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1 is the human homolog of the Drosophila Discs-large tumor suppressor.
2 emonstrated that the HIPPO central component large tumor suppressor 1 (LATS1) is inactivated in small
3  signals, or cell polarity among others, the large tumor suppressor 1 (LATS1) kinase catalyzes inhibi
4 ns showed enrichment of shRNAs targeting the large tumor suppressor 1 (LATS1) kinase that inhibits th
5 nction of the Hippo pathway kinases LATS1/2 (large tumor suppressor 1 and 2) in cancer cells.
6 , loss of the Hippo pathway kinases LATS1/2 (large tumor suppressor 1 and 2) in tumor cells inhibits
7 m its previously described role in degrading large tumor suppressor 1 to the inhibition of YAP and ce
8 AP by AIP4 and prevents AIP4 from binding to large tumor suppressor 1.
9 ation of their negative regulators, LATS1/2 (large tumor suppressor 1/2) kinases, to constitute a neg
10 at KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating t
11 targets included the tumor-suppressive genes large tumor suppressor 2 (LATS2) and PP2A regulatory sub
12 rough regulation of the Hippo pathway kinase large tumor suppressor 2 (LATS2) and yes-associated prot
13   KIBRA also promotes the phosphorylation of large tumor suppressor 2 (Lats2) on Ser(83) by activatin
14  activation of mammalian sterile 20-like 1/2-large tumor suppressor 2 signaling pathway and inhibitio
15 man homologue (hDIg) of the Drosophila discs-large tumor suppressor (DIg) is a multidomain protein co
16 tic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), zonula occludens-1 protei
17 lymphocyte homologue of the Drosophila discs large tumor suppressor) do not bind the cytoplasmic doma
18 tion of its phosphorylated state mediated by large tumor suppressor gene 1 and 2 (LATS1/2).
19 n genome, it represents another example of a large tumor suppressor gene, like FHIT and WWOX, located
20  of the membrane-associated Drosophila discs-large tumor suppressor has implicated this cellular fact
21 es the activity of YAP and TAZ by repressing large tumor suppressor homolog (LATS), and we identify t
22            We further identified that LATS2 (large tumor suppressor homolog 2) is a downstream target
23 functions of the main Hippo pathway kinases, large tumor suppressor homolog kinases 1 and 2 (Lats1 an
24            The Hippo pathway kinase Lats1/2 (large tumor suppressor homolog) reduces Yap/Taz nuclear
25 alian STE20-like protein kinases 1 and 2 and large tumor suppressor homologs 1 and 2 (LATS1/2) contro
26  inhibits the association between MST1/2 and large tumor suppressor homologs 1/2 (LATS1/2), uses its
27 ivation of Yes-associated protein (YAP) in a large tumor suppressor homologue (Lats)-dependent manner
28 show that beta-HPV 8E6 reduced activation of large tumor suppressor kinase (LATS), an HP kinase.
29 g lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1 (LATS1) and inhibiting t
30 ine model were largely rescued via a genetic large tumor suppressor kinase 1 (LATS1) deficiency or th
31 an STE20-like protein kinase 1/2 (MST1/2) or large tumor suppressor kinase 1/2 (Lats1/2), two sets of
32 a activating the core Hippo kinases LATS1/2 (large tumor suppressor kinase 1/2).
33 tes experimental atherosclerosis through the large tumor suppressor kinase 2 (LATS2)/Hippo pathway.
34 phosphorylation of the hippo effector kinase large tumor suppressor kinase-1 and reduces nuclear accu
35 phosphorylation of the hippo effector kinase large tumor suppressor kinase-1 and reduces nuclear accu
36 known regulator of the hippo effector kinase large tumor suppressor kinase-1 and regulate ovarian tum
37  mice by deleting the YAP and TAZ inhibitory large tumor suppressor kinases (LATSs).
38                                          The Large Tumor Suppressor Kinases 1 and 2 (LATS1/2) are ser
39  find that pancreas-specific deletion of the large tumor suppressor kinases 1 and 2 (Lats1/2PanKO) fr
40 ting protein [WTIP]) can bind and inactivate large tumor suppressor kinases 1 and 2, (LATS1/2) two of
41 ian STE20-like protein kinases 1/2 (MST1/2), large tumor suppressor kinases 1/2 (LATS1/2), and Yes-as
42                                              Large Tumor Suppressor kinases LATS1 and 2 (LATS1/2) are
43           Here, we show that warts, encoding large tumor suppressor (Lats) and melted encoding a PH-d
44  Hpo increases its affinity with Warts (Wts)/large tumor suppressor (Lats) serine/threonine protein k
45  (Hpo), Salvador (Sav)/Shar-pei, Warts (Wts)/Large tumor suppressor (Lats), and Mob as tumor suppress
46 similar effect is achieved upon silencing of large tumor suppressor (LATS)-1 and LATS2, direct substr
47           Recent studies have identified the Large tumor suppressor (Lats)/Warts (Wts) protein kinase
48                                              Large tumor suppressor (LATS)1/2 protein kinases transmi
49 d the ovarian functions of the Hippo kinases large tumor suppressors (LATS)1 and 2, which serve to in
50 Mahj forms a protein complex with Warts (Wts/large tumor suppressor [Lats]), a kinase of the Hippo si
51  (YAP) oncogenic activity through inhibiting large tumor suppressor (Lats1/2) core kinases of the Hip
52  which was first found in a Drosophila Discs-large tumor suppressor protein (also known as GLGF or PD
53      Human homologue of the Drosophila discs large tumor suppressor protein (hDlg) belongs to a newly
54  The human homologue of the Drosophila discs large tumor suppressor protein (hDlg), a member of the m
55  the human homologue of the Drosophila discs large tumor suppressor protein (hDlg).
56 lymphocyte homologue of the Drosophila Discs Large tumor suppressor protein (hDlg).
57  a mammalian homolog of the Drosophila discs large tumor suppressor protein and which also binds the
58  hDlg (human homolog of the Drosophila discs large tumor suppressor protein) PDZ (postsynaptic densit
59 , the mouse ortholog of the Drosophila discs-large tumor suppressor, results in congenital hydronephr
60 -like serine-threonine protein kinase)-LATS (large tumor suppressor serine-threonine protein kinase)
61 denomatous polyposis coli (APC) protein is a large tumor suppressor that is truncated in most colorec
62 ostsynaptic density protein, drosophila disc large tumor suppressor, zonula occludens-1 protein (PDZ)