ライフサイエンスコーパス: lead

1 rsenic, 20 ppb copper, 5 ppb cadmium, 10 ppb lead, 10 ppb bisphenol A, and 1 ppb paraoxon, tested as

2 The lead agent protects neurons from death in vivo.

3 and with significant increases in cord blood lead and cadmium.

4 ed with nonsignificant increases in maternal lead and with significant increases in cord blood lead a

5 is here reported, which took SAC and ACE as leads and produced a series of 2H-benzo[e][1,2,4]thiadia

6 This study describes the determination of lead at trace levels by slotted quartz tube flame atomic

7 identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 x 10(-10)).

8 imit of detection, without interference from lead, cadmium, atrazine, and paraoxon, and without matri

9 However, the leading Cas9 and Cas12a enzymes are limited in their abi

10 Peri-implantitis is the leading cause for IR.

11 Noroviruses are a leading cause of acute gastroenteritis.

12 Pneumonia is the leading cause of antibiotic use and hospitalization in V

13 Tuberculosis (TB) is the leading cause of death from a single infectious agent, r

14 Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myelop

15 Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable incr

16 Stroke is the second leading cause of death worldwide and a leading cause of

17 However, stroke remains the second leading cause of death worldwide and the number one caus

18 Suicide is a leading cause of death.

19 econd leading cause of death worldwide and a leading cause of disability.

20 Excessive alcohol use is the third leading cause of mortality in the United States, where a

21 Chronic ethanol consumption is a leading cause of mortality worldwide, with higher risks

22 Staphylococcus aureus is a leading cause of pneumonia.

23 impact on patients and relatives, and is the leading cause of the global burden from skin disease.

24 Stroke remains one of the leading causes of permanent disability and death worldwi

25 Bordetella pertussis is among the leading causes of vaccine-preventable deaths and morbidi

26 Although generic language always led children to believe that properties were nonaccident

27 The lead compound 48c, induced necrosis in several mutant an

28 We identified DBeQ as a promising lead compound for structural optimization aimed at selec

29 n of design cycles needed to optimize hit or lead compounds into high-quality chemical probes or drug

30 Alzheimer agents beyond that of the original lead CR-6.

31 Moreover, the lead cyclic dnCSP, CSP1-E1A-cyc(Dap6E10), was found to p

32 F screening pathways using the ubiquitous 12-lead ECG to detect asymptomatic paroxysmal AF in at-risk

33 nds duration confirmed by rhythm strip or 12-lead ECG.

34 ta1 regulated the positioning of Abi1 at the leading edge.

35 nerate thrust on their anterior bodies using leading-edge suction mechanics, much like an airfoil.

36 s work has established that risk factors for lead exposure include race/ethnicity, poverty, Medicaid

37 otinic acetylcholine receptors (nAChRs) as a lead for the development of alternative antivenoms.

38 eport clear evidence of water stability in a lead-free metal halide perovskite, namely DMASnBr(3) , o

39 using macrocyclic cores for in silico-based lead generation and also inspire the design of future ma

40 Bright lead halide perovskite nanocrystals, which have been ext

41 es have emerged as promising alternatives to lead halide perovskites in optoelectronic applications.

42 The performance of lead-halide perovskite light-emitting diodes (LEDs) has

43 uced are compared with those produced by two leading hyperspectral visualization techniques in the fi

44 After a 2-week lead-in period of cognitive training, 100 participants w

45 idental and lagging indicators actually show leading indicator characteristics.

46 Tuberculosis (TB) is the leading infectious cause of death globally, and drug-res

47 cesses, as well as the recent discoveries by leading investigators with an emphasis on significant op

48 terestingly, PRV infection of neuronal cells leads not only to a nonspecific depletion of KIF1A mRNA

49 Lead optimization involved modulating potency, selectivi

50 global records of anthropogenic atmospheric lead (Pb) spanning the last 4000 years, an effective ind

51 We measured manganese (Mn), lead (Pb), copper (Cu), and chromium (Cr) in hair, blood

52 ress these issues, we exposed Moina dubia to lead (Pb, 50 mug/L) under two temperatures (25 and 28 de

53 om extinction, condors remain compromised by lead poisoning and limited genetic diversity.

54 Fetal alcohol exposure (FAE) is the leading preventable developmental cause of cognitive dys

55 al Delphi survey represents the first expert-led process for developing a standardized approach for e

56 Cigarette smoking remains one of the leading public health threats worldwide.

57 with a low-power blue light emitting diode (LED), resulting in local anesthesia.

58 sts and clinical immunologists should have a leading role in this unprecedent challenge.

59 Pb reduction actions (i.e., combinations of lead service lines [LSL] and corrosion control treatment

60 ne novel genomic risk locus on chromosome 8 (lead SNP rs17052966, p = 4.53 x 10(-9), odds ratio = 1.2

61 The lead SNP was also associated with lower lymphocyte count

62 first noted in the early 20(th) century and led some researchers to later question its value as a mo

63 ork restart and the division of labor during leading-strand synthesis generally.

64 Lead structure optimization is needed to minimize the pe

65 s with the 2-lead system compared with the 3-lead system (0% versus 8%; P=0.03).

66 Optimizer-related adverse events with the 2-lead system compared with the 3-lead system (0% versus 8

67 proteins, lipid immunogens, and live mutants lead the design of canonical vaccines aimed at disruptin

68 H) Scientific Workforce Diversity office has led the charge to develop and implement evidence-informe

69 r expands, the predictions improve while the lead-time for vaccine development and other intervention

70 rable combinations of lifestyle risk factors lead to a high likelihood of hepatic steatosis.

71 s associated with poor fungal immunity could lead to a personalized assessment for the continued need

72 on of NNRTI-based ART, introducing DTG would lead to a reduction in NNRTI PDR in all scenarios if ART

73 port within such structures will potentially lead to accessible device fabrication for 'on-demand' ap

74 For instance, defects can lead to an enhanced photoconduction, a complicated proce

75 ssue damage, but its aberrant activation can lead to autoinflammatory diseases.

76 n: Peptide receptor radionuclide therapy can lead to bowel obstruction in patients with mesenteric or

77 transcription of genes, including those that lead to cellular accumulation of protective organic osmo

78 o routinely predict which specific stressors lead to declines in different populations or contexts, h

79 Aberrant ferroportin activity can lead to diseases of iron overload, such as haemochromato

80 rognostic accuracy over time and in addition lead to enhancements in treatment response and outcomes.

81 Sites of equal area but different shape lead to equal occupancy if shapes are isotropic (e.g., s

82 inear regression) do not consider, which can lead to false positives and false negatives.

83 the alternative to making these changes will lead to further drop-off in the physician scientist pipe

84 increased rates of protein synthesis, which lead to growth inhibition and hypersensitivity to osmoti

85 come deposited on the cell membranes and can lead to hemolysis.

86 We tested whether longer photoperiods lead to higher parasitism rates by a day-active parasito

87 in human cells, how DNA repair failures can lead to human disease, and how PARP inhibitors have emer

88 ethods for characterizing communities, might lead to improved fertilizer use efficiency and mitigatio

89 g the most commonly found mutations in CHIP, lead to increased expression of inflammatory genes in in

90 or targeted households, but knock-on effects lead to increased harvest of nearshore fish, making them

91 Ultimately, C starvation may lead to increased mortality vulnerability, but hydraulic

92 ptibility of host cells to MNV infection can lead to insights on the roles that specific cell types p

93 Specifically, mass-transport limitations lead to large concentration gradients in the solution-ph

94 infection based on antibody detection might lead to less invasive, early interventions.

95 elength IR region, performed at 4 degrees C, lead to marked sensitivity improvements over conventiona

96 s that use endogenous transport pathways may lead to more effective treatments for diseases within th

97 scillations in the motor cortex are known to lead to muscle responses of greater amplitude.

98 f the genetic basis of sex determination may lead to new methods of managing these troublesome weeds.

99 This understanding may lead to new targets or approaches for drug development o

100 of homeostatic and hedonic brain nuclei can lead to pathological feeding behaviors, namely overconsu

101 This hazard can lead to physical and mental health problems for nurses a

102 onclusion, a defect in folate metabolism can lead to prenatal aqueduct stenosis and resultant hydroce

103 Such changes can lead to profound changes in behavior, but little is know

104 of highly conserved DNA-binding regions can lead to profound changes in protein function.

105 that, in the context of a ubiquitin ligase, lead to protein degradation(1).

106 nits of the adaptor protein complex 4 (AP-4) lead to prototypical yet poorly understood forms of chil

107 level implementation of azithromycin MDA may lead to selection of multiresistant pathogens.

108 dipose tissues and their dysfunctions, which lead to several metabolic diseases including obesity or

109 t mutations and supernumerary copy variants, lead to severe and fatal disease.

110 pothesized that common intracellular targets lead to similarities in cellular responses.

111 Changes observed were temporary and did not lead to structural reorganisation of the transportation

112 ndings also revealed that high doses of BrdU lead to the activation of apoptotic cellular events as e

113 lish and maintain a persistent infection may lead to the development of new therapeutic strategies ag

114 ability of gene expression estimation, which lead to the improved downstream gene expression-based pr

115 anisms by which alpha2-Na/K ATPase mutations lead to the migraine phenotype remain incompletely under

116 ation of these properties in one filter will lead to the production of an effective device, comprehen

117 The functional mechanisms that lead to their clearance of harmful substances involve ph

118 ny small benefit to surviving clonemates can lead to this retaliatory strategy being favored by natur

119 ork presents an efficient strategy which can lead to time and cost saving post-translational, covalen

120 s in pediatric patients is difficult and can lead to treatment delay.

121 bute to periodontal disease pathogenesis may lead to treatment options that address individual biolog

122 steroid (BR) biosynthesis gene DWARF1 (DWF1) lead to variation of the DWF1 transcript level that cont

123 scales relevant for the implemented models, leading to a higher frequency of nearby premises compare

124 umulating in biota and metabolizing to PFBS, leading to a higher than expected TMFs for this compound

125 d proteasomal degradation of KIF1A proteins, leading to a near depletion of KIF1A protein late in inf

126 s and (2) a direct nucleophilic substitution leading to a stereoselective synthesis of the compounds

127 well as enhanced phospho-signalling within, leading to a submicron gradient of activated CtrA-P(19)

128 frequently harbor activating NRAS mutations leading to activation of MAPK kinase (MEK) and extracell

129 t any types of abdominal and pelvic surgery, leading to adverse consequences.

130 e probe compounds for the monodentate attack leading to an ozone adduct.

131 ty, electrically insulating single crystals, leading to anomalous transport properties well above cry

132 atic environments in the region, potentially leading to bioaccumulation in fish and exposure to commu

133 te specific binding by the SHP2 active site, leading to blockade of RasGAP binding and optimal signal

134 n fundamental understanding of all processes leading to catalytic activity, i.e., light absorption, c

135 thanolysis of the cyclic anhydride (+/-)-10, leading to chromatographically separable pairs of enanti

136 disturbed flow (DF) induces GCX degradation, leading to CTC homing to the endothelium, a first step i

137 s of direct virus-induced neural-cell damage leading to demyelination and axonal loss, which are path

138 ugates also retain T-independent properties, leading to detrimental effects on immune responses.

139 ested in our patient-derived xenograft model leading to disease attenuation and prolonged survival.

140 extensively rewired among the three species, leading to distinct anatomical and morphological outcome

141 actions appear to reshape network structure, leading to dramatic community changes, including loss of

142 hibitor efficiency and substrate specificity leading to drug resistance is unclear.

143 roblasts in the pericystic microenvironment, leading to fibrosis in ADPKD.

144 ed because of the underlying pathophysiology leading to Fontan palliation, remodelling, or increased

145 fibril sliding is one of the key mechanisms leading to fracture.

146 ay an important role in Gag:RNA interactions leading to genome packaging.

147 s indicates that anthropogenic modifications leading to habitat fragmentation and a higher genetic di

148 ructural and functional changes in the heart leading to heart failure.

149 alized surfaces was found to proceed rapidly leading to high grafting densities, while o-methylbenzal

150 ne oxides are highly polar functional groups leading to high solubility and metabolic stability but o

151 xibility, speed and uniformity at less cost, leading to high throughput and practical preclinical in

152 A damage to hematopoietic stem cells (HSCs), leading to HSC depletion and dysfunction and the risk of

153 al to rebalance disordered lipid metabolism, leading to improvements in nonalcoholic steatohepatitis

154 kinase 1 (SIK1) stabilized the deacetylase, leading to increased expression of c-Myc, which in turn

155 es, and upregulates the fabA and fabB genes, leading to increased production of unsaturated fatty aci

156 umans via an undetermined intermediate host, leading to infections in humans and other mammals.

157 aft rejection remain long-term complications leading to late graft failure in penetrating keratoplast

158 e, as it can damage the polymer's integrity, leading to loss of function and properties.

159 en-carrier adducts in re-challenge reactions leading to mast cell degranulation and anaphylaxis is un

160 le atherosclerotic plaques and their rupture leading to MI.

161 eview the evidence on the complex mechanisms leading to MIF, as well as its contribution to systolic

162 of fragment ions and complementary ion pairs leading to more complete functional group characterizati

163 messenger RNA (mRNA) can act cooperatively, leading to more repression of the target mRNA than expec

164 to inflamed arteries is implicated in events leading to mortality following MI.

165 tly enhanced by up to 3 orders of magnitude, leading to much higher spatial resolution.

166 eport that BRD4 phosphorylates MYC at Thr58, leading to MYC ubiquitination and degradation, thereby r

167 oteasomal degradation, the precise mechanism leading to neurodegeneration in both sporadic and famili

168 from binding of multiply charged ions, often leading to overall compaction of the protein depending o

169 fuse, and evolve via internal rearrangement, leading to overall hydrogelation.

170 nociceptive output in pathologic conditions, leading to pain hypersensitivity.SIGNIFICANCE STATEMENT

171 alaria (CM), driven by a high parasite load, leading to parasite sequestration in organs and conseque

172 progressive vasoproliferation with traction leading to phthisis (n = 2).

173 to ER-negative DCIS.com breast cancer cells, leading to populations enriched with highly plastic hybr

174 oad and exacerbated organ damage, ultimately leading to premature deaths.

175 ymal hematoma triggers a series of reactions leading to primary and secondary brain injuries and perm

176 ver, the underlying intracellular mechanisms leading to product aggregate formation remain unknown.

177 production rates and poor process stability, leading to reactor failure after 40 days.

178 translation of specific mRNAs was remodeled leading to reduced production of collagens, loss of stru

179 ften include minimal residual disease (MRD), leading to relapse and repeated treatments.

180 rdered cyclic or bicyclic transition states, leading to remarkable levels of diastereoselectivity.

181 pol beta than those removed by FEN1, thereby leading to repeat deletion.

182 complicated by frequent acute exacerbations leading to significant health care burden and impaired q

183 e major pathology and mortality to livestock leading to significant welfare and socio-economic issues

184 d decomposition in the adaptation scenarios, leading to similar SOC stocks under different climate ch

185 In addition, the mechanism leading to suppression of predicted sensory information

186 nuous conduits for flow dictated by geology, leading to surface expression that can be greater or les

187 ed into routine clinical care, in some cases leading to surgery with intent to cure.

188 es whether the two states have fused or not, leading to the creation of a W state of n + m - 2 electr

189 he transcription factors AP-1 and NF-kappaB, leading to the down-regulation of LINE-1 promoter activi

190 All the steps leading to the final grafted molecular complex have been

191 the tripeptide aldehyde protease inhibitors, leading to the formation of "pro-pyrazinones" featuring

192 lds of the hippocampus, while simultaneously leading to the formation of integrated representations o

193 g-KO mice was compared with that of WT mice, leading to the identification of similar abnormalities i

194 identifying errors in the provided metadata, leading to the potential for error propagation.

195 AP1 risk allele mediates enhanced autophagy, leading to the survival of autoreactive lymphocytes and

196 e division rates in a dose-dependent manner, leading to tumorous overproliferation when the canonical

197 dysregulation of the cAMP signaling cascade, leading to upregulation of phosphodiesterase type 4 (PDE

198 imulated genes in response to type I IFN and leads to 1) promotion of cell-to-cell spread by L. monoc

199 0% increase in the intake of fruit/vegetable leads to 3-6% decrease in SBP; or, a 10% increase in cer

200 barely affects the core clock mechanism but leads to a reprogramming of circadian gene expression in

201 pathological effects, as dysfunction of RPEs leads to AMD.

202 antigen epitopes derived from mutations, and leads to an effective rejection of both virus-injected a

203 The effect of ionizing radiation leads to an elevated quasiparticle density, which we pre

204 found that a more extensive lymphadenectomy leads to better disease-specific survival in patients tr

205 rant photoreceptor function or morphogenesis leads to blinding retinal degenerative diseases, the maj

206 In conclusion, we show that MEKi leads to CD8(+) T cell reprogramming into T(SCM) that ac

207 the liver, and in its absence, AP activation leads to chronic inflammation and promotes hepatic carci

208 In infected cells, NucC activation leads to complete destruction of the bacterial chromosom

209 Radiation damage usually leads to detrimental effects such as embrittlement, acce

210 hermore, treatment with CI- and SEC-exosomes leads to differential biophysical and functional changes

211 nct from conventional glucose metabolism and leads to distinct metabolic requirements and biological

212 nteraction of SUB2-null merozoites with RBCs leads to either abortive invasion with rapid RBC lysis,

213 Notably, in vivo TPC1 deficiency in mice leads to enhanced passive systemic anaphylaxis, reflecte

214 t activate the kinase cyclin D-CDK4/6, which leads to eventual inactivation of the retinoblastoma pro

215 st that long-term treatment with gemcitabine leads to extensive reprogramming of the pancreatic tumor

216 interaction between boundary-following cells leads to formation of areas with preferential direction

217 Unbalance leads to formation of branched muscles, and this correla

218 n the mRNA entry channel of the ribosome and leads to global inhibition of mRNA translation upon infe

219 er hand, sampling of protonation states only leads to good results when combined with high-quality st

220 polymorphism (SNP)-trait associations, which leads to high sequencing cost.

221 extracellular matrix (ECM) and that its loss leads to impaired ECM engulfment and a concomitant accum

222 that global genetic ablation of EHD2 in mice leads to increased lipid droplet size in fat tissue.

223 ic relaxation of an excited atom or molecule leads to ionization of a neighboring one via Coulombic e

224 Chronic cytomegalovirus (CMV) infection leads to long-term maintenance of extraordinarily large

225 solutions or pH-controlled deposition often leads to low metal loadings or a range of metal species.

226 h vinblastine, crocin, or colchicine; and 6) leads to microtubule depolymerization in PC3 cells.

227 immune response following RSV infection that leads to more severe immunopathology.

228 ansition pore) and that opening of this pore leads to necroptosis, a regulated form of necrotic cell

229 mechanisms by which mutant huntingtin (mHTT) leads to neuronal cell death in Huntington's disease (HD

230 -selective oxidative etching of Au(0), which leads to nonuniform growths along different lateral dire

231 Chronic hypoxia leads to pathologic remodeling of the pulmonary vasculat

232 This leads to peaks in the electropherogram from the injectio

233 shock, unlike the unfolded protein response, leads to reduced spreading of roX2 on the X chromosome,

234 on of the centrosome toward the contact site leads to reorganization of microtubules and associated o

235 ion of B cells, macrophages, and fibroblasts leads to robust activation of the B2 family of SINEs in

236 tRNA(Gln) in amino-acid-deprived cells also leads to specific depletion of proteins containing polyg

237 endogenous promoter of the respective LRR-RK leads to strong gain-of-function brassinosteroid, floral

238 g pathway downstream of PAR4 activation that leads to such events.

239 Perception of cytokinin ultimately leads to the activation of proteins belonging to the typ

240 Depletion of YTHDF2 in HeLa cells leads to the delay of mitotic entry due to overaccumulat

241 ipitation (MICP) in which microbial activity leads to the formation of calcium carbonate precipitates

242 Api-mediated translation arrest leads to the futile activation of the ribosome rescue sy

243 This primary H/D KIE leads to the inference that hole-driven scission of the

244 neuronal activity, Bax and Bak, or caspase-9 leads to the maintenance of ipsilateral projections of C

245 onfined only to the laser-irradiated region, leads to the selective reaction of graphene, thereby com

246 sing these low-effective-diffusion constants leads to times that are unphysically large.

247 spread of exotic and invasive species often leads to unintentional and harmful consequences.

248 clusters had 1118 eligible index cases that led to 342 interventions covering 8948 individuals.

249 Infection led to a 3-fold depletion of ILC3 in the colon and an in

250 nflammatory or neuropathic hyperexcitability led to a change in the temporal pattern of AP firing, em

251 Pharmaco- and optogenetic inhibition of MEC led to a disruption of border coding in RSC, but not vic

252 king temperatures in the winter of 2015/2016 led to a February onset of plant growth and the ecosyste

253 d that the presence of RBD near the membrane led to a local enrichment of anionic lipids that could p

254 Cyclosporine led to a more pronounced global transcriptome reversion

255 (H)17 cell/IL23 signaling, whereas dupilumab led to a stronger increase in level of epidermal differe

256 compounds extracted by emerging technologies led to a sustainable alternative to control microorganis

257 etastases and their response to therapy have led to adoption of some of these methods into routine cl

258 The gain in affinity led to almost equal inhibition of wildtype PfFNT and the

259 The rise in metagenomics has led to an exponential growth in virus discovery.

260 ell culture conditions or in Balb/C mice and led to an over 2-fold increase in CTC attachment to ECs

261 constitutive activation of SARM1 and thereby led to axonal degeneration.

262 Systematic evaluations led to benzophenone-containing probes that efficiently a

263 Computational analysis revealed that reward led to both an increase in feedback correction in the mi

264 Seminal studies using squid as a model led to breakthroughs in neurobiology.

265 Interventions that led to changes in degree of AI and AS did not seem to in

266 5 mutant plants, loss of the ZmNLP5 function led to changes in expression for a significant number of

267 mpared with ceCT, (68)Ga-FAPI PET/CT results led to changes in TNM staging in 10 of 19 patients.

268 Likewise, Gas5 overexpression led to decreased cocaine intake, decreased motivation, a

269 t the organism level-a top-down approach-has led to definition of unifying properties, a hallmark of

270 lture of MAIT cell supernatants with B cells led to greater tissue like memory B cell frequencies.

271 er IPA compared with chewed prasugrel, which led to higher active metabolite concentration but not gr

272 lution of these procedures is unique and has led to improved vector delivery.

273 re to e-cigarette aerosols in human subjects led to increased blood pressure and heart rate, similar

274 treatment within 7 days after symptom onset led to lower 90-day mortality than use of placebo (relat

275 This limitation has led to models of early life in which the first cells use

276 its C-terminal lysine residue; its deletion led to modest reductions in complement resistance.

277 al nearby tissue types in this data set also led to our identification of functional convergence in e

278 2 binding over tetramerization; this in turn led to preferred integration of single spacers over two

279 Interference with U3 snoRNA expression led to reduction of rRNA levels and translational capaci

280 -type monocytes (~3-fold increase; P < 0.05) led to reductions in cerebral soluble amyloid-beta1-42,

281 tree mortality concomitant with drought has led to short-term (mean 5 y, range 1 to 23 y after morta

282 for reforms of the research culture that has led to shortcomings in rigor.

283 d extended longevity, and exposure to stress led to splicing and activation of xbp-1 in these neurons

284 Hippo pathway kinase LATS2, and this effect led to subsequent activation of oncogenic YAP.

285 es in the literature where this approach has led to substantial progress in understanding host-microb

286 sis of bruceol, a pentacyclic meroterpenoid, led to the anticipation, isolation, and synthesis of iso

287 can be time-consuming and costly, which has led to the development of programmes for performing comp

288 se health effects in humans and wildlife has led to the development of scientific and regulatory appr

289 The suppression of storage proteins led to the elaboration of membrane stacks enriched with

290 standing of the mechanisms underlying UC has led to the emergence of new treatments.

291 pressure to reduce reflected bioluminescence led to the evolution of ultra-black skin (reflectance <0

292 the best strategy was threshold-based, which led to the fewest infections of all strategies tested (9

293 For topological reasons, this led to the generation of four defects in the resulting h

294 ency, selectivity, and ADME properties which led to the identification of the clinical candidate PF-0

295 Global financial crises have led to the understanding that classical econometric mode

296 Switching mice to a high lysine/low PN diet led to vigorous seizures and a quick death in KO mice.

297 lared 2017 nuclear release of ruthenium that led to widespread detections of the radioisotope (106)Ru

298 ter than 20%, normally employ methylammonium lead tri-iodide with a sub-optimal bandgap.

299 This finding leads us to hypothesize that the therapeutic effects of

300 A leading vaccine candidate targets 30 of the > 200 emm ty