ライフサイエンスコーパス: landscape

1 ght me to where I am in this rich scientific landscape.

2 n, 3D genome organization and the epigenetic landscape.

3 likely experienced a varied and more dynamic landscape.

4 ating to this complex and evolving treatment landscape.

5 uencing (WGS), have dramatically changed the landscape.

6 iates in shale in three boreholes across the landscape.

7 copathologic features, mutational and immune landscape.

8 to define the molecular identity of the BRC landscape.

9 e isomers, due to the relatively flat energy landscape.

10 ment, where sponges may dominate the benthic landscape.

11 one of the present studies has shown a whole landscape.

12 here resource density is enhanced within the landscape.

13 histories of interacting species across the landscape.

14 n of the standardization and regulatory body landscape.

15 a "target" strain over a path in the energy landscape.

16 r than remodeling of the local recombination landscape.

17 turb the normal pregnancy-induced epigenomic landscape.

18 located them on a continuous transcriptional landscape.

19 structural representation of the cell state landscape.

20 e are the primary determinants for gammaH2Ax landscapes.

21 framework can be applied to more species and landscapes.

22 h-care needs, and environmental and economic landscapes.

23 vergreen shrub, Morella cerifera, in coastal landscapes.

24 xperimental approach to "de-risk" solid form landscapes.

25 (i) to calculate two-dimensional free energy landscapes.

26 that feed on highly mobile prey across broad landscapes.

27 margins and ditches surrounding agricultural landscapes.

28 vealing striking differences in their immune landscapes.

29 evalence of migratory behaviour across large landscapes.

30 ing carnivore coexistence in human-dominated landscapes.

31 asslands and tundra) or arid (e.g., deserts) landscapes.

32 eolite catalysts modify reaction free energy landscapes.

33 n the context of genome-wide transcriptional landscapes.

34 unting for all C losses across heterogeneous landscapes.

35 Our work contributes to resolving the HSGOC landscape(3-5) and provides a resource for the developme

36 eatures an overview of the COVID-19 'vaccine landscape', a clinical trials database and a 'living rev

37 ions to characterize the CheY conformational landscape accessed by FliM(N) and D13K-Y106W.

38 is article will consider the current testing landscape, address current challenges in the use of liqu

39 Which features of the energy landscape affect the flux distribution?

40 possibility that species disperse within the landscape along differing paths presents a relatively un

41 edical research domain, Movember conducted a landscape analysis with the aim of maximizing the effect

42 recruits effectors that alter the epigenetic landscape and chromatin structure, but how HUSH recogniz

43 ent and the OM in modulating the OMP-folding landscape and discuss the factors that guide folding in

44 nology has revolutionized the biofabrication landscape and driven numerous pivotal advancements in ti

45 nderstanding the regulation of the chromatin landscape and epigenetic barriers that must be overcome

46 scription of the ASCP genomic and epigenomic landscape and identify candidate therapeutic targets for

47 mulation in relation to a suite of climatic, landscape and local factors.

48 Over a 50-year co-evolution of landscape and SOC turnover, we find that the dominant me

49 discussion of the modern and near-future HPC landscape and the relevant computational traits of the m

50 Herein we explore the Fe-Ge-S reaction landscape and the role of the base.

51 ogical dynamics in a synthetically generated landscape and three representative wetlandscapes in the

52 Here, we investigate the landscape and timing of mutational processes shaping mul

53 novation has profoundly reshaped the world's landscapes and biodiversity, the ecological circumstance

54 on, which correlates with altered epigenetic landscapes and can be overcome by wild introgression.

55 rangement and composition of habitats within landscapes and fine-scale habitat characteristics influe

56 g" epistasis creates sinkholes in SD fitness landscapes and may profoundly impact the evolution and f

57 asets and demonstrate consistency among cell landscapes and phase portraits.

58 FiTAc-seq generates high-quality enhancer landscapes and super-enhancer (SE) annotation in numerou

59 this facilitation cascade across creekshed, landscape, and patch scales.

60 endence on genetic network features, fitness landscapes, and developmental system drift.

61 This review summarizes the regulatory landscape, applications to clinical practice, opportunit

62 Here, we show that an energy landscape approach elucidates the underlying physical pr

63 hway protein folding transitions, our energy landscape approach from first principles is the beginnin

64 d wildlife's subsequent dispersal across the landscape are hypothesized to play an important role in

65 rant and populations occupying less forested landscapes are most vulnerable to extreme winter weather

66 Yet landscapes are rarely managed to suppress pests, in part

67 Protein mutational landscapes are shaped by the cellular environment, but k

68 this is challenging because P varies within landscapes as a function of geology, topography and clim

69 des multi-tissue single-cell transcriptional landscapes associated with aging and CR in a mammal, enh

70 ctors that establish a permissive epigenetic landscape at a subset of developmentally important bival

71 truction model to dissect the transcriptomic landscape at the single-cell level during renal injury a

72 cribe the characterization of folding energy landscapes at high resolution, studies of structurally c

73 ced methods for sampling complex free-energy landscapes at near nonergodicity conditions and for esti

74 transcription by remodeling local epigenetic landscapes at sgRNA-targeted enhancers and associated ge

75 rapies) are profoundly changing the oncology landscape, bringing with them new requirements and chall

76 tion of specific features of many mutational landscapes but it remains difficult to retrospectively d

77 ions have contributed to its present genetic landscape, but the territory of present-day France has y

78 In this study, we characterize the R(ee) landscape by measuring P(R(ee)) for low molecular weight

79 this paradigm to measuring proteome activity landscapes by acquiring and integrating quantitative dat

80 suggest possibilities for tuning mutational landscapes by modulating the cellular environment, with

81 The results of the landscape calculations helped to propose a plausible seq

82 cross many taxa and biomes-that agricultural landscapes can support over the short term(1,3,4).

83 , making the design of biodiversity-friendly landscapes challenging.

84 four-fold in simplified, vineyard-dominated landscapes compared to complex landscapes in which viney

85 Our results suggest increasing landscape complexity may mitigate pest populations and i

86 ce dispersal dynamics in simple experimental landscapes composed of homogeneous habitat patches.

87 n more abundant in fine-grained agricultural landscapes comprising smaller patches and can increase o

88 erstanding of how genetic or gene expression landscapes connect to specific CIN mechanisms, causes of

89 Climate warming and landscape conversion may reduce the genetic connectivity

90 icient and effective restoration of degraded landscapes depends on the inclusion of such 'keystone' p

91 Detailed energy landscapes derived from these data provide a rare glimps

92 namics of thin filament components by energy landscape determination and molecular dynamics simulatio

93 The hierarchy of channel networks in landscapes displays features that are characteristic of

94 ing mating events and pollen flow across the landscape, distinct types of pollinators may cause diffe

95 o nongrazed creekheads, have increased marsh-landscape drainage density by 8 to 35% across the region

96 rtly attributed to a range of atmospheric or landscape drivers, one often-forgotten driver of changes

97 mA has a key role in changing the epigenetic landscape during cell fate transitions in early developm

98 t variation and evolution of the methylation landscape during maize domestication remain largely unkn

99 e coast during spring and inland in forested landscapes during autumn, suggesting seasonal difference

100 xtinction and colonization, in more forested landscapes during extreme cold-presumably enabling them

101 RGC development and survival, and chromatin landscape effects, we show that the SE ensures robust At

102 varying ex situ treatment units in flexible landscape environments.

103 m of partial differential equations coupling landscape evolution dynamics with a specific catchment a

104 , regional climate-glacier systems and local landscape evolution.

105 es, driven primarily by interactions between landscape features and decadal trends in weather conditi

106 nomics on 18 sites representing a variety of landscape features and edaphic variables.

107 Leucocytozoon diversity and infection rates, landscape features, such as vegetation cover and water b

108 Untangling the nuanced relationships between landscape, fire disturbance, human agency, and climate i

109 3 Batten disease and broaden the therapeutic landscape for ASOs in the treatment of other diseases us

110 venetoclax have transformed the therapeutic landscape for chronic lymphocytic leukemia (CLL).

111 Our work demonstrates the anomalous landscape for electron hydrodynamics in systems beyond g

112 bitors (ICIs) have transformed the treatment landscape for oncology, leading to durable remissions in

113 that mean they might change the therapeutic landscape for people with neuromyelitis optica spectrum

114 dictate affinity thresholds and competitive landscapes for B cells in vivo, with implications for va

115 nisms, especially plants, can alter resource landscapes for mobile consumers driving bottom-up effect

116 Analogous to free-energy landscapes for multipathway protein folding transitions,

117 and proteomic data, we create a 'targetable landscape' for CAR cell therapies based on 13,206 protei

118 tered land-use and climate change, affecting landscape function, biodiversity, and productivity.

119 toes in exquisite detail on complex resource landscapes generated by spatial point processes.

120 We develop a mathematical model for fitness landscapes generated by such tradeoffs, based on experim

121 We encourage landscape geneticists to utilize multiscale, replicated

122 Here, we used a landscape genetics approach to test whether isolation by

123 of replication and multiscale approaches in landscape genetics.

124 etermined the relative influence of climate, landscape, geography and host phylogeny on regional para

125 logical patterns of snakes within an African landscape half a century ago.

126 ic, epigenomic, transcriptomic and proteomic landscapes have now been mapped for an unprecedented num

127 Local and landscape heterogeneity may provide conditions for spati

128 r task demands constraining the optimization landscape in a fashion that reduces the number of 'good'

129 scape of cells and the role of the molecular landscape in cell function.

130 CE There are limited data about the proviral landscape in children exhibiting long-term suppression a

131 g general platform for mapping the chromatin landscape in different cellular populations from diverse

132 The precancerous landscape in fallopian tubes contains multiple concurren

133 pectroscopy to characterize the ionic defect landscape in methylammonium lead triiodide (MAPbI(3)) pe

134 chemically access the underlying free energy landscape in MOFs.

135 ach can be extended to examine the antigenic landscape in patient sera to facilitate investigation of

136 typing, an indirect measure of the molecular landscape in the cell, which has critical limitations.

137 Reviewed here is the treatment landscape in this rapidly evolving field with an emphasi

138 outcrossing, wtf drivers generate a fitness landscape in which atypical spores, such as aneuploids a

139 methods, enabling the measurement of energy landscapes in vivo.

140 ard-dominated landscapes compared to complex landscapes in which vineyards are surrounded by semi-nat

141 The oldest terrains of Mars are cratered landscapes, in which extensive valleys and basins are co

142 Human modification of landscapes includes extensive addition of linear feature

143 mouse PROM1(+) cells, reveals transcriptomic landscapes indicative of their identities as ductular re

144 detailed information on folding free energy landscapes, intermediates, and pathways.

145 While the payment landscape is changing, with an increasing proportion of

146 although the number of minima increases, the landscape is characterized by many minima with similar l

147 As Earth's landscape is increasingly dominated by anthropogenic lan

148 nding of the impact of humans on the natural landscape is limited by difficulties in accurately compa

149 The landscape is nearly smooth at low and high concentration

150 Evidence of a geothermally active landscape is reported via an unusual biomarker distribut

151 Biodiversity conservation in transformed landscapes is becoming increasingly important.

152 shifts in competitive hierarchies across the landscape, leads to coexistence across a much broader ra

153 On the landscape level, On the landscape level, the high emissi

154 On the landscape level, On the landscape level, the high emissions from C. panamensis f

155 ns of wildlife: what are the population- and landscape-level effects of infection on host mortality?

156 Landscape-level relative forest loss was greater in the

157 a and transition states of the loss-function landscape (LFL) along with their connectivity.

158 that include low rates of occurrence on the landscape, low prevalence at a site, and imperfect detec

159 able potential to reshape the TB diagnostics landscape, making diagnosis and treatment in one office

160 v) The spatio-temporal intra-tumoural oxygen landscape may impact HAP efficacy.

161 anent grassland sanctuaries within intensive landscapes may offset ecological debts.

162 otecting, connecting, and restoring mountain landscapes may otherwise be misguided.

163 results in acquisition of a DNA methylation landscape mirroring the cancer DNA methylome, with gradu

164 Consistent with this energy landscape model, in bulk experiments we observe promiscu

165 ime shift from grasslands to shrub-dominated landscapes occur worldwide driven by altered land-use an

166 his point, we have characterized the genomic landscape of 34 BI-ALCLs (15 tumor and 19 in situ subtyp

167 udy the structure, expression and epigenetic landscape of 35S rDNA in an allotetraploid grass that ex

168 eds of targets and thus shape the expression landscape of a cell.

169 be used to better reconstruct the regulatory landscape of a heterogeneous sample.

170 ent of disorder and the nature of the energy landscape of a highly reactive, intrinsically disordered

171 IMS contour plots present a detailed, global landscape of a molecule that sums all possible resonance

172 ating, for the first time, the translational landscape of a representative of the third domain of lif

173 To increase understanding of the genomic landscape of acral melanoma, a rare form of melanoma occ

174 Thus, scATAC-seq was applied to define the landscape of active regulatory DNA in AS.

175 Little is known about the mutational landscape of advanced hepatocellular carcinoma (HCC), an

176 The treatment landscape of advanced prostate cancer is changing rapidl

177 he molecular basis and underlying functional landscape of allostery.

178 In summary, this study charts the proteomic landscape of ALS-related Ubqln2 mutants and identifies c

179 e to differences in the accessible chromatin landscape of alternatively activated macrophages on diff

180 mostasis and thrombosis, details the current landscape of antithrombotic agents, addresses challenges

181 ults suggest that the genomic and epigenomic landscape of ASCP provide new strategies for targeting t

182 This work charts the phenotypic landscape of ASD-associated genes, offers in vivo varian

183 e-cell RNA sequencing to generate a cellular landscape of basal TSPO gene expression in the hippocamp

184 Several studies provide insight into the landscape of breast cancer genomics with the genomic cha

185 genome-wide association studies, the genetic landscape of cardiovascular diseases, particularly for t

186 ing in tissue, we have uncovered the diverse landscape of CD8(+) T cells in psoriatic and healthy ski

187 al to advance understanding of the molecular landscape of cells and the role of the molecular landsca

188 However, the transcriptomic landscape of central nervous system (CNS) innate immune

189 d a multiomics approach to reveal the global landscape of cotranslational mRNA decay during Arabidops

190 The landscape of driver mutations in these tumors is dominat

191 p of cell-type-specific interactions and the landscape of dysregulated receptor-ligand crosstalk in c

192 , 3D genome architecture and transcriptional landscape of engram cells over the lifespan of memory fo

193 ole for SUV420H2 in regulating the chromatin landscape of ES cells.

194 al only a portion of the repetitive sequence landscape of eukaryotic genomes and that population-leve

195 stigations are needed to fully elucidate the landscape of germline genetic alterations in children wi

196 he Affordable Care Act, the rapidly changing landscape of healthcare delivery systems, and our evolvi

197 acting antivirals (DAAs) has transformed the landscape of hepatitis C virus (HCV) management.

198 The chromatin landscape of human brain cells encompasses key informati

199 Identification of the regulatory landscape of human SAN-like pacemaker cells and function

200 enes and processes, indicating an unexplored landscape of infrequent driver mutations in the non-codi

201 1,2) analysis has revealed a complex genomic landscape of internal chromosomal structures in vertebra

202 The landscape of kidney disease in diabetes has shifted.

203 The landscape of lung epithelial stem cells is getting more

204 n, adding new perspectives to the functional landscape of multigenic loci.

205 al of this study was to describe the genomic landscape of myeloma using deep whole-genome sequencing

206 unravel a comprehensive map of the energetic landscape of nuclease-dead Cas12a (dCas12a) from Francis

207 f this RNA genome relative to the structural landscape of other well-known viral RNAs.

208 this study provides the whole transcriptome landscape of ovarian cells and unearths new insights dur

209 To expand the TAA landscape of pancreatic ductal adenocarcinoma (PDAC), we

210 nding on the mechanical stability and energy landscape of proteins are incompletely understood.

211 ow how DNA supercoiling modulates the energy landscape of R-loop formation and dictates access to sta

212 etabolism is an integral part of the complex landscape of regulatory mechanisms underlying cell diffe

213 ble toxicity profile are poised to alter the landscape of RET-dependent cancers.

214 mprehensive review, we summarize the current landscape of risk estimation, diagnosis, treatment and p

215 canning (DMS) studies exploit the mutational landscape of sequence variation by systematically and co

216 leading technology for probing the chromatin landscape of single and aggregated cells.

217 ualization of the genomic and transcriptomic landscape of single cell and bulk RNA sequencing data.

218 These data further define the complex landscape of somatic structural variation in neuroblasto

219 We assessed the genomic landscape of sRCC using targeted panel sequencing includ

220 o-binds with and remodels the conformational landscape of SRP on the ribosome to regulate its interac

221 tion by significantly reshaping the proteome landscape of the cells towards an islet-like signature.

222 behavior in DCvNs emerges from the chemical landscape of the dynamic chemistry at the junction.

223 e fundamental understanding of the antigenic landscape of the overall T cell response.

224 nized our ability to reconstruct the genetic landscape of the past.

225 The epigenetic landscape of the region, and Hi-C RO data, showed that Y

226 omprehensive information about the proteomic landscape of this biological fluid.

227 Analysis of the genomic landscape of this disease has led to the identification

228 three organisms, and suggest the mutational landscape of those genes with respect to FQ resistance i

229 The dynamic landscape of transcription initiation suggests a kinetic

230 and entropies that comprise the free energy landscape of transfer hydrogenation catalysis.

231 rapies for cancer, dramatically changing the landscape of treatment approaches for several malignanci

232 erapies - has markedly changed the treatment landscape of type 2 diabetes mellitus.

233 Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearl

234 st responsible, but defining this underlying landscape of variation is an essential first step to und

235 zed transcriptional and accessible chromatin landscapes of acutely isolated mouse CNS ECs.

236 The conformational free energy landscapes of free alpha-l-arabinofuranose and several r

237 clinically actionable genomic and epigenomic landscapes of N/S HNSTs.RESULTSWhole-exome sequencing wi

238 Further, we revealed landscapes of polytract enrichment with respect to nearl

239 e we establish epigenomic and transcriptomic landscapes of primary OCs using H3K27ac ChIP-seq and RNA

240 that is capable of simulating the mutational landscapes of thousands of cancer genomes at different r

241 s, this comprehensive resource of the immune landscape offers insights into possible strategies to ov

242 ith coevolutionary information and an energy landscape optimized force field (AWSEM), we predict atom

243 vel ecosystem impacts of alternate bioenergy landscapes, our results suggest that niche breadth and t

244 tition dramatically slows expansion across a landscape over multiple generations.

245 ciality by changes in the capsid free-energy landscape partition function when an interaction is remo

246 Thus, G4 landscapes reveal additional IC-related intratumor heter

247 Transcriptome landscape reveals the molecular mechanisms involved in t

248 years in spatially distinct habitats at the landscape scale (top and bottom of watersheds) and withi

249 Landscape-scale bark beetle outbreaks alter forest struc

250 a keystone species that is driving dynamic, landscape-scale changes in salt-marsh geomorphic evoluti

251 Landscape-scale reconstructions of ancient environments

252 pts with empirical support to design optimal landscape scenarios for forest-dwelling species.

253 Its unique genomic landscape shaped by oncogenic drivers promotes immune su

254 l explorations of how the complexity of real landscapes shapes the ecological and evolutionary proces

255 g in-depth characterization of the molecular landscape shaping these complex phenotypes.

256 competitive differences between species, and landscape spatial patterning.

257 In highly modified landscapes, spatial nutrient transport theory suggests t

258 k factors associated with storm meteorology, landscape structure, and forest attributes.

259 distributed in a regular pattern across the landscape such that they were not contiguous with each o

260 alculations of the benzene-to-phenyl hydride landscape suggest a single linear sequence for this tran

261 ncertainties including model initialization (landscape susceptibility to invasion) and expert-identif

262 us plant green-up that progresses across the landscape (termed "green-wave surfing").

263 T promoter harbors a more complex mutational landscape than previously thought.

264 future opportunities within the bioprinting landscape that are facilitated with light.

265 g to produce a comprehensive transcriptional landscape that highlights their maturation, function, an

266 In addition to predicting a free-energy landscape that is consistent with previous experimental

267 studies have revealed the unusual chromatin landscapes that are present in oocytes, sperm and early

268 st generation of accurate somatic mutational landscapes that can be used as a realistic null hypothes

269 e aberrant activation of super enhancer (SE) landscapes that drive the expression of key oncogenes, i

270 these factors drive selection of regulatory landscapes that specify distinct phenotypes of AMs and I

271 We first landscape the m6A modifications on skin epithelial proge

272 , we evaluated the association between urban landscape, thermal features, and mosquito infestations.

273 e cell commitment, remodeling the epigenomic landscape to define the presumptive neural crest.

274 g selection remains crucial in this evolving landscape to derive maximum benefit for the patients.

275 oordinated remodeling of the transcriptional landscape to enable the growth and differentiation of ne

276 s studies incorporate aspects of the spatial landscape to study evolutionary processes, efficient sim

277 urring and anthropogenic Hg from terrestrial landscapes to aquatic environments in the region, potent

278 contributing to the vulnerability of forest landscapes to climate-induced productivity losses and mo

279 Our work indicates that landscapes today are once again exhibiting low resilienc

280 ing the underlying non-equilibrium potential landscape topography and the kinetics of state switching

281 es and within ecosystems and was mediated by landscape topography, climate, and soil characteristics.

282 a set defines the dynamic genomic regulatory landscape underlying heart failure and serves as an impo

283 the organism, the regulatory transcriptional landscape underpinning ER stress management is largely u

284 ted settlement and human modification to the landscape until about 1,000 to 1,500 y ago.

285 s of these regulators on the DNA methylation landscape using a panel of knockout human embryonic stem

286 open state pore revealed more rugged energy landscapes using polarizable force fields, and the hydra

287 transcriptomics have opened up an unexplored landscape where transcript information is put in a spati

288 This phenomenon shapes fitness landscapes, which have the power to reveal evolutionary

289 ities to navigate to objects in a complex 3D landscape while in flight.

290 ch dynamics are governed by the conformation landscape whose study requires characterization of the g

291 nes, human management of disturbance-adapted landscapes will become increasingly important for mainta

292 erent orientations generate an electrostatic landscape with an interfacial energy offset of 0.4 eV, w

293 nimal prophylaxis studies revealed a complex landscape with protective epitopes clustering in at leas

294 reserves while foraging and reproducing on a landscape with resources that range from uniformly distr

295 eneticists to utilize multiscale, replicated landscapes with both genetic diversity, and differentiat

296 1 and Vdelta2 PCGDTLs harbor similar genomic landscapes with potentially targetable oncogenic mutatio

297 romatin marks and display a primed chromatin landscape, with bivalently marked primed pluripotency ge

298 lled HemoSYS for quantifying the hemodynamic landscape within angiogenic microenvironments.

299 can shape the sensory and sympathetic nerve landscape within the cornea, with implications for the t

300 t heterogeneous and fast evolving regulatory landscape worldwide.