ライフサイエンスコーパス: lateral line

1 or GCaMP in mechanosensory hair cells of the lateral line.

2 ctional mechanotransduction in the zebrafish lateral line.

3 position, and variation in the neurosensory lateral line.

4 in the developing ear and neuromasts of the lateral line.

5 linked to the mechanosensory function of the lateral line.

6 ls, and abnormal neuromasts on the posterior lateral line.

7 nsory hair cell function in the inner ear or lateral line.

8 as the migrating primordium of the posterior lateral line.

9 tion of germ cells and sensory organs of the lateral line.

10 spikes) in hair-cell afferent neurons of the lateral line.

11 red for mechanotransduction in the zebrafish lateral line.

12 ression and loss of Kremen1 in the zebrafish lateral line.

13 ation in vivo in the zebrafish inner ear and lateral line.

14 ion of supporting cells in the inner ear and lateral line.

15 regeneration of hair cells in the zebrafish lateral line.

16 m the mechanosensory organs of the posterior lateral line.

17 hair cell organs, including the cochlea and lateral line.

18 etent to respond to cues associated with the lateral lines.

19 Evolved over millions of years, fish use the lateral line, a distributed linear array of flow sensing

20 We investigated this question in the lateral line, a sensory system that allows fish and amph

21 al symmetry in myelinated reticulospinal and lateral line afferent axons.

22 Many auditory, vestibular, and lateral-line afferent neurons display spontaneous action

23 These results indicate that lateral-line afferent neurons do not require synaptic ac

24 we recorded robust spontaneous spiking from lateral-line afferent neurons in the absence of external

25 emoving specific neuromasts of the posterior lateral line along the body, we show how the location an

26 Sema Z1a helps guide the growth cones of the lateral line along their normal pathway.

27 ory organ, adenohypophysis, lens, inner ear, lateral line and cranial ganglia.

28 terior portion, which is associated with the lateral line and eighth nerve senses, and the posterior

29 and an anterior caudal lobe associated with lateral line and eighth nerve senses.

30 onfiguration is reached only in the juvenile lateral line and in the inner ear from >2 months after h

31 and synaptic activity in hair cells from the lateral line and inner ear in vivo and using near-physio

32 The lateral line and its associated sensory nerves develop f

33 We also quantify differences in the lateral line and vision between cavefish and surface fis

34 h ganglionic placodes, including trigeminal, lateral line, and epibranchial placodes.

35 atrial siphon primordia and posterior (otic, lateral line, and epibranchial) placodes of vertebrates

36 t, skeletal muscle, otic vesicle, forebrain, lateral line, and ganglions, most of which have not been

37 line nerve for this head segment, the middle lateral line, appears to develop normally.

38 cells in the chick cochlea and the zebrafish lateral line are able to regenerate, prompting studies i

39 ing that in C. punctatum, glial cells in the lateral line are likely of neural crest origin.

40 ting experiments demonstrated that T. torosa lateral lines are competent to generate a melanophore-fr

41 , as did thalamic and hindbrain auditory and lateral line areas and vocal-acoustic integration sites

42 -pronged drug screen employing the zebrafish lateral line as an in vivo readout for ototoxicity and k

43 teral current profile of hair cells from the lateral line becomes more segregated with age, and that

44 ccule in the inner ear and from the anterior lateral line both terminate in the medial vestibular nuc

45 olfactory neurons, and sensory cells of the lateral line, but not in the retina.

46 that hair cells and supporting cells of the lateral line can be directly patch-clamped, providing th

47 We show that the artificial lateral line can successfully perform dipole source loca

48 The raised orbits, lateral line canals and weakly ossified postcranial skel

49 We found that the isolated lateral line cells are positioned by two antagonistic cu

50 tions between melanophores and xanthophores, lateral line-dependent alterations of the subepidermal b

51 ave been retained in T. torosa as redundant, lateral line-dependent mechanisms for stripe formation h

52 These results indicate that lateral line-dependent pattern-forming mechanisms are co

53 placodes (trigeminal, auditory, vestibular, lateral line) develop independently of the endoderm and

54 re, we attempt to highlight the diversity of lateral line development and the limits of the current r

55 ceptor and reveal its additional role in the lateral line development in zebrafish.

56 Moreover, prevention of lateral line development results in greater densities of

57 milar melanophore-free region forms prior to lateral line development, and ablation of the lateral li

58 ion and differentiation during inner ear and lateral line development.

59 Here, we show that in the zebrafish lateral line, disruptions of the PCP and Wnt pathways ha

60 ateral line development, and ablation of the lateral lines does not perturb the horizontal stripe pat

61 Lateral line effects on melanophores are inferred to be

62 We have used RNA-seq to generate a lateral line-enriched gene-set from late-larval paddlefi

63 w that each afferent neuron of the posterior lateral line establishes specific contacts with hair cel

64 ent expression was observed in the posterior lateral line ganglia and developing trunk/tail.

65 Both lateral line ganglia and neuromasts develop on a stereot

66 also identify Tbx3 as a specific marker for lateral line ganglia in shark embryos.

67 st in trigeminal, Rohon-Beard, and posterior lateral line ganglia neurons, which are among the earlie

68 Early in this pathway, in the lateral line ganglia, neurons respond almost exclusively

69 le, we analyzed (1) the pathways followed by lateral line growth cones in mutants in which the expres

70 tered in an interesting way, (2) response of lateral line growth cones to exogenous Sema Z1a in livin

71 ing embryos, and (3) the pathway followed by lateral line growth cones when Sema Z1a is misexpressed

72 l fate analyses of all dividing cells during lateral line hair cell regeneration revealed that suppor

73 cellular Ca(2+) underlies death in zebrafish lateral line hair cells after exposure to aminoglycoside

74 Channelrhodopsin (ChR2) expressed in ear and lateral line hair cells and acquired high-speed videos o

75 In lateral line hair cells from juvenile zebrafish, exocyto

76 t to mammalian hair cells, zebrafish ear and lateral line hair cells regenerate from poorly character

77 In contrast, zebrafish lateral line hair cells, which detect water motion, requ

78 mycin for 1 h results in death of almost all lateral line hair cells.

79 bundles and mechanosensitivity of individual lateral-line hair cells in vivo, we uncovered a central

80 e found that TRPN1 is prominently located in lateral-line hair cells, auditory hair cells, and ciliat

81 ocalizes to ribbon synapses in inner ear and lateral-line hair cells.

82 ted or inhibited D1-like receptors (D1Rs) in lateral-line hair cells.

83 chooling tendency in A. mexicanus, while the lateral line has a small effect on this behavior.

84 that develop supernumerary neuromasts in the lateral line has revealed an inhibitory mechanism, media

85 ic survey also revealed that ablation of the lateral lines has qualitatively similar effects on melan

86 tatoacoustic ganglion (SAG) development, and lateral line HC differentiation.

87 ot fully established, as isolated cells with lateral line identity are present caudal to the main pri

88 ent neurons that innervate the inner ear and lateral line in a sound-producing teleost fish while evo

89 in the migrating primordia of the posterior lateral line in dog embryos and as well as in regions of

90 siological properties from hair cells of the lateral line in juvenile zebrafish.

91 ere we show that neuromasts of the posterior lateral line in medaka are composed of two independent l

92 amenable model is provided by the posterior lateral line in zebrafish, which is formed by a cohesive

93 nsory neurons, the posterior ganglion of the lateral line, in zebrafish.

94 ine which receive auditory and which receive lateral line information.

95 bration stimuli peaking at 35 Hz, blocked by lateral line inhibitors, first detected after developmen

96 itory input via the medial pretoral nucleus, lateral line input via the ventrolateral toral nucleus,

97 free region, including steric effects of the lateral lines, interactions between melanophores and xan

98 and multiple pathways in vivo transforms the lateral line into a powerful paradigm to mechanistically

99 The lateral line is a placodally derived mechanosensory orga

100 The development of the artificial lateral line is aimed at fundamentally enhancing human a

101 The zebrafish lateral line is emerging as an excellent in vivo model f

102 GNIFICANCE STATEMENT In aquatic animals, the lateral line is important for detecting water flow stimu

103 We speculate that directional input from the lateral line is less important at an early age, whereas

104 The mechanosensory lateral line is located externally on the animal and the

105 The lateral line (LL) is a sensory system that allows fish a

106 SK channels.SIGNIFICANCE STATEMENT The fish lateral line (LL) mechanosensory system shares structura

107 athway; in the nucleus of the electrosensory lateral line lobe (ELL) and the big cells of the nucleus

108 hanisms was identified in the electrosensory lateral line lobe (ELL) in the hindbrain by field potent

109 Phase-locking neurons in the electrosensory lateral line lobe (ELL) of a weakly electric fish, Gymna

110 hase-sensitive neurons in the electrosensory lateral line lobe (ELL) of the African electric fish, Gy

111 formation transmission in the electrosensory lateral line lobe (ELL) of the hindbrain.

112 e describe correlations among electrosensory lateral line lobe (ELL) pyramidal cells' highly variable

113 I-type pyramidal cells in the electrosensory lateral line lobe (ELL) to random distortions of a mimic

114 ordered hindbrain maps of the electrosensory lateral line lobe (ELL), the dorsolateral zone (DLZ), an

115 n for central processing, the electrosensory lateral line lobe (ELL), were investigated by the in viv

116 olds of output neurons of the electrosensory lateral line lobe (ELL), where the representation of tim

117 sory feedback pathways to the electrosensory lateral line lobe (ELL).

118 nhibitory interneurons in the electrosensory lateral line lobe (ELL).

119 neurons in the nucleus of the electrosensory lateral line lobe (NELL) act as relays of peripheral res

120 Pyramidal cells in the electrosensory lateral line lobe burst in response to low-frequency, lo

121 nucleus in electric fish, the electrosensory lateral line lobe, resulted in markedly different behavi

122 s, the pyramidal cells in the electrosensory lateral-line lobe.

123 The external location of the zebrafish lateral line makes it a powerful model for studying mech

124 unk during embryonic development to form the lateral line mechanosensory system.

125 pathways mediating auditory, vestibular, and lateral line modalities as the animal transforms from an

126 ordium plays a crucial role in orchestrating lateral line morphogenesis.

127 sensory and electrosensory components of the lateral line must be dissociable.

128 medialis, the principal termination site of lateral line nerve afferents in the medulla, whereas ter

129 Interneuromast cells lie adjacent to the lateral line nerve and associated glia.

130 al tracer BDA into different branches of the lateral line nerve and into different parts of the dorsa

131 The proposed corresponding lateral line nerve for this head segment, the middle lat

132 Here, we show that the posterior lateral line nerve in zebrafish initially grows in the e

133 nd posterior to the otic vesicle: the middle lateral line nerve innervates the middle line, whereas t

134 recent study has addressed how the zebrafish lateral line nerve matches up with its glia.

135 The left, infraorbital, anterior lateral line nerve of brown ghosts (Apteronotus leptorhy

136 trunk canal and the ramules of the posterior lateral line nerve that innervate them seem to be organi

137 Otolithic, semicircular canal, and anterior lateral line nerves all project to the MgON, which may s

138 We describe the organization of lateral line nerves and ganglia in the embryonic zebrafi

139 Two lateral line nerves are found anterior to the otic vesic

140 An additional two lateral line nerves are found posterior to the otic vesi

141 Anterior and posterior lateral line nerves project to the CON and MON, with den

142 ne receptors are innervated by five pairs of lateral line nerves whose rami are secondarily associate

143 The regeneration of sensory hair cells in lateral line neuromasts of axolotls was investigated via

144 nd to possess significantly more superficial lateral line neuromasts than hatchery-reared juveniles,

145 umbers of hair cells in the otic vesicle and lateral line neuromasts with impaired sensory responses.

146 detailing the patterning and development of lateral line neuromasts, little is known about the organ

147 sensory hair cells in the developing ear and lateral line neuromasts.

148 ph9 in the kinocilia of the inner ear and/or lateral line neuromasts.

149 of the process of hair cell regeneration in lateral line neuromasts; numbers of macrophages were obs

150 cellular nuclei receive their input from the lateral line nucleus of the medulla.

151 rmation by each hair cell of the zebrafish's lateral line occurs during a particular interval after t

152 elopment, morphogenesis, and polarity in the lateral line of Danio rerio and the embryo of Caenorhabd

153 mechanosensitive neuromast cells within the lateral line of fish prevented the rescue of pth2 levels

154 cal properties of mature hair cells from the lateral line of juvenile zebrafish.

155 We have investigated this process in the lateral line of larval zebrafish (male and female) to un

156 In the posterior lateral line of larval zebrafish, each afferent neuron f

157 cell damage, we examined hair cells from the lateral line of the zebrafish, Danio rerio.

158 Investigating this issue in the lateral line of the zebrafish, we found that hair cells

159 mal number of neuromasts along the posterior lateral line of zebrafish larvae.

160 Hair cells in the posterior lateral lines of mutants contain numerous lysosomes and

161 nsory structures (e.g., auditory, gustatory, lateral line, olfactory, and visual nuclei) and motor nu

162 The lateral line organ is a mechanosensory organ of fish and

163 e patterns in an in vitro preparation of the lateral line organ of Xenopus laevis.

164 The lateral line organ of zebrafish has been used as a model

165 CGRP suppressed responses of the lateral line organ to displacement while increasing spon

166 ransduction, including cells of the ear, the lateral line organ, and the olfactory placodes.

167 ively expressed in hair cells of the ear and lateral line organ.

168 the overall development of the inner ear and lateral-line organ appeared normal, the sensory epitheli

169 ation, these results establish the posterior lateral-line organ as a vertebrate system for the in viv

170 ation of mechanosensory hair cells along the lateral-line organ of a fish or amphibian is essential f

171 The posterior lateral-line organ of larval zebrafish consists of polar

172 anosensory organs, such as the inner ear and lateral-line organ, is not clearly understood.

173 nically sensitive cells of the inner ear and lateral-line organ.

174 ranial ganglia, neural crest, and hindbrain, lateral line organization was analyzed in valentino muta

175 e axonal projections from the mechanosensory lateral line organize a somatotopic neural map.

176 scRNA-Seq of lateral line organs uncovered five different support cel

177 y organ, retina, lens, cornea, otic vesicle, lateral line organs, and Rohon-Beard neurons.

178 Information about water flow, detected by lateral line organs, is critical to the behavior and sur

179 hypersensitive mutants have additional trunk lateral line organs.

180 ant, progressive hair cell loss in zebrafish lateral-line organs.

181 cyte/xanthophore, iridophore, intraray glia, lateral line, osteoblast, dermal fibroblast, vascular en

182 The organization of the central lateral line pathways in the midshipman fish, Porichthys

183 he neuromasts, known mechanoreceptors of the lateral line peripheral nervous system.

184 mal derivatives including neurons, glia, the lateral line, peripheral sensory structures, and tissues

185 evelop normally, results in abnormal ear and lateral line phenotypes.

186 Intensive study of the migrating posterior lateral line placode in zebrafish has yielded a wealth o

187 mapping data that conclusively demonstrate a lateral line placode origin for ampullary organs and neu

188 nfirms that ampullary organs are ancestrally lateral line placode-derived in bony fishes.

189 at jawed vertebrates primitively possessed a lateral line placode-derived system of electrosensory am

190 of the lobe-finned clade of bony fishes) are lateral line placode-derived, non-placodal origins have

191 nt research focus on the zebrafish posterior lateral line placode.

192 ttle skate, Leucoraja erinacea, we show that lateral line placodes form both ampullary electrorecepto

193 Here, we test the hypothesis that lateral line placodes form electroreceptors in cartilagi

194 eral lines were ablated (by removing cranial lateral line placodes), the melanophore-free region did

195 and ampullary organ formation by elongating lateral line placodes, and even of other zebrafish later

196 function, suggesting that two derivatives of lateral line placodes, ganglia and migrating primordia,

197 l line placodes, and even of other zebrafish lateral line placodes, is sparse or non-existent.

198 tem throughout its development, expressed in lateral line placodes, sensory ridges and migrating prim

199 bony fish ampullary organs are derived from lateral line placodes, whereas a neural crest origin has

200 ntire system arises from a series of cranial lateral line placodes, which exhibit two modes of sensor

201 euromasts and ampullary organs, develop from lateral line placodes.

202 ogfish, with a focus on the epibranchial and lateral line placodes.

203 , Danio rerio, are expressed in the otic and lateral-line placodes at their earliest stages of develo

204 The zebrafish posterior lateral line (pLL) is a sensory system that comprises cl

205 Here we show that the posterior lateral line (PLL) of zebrafish is a suitable system to

206 regular intervals by the migrating posterior lateral line (pLL) primordium.

207 and the superficial horizontal myoseptum and lateral line primordia were not properly formed in the q

208 f proneuromast deposition from the posterior lateral line primordia.

209 In this study, we use the zebrafish lateral line primordium (LLP), a group of migrating epit

210 Here, we study the posterior lateral line primordium (PLLP) a group of about 100 cell

211 igration of cells in the zebrafish posterior lateral line primordium (PLLp) along a path defined by C

212 Migration of the posterior lateral line primordium (pLLP) generates the zebrafish s

213 The posterior lateral line primordium (PLLp) migrates caudally and per

214 The posterior lateral line primordium (pLLp) migrates caudally, deposi

215 modulation of Wnt signaling in the posterior lateral line primordium (pLLP), a cohort of ~100 cells t

216 rosette formation in the zebrafish posterior lateral line primordium (pLLp), a group of approximately

217 We captured dynamic changes in the zebrafish lateral line primordium and observed interactions betwee

218 ogenic cell migration, such as the zebrafish lateral line primordium and primordial germ cells, Droso

219 ecause melanophores retreat from the midbody lateral line primordium as it migrates caudally along th

220 g in which it enables the coalescence of the lateral line primordium from an initial fuzzy pattern in

221 The posterior lateral line primordium in zebrafish provides an amenabl

222 The Zebrafish Posterior Lateral Line primordium migrates in a channel between th

223 of this problem is afforded by the migrating lateral line primordium of the zebrafish.

224 The posterior lateral line primordium periodically deposits prosensory

225 R7 acts as a sink in the migrating zebrafish lateral line primordium to generate SDF1 gradients.

226 during migration of the zebrafish posterior lateral line primordium, a cohort of about 200 cells tha

227 lar architecture for the zebrafish posterior lateral line primordium, an experimentally tractable mod

228 ys in the initial formation of the posterior lateral line primordium, as well as during organ pattern

229 her a moving tissue, the zebrafish posterior lateral line primordium, buffers its attractant in this

230 d vessel sprouting, and the migration of the lateral line primordium, neural crest cells, or head mes

231 lopmental contexts, such as in the zebrafish lateral line primordium, the vertebrate pancreas, the Dr

232 skin in directed migration of the Posterior Lateral Line primordium.

233 e collectively migrating zebrafish posterior lateral line primordium.

234 ErbB expressing Schwann cells inhibit lateral line progenitor proliferation and differentiatio

235 play a crucial role in negatively regulating lateral line progenitor proliferation.

236 rotransmitter phenotypes, as well as correct lateral line progression and survival to adulthood.

237 e otolithic organs, semicircular canals, and lateral lines, project to seven hindbrain nuclei in dive

238 in stable across larval development, whereas lateral line projections degenerate during metamorphic c

239 The lateral line provides hydrodynamic information for intri

240 The lateral line receptors are innervated by five pairs of l

241 brain and hindbrain vocal circuitry, and the lateral line recipient nucleus medialis in the rostral h

242 into physiologically identified sites in the lateral line-recipient nucleus ventrolateralis in the mi

243 Mechanosensory hair cells of the zebrafish lateral line regenerate rapidly following damage.

244 Detection of water motion by the lateral line relies on mechanotransduction complexes at

245 Single afferent neuron recordings from the lateral line revealed a similar intensity-dependent decr

246 In contrast, the eight mechanosensory lateral lines running over the head surface and the nume

247 re were no differences for all three traits, lateral-line scales, pectoral-fin rays and pelvic-fin ra

248 Lateral line sensory neuromasts develop independently of

249 (MON) is the principal first-order medullary lateral line sensory nucleus found in the majority of an

250 roreception is an ancient subdivision of the lateral line sensory system, found in all major vertebra

251 correlates with the development of the trunk lateral line sensory system.

252 defective in formation of the inner ear and lateral line sensory systems.

253 n; specific cells in the trigeminal (fifth), lateral line (seventh), and vestibular (eighth) cranial

254 chanosensory hair cells within the zebrafish lateral line spontaneously regenerate after aminoglycosi

255 es on several morphological traits including lateral line structure, otolith composition (a proxy for

256 s expressed in the migrating melanocytes and lateral line structures.

257 served DiI cells and Sox9 labeling along the lateral line, suggesting that in C. punctatum, glial cel

258 n the continued regenerative capacity of the lateral line, support cells presumably have the ability

259 reased number of neuromasts in the posterior lateral line system and decreased body length, suggestin

260 imilarly, HCs in neuromasts of the zebrafish lateral line system are generated as pairs, and two sibl

261 Using the zebrafish lateral line system as a platform for drug screen and su

262 The sensory lateral line system consists of only a few hundred cells

263 Our analysis of the posterior lateral line system defines a new process in which Schwa

264 morphological and molecular data describing lateral line system development in the basal ray-finned

265 ved S100-positive cells in neuromasts of the lateral line system in 2 dpf larvae, suggesting that the

266 siting neuromasts to establish the posterior lateral line system in zebrafish.

267 The lateral line system of anamniote vertebrates enables the

268 The lateral line system of larval zebrafish is emerging as a

269 to the inner ear of all vertebrates, and the lateral line system of some aquatic vertebrates, represe

270 The lateral line system of the channel catfish is formed by

271 We identify Eya4 as a novel marker for the lateral line system throughout its development, expresse

272 In this work, we used the zebrafish lateral line system to monitor the dynamic behavior of m

273 ior called rheotaxis, whereby they use their lateral line system to orient upstream in the presence o

274 (olfactory organs, inner ears and anamniote lateral line system), as well as the eye lenses, and mos

275 The anamniote lateral line system, comprising mechanosensory neuromast

276 s differs between the anterior and posterior lateral line system, suggesting potential differences in

277 quantifying morphological connections in the lateral line system, this study provides a detailed foun

278 so requires neither a functioning visual nor lateral line system.

279 tire postfacial body appear to function as a lateral line system.

280 monstrate here a proof-of-concept artificial lateral line system.

281 sensory cells of neuromasts belonging to the lateral line system.

282 sette-shaped sensory organs in the zebrafish lateral line system.

283 e expression in hair-cell progenitors of the lateral-line system.

284 The fibers of the gustatory and lateral line systems may use the neural crest, the devel

285 roreception or vibratory sensing through the lateral line systems plays a role in social signaling, a

286 The organs of the vestibular, auditory and lateral line systems rely on a common strategy for the s

287 ondary targets of the olfactory, visual, and lateral line systems, as well as telencephalic regions t

288 ssing information from both the auditory and lateral line systems, including the eighth nerve-recipie

289 Hair cells in the auditory, vestibular, and lateral-line systems of vertebrates receive inputs throu

290 cal signals in the auditory, vestibular, and lateral-line systems of vertebrates.

291 stant and step stimuli in the vestibular and lateral-line systems.

292 ision of a precursor cell in the zebrafish's lateral line, the daughter hair cells differentiate with

293 In addition to the lateral line, these findings have important implications

294 We took advantage of the zebrafish sensory lateral line to define niche-progenitor interactions to

295 , we show that fish use their mechanosensory lateral line to first sense the curl (or vorticity) of t

296 -known mechanoreceptors of the inner ear and lateral line, typically exhibiting an apical hair bundle

297 We map mechanosensitivity along the lateral line using imaging and electrophysiology to dete

298 Using hair cells of the zebrafish lateral line, we found that chemical inhibition of mecha

299 he inner ear or by neomycin treatment in the lateral line, we observe rapid activation of several com

300 When the trunk lateral lines were ablated (by removing cranial lateral

301 other placodally derived sensory system, the lateral line, while hypersensitive mutants have addition