ライフサイエンスコーパス: lamprey

1 ed after the separation of gnathostomes from lampreys".

2 rived enteric neural crest population in the lamprey.

3 Lakes that harbor the invasive parasitic sea lamprey.

4 lated from water conditioned with larval sea lamprey.

5 r to those of rainbow trout but not with sea lamprey.

6 g head skeleton development in the agnathan, lamprey.

7 avior of upstream migrating adult salmon and lamprey.

8 ylogenetically oldest vertebrates, the river lamprey.

9 d these questions in a basal vertebrate, the lamprey.

10 bipolar-cell dendrites, are both present in lamprey.

11 gins of jaws that has focused on the jawless lamprey.

12 mologs of the SNr and PPN are present in the lamprey.

13 use and zebrafish to the jawless vertebrate, lamprey.

14 the phylogenetically oldest vertebrates, the lamprey.

15 he MHb and LHb circuitry is conserved in the lamprey.

16 ng the larval stage and in newly transformed lamprey.

17 ctively remove most, but not all, larval sea lamprey.

18 terior axis of a jawless vertebrate, the sea lamprey.

19 inal neurons in the four reticular nuclei of lampreys.

20 d DA modulation of olfactory transmission in lampreys.

21 we report in this study a BAFF-like gene in lampreys.

22 ed to the mono- or dichromacy found in other lampreys.

23 a in both control and spinal cord-transected lampreys.

24 s is shared by all these species, except for lampreys.

25 ed bile salt homeostasis in larval and adult lampreys.

26 role in the respiratory rhythm generation in lampreys.

27 nce of excitatory (glutamatergic) neurons in lampreys.

28 spiratory changes in relation to movement in lampreys.

29 so observed around reticulospinal neurons of lampreys.

30 actory inputs to the motor command system of lampreys.

31 analysis, we discovered three Pax6 genes in lampreys.

32 fter activation of the B-like lymphocytes in lampreys.

33 ebrates and expose others that are unique to lampreys.

34 as a partial reduction in the ability of the lamprey 5-hydroxytryptamine1b-type serotonin receptor to

35 lectrosensory inputs, as investigated in the lamprey - a phylogenetically conserved vertebrate.

36 stoma), but occur in Petromyzon marinus (Sea Lamprey), a jawless vertebrate.

37 e discovered the first FXYD homologue in sea lamprey, a basal jawless vertebrate, which suggests smal

38 ulatory comparisons between gnathostomes and lamprey, a jawless extant vertebrate, to investigate con

39 The sea lamprey, a jawless fish, can provide unique insights int

40 regulatory genes, the embryonic brain of the lamprey, a jawless vertebrate, had been regarded as repr

41 Our results indicate that the sea lamprey, a jawless vertebrate, may be in an evolutionari

42 amphioxus, an invertebrate chordate, the sea lamprey, a representative of agnathans, and the elephant

43 ural networks controlling respiration in the lampreys, a basal vertebrate.

44 the known morphological disparity of extinct lampreys, a chordate affinity for T. gregarium resolves

45 We discovered that the sea lamprey adapts to biliary atresia through a unique mecha

46 Lampreys also possess SCCs that are particularly numerou

47 tergic populations reported in the adult sea lamprey , although some important differences were noted

48 commonality of habitats between sturgeon and lamprey ammocoetes, suggests that there may be effects a

49 e., lamprey pesticides) to target larval sea lamprey and barriers to prevent adult lamprey from reach

50 e two forces for undulatory swimmers such as lamprey and eels, where most parts of the body are simul

51 many-to-many orthology relationship between lamprey and gnathostome Hox clusters.

52 occurred before the divergence of ancestral lamprey and gnathostome lineages.

53 ation may have occurred independently in the lamprey and gnathostome lineages.

54 nhancers mediate equivalent NC expression in lamprey and gnathostomes, revealing ancient conservation

55 nt in these fish, and further studies of the lamprey and hagfish genomes will determine just how expl

56 Lamprey and hagfish, the extant jawless vertebrates, hav

57 agnathans became cyclostomes, which include lamprey and hagfish.

58 The relative age of lamprey and human paralogs supports this hypothesis.

59 ting range in darkness is nearly the same in lamprey and in amphibian or mammalian rods and cones; mo

60 ated through dopamine D1 and D2 receptors in lamprey and in mammals.

61 Comparisons between lamprey and jawed vertebrates have yielded important ins

62 ew possibilities for studying development in lamprey and other non-traditional model organisms with l

63 In addition, sea lamprey and sturgeon cytosolic extracts showed concentra

64 trate that S is an osmoregulatory hormone in lamprey and that receptor-mediated discriminative cortic

65 With the exception of tfap2d (lamprey and zebrafish), all are able to do so.

66 afba), Krox20 (also known as Egr2a)) in both lamprey and zebrafish.

67 Thus, comparisons between lampreys and gnathostomes can identify deeply conserved

68 Lampreys and hagfish are primitive jawless vertebrates c

69 ation of three orthologous VLR genes in both lampreys and hagfish suggests that this anticipatory rec

70 endently in cyclostomes (jawless vertebrates-lampreys and hagfish) and gnathostomes (jawed vertebrate

71 Cyclostomes, the lampreys and hagfish, instead use leucine-rich repeat pr

72 Lampreys and hagfish, which together are known as the cy

73 omes, comprising jawless vertebrates such as lampreys and hagfishes, are the sister group of living j

74 etween these two VLR isotypes occurs in both lampreys and hagfishes.

75 ly basal vertebrate group Agnatha, including lampreys and hagfishes.

76 ulation algorithm applied to freely swimming lampreys and jellyfish.

77 e known to be "bad regenerators." Results in lampreys and mammals suggest that the UNC5-Netrin axonal

78 eal skeleton and autonomic nervous system of lampreys and modern gnathostomes.

79 ndings show similarities between the SCCs in lampreys and other vertebrates and suggest that gill SCC

80 AANATs from Agnathans (lamprey) and Chondrichthyes (catshark and elephant shark

81 s contrast with those previously reported in lampreys-anguilliform swimmers-which produce thrust with

82 KEY POINTS: Lamprey are cyclostomes, a group of vertebrates that div

83 Lampreys are extant members of the agnathan (jawless) ve

84 Lampreys are extant representatives of agnathans.

85 Lampreys are jawless fishes that last shared a common an

86 Lampreys are one of two extant representatives of the ea

87 Lampreys are representatives of an ancient vertebrate li

88 We use the lamprey as a model for investigating the role of this ph

89 at suggest the somatopleure is eliminated in lamprey as the LPM is separated from the ectoderm and se

90 After spinal cord transection in lampreys, axons of the large, identified reticulospinal

91 Like mammalian BAFF and APRIL, the lamprey BAFF-like gene is expressed in T-like, B-like, a

92 In vitro analyses indicated that the lamprey BAFF-like protein can bind to a BCMA-like recept

93 e intrinsic organization and function of the lamprey basal ganglia is highly conserved.

94 s study we identified two BCMA-like genes in lampreys, BCMAL1 and BCMAL2, which were found to be pref

95 Lampreys belong to the agnathan lineage, and they are th

96 ey larvae was demonstrated, and treatment of lamprey blood cells with rIL-17D.1 protein enhanced tran

97 nalysis of motor responses to bending of the lamprey body in different planes and at different rostro

98 of this receptor is broadly expressed in the lamprey brain, being especially abundant in hypothalamic

99 ically, the largest reticular neurons of the lamprey brainstem (Muller cells) showed ASP immunoreacti

100 646,800 synapses) computational model of the lamprey brainstem-spinal cord network.

101 lization of glutamatergic neurons in the sea lamprey brainstem.

102 and PRLR arose prior to the emergence of the lamprey branch of agnathans.

103 detail in a swimmer using body undulations (lamprey), but in tetrapods the downstream projections fr

104 )/ventral tegmental area (VTA) is present in lamprey, but only scarce data exist about its connectivi

105 ays are present throughout the life cycle of lampreys, but olfactory-driven behaviors differ accordin

106 tem and rostral spinal cord of the adult sea lamprey by using ASP immunohistochemistry.

107 y the expression pattern of this receptor in lampreys by in situ hybridization and to analyze the phy

108 tly: following SCI in various animal models (lamprey, chick, rodents, nonhuman primates), different f

109 pared these results with published data from lampreys, chondrichthyes, teleosts, amphibians, reptiles

110 , and compared them with published data from lampreys, chondrichthyes, teleosts, reptiles, birds, and

111 everal chordates including chicken, axolotl, lamprey, Ciona, and amphioxus, revealing a universal ups

112 he Great Lakes, and the consequences for sea lamprey control efforts.

113 ophenol (TFM), is a primary component to sea lamprey control in the Laurentian Great Lakes.

114 Sea lamprey control relies on surveys to monitor abundance o

115 the ecosystem level in streams that undergo lamprey control treatments.

116 Lastly, we show that the lamprey CR expresses an ancestral, spironolactone-as-ago

117 aled that the transcriptional profile of the lamprey cranial neural crest is more similar to the trun

118 cyclostomes to the stem of either hagfish or lamprey crown groups.

119 hylogenetically homologous photoreceptors in lamprey: crucially, the efficient amplification of the e

120 recent report of a new lymphocyte lineage in lampreys, defined by the antigen receptor VLRC, suggests

121 spinal neurons of mature larval or adult sea lampreys detected by in situ hybridization in wholemount

122 Descriptions of lamprey development, physiology and genome have provided

123 Lampreys diverged from other vertebrates before the acqu

124 , via a comparative morphometric analysis in lamprey, dogfish, zebrafish and mouse, we propose that e

125 Cross-species deployment of lamprey elements identifies the deep conservation of lam

126 (CNEs) were predicted in the Hox clusters of lamprey, elephant shark, and human.

127 Lampreys emerged from a basal branch of the tree of vert

128 ed protein encoded by this BAFF-like gene in lampreys exhibits higher sequence similarity with mammal

129 Furthermore, lampreys express only a single, ancestral corticosteroid

130 Sea lamprey extracts produced the highest concentrations (50

131 he single species of the southern hemisphere lamprey family Geotriidae, Geotria australis, possesses

132 Migratory sea lamprey follow a larval cue into spawning streams; once

133 1891) described 'granule blood cells' in the lamprey, frog, fowl, horse, elephant and man.

134 al sea lamprey and barriers to prevent adult lamprey from reaching spawning grounds are the most impo

135 ells suggests that visual information in the lamprey G. australis is processed in parallel streams, a

136 dies, indicate that the visual system of the lamprey G. australis represents the upper limit of visua

137 ated in close proximity to each other in the lamprey genome and indicate the interspersed arrangement

138 The lamprey genome provides an important resource for recons

139 we report a CRISPR/Cas system optimized for lamprey genomes and use it to disrupt genomic loci in th

140 In the present study, a lamprey genomic database was used to identify homologs o

141 he retina of the southern hemisphere pouched lamprey, Geotria australis, is unique, in that it posses

142 Phylogenetic analysis revealed that lamprey GHR and PRLR cluster at the base of gnathostome

143 In the sea lamprey, GHR and PRLR displayed a differential but overl

144 m of many vertebrates, including papillae on lamprey gill pores.

145 p progressive disease, the postmetamorphosis lampreys grow normally to adult size.

146 We found that the sea lamprey has a gnathsotome-like complement of edn and edn

147 te its key phylogenetic position, studies of lamprey have been limited by their complex life history,

148 These results illustrate that sea lamprey have the potential to evolve resistance to their

149 Lamprey have two kinds of photoreceptors, called "short"

150 gents, we found that proper formation of the lamprey head skeleton requires two phases of FGF signali

151 s drive segmental reporter expression in the lamprey hindbrain and require the same transcriptional i

152 We isolated lamprey homologs of FGF3, FGF8 and FGF receptors and ask

153 ry selective, fibers densely innervating the lamprey homologue of the mammalian medial nucleus, but n

154 Interestingly, CNEs in individual lamprey Hox clusters are frequently conserved in multipl

155 Compared with gnathostome Hox clusters, lamprey Hox clusters are unusually large.

156 We find that lamprey hox genes display dynamic segmentally restricted

157 This suggests that the lamprey hoxalpha2 enhancer retains ancestral activity an

158 In characterizing a lamprey hoxalpha2 NC/hindbrain enhancer, we identify ess

159 We identified five members of the sea lamprey IL-17 family (IL-17D.1, IL-17D.2, IL-17E, IL-17B

160 n surveys to monitor abundance of larval sea lamprey in Great Lakes tributaries.

161 he overall abundance and distribution of sea lamprey in the Great Lakes.

162 l invasions in a changing world, such as sea lamprey in the Great Lakes.

163 phylogenetic analyses recovered hagfish and lampreys in a clade of cyclostomes (congruent with the c

164 The abundance of parasitic, juvenile sea lampreys in the lakes is calculated by surveying woundin

165 d epigenomic profiles of NC cells in the sea lamprey, in order to gain insight into the ancestral sta

166 critical metamorphic period during which sea lamprey increase osmoregulatory capacity and acquire sea

167 d similarly to those previously described in lampreys, indicating that the anatomo-physiological feat

168 Lamprey is incapable of elongating C22 substrates.

169 Lamprey is one of only two living jawless vertebrates, a

170 genetic study showed that the Y1 receptor of lampreys is basal to the Y1/6 branch of the Y1-subfamily

171 forces the view that the branchial basket of lampreys is probably derived.

172 genomic structure of the VLRA/VLRC locus in lampreys is reminiscent of the interspersed nature of th

173 act with the CR to control osmoregulation in lampreys is still unknown.

174 Sea lamprey (jawless fish) and zebrafish (bony fish) support

175 ial subpopulation of the neural crest of the lamprey lacks most components of a transcriptional circu

176 Three animal models, sea lamprey, lake sturgeon (Acipenser fulvescens), and rainb

177 hb locus of a jawless vertebrate, the river lamprey (Lampetra fluviatilis), shares a range of struct

178 rinus), L. camtschaticum, and European brook lamprey (Lampetra planeri).

179 Moreover, further investigation of lamprey larvae revealed that these domains are also pres

180 A.1-expressing B-like cells and monocytes of lamprey larvae was demonstrated, and treatment of lampre

181 equencing of genomic DNA samples of injected lamprey larvae, were 68/69, 47/56, 38/39, 36/37 and 36/4

182 VLRC, has recently been identified in arctic lamprey (Lethenteron camtschaticum), and our analysis in

183 sea lamprey (Petromyzon marinus) and Arctic lamprey (Lethenteron camtschaticum), extant members of o

184 or at least six Hox clusters in the Japanese lamprey (Lethenteron japonicum).

185 isrupt genomic loci in the Northeast Chinese lamprey (Lethenteron morii) with efficiencies ranging be

186 feeding juvenile and the adult stages of the lamprey life cycle.

187 as abundance at the different stages of the lamprey life cycle.

188 This suggests that the lamprey lineage has experienced an additional genome dup

189 Our review suggests that Great Lakes sea lamprey may benefit from climate change with longer grow

190 It has been suggested that lamprey may represent an intermediate state where nested

191 that a unique molecular switch occurs during lamprey metamorphosis resulting in distinct gill carboni

192 The lamprey neurohypophysis was not innervated by Galphat-S-

193 ion of glutamate and GABA, suggest that some lamprey neurons may co-release both excitatory and inhib

194 -specific enhancer is located in intron 7 of lamprey nprl3, which corresponds to the NPRL3 intron 7 M

195 the biochemical properties of AID from a sea lamprey, nurse shark, tetraodon, and coelacanth: represe

196 ociated receptor (TAAR)-like receptor in the lamprey olfactory epithelium.

197 low as 10-14 molar, spermine stimulated the lamprey olfactory system and attracted ovulatory females

198 sal ganglia in all vertebrates including the lamprey, one of the phylogenetically oldest vertebrates.

199 ated the organization of these nuclei in the lamprey, one of the phylogenetically oldest vertebrates.

200 ulatory network underlying Hox expression in lamprey or its relationship to hindbrain segmentation.

201 In contrast to lamprey, our findings support an LPM contribution to the

202 rtue of this deeply shared ancestry, the sea lamprey (P. marinus) genome is uniquely poised to provid

203 Previous studies have shown that the lamprey paratrigeminal respiratory group (pTRG) plays a

204 Pax6 present in some gnathostomes, all three lamprey Pax6 have a highly conserved full-length paired

205 Notably, lamprey Pax6alpha transcripts are found in the pancreas,

206 single conserved non-coding element, in the lamprey Pax6beta locus, with similarity to the PAX6 neur

207 Chemical control using lampricides (i.e., lamprey pesticides) to target larval sea lamprey and bar

208 , we recorded from photoreceptors of the sea lamprey Petromyzon marinus and show that their rods have

209 le to catch up to 75% of tagged invasive sea lamprey Petromyzon marinus in free-flowing streams.

210 e genes Tyrosinase and FGF8/17/18 in the sea lamprey Petromyzon marinus, and detail optimized paramet

211 ocomotion have been characterized in the sea lamprey (Petromyzon marinus L.), a basal vertebrate.

212 genes encoding putative GHR and PRLR in sea lamprey (Petromyzon marinus) and Arctic lamprey (Lethent

213 s corticosteroids in vivo and ex vivo in sea lamprey (Petromyzon marinus) during the critical metamor

214 The sea lamprey (Petromyzon marinus) is a genetically programmed

215 stem in the basal jawless vertebrate the sea lamprey (Petromyzon marinus) to gain insight into its ev

216 d tracks and two animal trajectories - a sea lamprey (Petromyzon marinus) tracked for 12 h and a wolf

217 The lamprey (Petromyzon marinus) undergoes developmentally p

218 pheromone from the milt (fish semen) of sea lamprey (Petromyzon marinus), a jawless fish that spawns

219 One such example could occur with sea lamprey (Petromyzon marinus), a parasitic invasive speci

220 tic and comparative genomic maps for the sea lamprey (Petromyzon marinus), a representative of an anc

221 Here we discovered that sea lamprey (Petromyzon marinus), a representative of extant

222 pesticide for the population control of sea lamprey (Petromyzon marinus), an invasive species of the

223 mography of a damaging invasive species, sea lamprey (Petromyzon marinus), in the Great Lakes, and th

224 hat VLRC sequences are well conserved in sea lamprey (Petromyzon marinus), L. camtschaticum, and Euro

225 f cytoplasmic carbonic anhydrases in the sea lamprey (Petromyzon marinus), that has a complex life hi

226 at giant reticulospinal synapses of the sea lamprey (Petromyzon marinus), we found that this NEF inh

227 be the earliest known CFTR, expressed in sea lamprey (Petromyzon marinus), with unique structural fea

228 thologs in all vertebrates including the sea lamprey (Petromyzon marinus).

229 receptors in the jawless vertebrate, the sea lamprey (Petromyzon marinus).

230 signal guides reliable communication in sea lamprey (Petromyzon marinus).

231 Here, we show that sea lampreys (Petromyzon marinus L.) have cutaneous papillae

232 Here, we show in lampreys (Petromyzon marinus) of either sex that increme

233 We studied this in larval sea lampreys (Petromyzon marinus; the sex of the animals was

234 noreactive (ir) system in the CNS of the sea lamprey, Petromyzon marinus.

235 o disrupt edn, ednr and dlx genes in the sea lamprey, Petromyzon marinus.

236 iculospinal (RS) neurons in the brain of the lamprey, Petromyzon marinus.

237 ebrate, and places it on the stem lineage to lampreys (Petromyzontida).

238 ds are the most important tools used for sea lamprey population control.

239 U.S. dollars annually, and help restore sea lamprey populations in Europe where they are native, but

240 ay also have management implications for sea lamprey populations.

241 Lampreys possess two T-like lymphocyte lineages that exp

242 the connectivity and neuronal properties of lamprey pretectal cells.

243 a truncated steroid biosynthetic pathway in lampreys produces two predominant circulating corticoste

244 The jawless lampreys provide a unique opportunity to constrain the t

245 on isolated brainstem preparations of adult lampreys provides a more precise localization of the pTR

246 After spinal cord transection, lampreys recover functionally and axons regenerate.

247 have previously shown that rods and cones in lamprey respond to light much like photoreceptors in oth

248 We show that lamprey rods and cones respond to light much like rods a

249 We cloned RPE65 and LRATb cDNAs from lamprey RPE and demonstrated appropriate enzymatic activ

250 We verified the presence of RPE65 in lamprey RPE by immunofluorescence microscopy, immunoblot

251 residues found in all authentic RPE65s, but lamprey RPE65 contained all of them.

252 populations with those reported for the sea lamprey, Siberian sturgeon, and zebrafish revealed some

253 elements identifies the deep conservation of lamprey SoxE1 enhancer activity, mediating homologous ex

254 Among lamprey species assessed thus far, the retina of the sou

255 We monitored regeneration of back-labeled lamprey spinal axons after spinal cord transection and d

256 In this study, using the lamprey spinal cord in vitro, we first report that 2-AG

257 In the lamprey spinal cord, they surround the central canal and

258 in the mechanism of axon regeneration in the lamprey spinal cord.

259 the regulation of cell proliferation in the lamprey spinal cord.

260 ular progenitor zone is found throughout the lamprey spinal cord.

261 rotonin-mediated inhibition of exocytosis in lamprey spinal neurons.

262 In lampreys, stretch receptor neurons (SRNs) are located at

263 Hedgehog- and Nkx2.1-positive domain in the lamprey subpallium was thought to be similar to mouse mu

264 nal activity is fed to a mechanical model of lamprey swimming.

265 ds also induce Omega-profile accumulation at lamprey synaptic active zones, suggesting that actin may

266 Lamprey T-like and B-like lymphocyte lineages have been

267 intestine, and gills and by the two types of lamprey T-like cells.

268 Indeed, in Xenopus, zebrafish, and lamprey Tgs, key residues, including the hormonogenic ty

269 Here, we show in lamprey that a separate evaluation circuit, which regula

270 olated a conserved exonic hox2 enhancer from lamprey that drives segmental expression in rhombomeres

271 Here, we report in lampreys that dopaminergic neurons release dopamine in t

272 ally degenerate vertebrate lineage sister to lampreys (the molecular-based cyclostome hypothesis).

273 a crucial role in stopping locomotion in the lamprey: their activation halts ongoing locomotion and t

274 To understand how the adult lamprey thrives without the ability to secrete bile, we

275 lts confirm that a Y5 receptor is present in lampreys, thus being highly conserved during the evoluti

276 We developed an eco-genetic model of sea lamprey to examine factors affecting the evolution of re

277 in early vertebrate progenitors by comparing lamprey to other vertebrates.

278 of early vertebrate progenitors by comparing lamprey to other vertebrates.

279 tified in all vertebrate species tested from lampreys to humans.

280 Lampreys, together with mixynes, belong to the oldest br

281 These findings indicate that adult lampreys tolerate cholestasis by altering hepatic bile s

282 Here, we cloned three sea lamprey UNC5 (UNC5L) receptors, and phylogenetic analyse

283 ceptors in which the diversity region of the lamprey variable lymphocyte receptor (VLR) has been fuse

284 icity containing the Ag-binding portion of a lamprey variable lymphocyte receptor specific for PE fus

285 situ hybridization study with probes for the lamprey vesicular glutamate transporter (VGLUT) provides

286 the unique hagfish VLR is the counterpart of lamprey VLRA and the previously identified hagfish "VLRA

287 ree types of these anticipatory receptors in lampreys (VLRA, VLRB, and VLRC) are expressed by separat

288 Surprisingly, we find lamprey VLRB and mouse Ig responses to influenza A virus

289 previously identified hagfish "VLRA" is the lamprey VLRC counterpart.

290 afish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived,

291 In lampreys, we recently showed that brainstem networks als

292 d whether this includes neurogenesis, larval lampreys were spinally transected and injected with 5-br

293 stantially advance integrated control of sea lamprey, which threaten a fishery valued at 7 billion U.

294 tified and characterized a BAFF-like gene in lampreys, which, with hagfish, are the only extant jawle

295 Here, we present the first lamprey whole-genome sequence and assembly.

296 t CRISPR/Cas9 is highly effective in the sea lamprey, with a majority of injected embryos developing

297 is widely expressed throughout the brain of lampreys, with some regions showing numerous positive ne

298 This broad distribution of the lamprey Y1 receptor is more similar to that found in oth

299 In phylogenetic studies, the lamprey Y5 receptor clusters in a basal position, togeth

300 eny, and brain expression pattern of the sea lamprey Y5 receptor.