 erve sheath, particularly perineurium, where laminin-421 is predominant.

48 the Kelch-like family protein KLHL35 and the laminin-5 complex to be upregulated and downregulated, r

49 (EAE), we show here that loss of endothelial laminin 511 results in enhanced disease severity due to

50 nd migration assays reveal higher binding to laminin 511 than laminin 411 but faster migration across

51 a6beta1- and alphavbeta1-mediated binding to laminin 511-high sites not only holds T cells at such si

52 inding to laminin alpha5 chain, a subunit of laminins 511 and 521.

53 extracellular matrices (ECMs) and identified laminin-511/521 as potent enhancers of cardiomyocyte mat

54 l isoform supporting tumor cell migration on laminin 521 and that the Lu:Lu(v13) ratio at the cell su

55 CM to its individual components; Collagen I, Laminin-521 and Fibronectin.

56 ve hPSC-derived cortical networks on defined laminin-521 substrate.

57 These data suggest that laminins act as links among pre- and post-synaptic lamin

58 the blood-brain barrier is rich in collagen, laminin, agrin, and perlecan.

59 Here, we show that laminin alpha 2 (lm-alpha2) is a component of the midbra

60 its extracellular matrix interaction partner laminin alpha 4 (LAMA4) emerged as the most consistently

61 Laminin alpha 5 (LAMA5) is a member of a large family of

62 A bioactive RGD-containing peptide from laminin alpha1 chain, A99 (AGTFALRGDNPQG), promotes stro

63 nidogen-2 in their pericellular matrix, and laminin-alpha1 enhanced collagen type II and reduced col

64 ncodes a structurally similar protein called laminin-alpha1, ameliorates muscle wasting and paralysis

65 genitor cells (CPCs) produced high levels of laminin-alpha1, laminin-alpha5, and nidogen-2 in their p

66 genetic model have shown that a deletion of laminin alpha2 impedes male fertility by disrupting ecto

67 Of more importance, a knockdown of laminin alpha2 in Sertoli cells was shown to induce the

68 rrier by a local axis in the testis: role of laminin alpha2 in the basement membrane.

69 In short, laminin alpha2 in the BM seems to play a crucial role in

70 Here, we show that laminin alpha2 in the BM serves as the crucial regulator

71 Laminin alpha2 is one of the constituent components of t

72 Furthermore, laminin alpha2 knockdown also perturbed microtubule (MT)

73 creases the overexpression of dystrophin and laminin alpha2 surrogates known to inhibit disease.

74 strophy type MDC1A is caused by mutations in laminin alpha2 that either reduce its expression or impa

75 ves as the crucial regulator in this axis as laminin alpha2, likely its 80-kDa fragment from the C te

76 Mutations in laminin alpha2-subunit (Lmalpha2, encoded by LAMA2) are

77 integrin, Ptrh2 expression was decreased in laminin-alpha2 dyW null gastrocnemius muscle.

78 Laminin-alpha2 is critical for the formation of laminin-

79 n shown to ameliorate disease pathology in a laminin-alpha2 knockout mouse model of muscular dystroph

80 Laminin-alpha2 related congenital muscular dystrophy (LA

81 utations in LAMA2 that lead to nonfunctional laminin-alpha2, which compromises the stability of muscl

82 Neuregulin 1 type III (Nrg1III) and laminin alpha2beta1gamma1 (Lm211) are the key axonal and

83 identify a concentration-dependent role for laminin alpha2beta1gamma1 (lm211) in regulating mDA prog

84 Laminin-alpha3 mutations are associated with tumour inva

85 tory T cell (Treg) environments with/without laminin alpha4 and/or alpha5.

86 Laminin alpha4 inhibited CD4+ T-cell proliferation and T

87 Immunity was associated with decreased laminin alpha4:alpha5 ratio, while tolerance was associa

88 Laminins alpha4 and alpha5 are coinhibitory and costimul

89 Stromal laminins alpha4 and alpha5 are differentially regulated

90 In diverse models, laminins alpha4 and alpha5 were differentially regulated

91 lycoprotein receptor capture also identified laminin-alpha4 and -gamma1.

92 LNSC-produced laminin alpha5 (Lama5) regulates CD4+ T cells but the un

93 promotes tumor cell migration by binding to laminin alpha5 chain, a subunit of laminins 511 and 521.

94 Laminin alpha5 favored T-cell activation and Th1, Th2, a

95 Laminin alpha5 receptors were blocked with anti-alpha6 i

96 Laminin alpha5 was also recognized by T cell alpha-DG an

97 Laminin alpha5 was recognized by T cell integrin alpha6

98 In isolated islets, laminin-alpha5 (found in both layers of the duplex BM) a

99 Collagen IV, pan-laminin, perlecan and laminin-alpha5 in the islet BM were significantly digest

100 PCs) produced high levels of laminin-alpha1, laminin-alpha5, and nidogen-2 in their pericellular matr

101 We find that laminin also preserves PGC quiescence during embryogenes

102 ations in human LAMB2 cluster in or near the laminin amino-terminal (LN) domain, a domain required fo

103 important virulence factor interacting with laminin, an extracellular matrix protein ubiquitously ex

104 own resulted in faster-growing axons on both laminin and aggrecan and enhanced crossing of axons from

105 ation (Ki-67), decreased neovascularization (laminin and alphaSMA), in addition to inflammation and a

106 The laminin and beta-dystroglycan immunolabelings altered al

107 On the other hand, both TG2/laminin and collagen III activate the receptor by dissoc

108 ndothelial tissues, is primarily composed of laminin and collagen IV and serves as a structural barri

109 singly, many matrix proteins move within the laminin and collagen scaffoldings.

110 xpression of extracellular matrices, such as laminin and collagen, in iPS-HSCs.

111 ervation of key proteins such as collagen-1, laminin and fibronectin and retention of growth factors

112 ion of extracellular matrix proteins such as Laminin and Fibronectin was also affected by the trypsin

113 ed an AR driven pathway that cooperates with laminin and hypoxia to drive resistance to PI3K inhibito

114 to induce Bnip3 is dependent on adhesion to laminin and integrin alpha6beta1-dependent nuclear trans

115 Lower levels of laminin and neurogenic locus notch homolog protein 1 but

116 two independent polymeric networks - one of laminin and one of type IV collagen (Figure 1, bottom).

117 Laminin and the basement membrane receptor dystroglycan

118 endfeet is dependent on interactions between laminin and the receptor dystroglycan.

119 s (BMs) are supramolecular matrices built on laminin and type IV collagen networks that provide struc

120 Laminins and their receptors modulate immune responses b

121 ize the vitreoretinal junction (fibronectin, laminin) and vitreous gel (opticin) markers.

122 M-2, junctional adhesion molecule-B (JAM-B), laminin, and cellular fibronectin, supported binding of

123 al components including smooth muscle cells, laminin, and elastin in airway and cystic walls using im

124 s of four matrix proteins-collagen I and IV, laminin, and fibronectin-in skin biopsies of patients wi

125 ure and composition in terms of collagen IV, laminin, and fibronectin.

126 LDH, PD, and P6 exhibited interactions with laminin, and mediated NTHi laminin-dependent adherence t

127 PrP(C), laminin, and metabotropic glutamate receptor 5 (mGluR5)

128 with increases in collagen IV, decreases in laminin, and varied changes in fibronectin.

129 muscle proteins, including utrophin, agrin, laminins, and integrins.

130 Laminin appeared to be a critical component in regulatin

131 Laminins are constituents of the extracellular matrix an

132 Laminins are differentially expressed upon immunity or t

133 We hypothesize that laminins are required for proper trans-synaptic alignmen

134 Laminins are trimeric proteins that are major components

135 wimming sperm and sperm bound to immobilized laminin as controls, we observed that over 96 h, the via

136 g of host cells and purified fibronectin and laminin, as well as Yop delivery, three mutations, F80A

137 Indeed, laminin association and integrin engagement are required

138 First, niche cell wrapping templates a laminin-based basement membrane around the gonad primord

139 rowth factor receptor alpha (PDGFRalpha) and laminin beta 1 (LAMB1) expression.

140 fied a rare single nucleotide variant in the laminin beta 4 gene (LAMB4) that segregated with disease

141 ane biofunctionalized with a fragment of the laminin beta1-chain to modulate the expression of MMP2 i

142 Binding of LAMR by the laminin-beta1 analog YIGSR promotes NCC migration.

143 (NCC-/-) mice that model HSCR and identified laminin-beta1 as upregulated in EdnrB(NCC-/-) colon.

144 /67 kDa laminin receptor (LAMR), which binds laminin-beta1, in human HSCR myenteric plexus and EdnrB(

145 nd neurologic defects caused by mutations in laminin beta2 (LAMB2), a major component of the glomerul

146 glycan can be co-immunoprecipitated with the laminin beta2 chain, demonstrating that they may bind la

147 In the absence of the laminin beta2 chain, the expression of many pre-synaptic

148 Mice with a targeted deletion of the laminin beta2 gene (Lamb2) exhibit retinal disruptions:

149 ing from defects in GBM structural proteins (laminin beta2 or collagen alpha3 IV), the GBM is irregul

150 of human nephrotic syndrome caused by mutant laminin beta2 protein-induced podocyte ER stress and AKI

151 We demonstrate in vitro that mAgrin enhances laminin binding to primary myoblasts and fibroblasts fro

152 uced a decrease of alphaDG glycosylation and laminin binding, even in WT animals.

153 pproach to determine if a specific region of laminin-binding alpha6beta1 integrin was required for sm

154 The putative laminin-binding alphaINA-1/betaPAT-3 integrin was select

155 The laminin-binding glycan (matriglycan) on alpha-dystroglyc

156 idoglycan-associated lipoprotein P6 as novel laminin-binding proteins (Lbps) of NTHi.

157 collagen-binding, Arg-Gly-Asp (RGD)-binding, laminin-binding, and leukocyte integrins.

158 ling led us to discover that GNPs respond to laminin, but not vitronectin, in the GZ microenvironment

159 ) and binding to the sialylated glycoprotein laminin by 95% failed to inhibit mycoplasma binding to s

160 utations in the extracellular matrix protein laminin cause severe consequences in glial wrapping and

161 We found that treating these cells with laminin causes endogenous agrin to localize to the cell

162 composed of collagen IV + heparan sulfate + laminin (CHL) or collagen IV + gelatin + heparan sulfate

163 mentin) and extracellular matrix components (laminin, collagen IV) correlate with tissue softening.

164 interact with multiple ECM components (e.g., laminin, collagens III and IV) to drive the formation of

165 Laminins colocalized with NP41 within nerve sheath, part

166 icrotubules and coincides with sites of high laminin concentration.

167 alpha6WT) produced a 3D invasive network on laminin-containing Matrigel and invaded into smooth musc

168 10%, and that of sperm bound to immobilized laminin decreased to about 50%, whereas viability of spe

169 of active MMPs, facilitating fibronectin and laminin degradation, and likely contributing to the vari

170 interactions with laminin, and mediated NTHi laminin-dependent adherence to pulmonary epithelial cell

171 ivating priming injuries, stimulated robust, laminin-dependent sensory axon regrowth past scar-formin

172 Exit from quiescence following laminin depletion requires glp-1/Notch and is accompanie

173 ow increased matrix protein (fibronectin and laminin) deposition and collagen remodeling compared to

174 We hypothesized that laminins directly regulated T-cell activation and polari

175 -dimensional matrix composed of a mixture of laminin, entactin and type-IV collagen (LEC matrix) 'res

176 g the globular domains, and also attached to laminin expressed on respiratory epithelial cells.

177 e used a reverse genetic approach to disrupt laminin expression in the vascular basement membrane and

178 Experimental reduction of Laminin expression leads to smaller protrusions and shor

179 Laminin expression was measured in several models of imm

180 ranches in ECs and increased collagen IV and laminin expression.

181 ctive oxygen species generation, and, matrix laminin expression.

182 alT1 adhere avidly to beta1 integrin ligands laminin, fibronectin, and collagen, while other platelet

183 Influence of BL proteins-laminin, fibronectin, collagen type IV, agrin, and perle

184 nce of degenerating cells and the leakage of laminin from the basement membrane across a compromised

185 itary neuropathies associated with decreased laminin function are characterized by focally thick and

186 Using a laminin-functionalized hydrogel system designed to mimic

187 Using a laminin-functionalized polyethylene glycol hydrogel, we

188 r the essential role of a conserved EGF- and laminin-G-domain-containing protein nlr-1/CASPR in the r

189 A global and inducible mouse model of laminin-gamma1 deficiency was generated to address this

190 turnover that results in rapid depletion of laminin-gamma1 in the intestine.

191 Laminin-gamma1 is required for early embryonic developme

192 onclude that the physiologic requirement for laminin-gamma1 synthesis in adult mice is dependent on a

193 embryonic development; however, the need for laminin-gamma1 synthesis in adulthood is unknown.

194 dependent on a tissue-specific basal rate of laminin-gamma1 turnover that results in rapid depletion

195 In contrast, laminin-gamma1 was significantly depleted in the small i

196 Laminin gamma2 was identified in the attachment of epith

197 Proteolytic processing of the laminin-gamma2 chain is a hallmark of basement membrane

198 r alpha3beta1 in promoting the processing of laminin-gamma2 in cultured keratinocytes in vitro and in

199 membrane assembly/maturation through reduced laminin-gamma2 processing via mTLD/BMP-1.

200 critical regulator of alpha3beta1-dependent laminin-gamma2 processing, thereby expanding the role of

201 al density is significantly increased in the laminin gamma3-null (Lamc3(-/-)) retinal superficial vas

202 acellular matrix protein containing multiple laminin globular (LG) domains, and in protein O-mannose

203 ch include F5-, noncollagenous 1 (NC1)-, and laminin globular (LG)3/4/5-peptide, to modulate cellular

204 d a missense mutation (V1727F) in the second laminin globular (LG2) domain of agrin that causes sever

205 ith glycan structures functional for binding laminin globular domain-containing proteins.

206 While laminins have a critical structural role, recent evidenc

207 Pathogenic mutations in some laminins have been shown to cause a range of largely syn

208 Laminin immunostaining and quantitation of tissue extrac

209 Our results identify a novel role for laminin in neural development and provide a possible mec

210 332, the latter isoform of which is the main laminin in the airway BM.

211 investigate the function of pericyte-derived laminin in vascular integrity.

212 Finally, the role of the laminins in autoimmune diseases and transplantation will

213 The retina expresses several laminins in the outer plexiform layer (OPL), where they

214 The extracellular matrix, including laminins, in the tumor microenvironment is important for

215 oteins bound at the heparin-binding sites of laminin, including the globular domains, and also attach

216 ted high levels of collagen in an apparently laminin-independent manner.

217 ne, we report that PDGFRbeta(+) cell-derived laminin inhibits their proliferation and adipogenesis, b

218 Here we report that ECM through laminin-integrin alpha6 upregulates ten-eleven transloca

219 glycosylation of alpha-dystroglycan disrupts laminin interaction with alpha-dystroglycan and the extr

220 teins involved with extracellular matrix and laminin interactions, and a decrease in levels of protei

221 More importantly, the NTHi laminin interactome consisting of the well-studied and n

222 Laminin is a well-defined component of the airway baseme

223 omposition with low CollagenIV levels, while Laminin is present along tracheal branches.

224 Laminin is thus a highly important target for PF ortholo

225 Sixteen laminin isoforms have been described, each with distinct

226 gh plasticity of interactions with different laminin isoforms via multiple heparin-binding sites.

227 ant P4 displayed a high binding affinity for laminin (Kd = 9.26 nM) and fibronectin (Kd = 10.19 nM),

228 store function of a polymerization-defective laminin, leading to normalized muscle structure and stre

229 f the well-studied and novel Lbps recognized laminin LG domains from the subunit alpha chains of lami

230 Netrin-1, a chemorepulsant, laminin-like matrix protein, promotes inflammation by pr

231 Laminin LN domain mutations linked to several of the Lma

232 immunohistochemical staining identifying the laminin (Ln) gamma2 chain specific for Ln-332, which is

233 Here, we investigate the efficacy of laminin (LN) isoforms preferentially expressed in the li

234 expanded at high yield by using recombinant laminin (LN)-511-E8 as culture substrate.

235 Endocytosed laminin localizes to lysosomes, results in increased int

236 d GPR179 become dissociated, suggesting that laminins mediate scaffolding of post-synaptic components

237 sults demonstrate a novel mechanism by which laminins modulate vascular branching and endothelial cel

238 These independent collagen and laminin networks are thought to be linked by several add

239 patch of conserved residues on the pentraxin/laminin-neurexin-sex-hormone-binding-globulin-like (PLL)

240 G1, an aGPCR with two domains [pentraxin and laminin/neurexin/sex hormonebinding globulin-like (PLL)

241 he complex of neurexophilin-1 and the second laminin/neurexin/sex-hormone-binding globulin domain (LN

242 oteins such as type IV and type VI collagen, laminin, nidogen and perlecan/HSPG2 that constitute the

243 h muscle-specific expression of alphaLNNd, a laminin/nidogen chimeric protein that provides a missing

244 detectable fibronectin and the decreases in laminin observed in vivo.

245 We identified that BB0406 interacts with laminin, one of the major constituents of the vascular b

246 aggrecan and enhanced crossing of axons from laminin onto aggrecan.

247 their intrinsic biophysical properties make laminin peptide-ELPs promising biomaterials for cell cul

248 Collagen IV, pan-laminin, perlecan and laminin-alpha5 in the islet BM wer

249 n-specific basement membrane proteins called laminins play important roles in the maintenance of phen

250 s into the specific functional importance of laminin polymerisation during development and tissue hom

251 al data indicated that this mutation impairs laminin polymerization, which we hypothesized to be the

252 issue of the JCI, McKee and colleagues use a laminin polymerization-competent, designer chimeric BM p

253 s endothelial cell growth, morphology, human laminin production, and inflammatory state.

254 growth, phenotype, inflammatory response and laminin production.

255 n total cardiac, pulmonary, hepatic or renal laminin protein.

256 alled ImmunoCloak, consisting of a matrix of laminin, proteoglycans, fibronectin, and collagens.

257 identified decreased expression of 37/67 kDa laminin receptor (LAMR), which binds laminin-beta1, in h

258 noma cells acting via 37/67 kDa non-integrin laminin receptor (LR/37/67 kDa) and downstream ERK1/2, P

259 endently of choline binding protein A (CbpA)/laminin receptor, CbpA/polymeric immunoglobulin receptor

260 Another potential laminin receptor, dystroglycan, is at the post-synaptic

261 A potential laminin receptor, integrin alpha3, is at the presynaptic

262 -3-gallate (EGCG) signals ECs via the 67 kDa laminin-receptor (67LR) resulting in protein kinase A de

263 neuropathies, results attributed to loss of laminin-receptor signaling.

264 ly, myotubes lacking integrin alpha7beta1, a laminin-receptor, also show a significant increase in pS

265 ns act as links among pre- and post-synaptic laminin receptors and alpha-DG and pikachurin in the syn

266 Laminin receptors were blocked, and TEa T-cell migration

267 We hypothesize that this laminin-related function is essential for the previously

268 Netrin1, a secreted laminin-related protein, is essential for nervous system

269 asured for the local ECM when cultured in 3D laminin-rich ECM.

270 al muscle, agrin binds with high affinity to laminin(s) and alpha-dystroglycan (alpha-DG), an integra

271 rophy, acting as a link between alpha-DG and laminin(s).

272 te collagen secretion, is also important for laminin secretion in glia via a collagen-independent mec

273 However, the expression of fibronectin- and laminin-specific matrix metalloproteinases (MMPs), parti

274 overcome polymerization deficits to increase laminin, stabilize BM structure, and substantially ameli

275 Gs transduced using AAV5-shRNA-fidgetin on a laminin substrate with spots of aggrecan, a growth-inhib

276 Heterozygous variants in laminin subunit beta 3 ( LAMB3) cause AI with dominant i

277 cell antigen 1, glutamine synthetase [GLNA], laminin subunit beta-2, lysophospholipase I, ras homolog

278 , P = 0.03; GLNA: 1.2 versus -0.4, P = 0.03; laminin subunit beta-2: 6.1 versus 5.4, P = 0.06; lysoph

279 Glial-specific loss of the beta or gamma laminin subunit disrupted glia morphology and led to ER

280 Glomerular and tubulointerstitial laminin subunit gamma-1 (LAMC1) expression decreased in

281 The retention of the unpaired laminin subunit was key to the glial disruption as loss

282 Prior studies have found that loss of laminin subunits from vertebrate Schwann cells causes lo

283 th an antibody against the gamma1 subunit of laminin, suggesting that the latter is crucial to the pr

284 tin, fibronectin, collagen 1A, vimentin, and laminin, suggestive of transition to a mesenchyme-like p

285 This review will summarize the structure of laminins, the modulation of their expression, and their

286 romote survival of CRPC cells selectively on laminin through the induction of autophagy and mitophagy

287 eavage and the presence of a matrix protein, laminin, to activate GPR56, whereas collagen III and 3-a

288 of Tango1 blocked secretion of the complete laminin trimer but did not lead to glial or locomotion d

289 required for extracellular polymerization of laminin trimers and basement membrane scaffolding.

290 re of the polymerisation of alpha/beta/gamma laminin trimers.

291 The major components of the GBM include laminins, type IV collagen, nidogens and heparan sulfate

292 Efficient binding of laminin via multiple interactions is important for nonty

293 associated with enhanced fibrosis (collagen, laminin, vimentin, periostin).

294 lpha3beta1 and alpha6beta1 to subendothelial laminin was a critical prerequisite for successful trans

295 seeding densities, hAEC production of human laminin was enhanced following serous seeding.

296 d islets, yet a significant reduction in pan-laminin was seen during the initial 24 h culture period.

297 Collagen IV and pan-laminin were present in the disorganized BM of isolated

298 ctively activated in the gonad and recruited laminin, which directed moderate collagen incorporation.

299 tion of polymerization-deficient recombinant laminins, with retention of collagen IV, reiterating the

300 ggrecan concentration gradient to cross onto laminin, without retracting or curving back.