ライフサイエンスコーパス: latency-associated transcript

1 reverse transcription-PCR detection of HSV-1 latency-associated transcripts).

2 including species derived from ICP0 and the latency-associated transcript.

3 encoded within the second exon of the HSV-1 latency-associated transcript.

4 latently infected neurons is limited to the latency-associated transcripts.

5 ined expression of four previously described latency-associated transcripts.

6 res of latent infection, including classical latency-associated transcripts, a punctate pattern of LA

7 At 48 and 72 h, although latency-associated transcripts accumulated to comparable

8 aracterized by the expression of a noncoding latency-associated transcript and a set of microRNAs.

9 similar to those of WT virus, the levels of latency-associated transcript and micro-RNAs were 50- to

10 egalovirus is accompanied by the presence of latency-associated transcripts and expression of immunog

11 We used RT-PCR to detect latency-associated transcripts and HSV-1 lytic cycle gen

12 me loads and exhibited reduced expression of latency-associated transcripts and reduced reactivation

13 d to support latency and expression of viral latency-associated transcripts and to undergo reactivati

14 nsory neurons in which only noncoding (e.g., latency-associated transcript) and micro-RNAs are expres

15 hich do not accumulate significant levels of latency-associated transcripts, and (iii) the activation

16 pes simplex virus, which is characterized by latency-associated transcripts, and from lytic VZV repli

17 n used as a model for latency; viral DNA and latency-associated transcripts are expressed in dorsal r

18 ome, corresponding to the 5' end of the LAT (latency-associated transcript) coding region, is respons

19 yed to study the effect of a deletion in the latency-associated transcript domain.

20 e percentage of neurons expressing the major latency-associated transcript during the latent infectio

21 genitors is characterized by the presence of latency-associated transcripts encoded in the ie1/ie2 re

22 root ganglia were positive for HSV-2 DNA and latency-associated transcripts for 5/8 animals in the gC

23 utilized by the herpes simplex virus type 1 latency-associated transcript in latently infected mice

24 Marek's disease virus (MDV) latency-associated transcripts include at least two MDV

25 alternative promoter usage by LMP2 and other latency-associated transcripts, intergenic splicing at t

26 tion of sensory ganglia of mice, in that HSV latency-associated transcript is expressed, but to be de

27 The latency associated transcript (LAT) is the only viral ge

28 d to inoculate rabbit corneas: 17deltaPst, a latency associated transcript (LAT) negative, low-reacti

29 pression was rescued by replacing either the latency associated transcript (LAT) or the the infected

30 xpressed in latently infected neurons is the latency associated transcript (LAT).

31 viral gene product is a non-coding RNA, the latency associated transcript (LAT).

32 In the presence of latency-associated transcript (LAT((+)); wt virus), CD8(

33 ese, miR-H7 and miR-H9, are derived from the latency-associated transcript (LAT) and are located anti

34 Finally, the copy numbers of latency-associated transcript (LAT) and CD4(+) and CD8(+

35 in the HSV-1 genome, specifically around the latency-associated transcript (LAT) and ICP0 and ICP4 re

36 HSV-2 latency-associated transcript (LAT) contains a cis-actin

37 CTRL2 regulatory element downstream from the latency-associated transcript (LAT) enhancer was bound b

38 ation of herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) expression and proce

39 urthermore, Abeta(42) colocalized with HSV-1 latency-associated transcript (LAT) expression.

40 stitution of a 2.8-kbp region from the HSV-1 latency-associated transcript (LAT) for native HSV-2 seq

41 s study, a chimeric HSV-2 that expressed the latency-associated transcript (LAT) from HSV-1 reactivat

42 The HSV-1 latency-associated transcript (LAT) functions by regulat

43 s of deletions in the promoter region of the latency-associated transcript (LAT) gene in impairing he

44 Expression of the latency-associated transcript (LAT) gene is a hallmark o

45 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential fo

46 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential fo

47 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential fo

48 productive ("lytic") infection, but only the latency-associated transcript (LAT) gene is expressed at

49 The latency-associated transcript (LAT) gene is required for

50 The latency-associated transcript (LAT) gene the only herpes

51 t of the herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene to analyze its

52 The HSV-1 latency-associated transcript (LAT) gene, the only viral

53 The herpes simplex virus (HSV-1) latency-associated transcript (LAT) has been shown to in

54 To determine the role of the latency-associated transcript (LAT) in inhibiting apopto

55 We next examined the role of latency-associated transcript (LAT) in spontaneous gangl

56 the amount of CS and the level of the HSV-1 latency-associated transcript (LAT) in trigeminal gangli

57 The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis.

58 indicated that the unusual stability of the latency-associated transcript (LAT) intron was due to it

59 m, the major transcript detected is the 2-kb latency-associated transcript (LAT) intron.

60 ed the detection of non-polyadenylated HSV-1 latency-associated transcript (LAT) intronic RNAs.

61 The herpes simplex virus type 1 (HSV-1) 2-kb latency-associated transcript (LAT) is a stable intron,

62 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is abundantly expres

63 The latency-associated transcript (LAT) is essential for the

64 During latency, the viral lncRNA termed the latency-associated transcript (LAT) is known to accumula

65 During latency, the latency-associated transcript (LAT) is known to impact e

66 The latency-associated transcript (LAT) is required for effi

67 The latency-associated transcript (LAT) is the only abundant

68 We and others originally reported that the latency-associated transcript (LAT) is the only abundant

69 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is the only abundant

70 The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is the only HSV-1 ge

71 In contrast to lytic infection, the latency-associated transcript (LAT) is the only viral ge

72 A major function of the HSV-1 latency-associated transcript (LAT) is to establish high

73 The HSV-1 latency-associated transcript (LAT) locus contains two s

74 l ganglia when only the transcription of the latency-associated transcript (LAT) locus is detected.

75 er cassette, when placed in the context of a latency-associated transcript (LAT) null mutant, resulte

76 The latency-associated transcript (LAT) of herpes simplex vi

77 The latency-associated transcript (LAT) of herpes simplex vi

78 Only the latency-associated transcript (LAT) of the herpes simple

79 ncy reactivation and the potential effect of latency-associated transcript (LAT) on IFNbeta activity

80 ER and dlsptk expressed higher levels of the latency-associated transcript (LAT) per genome earlier i

81 fluence latency-associated transcription and latency-associated transcript (LAT) phenotypes, we studi

82 IMPORTANCE HSV-1 latency-associated transcript (LAT) plays a major role i

83 The HSV-1 latency-associated transcript (LAT) plays a major role i

84 Herpes simplex virus 1 (HSV-1) latency-associated transcript (LAT) plays a significant

85 and HSV-2) establish latency and express the latency-associated transcript (LAT) preferentially in di

86 udies have demonstrated that histones in the latency-associated transcript (LAT) promoter and intron

87 A previous study demonstrated that the latency-associated transcript (LAT) promoter and the LAT

88 ownstream of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter and upstrea

89 Latency-associated transcript (LAT) promoter deletion mu

90 e herpes simplex virus type 1 (HSV-1) or the latency-associated transcript (LAT) promoter deletion mu

91 primary herpes simplex virus type 2 (HSV-2) latency-associated transcript (LAT) promoter influences

92 The latency-associated transcript (LAT) promoter of herpes s

93 he murine IL-2 gene under the control of the latency-associated transcript (LAT) promoter of HSV-1 in

94 designated miR-H6 is located upstream of the latency-associated transcript (LAT) promoter region on t

95 scribed from divergent noncoding RNAs in the latency-associated transcript (LAT) promoter region.

96 acted from whole ganglia, (ii) the number of latency-associated transcript (LAT) promoter-positive ne

97 HSV, we have shown previously that the viral latency-associated transcript (LAT) promotes lytic gene

98 Recent studies have suggested that the latency-associated transcript (LAT) region of herpes sim

99 k the meq oncogene and three that map to the latency-associated transcript (LAT) region of the genome

100 ganglia (DRG), chromatin associated with the latency-associated transcript (LAT) region of the viral

101 ssed from the herpes simplex virus 1 (HSV-1) latency-associated transcript (LAT) region remain largel

102 RNAs (miR-H1/H6) that are encoded within the latency-associated transcript (LAT) region, a portion of

103 ne, and a second cluster is found within the latency-associated transcript (LAT) region.

104 The latency-associated transcript (LAT) regulates the establ

105 The percentage of latency-associated transcript (LAT) RNA-positive neurons

106 Latency-associated transcript (LAT) sequences regulate h

107 I, encoded by herpes simplex virus 2 (HSV-2) latency-associated transcript (LAT) through small RNA cl

108 nase is crucial for the ability of the HSV-1 latency-associated transcript (LAT) to inhibit apoptosis

109 Further analysis confirmed that this SVV latency-associated transcript (LAT) was oriented antisen

110 In particular, the transcription of the latency-associated transcript (LAT), IE genes, and genes

111 During latency only one locus, the latency-associated transcript (LAT), is abundantly trans

112 addition, we show that in the absence of the latency-associated transcript (LAT), the latent genome s

113 Latency-associated transcript (LAT), the only known vira

114 ross talk appears to occur between the HSV-1 latency-associated transcript (LAT), the only viral gene

115 Interestingly, latency-associated transcript (LAT), the only viral gene

116 tream of the transcription start site of the latency-associated transcript (LAT), were detected durin

117 anglia, HSVs express a long noncoding RNA, a latency-associated transcript (LAT), which plays a key r

118 a harvested during HSV latency, 25% of HSV-1 latency-associated transcript (LAT)- and 4% of HSV-2 LAT

119 sed to examine the role of the cornea in the latency-associated transcript (LAT)-mediated reactivatio

120 Herpes simplex virus type 1 latency-associated transcript (LAT)-null mutants have de

121 ular inoculation with HSV strain KOS, 81% of latency-associated transcript (LAT)-positive trigeminal

122 ing the gene for murine IL-4 in place of the latency-associated transcript (LAT).

123 f key HSV-1 genes, including ICP0, ICP4, and latency-associated transcript (LAT).

124 n depend on the anti-apoptotic activities of latency-associated transcript (LAT).

125 tional copies of the gK gene in place of the latency-associated transcript (LAT).

126 ctively transcribed: the region encoding the latency-associated transcript (LAT).

127 pression is tightly repressed except for the latency-associated transcript (LAT).

128 The latency-associated transcripts (LAT) family members are

129 herpes simplex virus type 1 (HSV-1) DNA and latency-associated transcripts (LAT) in the latently inf

130 ive by in situ hybridization (ISH) for HSV-1 latency-associated transcripts (LAT), the classical surr

131 erized by the constitutive expression of the latency-associated transcripts (LAT), which originate fr

132 expressed HSV-1 protein and 13.1% expressed latency-associated transcripts (LAT).

133 fection, viral gene expression is limited to latency-associated transcripts (LAT).

134 pression of viral gene expression except for latency-associated transcripts (LATs) and miRNAs.

135 latently infected ganglia is reduced by the latency-associated transcripts (LATs) and whether splici

136 These latency-associated transcripts (LATs) are derived from t

137 e expression is severely repressed; only the latency-associated transcripts (LATs) are expressed abun

138 and HSV-2 also preferentially express their latency-associated transcripts (LATs) in different senso

139 s type 1 is required to generate a series of latency-associated transcripts (LATs) in sensory neurons

140 sly, we documented the focal presence of the latency-associated transcripts (LATs) in the hippocampi

141 detectable viral proteins, expression of the latency-associated transcripts (LATs) is likely regulate

142 The latency-associated transcripts (LATs) of herpes simplex

143 of HSV genes and accumulation of the stable latency-associated transcripts (LATs), as occurs in neur

144 1 and -2 to establish latency and to express latency-associated transcripts (LATs), virulent strains

145 e in the numbers of neurons that express the latency-associated transcripts (LATs).

146 cription of viral genes is restricted to the latency-associated transcripts (LATs).

147 onally active, producing the 2.0- and 1.5-kb latency-associated transcripts (LATs).

148 of both the gamma(1)34.5 transcripts and the latency-associated transcripts (LATs).

149 ue, the only abundant viral products are the latency-associated transcripts (LATs).

150 n limited to a single locus that encodes the latency-associated transcripts (LATs).

151 re detected by in situ hybridization for HSV latency-associated transcripts (LATs).

152 ries of 5' coterminal transcripts termed the latency-associated transcripts (LATs).

153 and expresses long noncoding RNAs termed the latency-associated transcripts (LATs).

154 gene expression is largely restricted to the latency-associated transcripts (LATs).

155 rpes simplex virus expresses a unique set of latency-associated transcripts (LATs).

156 type 1 gene expression is restricted to the latency-associated transcripts (LATs).

157 In this study, we tested whether the LAT (latency-associated transcript) locus regulates the frequ

158 ering in and near ORF61 and antisense to the latency-associated transcript of VZV can positively infl

159 Latency-associated transcript ORF 73 was unaffected by t

160 we ocularly infected LTalpha(-/-) mice with latency-associated transcript-positive [LAT(+)] and LAT(

161 HSV expressing the epitope from the full latency-associated transcript promoter did not efficient

162 The HSV-1 latency-associated transcript region is known to regulat

163 se two viruses are within or proximal to the latency-associated transcript region.

164 These, along with the latency-associated transcript, represent the only viral

165 ICP4, thymidine kinase, glycoprotein C, and latency-associated transcript RNA by in situ hybridizati

166 mice, as determined by the expression of the latency-associated transcript RNAs.

167 LAT (latency-associated transcript), the only known viral gen

168 cription during latency is restricted to the latency-associated transcript (VLT) and RNA 63 (encoding

169 Moreover, we discover numerous VZV latency-associated transcripts (VLTs)-like circRNAs (cir

170 t to latently infected TG neurons, the HSV-1 latency-associated transcript was not detected in NALT o

171 iral genome became relatively quiescent, the latency-associated transcript was specifically upregulat

172 Expression of HSV-1 latency-associated transcripts was noted in TG cell cult

173 : sense and antisense meq, ORF L1, ICP4, and latency-associated transcripts, which are antisense to I

174 ve (NgK) form of the gK gene in place of the latency-associated transcript with a myc epitope tag to