ライフサイエンスコーパス: late-stage

1 heterogeneous disease usually diagnosed at a late stage.

2 ages but the dominance of local diffusion in late stages.

3 and contradiction of intercrops at early and late stages.

4 for maintenance of stem cell progenitors in late stages.

5 tilizing hPSC-cardiomyocytes from early- and late-stage 2-dimensional monolayer culture and 3-dimensi

6 he central pyrrole core was constructed in a late-stage [4 + 1] condensation between ethyl bromoaceta

7 After treatment for 2 mo, four mice with late-stage active MDR tuberculosis had a significant dec

8 disease pseudotime samples are enriched for late stage AD cases and show changes in neuroinflammatio

9 evealing up-regulation of LRP1 in early- and late-stage AD.

10 Inherited retinal dystrophies and late-stage age-related macular degeneration, for which t

11 ct regarding the development of nonexudative late-stage AMD (hazard ratio [HR], 5.88; 95% confidence

12 predictors for the development of exudative late-stage AMD (P > 0.05).

13 by preparing commercial medicines and by the late-stage amination-aromatization of natural products,

14 A visible-light-mediated late-stage aminocarbonylation of unactivated alkyl iodid

15 es from heart, liver, and brain tissues in a late-stage amyloid precursor protein/presenilin-1 (APP/P

16 alyzed collagen cross-links were enriched in late-stage and RLNM-positive tumors, LH2-mediated stable

17 the evolution of cancers from their early to late stages, and that the genomic landscape of early can

18 eration can be potentially modulated even in late-stage APAP-induced acute liver failure.

19 his case highlights a unique presentation of late stage appendiceal MAA.

20 ust have been preserved during the extensive late-stage aqueous processing.

21 lobular species during early disassembly and late-stage assembly events.

22 alyze Massachusetts Cancer Registry data for late stage at diagnosis for cervical, breast, lung, and

23 or example, a substantially elevated risk of late stage at diagnosis occurred among men with lung can

24 C-redlined area imposed an elevated risk for late stage at diagnosis, even for residents of census tr

25 steogenic cells likely to be detrimental for late-stage atherosclerosis plaque pathogenesis.

26 gin, and function of many cells that make up late-stage atherosclerotic lesions, as well as the mecha

27 IA3 protein in VSMCs in thin fibrous caps of late-stage atherosclerotic plaques compared to early fib

28 L-2Ralpha-KO mice that develop early- versus late-stage autoimmune disease.

29 in "any-stage" functionalization, including late-stage azetidinylation of approved drugs and other c

30 ritical for, and the result of, A. fumigatus late-stage biofilm architecture.

31 hanism exerted by gammadelta T cells to kill late-stage blood-residing P. falciparum.

32 A late-stage bone marrow DC progenitor expressed low amoun

33 Prevalence of late-stage breast cancer at diagnosis remained high thro

34 with the number of days brooding, such that late-stage brooding females had larger AVT cells than mi

35 We show this late-stage C(sp(3))-H methylation on 41 substrates housi

36 Central to the success of the synthesis is a late-stage C-H insertion reaction to functionalize a ste

37 tibility and is demonstrated to work for the late-stage C-H methylation of biologically active compou

38 This approach gave access to a late-stage C14,C15 alkene divergent intermediate that co

39 The predicted prevalence of late-stage cancer at diagnosis was highest for women who

40 However, the activation of this pathway in late-stage cancer cells could facilitate the epithelial-

41 Like mid-to late-stage cancer, SARS-CoV-2 infection is associated wi

42 e with the approved ADCs and other promising late-stage candidates on the horizon, following an overv

43 ation, it is surprisingly dispensable during late-stage cDC1 differentiation.

44 Because at this late stage, cells have become filled with dysfunctional

45 itive psychotic symptoms has progressed to a late stage characterized by long-term negative symptoms

46 pment that displays multiple key features of late stage chronic kidney disease-mineral bone disorder

47 ERE NEXT?: Several new oral compounds are in late-stage clinical development.

48 und for the microsatellite stable subtype or late stage colorectal cancer.

49 ts, 619 of whom with early stage and 91 with late stage colorectal cancers.

50 nt and application of a method for the mild, late-stage conversion of primary sulfonamides to several

51 ting previously inaccessible human-specific, late-stage cortical development and disease-relevant mec

52 lysis showed a better diagnostic accuracy in late stage CRC and sensitivity higher in distal than pro

53 preparation of olivacine and ellipticine via late-stage D-ring cyclization is described.

54 ential aspects of early DC progenitor versus late-stage DC cell fate decisions.

55 hylation status of gene candidates to define late-stage (DCIS and invasive), invasive stage only or D

56 sease is often undetected until irreversible late-stage decompensated disease manifests.

57 unusual reactivity of bilobalide to enable a late-stage deep oxidation that symmetrizes the molecular

58 difluoromethylisoxazoles were synthesized by late-stage deoxofluorination of the corresponding 5-hydr

59 ishing drug-like small molecules, as well as late stage derivatization of natural compounds.

60 The late-stage derivatization of a bromine-substituted, tetr

61 e synthesis of unnatural amino acids and the late-stage derivatization of a tripeptide.

62 mon functional groups, as exemplified by the late-stage derivatization of several complex pharmaceuti

63 reds of diverse nucleophiles, as well as the late-stage derivatization of the natural product k252a.

64 directed metalation group dance strategy, a late-stage deuteration of an antipsychotic drug is descr

65 oblasts, which contribute to the initial and late-stage development of the adhesion, respectively.

66 n human glomeruli of patients with early and late-stage diabetic nephropathy, as well as other nondia

67 The late-stage diagnosis of these patients results in the me

68 HIV-1 infection expands large populations of late-stage differentiated CD8 T cells that may persist l

69 Late stage disease pseudotime samples are enriched for l

70 ed mortality in the United States due to the late-stage disease at diagnosis.

71 Female sex, older age, viral load, and late-stage disease were associated with pre-ART biomarke

72 n PBC patients with cirrhosis (indicative of late-stage disease) than in those without cirrhosis.

73 e treatments are available for patients with late-stage disease.

74 ression across the full spectrum of early to late-stage disease.

75 desperately needed to improve prognosis for late-stage disease.

76 mals in cervical and thoracic spinal cord in late-stage disease.

77 n of podocyte-specific genes and proteins in late-stage disease.

78 motryptophan was exploited as a platform for late-stage diversification by Suzuki-Miyaura cross-coupl

79 Late-stage diversification from a common intermediate en

80 cid coupling system, as we show here via the late-stage diversification of drugs and natural products

81 re, nitroalkane reagents can be used for the late-stage diversification of peptides and for the synth

82 Our late-stage diversification strategy provides efficient a

83 Late-stage diversification then provides ready access to

84 This unlocks late-stage diversification through Suzuki cross-coupling

85 liquid chromatography (HPLC) data for these late-stage diversified cyclic RGD peptides and to furthe

86 active catalyst is shown to be effective for late stage drug modification.

87 anomalies in mitochondrial ultrastructure in late stage, E18.5, Krt6a/Krt6b null embryonic mouse skin

88 We also describe the late-stage embryogenesis of Vargula tsujii and discuss t

89 ver, determined that a rapid accumulation of late stage endosomes/lysosomes precedes membrane permeab

90 with promoters and enhancers in embryos with late stage enrichments biased toward both active and poi

91 t-forming unit-erythroid and an expansion of late-stage erythroblasts that was independent of iron ov

92 possible metabolites minimises the risks of late stage failures.

93 tomatic (Pre_S) to tissue from patients with late stage FECD (FECD_REP).

94 angiogenesis and portal hypertension during late-stage fibrosis, and heterogeneity via serial molecu

95 0-kDa heat-shock protein (Hsp90) assists the late-stage folding and activation of diverse types of pr

96 The strategy involves a late-stage fragment coupling between a tertiary carbon r

97 The approach involves late-stage fragment coupling of a tertiary-carbon radica

98 Recently, late stage functionalization (LSF) has become increasing

99 The late stage functionalization (LSF) of complex biorelevan

100 well as the suitability of this protocol for late-stage functionalization are demonstrated.

101 This late-stage functionalization method tolerates a remarkab

102 A favorable free energy pathway of late-stage functionalization of (R)-muscone paves the pa

103 enols into six fluoroalkyl analogues through late-stage functionalization of a natural product-derive

104 s protocol in synthesis was showcased in the late-stage functionalization of a variety of pharmaceuti

105 Hf(12)-Ir-OTf also competently catalyzed late-stage functionalization of bioactive and drug molec

106 group tolerance, and can be employed for the late-stage functionalization of complex druglike molecul

107 fers a simple alternative approach to direct late-stage functionalization of complex organic molecule

108 the overall transformation is applicable to late-stage functionalization of complex, drug-like small

109 H methylation method that is compatible with late-stage functionalization of drug scaffolds and natur

110 hesis of the CNKSPR1 inhibitor precursor and late-stage functionalization of glutathione.

111 An appealing late-stage functionalization of indoprofen applying this

112 Diversification of alkylated product and late-stage functionalization of ketoxime derivatives of

113 Examples are demonstrated of the late-stage functionalization of natural products and dru

114 In addition, the late-stage functionalization of pharmaceuticals is also

115 s method can be used for the preparation and late-stage functionalization of pharmaceuticals, as high

116 riety of substrates, including synthesis and late-stage functionalization of scaffolds relevant to me

117 To enable the general late-stage functionalization of secondary sulfonamides,

118 ty of the method is demonstrated through the late-stage functionalization of several drug analogues.

119 ore, it is shown that the prerotaxanes allow late-stage functionalization of the ring fragment introd

120 We report a high-pressure approach to facile late-stage functionalization of unclosed cryptands (UCs)

121 This late-stage functionalization protocol generates molecule

122 e has been investigated for this DG-mediated late-stage functionalization reactions along with the cr

123 eral method has the significance in terms of late-stage functionalization to access new molecular ent

124 e catalysis is a unique tool, especially for late-stage functionalization, to furnish the targeted co

125 rate the utility of this new methodology for late-stage functionalization, we have directly derivatiz

126 broad applicability, even in the context of late-stage functionalization.

127 Site-selective late-stage functionalizations of a pyrano[3,2- a]carbazo

128 a CPP scaffold enables facile and selective late-stage functionalizations that cannot be accomplishe

129 In late-stage glaucoma, particularly when VF MD is worse th

130 ted down-regulation of immune responses at a late stage (> 24 h) following bacterial challenge.

131 be halogenated, and the method is viable for late-stage halogenation of complex pharmaceuticals.

132 sive HNSCC, most patients are diagnosed with late-stage HNSCC without a clinically evident antecedent

133 l demonstrated that among people living with late-stage human immunodeficiency virus (HIV) infection

134 ommon intermediate 8 are detailed, enlisting late-stage, hydrogen atom transfer (HAT)-mediated free r

135 ram-scale vinylstannane synthesis as well as late-stage hydrostannylation in a natural-product settin

136 em can process two words in parallel up to a late stage in the ventral stream.

137 ine inhibited influenza virus infection at a late stage in the virus life cycle.

138 d that most converging forks stall at a very late stage, indicating a role for additional factors.

139 vels of CD4 (CD4-intermediate cells) than in late-stage infected cells expressing low levels of CD4 (

140 Comparing RNA sequencing (RNAseq) data for late-stage infections in Saimiri and Aotus erythrocytes

141 Strikingly, unlike other late stage inhibitors, EACC does not have any effect on

142 rapid metallaphotoredox-catalysed method for late-stage installation of both tritium and carbon-11 in

143 e one-pot synthesis to avoid the complicated late-stage installation of these acidic sugars.

144 An intricate radical cyclization of a late stage intermediate followed by an oxidative quench

145 strategy include gram-scale preparation of a late stage intermediate, pinpoint stereocontrol around t

146 devising syntheses of NP leads, diversifying late-stage intermediates, or derivatizing the NP target.

147 This method enables the late-stage introduction of complex alkoxy groups into bi

148 The late-stage introduction of this functional group is chal

149 reased survival was observed in the model of late-stage IPF.

150 Late-stage isolated medial knee osteoarthritis can be tr

151 l product alkaloid classes by distinguishing late stage key strategic bond formations within the unde

152 among seeds hosting developmentally early or late-stage larvae with high accuracy.

153 An experimental approach is described for late-stage lead diversification of frontrunner drug cand

154 The synthesis features a late-stage Lewis acid-catalyzed stereoselective intramol

155 of immunopathologic AMR but serves more as a late-stage marker.

156 this study, we collected 115 samples from 47 late stage melanoma patients over 1.5 years alongside th

157 f the sphingosine-1-phosphate receptor-1-via late-stage methylation from the drug or its advanced pre

158 Late-stage methylene oxidation is demonstrated on four d

159 g sites and the left side of the enhancer in late-stage minichromosomes while also allowing late tran

160 ulator of human MK PPF via inhibition of the late-stage MK invagination system, podosome and PPF, and

161 Moreover, this toolbox can be applied to late-stage modification of biorelevant substrates with c

162 functional groups and can be applied to the late-stage modification of complex amino-containing phar

163 unctionalization reactions applicable to the late-stage modification of complex molecules is of inter

164 ale-up options and created opportunities for late-stage modification of peptides, nucleosides, carbon

165 The late-stage modification of pharmaceuticals by this metho

166 this transformation has been applied to the late-stage modification of the bioactive molecule dehydr

167 al Chinese medicines (TCMs) as examples in a late-stage modification toolbox approach to annotate the

168 he library to 278 discrete compounds through late-stage modification was made possible through SuFEx

169 thers and was demonstrated in the context of late-stage modifications..

170 ons mild enough to modify polyfunctional and late-stage molecules.

171 rly-stage motor defects and partially rescue late-stage motor function to extend lifespan.

172 inate subunit joining through the release of late-stage mtLSU assembly factors.

173 sclerosis is commonly found in patients with late-stage myelofibrosis (MF).

174 The late-stage nature of the debris measurement means that t

175 ipid phagocytes on histology and typical for late-stage necrosis.

176 work, whereas leptin was the hub for mid- or late-stage networks.

177 ant tumor suppressors Nf1, Trp53 and Pten in late-stage neuronal progenitors, neuroblasts and differe

178 learning as well as in the intermediate and late stages (new learning) after microinfusions of D2R a

179 highly diversified KIR repertoires including late stage NKG2A(-)KIR(+) effector cells that are common

180 ave been shown to influence the formation of late-stage non-reversible Tau aggregates.

181 upper-layer neurons, which were derived from late-stage NPCs.

182 Overall, the field of late-stage nucleophilic C-H fluorination has progressed

183 ovial lubricin were found to be decreased in late-stage OA patients, coinciding with an increase in u

184 colonic biopsies from nine SBS patients in a late stage of adaptation as well as healthy and disease

185 Geographic atrophy (GA), a late stage of age-related macular degeneration (AMD), is

186 eta-barrel protein bound stably to BamA at a late stage of assembly in vivo.

187 se for stable C degradation increased at the late stage of collapse (16 years since collapse), largel

188 aster stable C decomposition occurred at the late stage of collapse compared to the control, which wa

189 of tests are already marketed or are in the late stage of development.

190 iently in high-CD4-expressing T cells at the late stage of disease, our observation that LY6E differe

191 the expression of Tet1 decreased during the late stage of NSC differentiation, morphine, but not nal

192 shment (48 hours post inoculation, hpi) to a late stage of symptom expression and pathogen sporulatio

193 ic therapy, supporting the role of NETs in a late stage of TB pathogenesis.

194 er-type effector genes were expressed at the late stage of the colonization.

195 nd maintained a relatively high level at the late stage of the experiment to downregulate the osteocl

196 APP regulation of Fe, which is disrupted in late stages of AD.

197 In the late stages of an epidemic, infections are often sporadi

198 reactive astrocytes were found at early and late stages of BM, and E2 upregulated BDNF in ER(+) reac

199 nd sigmoidal growth, relevant for early- and late stages of cancer growth.

200 f 4T1 breast cancer cells, both in early and late stages of cancer progression.

201 differentiation into cardiomyocytes only at late stages of cardiac maturation, the availability of P

202 In turn, NECAP recruits drivers of late stages of CCP formation, including SNX9, via a site

203 Best known for their role in fission at the late stages of CME, many studies have suggested that dyn

204 h gain DNA methylation between the early and late stages of decidualisation.

205 n soil fauna are absent or litter is in very late stages of decomposition (near-humus).

206 tions, their dynamic regulation in early and late stages of disease (i.e., fibrosis), and their curre

207 mune cell subsets in the heart, at early and late stages of disease and in controls.

208 riple transgenic (3xTg-AD) mice in early and late stages of disease progression, and characterized ti

209 gh level of metalloprotease 9 (MMP-9) at the late stages of disease.

210 opposite functions for Ezh2 at the early and late stages of disease.

211 During late stages of fetal development, non-CG methylation acc

212 At late stages of fracture healing, CSC mice were character

213 es is a geometry-dependent checkpoint during late stages of Gag assembly and HIV-1 budding and templa

214 The presence of lutein esters at late stages of grain development may have a complementar

215 measurement of the step-edge velocity in the late stages of growth after crystalline mounds have form

216 mer is expressed in HD mice at early but not late stages of HD, correlating with HD progression.

217 Indeed, outcomes in late stages of HF approximate those seen in patients wit

218 The early and late stages of human immunodeficiency virus (HIV) replic

219 We focused on the late stages of infection after bacteria escape from phag

220 transcription start sites between early and late stages of infection and that ASFV RNA polymerase (R

221 are attenuated compared to the wild-type at late stages of infection where membrane-associated uORF

222 tion defect, demonstrating the role of XP at late stages of infection.

223 tes the induction of an M2-like phenotype in late stages of M1 macrophage activation to promote wound

224 ent OCA2 activity to support melanization at late stages of melanosome maturation, and that a common

225 tions and other branched species at the very late stages of mitosis.

226 nded primarily on Kupffer cells at early and late stages of NASH, involving hyaluronan-CD44 binding.

227 in cartilage destruction than [-1A]TIMP3 at late stages of OA.

228 is transiently induced in follicle cells in late stages of oogenesis via ecdysteroid signaling.

229 esented minority scientists in the early and late stages of our scientific training, we frame the tra

230 ling cells was strikingly reminiscent of the late stages of postnatal development, with fewer transve

231 compared to those with gingivitis in mid and late stages of pregnancy.

232 nts maturated through the early, middle, and late stages of puberty (all p < 0.0001).

233 that retained NF-kappaB activation into the late stages of repair.

234 which precursors of VOCs, characterized the late stages of ripening.

235 by confocal microscopy during both early and late stages of S. epidermidis biofilm formation, and we

236 gly, the four helicases participating in the late stages of splicing are all DEAH-box helicases that

237 eptomyces coelicolor, it is required for the late stages of sporulation, but precisely how it functio

238 and a detailed picture of the outcome of the late stages of stellar evolution(6).

239 of nontreponemal tests, particularly in the late stages of syphilis, with clinically well-characteri

240 ass-supported bilayers revealed that whereas late stages of T cell activation are thought to be subst

241 n of the matrix protein periostin during the late stages of tendon repair, suggesting that persistent

242 aching out to health care services until the late stages of the abuse cycle during the COVID-19 pande

243 we propose that AtCGL20 participates in the late stages of the biogenesis of 50S ribosomal subunits

244 zation of liquid ridges that form during the late stages of the dewetting process.

245 ent VEPs from the affected side of the SC in late stages of the disease.

246 attern of inflammation in both the early and late stages of the disease.

247 ocytes (NOKs) that are capable of supporting late stages of the HPV16 life cycle.

248 nce-related genes in strains associated with late stages of the pandemic.

249 or deuterium incorporation at both early and late stages of the synthesis of a drug(6,7), these proce

250 MAP20 is expressed during the late stages of vascular bundle development and localizes

251 oreactive B cells to breach central, but not late, stages of peripheral tolerance.

252 erentiation level of KC (proliferated<early-<late-stage of differentiated KC); 3) expression of SPHK1

253 ting our protocol, we have also demonstrated late-stage olefination and alkynylation of 2-pyridone, c

254 redirect TAMs to serve as tumor killers for late-stage or drug-resistant cancers.

255 obust methods to access both early-stage and late-stage organoboron intermediates amendable for furth

256 r fracture in humans and horses and in human late-stage osteoarthritis; however, it is unknown how sy

257 ile implants in addressing the challenges of late-stage ovarian cancer.

258 linkers required advances in stereoselective late-stage oxidation and thiolation chemistry in complex

259 s an MHAT-induced radical bicyclization with late-stage oxidation to regenerate the aromatic terminat

260 Subsequent late-stage oxidations and modifications allow efficient

261 bial agents that interfere specifically with late-stage P. aeruginosa development.

262 oma establishment, switched off p53 to model late-stage p53 inactivation.

263 -type lymphomas, but became reexpressed upon late-stage p53 inactivation.

264 ge response is known to be hyperactivated in late-stage PanINs.

265 ntial by saving the lives of a proportion of late stage patients with immunogenic tumor types.

266 remarkably related with poorer prognosis in late stage patients.

267 e fibrosis pathway and immune system seen in late-stage patients.

268 ptide macrocyclization as a special class of late-stage peptide derivatization method.

269 he cell, namely, through the localization of late-stage PGN synthesis proteins.

270 intervention for the acute stabilization of late-stage plaques.

271 We also identify a set of late stage pseudotime samples that are controls and show

272 Males exhibited only late stage reductions in acylcarnitines and elevations i

273 st, detection of a Co(III) intermediate, and late-stage removal of the directing group are important

274 course, identifying iron accumulation during late-stage repair.

275 The route involved the late-stage resolution of a racemic intermediate to provi

276 cell specification trajectories reveals that late-stage retinal neural progenitors transcriptionally

277 Using the late stage ring closure approach, an S-linked analogue o

278 sized for the first time, employing either a late stage ring closure to install the required 3,6-anhy

279 of cone production, whereas misexpression in late-stage RPCs triggers ectopic cone production at the

280 nd that Rgnef protein levels are elevated in late-stage serous ovarian cancer, high Rgnef mRNA levels

281 ility of the approach is demonstrated by the late-stage site-selective modification of bioactive amin

282 ze to kinetochores and enables a response to late-stage spindle defects.

283 In late-stage STGD1-like patient and blue light-illuminated

284 an unusual Mislow-Evans rearrangement and a late-stage Stille ketene acetal coupling.

285 ing function and survival, overactivation of late-stage stress effectors cause dysfunction and death.

286 n, and survival, preceded by upregulation of late-stage stress-response genes activating transcriptio

287 The mild conditions enable late-stage structural diversification of biologically re

288 fection was a strategy commonly used to cure late-stage syphilis.

289 cell subset with regulatory capacity against late stage T1D.

290 ng changes is similar in pre-symptomatic and late stage tissue.

291 nd derivatives and polyaromatics, and in the late-stage trifluoromethylthiolation of medicines and ag

292 2 (LOXL2) were significantly upregulated in late-stage tumors and associated with poor patient progn

293 ied the problem of discriminating early- and late-stage tumors of several cancers using genomic infor

294 The methodology avoids late-stage usage of azides and tolerates a wide range of

295 Importantly, while the late stage was Arf1 dependent, as expected for canonical

296 ility to methylate such complex molecules at late stages will reduce synthetic effort and thereby exp

297 chlorides and acyl chlorides at an early and late stage with broad functional group compatibility.

298 nically into early-stage (without edema) and late-stage (with edema) disease.

299 eliminate or shrink tumors at early, mid and late stages without any apparent cytotoxicity, as reveal

300 Transfer of cDC2s isolated from late-stage wounds into healthy skin was sufficient to in