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1 imulated genes in response to type I IFN and leads to 1) promotion of cell-to-cell spread by L. monoc
2 0% increase in the intake of fruit/vegetable leads to 3-6% decrease in SBP; or, a 10% increase in cer
4 c coronary artery disease, ischemic episodes lead to a global pattern of cardiomyocyte remodeling and
6 s associated with poor fungal immunity could lead to a personalized assessment for the continued need
7 on of NNRTI-based ART, introducing DTG would lead to a reduction in NNRTI PDR in all scenarios if ART
8 he creation of host nutritional deficiencies leading to a compromised host-symbiont state and (ii) th
9 scales relevant for the implemented models, leading to a higher frequency of nearby premises compare
10 umulating in biota and metabolizing to PFBS, leading to a higher than expected TMFs for this compound
11 d proteasomal degradation of KIF1A proteins, leading to a near depletion of KIF1A protein late in inf
12 s and (2) a direct nucleophilic substitution leading to a stereoselective synthesis of the compounds
13 well as enhanced phospho-signalling within, leading to a submicron gradient of activated CtrA-P(19)
14 ed collagenolysis confirm that hyperglycemia leads to a chronic inflammation in and around the implan
16 barely affects the core clock mechanism but leads to a reprogramming of circadian gene expression in
19 nflammatory or neuropathic hyperexcitability led to a change in the temporal pattern of AP firing, em
20 Pharmaco- and optogenetic inhibition of MEC led to a disruption of border coding in RSC, but not vic
21 king temperatures in the winter of 2015/2016 led to a February onset of plant growth and the ecosyste
22 navirus disease 2019 (COVID-19) pandemic has led to a large increase in mortality in the United State
23 d that the presence of RBD near the membrane led to a local enrichment of anionic lipids that could p
25 1/5/8 in the mouse submandibular glands, and led to a recovery of SG function and a decrease in infla
27 re, we found that the rd10 mutation in Pde6b led to a reduction in the assembled PDE6alphabetagamma2
28 (H)17 cell/IL23 signaling, whereas dupilumab led to a stronger increase in level of epidermal differe
29 compounds extracted by emerging technologies led to a sustainable alternative to control microorganis
30 tion of the TMEM189 gene in human HAP1 cells led to a total loss of plasmanylethanolamine desaturase
31 ulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion,
32 port within such structures will potentially lead to accessible device fabrication for 'on-demand' ap
33 frequently harbor activating NRAS mutations leading to activation of MAPK kinase (MEK) and extracell
34 etastases and their response to therapy have led to adoption of some of these methods into routine cl
40 antigen epitopes derived from mutations, and leads to an effective rejection of both virus-injected a
42 to regulate transcriptional repression that leads to an inhibition of shoot growth in response to et
43 t beam-induced degradation of the perovskite leads to an initial loss of formamidinium [CH(NH(2))(2)
46 ell culture conditions or in Balb/C mice and led to an over 2-fold increase in CTC attachment to ECs
47 ty, electrically insulating single crystals, leading to anomalous transport properties well above cry
48 ing with respect to the exo-tert-butyl ones, leading to apparent association constants more than one
49 ation and K(+)-selective transport in hERG1, leading to arrhythmogenic phenotypes associated with lon
53 found that a more extensive lymphadenectomy leads to better disease-specific survival in patients tr
54 atic environments in the region, potentially leading to bioaccumulation in fish and exposure to commu
55 rant photoreceptor function or morphogenesis leads to blinding retinal degenerative diseases, the maj
56 te specific binding by the SHP2 active site, leading to blockade of RasGAP binding and optimal signal
57 Computational analysis revealed that reward led to both an increase in feedback correction in the mi
58 n: Peptide receptor radionuclide therapy can lead to bowel obstruction in patients with mesenteric or
60 n fundamental understanding of all processes leading to catalytic activity, i.e., light absorption, c
62 transcription of genes, including those that lead to cellular accumulation of protective organic osmo
65 5 mutant plants, loss of the ZmNLP5 function led to changes in expression for a significant number of
67 thanolysis of the cyclic anhydride (+/-)-10, leading to chromatographically separable pairs of enanti
68 the liver, and in its absence, AP activation leads to chronic inflammation and promotes hepatic carci
70 e incapability of precise weight updates can lead to convergence problems and slowdown of on-chip tra
71 disturbed flow (DF) induces GCX degradation, leading to CTC homing to the endothelium, a first step i
72 o routinely predict which specific stressors lead to declines in different populations or contexts, h
74 t the organism level-a top-down approach-has led to definition of unifying properties, a hallmark of
75 s of direct virus-induced neural-cell damage leading to demyelination and axonal loss, which are path
80 hermore, treatment with CI- and SEC-exosomes leads to differential biophysical and functional changes
81 ested in our patient-derived xenograft model leading to disease attenuation and prolonged survival.
83 extensively rewired among the three species, leading to distinct anatomical and morphological outcome
84 nct from conventional glucose metabolism and leads to distinct metabolic requirements and biological
85 compromising bipolar filament formation but led to divergent adhesion phenotypes and NMIIA contracti
87 actions appear to reshape network structure, leading to dramatic community changes, including loss of
89 nteraction of SUB2-null merozoites with RBCs leads to either abortive invasion with rapid RBC lysis,
90 Notably, in vivo TPC1 deficiency in mice leads to enhanced passive systemic anaphylaxis, reflecte
91 rognostic accuracy over time and in addition lead to enhancements in treatment response and outcomes.
93 t activate the kinase cyclin D-CDK4/6, which leads to eventual inactivation of the retinoblastoma pro
94 of Pten gene through deletions and mutations leading to excessive pro-growth signaling pathway activa
95 st that long-term treatment with gemcitabine leads to extensive reprogramming of the pancreatic tumor
99 lines has identified genes whose disruption leads to fitness defects, a critical step in identifying
100 ed because of the underlying pathophysiology leading to Fontan palliation, remodelling, or increased
101 interaction between boundary-following cells leads to formation of areas with preferential direction
104 the alternative to making these changes will lead to further drop-off in the physician scientist pipe
106 n the mRNA entry channel of the ribosome and leads to global inhibition of mRNA translation upon infe
107 er hand, sampling of protonation states only leads to good results when combined with high-quality st
108 lture of MAIT cell supernatants with B cells led to greater tissue like memory B cell frequencies.
109 increased rates of protein synthesis, which lead to growth inhibition and hypersensitivity to osmoti
110 s indicates that anthropogenic modifications leading to habitat fragmentation and a higher genetic di
113 alized surfaces was found to proceed rapidly leading to high grafting densities, while o-methylbenzal
115 ne oxides are highly polar functional groups leading to high solubility and metabolic stability but o
116 xibility, speed and uniformity at less cost, leading to high throughput and practical preclinical in
119 er IPA compared with chewed prasugrel, which led to higher active metabolite concentration but not gr
120 A damage to hematopoietic stem cells (HSCs), leading to HSC depletion and dysfunction and the risk of
121 in human cells, how DNA repair failures can lead to human disease, and how PARP inhibitors have emer
123 extracellular matrix (ECM) and that its loss leads to impaired ECM engulfment and a concomitant accum
124 atically characterizing these algorithms has led to important insights, including the discovery of gu
125 ethods for characterizing communities, might lead to improved fertilizer use efficiency and mitigatio
126 (IDH2) mutant-specific inhibitor enasidenib, leading to improved quality of life without a reduction
128 nic profile in several cases, and one design led to improvement of cross-neutralization of heterologo
129 al to rebalance disordered lipid metabolism, leading to improvements in nonalcoholic steatohepatitis
130 g the most commonly found mutations in CHIP, lead to increased expression of inflammatory genes in in
131 or targeted households, but knock-on effects lead to increased harvest of nearshore fish, making them
133 kinase 1 (SIK1) stabilized the deacetylase, leading to increased expression of c-Myc, which in turn
134 es, and upregulates the fabA and fabB genes, leading to increased production of unsaturated fatty aci
135 d (ABA) initiates a signaling cascade, which leads to increased H(2)O(2) and Ca(2+) levels and F-acti
136 that global genetic ablation of EHD2 in mice leads to increased lipid droplet size in fat tissue.
137 re to e-cigarette aerosols in human subjects led to increased blood pressure and heart rate, similar
139 larization and tight junction breakdown, and led to inhibition of RPE65 expression, diminishment of R
140 ptibility of host cells to MNV infection can lead to insights on the roles that specific cell types p
141 ic relaxation of an excited atom or molecule leads to ionization of a neighboring one via Coulombic e
142 Specifically, mass-transport limitations lead to large concentration gradients in the solution-ph
143 aft rejection remain long-term complications leading to late graft failure in penetrating keratoplast
146 macrophages caused stellate cell activation, leading to liver injury, by a mechanism involving AQP3-m
149 solutions or pH-controlled deposition often leads to low metal loadings or a range of metal species.
150 treatment within 7 days after symptom onset led to lower 90-day mortality than use of placebo (relat
153 elength IR region, performed at 4 degrees C, lead to marked sensitivity improvements over conventiona
155 en-carrier adducts in re-challenge reactions leading to mast cell degranulation and anaphylaxis is un
157 h vinblastine, crocin, or colchicine; and 6) leads to microtubule depolymerization in PC3 cells.
158 eview the evidence on the complex mechanisms leading to MIF, as well as its contribution to systolic
161 s that use endogenous transport pathways may lead to more effective treatments for diseases within th
162 of fragment ions and complementary ion pairs leading to more complete functional group characterizati
163 messenger RNA (mRNA) can act cooperatively, leading to more repression of the target mRNA than expec
168 eport that BRD4 phosphorylates MYC at Thr58, leading to MYC ubiquitination and degradation, thereby r
169 ansition pore) and that opening of this pore leads to necroptosis, a regulated form of necrotic cell
170 oteasomal degradation, the precise mechanism leading to neurodegeneration in both sporadic and famili
171 mechanisms by which mutant huntingtin (mHTT) leads to neuronal cell death in Huntington's disease (HD
172 f the genetic basis of sex determination may lead to new methods of managing these troublesome weeds.
175 es (e.g., carbon, nitrogen, and phosphorus), leading to nonlinear and interactive effects on particul
176 -selective oxidative etching of Au(0), which leads to nonuniform growths along different lateral dire
178 le successful latent cell reactivation event leads to observable viremia after a period of exponentia
179 al nearby tissue types in this data set also led to our identification of functional convergence in e
180 from binding of multiply charged ions, often leading to overall compaction of the protein depending o
182 nociceptive output in pathologic conditions, leading to pain hypersensitivity.SIGNIFICANCE STATEMENT
183 alaria (CM), driven by a high parasite load, leading to parasite sequestration in organs and conseque
186 of homeostatic and hedonic brain nuclei can lead to pathological feeding behaviors, namely overconsu
188 t of PHH with both HBV particles and Pam3Cys led to phosphorylation of ERK (extracellular signal-regu
191 to ER-negative DCIS.com breast cancer cells, leading to populations enriched with highly plastic hybr
192 or downstream transcriptome analyses and can lead to precise molecular mechanisms for understanding c
193 2 binding over tetramerization; this in turn led to preferred integration of single spacers over two
195 onclusion, a defect in folate metabolism can lead to prenatal aqueduct stenosis and resultant hydroce
196 ymal hematoma triggers a series of reactions leading to primary and secondary brain injuries and perm
197 ver, the underlying intracellular mechanisms leading to product aggregate formation remain unknown.
200 ed diet in mice induced 2,8-DHA nephropathy, leading to progressive kidney disease, characterized by
202 nits of the adaptor protein complex 4 (AP-4) lead to prototypical yet poorly understood forms of chil
203 ion of Shank3 in vS1 inhibitory interneurons led to pyramidal neuron hyperactivity and increased stim
205 translation of specific mRNAs was remodeled leading to reduced production of collagens, loss of stru
206 shock, unlike the unfolded protein response, leads to reduced spreading of roX2 on the X chromosome,
208 -type monocytes (~3-fold increase; P < 0.05) led to reductions in cerebral soluble amyloid-beta1-42,
210 rdered cyclic or bicyclic transition states, leading to remarkable levels of diastereoselectivity.
211 on of the centrosome toward the contact site leads to reorganization of microtubules and associated o
213 e that DYRK1A controls cyclin L2 expression, leading to restriction of HIV replication in macrophages
214 ion of B cells, macrophages, and fibroblasts leads to robust activation of the B2 family of SINEs in
217 dipose tissues and their dysfunctions, which lead to several metabolic diseases including obesity or
219 plastic mast cells (MCs) in various tissues, leading to severe symptoms and organ damage (eg, cytopen
220 tree mortality concomitant with drought has led to short-term (mean 5 y, range 1 to 23 y after morta
222 ophagitis (EoE) has received the most focus, leading to significant advances in understanding of dise
223 complicated by frequent acute exacerbations leading to significant health care burden and impaired q
224 e major pathology and mortality to livestock leading to significant welfare and socio-economic issues
225 Recent advances in molecular techniques have led to significant progress in the elucidation of the ro
226 d decomposition in the adaptation scenarios, leading to similar SOC stocks under different climate ch
228 tRNA(Gln) in amino-acid-deprived cells also leads to specific depletion of proteins containing polyg
229 d extended longevity, and exposure to stress led to splicing and activation of xbp-1 in these neurons
230 The use of specific extraction methods may lead to standardised grade extracts, both from native ra
231 endogenous promoter of the respective LRR-RK leads to strong gain-of-function brassinosteroid, floral
232 Changes observed were temporary and did not lead to structural reorganisation of the transportation
234 es in the literature where this approach has led to substantial progress in understanding host-microb
237 nuous conduits for flow dictated by geology, leading to surface expression that can be greater or les
240 ndings also revealed that high doses of BrdU lead to the activation of apoptotic cellular events as e
241 lish and maintain a persistent infection may lead to the development of new therapeutic strategies ag
242 ability of gene expression estimation, which lead to the improved downstream gene expression-based pr
243 anisms by which alpha2-Na/K ATPase mutations lead to the migraine phenotype remain incompletely under
244 ation of these properties in one filter will lead to the production of an effective device, comprehen
245 y and sublimation rates were anticorrelated, leading to the conclusion that high densities of low-coo
246 es whether the two states have fused or not, leading to the creation of a W state of n + m - 2 electr
247 ocus on the computational level of analysis, leading to the development of mechanistic models at the
248 zation of, Kv4.2 at the pThr(607)-Pro motif, leading to the dissociation of the Kv4.2-DPP6 complex.
249 he transcription factors AP-1 and NF-kappaB, leading to the down-regulation of LINE-1 promoter activi
251 the tripeptide aldehyde protease inhibitors, leading to the formation of "pro-pyrazinones" featuring
252 lds of the hippocampus, while simultaneously leading to the formation of integrated representations o
253 g-KO mice was compared with that of WT mice, leading to the identification of similar abnormalities i
255 ay have been identified, enzymatic reactions leading to the production of these cis-isomers from tran
256 AP1 risk allele mediates enhanced autophagy, leading to the survival of autoreactive lymphocytes and
258 the difficulty of designing a DC library and leads to the creation of many undesired variants that ca
260 We found that vaccination with Ad4-prM-E leads to the development of a strong anti-ZIKV T-cell re
261 antibodies, while vaccination with Ad5-prM-E leads to the development of both anti-ZIKV antibody and
262 ipitation (MICP) in which microbial activity leads to the formation of calcium carbonate precipitates
265 neuronal activity, Bax and Bak, or caspase-9 leads to the maintenance of ipsilateral projections of C
266 dvanced shock in critically injured patients leads to the pulmonary sequestration of neutrophils (PMN
267 onfined only to the laser-irradiated region, leads to the selective reaction of graphene, thereby com
268 sis of bruceol, a pentacyclic meroterpenoid, led to the anticipation, isolation, and synthesis of iso
269 synthesis and fabrication technologies have led to the development of integrated soft electronic dev
270 can be time-consuming and costly, which has led to the development of programmes for performing comp
271 se health effects in humans and wildlife has led to the development of scientific and regulatory appr
275 pressure to reduce reflected bioluminescence led to the evolution of ultra-black skin (reflectance <0
276 the best strategy was threshold-based, which led to the fewest infections of all strategies tested (9
281 ency, selectivity, and ADME properties which led to the identification of the clinical candidate PF-0
282 -affinity receptor, plexinD1, on macrophages led to the improvement in clinical disease following exp
286 ny small benefit to surviving clonemates can lead to this retaliatory strategy being favored by natur
287 ork presents an efficient strategy which can lead to time and cost saving post-translational, covalen
290 onal response but also interact extensively, leading to transcriptional and epigenetic heterogeneity
292 bute to periodontal disease pathogenesis may lead to treatment options that address individual biolog
294 e division rates in a dose-dependent manner, leading to tumorous overproliferation when the canonical
296 dysregulation of the cAMP signaling cascade, leading to upregulation of phosphodiesterase type 4 (PDE
297 steroid (BR) biosynthesis gene DWARF1 (DWF1) lead to variation of the DWF1 transcript level that cont
298 Switching mice to a high lysine/low PN diet led to vigorous seizures and a quick death in KO mice.
299 low-carbohydrate and low-fat diets can both lead to weight-loss, a substantial variability in achiev
300 lared 2017 nuclear release of ruthenium that led to widespread detections of the radioisotope (106)Ru