ライフサイエンスコーパス: leader sequence

1 as cofactor and in the periplasm (29-residue leader sequence).

2 and (iv) secondary structure within the mRNA leader sequence.

3 at a Rho-independent termination site in the leader sequence.

4 ator located within the 5' untranslated pyrG leader sequence.

5 or without the tissue plasminogen activator leader sequence.

6 ein (224-235 amino acids) with a hydrophobic leader sequence.

7 e-tRNA binding by directly contacting the 5'-leader sequence.

8 asmic space upon cleavage of a 23-amino-acid leader sequence.

9 ns and encodes a 231-aa protein with a 21-aa leader sequence.

10 xon, and it begins with the SL1 trans-splice leader sequence.

11 these proteins do not contain a hydrophobic leader sequence.

12 hat contains a 33-aa classical mitochondrial leader sequence.

13 n the presence or absence of an untranslated leader sequence.

14 mRNA than from mRNA that was deleted for its leader sequence.

15 s PLP and DM20 proteins with a 12 amino acid leader sequence.

16 ept for several insertions in the N-terminal leader sequence.

17 sive element in the transcribed noncoding 5' leader sequence.

18 high affinity AP2 sites in the untranslated leader sequence.

19 tting AT-rich regions, similar to the CRISPR leader sequence.

20 ic negative-strand RNAs to add a copy of the leader sequence.

21 fic mRNAs, most of which do not possess a 5' leader sequence.

22 t they can be located in the 5' untranslated leader sequence.

23 otein coding region into the 5' untranslated leader sequence.

24 tion termination near the 3' end of a 371-bp leader sequence.

25 of proteins that lack N-terminal hydrophobic leader sequences.

26 ally presents peptides derived from class Ia leader sequences.

27 am-positive bacteria containing similar pyrG leader sequences.

28 on of hydrophobic residues in NH(2)-terminal leader sequences.

29 sent in HLA-E-binding peptides from class Ia leader sequences.

30 er, and TcpB, all of which contain type IV-A leader sequences.

31 acteria is by riboswitches found within mRNA leader sequences.

32 YopM consists of a 71-residue leader sequence, 15 LRRs, and a 32-residue tail.

33 P12 and J11/12) that were crosslinked to the leader sequence 5' immediately to the cleavage site in t

34 ated by four upstream AUGs present in the 5' leader sequence (5'-LS).

35 ter was fused with DNA segments encoding the leader sequence (5'-untranslated region [UTR]) of plasti

36 e they differ only in the length of their 5' leader sequence (5'LS).

37 were demonstrated in 79% of cases (74% with leader sequences, 64% with FR1, and 45% with FR3 primers

38 etion based on the presence of a hydrophobic leader sequence, a leader-sequence cleavage site, and th

39 The leader sequence adjacent to the repeat further stabilize

40 dCat) and catalase cDNA with a mitochondrial leader sequence (AdmCat).

41 To examine how 5[prime] leader sequences affect 3' processing efficiency, we per

42 However, amino acid variations in class I leader sequences affected the stability of HLA-E.

43 a 70.9-kDa, soluble, periplasmic (37-residue leader sequence) alcohol dehydrogenase containing PQQ an

44 reas addition of either a TMG-cap or spliced leader sequence alone decreased reporter activity.

45 ns, like their human counterpart, contains a leader sequence, an amino-terminal globular domain, 10 l

46 ressed in all tissues tested, and contains a leader sequence, an LDLa domain, two EF-hand domains, an

47 ents that are synthesized with an N-terminal leader sequence and a C-terminal propeptide.

48 al region of the CRISPR array, guided by the leader sequence and a pair of inverted repeats inside th

49 The VDJ segment has a split leader sequence and a single open reading consistent wit

50 g this isotype are composed of a typical IgH leader sequence and a VDJ rearranged segment followed by

51 NA consisting of two domains, a catalytic 5'-leader sequence and an aminoacyl-acceptor tRNA.

52 function does not require the mitochondrial leader sequence and appears to affect transcription of n

53 essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity

54 ng a pelB leader sequence with a gene 3 (g3) leader sequence and by using a single lacZ promoter sequ

55 lized to the mitochondria by a mitochondrial leader sequence and encoded by a nuclear gene (Trx-2).

56 The deduced protein contains a leader sequence and four predicted proline-rich peptides

57 IHF binds to the leader sequence and induces a sharp DNA bend, allowing t

58 An alfalfa mosaic virus untranslated leader sequence and Lys-Asp-Glu-Leu (KDEL) endoplasmic r

59 n conserved residues of the alpha-neurexin 1 leader sequence and of an epidermal growth factor (EGF)-

60 as an 8-kDa protein without its hydrophobic leader sequence and purified to homogeneity.

61 artificially at specific positions along the leader sequence and tested for the ability to recognize

62 ted into a vector downstream of a 5' Igkappa leader sequence and the hemagglutinin A (HA) sequence.

63 uorescent protein was introduced between the leader sequence and the rest of the putative mitochondri

64 ed a potential open reading frame within the leader sequence and the termination of this potential pr

65 orescent protein was fused to the galectin-3 leader sequence and transiently transfected into BT-549

66 s found in the middle of the 5'-untranslated leader sequence and was shown to robustly enhance the pr

67 retained when approximately one-third of the leader sequence and/or the length of the leader is signi

68 quence similarity, and both proteins contain leader sequences and putative C-terminal transmembrane r

69 in bacterial genomes can contain regulatory leader sequences and small RNAs (sRNAs), which both serv

70 sembled with peptides derived from different leader sequences and soluble CD94/NKG2-A and CD94/NKG2-C

71 insight into the regulatory code within mRNA leader sequences and their capacity to modulate translat

72 such as oxidation and deamidation, residual leader sequence, and proteolytic cleavage.

73 licing, cis-acting elements in the late mRNA leader sequence, and the production of viral microRNA.

74 We systematically define mRNA 5' leader sequences, and 3' UTRs, as well as antisense tran

75 s, including splice junctions, trans-spliced leader sequences, and polyadenylation tracts.

76 mes differ in their kinetic properties and N-leader sequences, and their regulation may vary with tis

77 g frames, and fewer occurred in untranslated leader sequences, antisense strands, and intergenic regi

78 This leader sequence appears to target these proteins to a di

79 ide precursors that trim away the N-terminal leader sequences (approximately 40 residues) while the C

80 f the start codon to the 5' terminus and the leader sequence are strong determinants of both ribosome

81 and other examples support the idea that 5' leader sequences are sometimes structured deliberately i

82 thesis was confirmed by the finding that the leader sequences are transcribed as parts of small RNAs

83 The lipase contained a putative leader sequence, as well as the conserved Ser, His, and

84 pecifically, the MAGE-3 gene was linked to a leader sequence at its NH2 terminus for secretion and to

85 containing unique uridine residues in the 5' leader sequence at positions -1, -3, -5, -7, or -10.

86 ntimicrobial activity after removal of their leader sequences at an engineered Factor Xa cleavage sit

87 probing of mutant ribosomes with additional leader sequences at the 5(') end of 16S rRNA compared to

88 is identical with the previously identified leader sequence binding site in RNaseP holoenzyme.

89 MD-2 contains a leader sequence but lacks a transmembrane domain, and we

90 tAR (N-62 StAR) that lacks the mitochondrial leader sequence but retains full activity and appears to

91 ISPR arrays with 1-2 spacers and preceded by leader sequences but devoid of cas genes.

92 the possibility that mRNAs in Hydra receive leader sequences by trans-splicing.

93 ights identified the presence of heavy chain leader sequence, C-terminal lysine, and C-terminal amida

94 The 5'-leader sequence (called Omega) of tobacco mosaic virus (

95 Our findings show that mRNA leader sequences can consist of complex regulatory eleme

96 Mutations to the N-terminal mitochondrial leader sequence causes a complete loss of mitochondrial

97 the fact that the translated desR gene has a leader sequence characteristic of secretory proteins, al

98 presence of a hydrophobic leader sequence, a leader-sequence cleavage site, and three possible N-glyc

99 ype I glycoproteins with a short hydrophobic leader sequence closely following the translation initia

100 ercistronic region, we demonstrate that this leader sequence confers functional internal ribosome ent

101 consisting of three domains: a 12-amino acid leader sequence containing a casein kinase I serine phos

102 ed that Isa2p harbors a bipartite N-terminal leader sequence containing a mitochondrial import signal

103 f aldehyde dehydrogenase so that an internal leader sequence could exist.

104 embrane domains with an immunoglobulin kappa leader sequence coupled to either an S-peptide tag (sG(S

105 sisting of murine immunoglobulin kappa-chain leader sequence coupled to sequence coding for murine en

106 n BCO2 isoforms possess cleavable N-terminal leader sequences critical for mitochondrial import.

107 ed variants that were missing the N-terminal leader sequence (Delta296nNOS) or missing the leader seq

108 nalysis of translational fusions with mutant leader sequences demonstrated that the principal reason

109 l position, and were nearly identical to the leader sequence-derived peptide previously shown to be a

110 lly recognize Qa-1 bound to the MHC class Ia leader sequence-derived peptide Qdm.

111 redominantly binds and presents MHC class Ia leader sequence-derived peptides for NK cell regulation.

112 he mitochondrial matrix (targeted using COX8 leader sequence) diffused freely (nearly 100% mobility)

113 The presence of a mitochondrial leader sequence does not prevent a portion of Rpm2p from

114 The 5'-leader sequence domain selectively self-charges phenylal

115 he mature bicistronic mRNAs have variable 5' leader sequences due to alternative splicing or promoter

116 me primarily responsible for cleaving the 5' leader sequence during maturation of tRNAs in all three

117 nding and explain the elusive role of CRISPR leader sequences during spacer acquisition.

118 n 11 within a novel 18 amino acid N-terminal leader sequence encoded through differential splicing.

119 egions of monocistronic reporter genes, both leader sequences enhanced translation efficiency in vege

120 ssociated protein 2, and alpha-CaM Kinase II leader sequences enhanced translation, whereas the dendr

121 We analyzed parasite mini-exon spliced-leader sequences following amplification of blood DNA by

122 s were determined by 5'-RACE revealing large leader sequences for each transcript.

123 isoleucyl-tRNA synthetase gene (ileS) T box leader sequences found in organisms of the phylum Actino

124 taxa, consisting in the transfer of a short leader sequence from a small SL RNA to the 5' end of a s

125 e P (RNaseP) catalyses the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5' t

126 pre-tRNAs) as it catalyzes removal of the 5'-leader sequence from pre-tRNAs with its NYN metallonucle

127 sis are proteolytic removal of an N-terminal leader sequence from the prepeptide LctA and export of t

128 A DNA sequence encoding the amino-terminal leader sequence from the tobacco pathogen related protei

129 The VP5 promoter and leader sequences from positions -36 to +20, containing t

130 ase P (RNase P) catalyzes the cleavage of 5' leader sequences from precursor tRNAs (pre-tRNAs).

131 RNase P is the enzyme that removes 5' leader sequences from precursor tRNAs.

132 ptidases cleave, among other substrates, the leader sequences from prepilin-like proteins that are re

133 The rrn leader sequences from Pseudomonas aeruginosa, Bacillus s

134 Nase P is a universal enzyme that removes 5' leader sequences from tRNA precursors.

135 thers has shown that insertion of psi (i.e., leader) sequences from the Moloney murine leukemia virus

136 were performed with modified non-functioning leader sequences fused to either the native or a non-fun

137 clustered mutations in the U5, PBS, and gag leader sequences (GLS), generating potential strain-spec

138 Eliminating the leader sequence had no impact on nNOS structure or catal

139 Structure probing indicated that the 5' leader sequences had little effect on pre-tRNA folding.

140 characterize in vivo requirements of the SL1 leader sequence have been severely constrained by the es

141 ouse hepatitis virus (MHV) are composed of a leader sequence, identical to the 5' 70 nucleotides of t

142 The predicted leader sequence, immunoglobulin-like IgV (variable)/IgC

143 A 5' leader sequence in dnaA mRNA represses gene expression b

144 the orientation and register of the pre-tRNA leader sequence in the central cleft places the protein

145 SD), focused on the base pairing of a unique leader sequence in the initiation site--the SD sequence-

146 dicistronic mRNA, the presence of the TEV 5' leader sequence in the intercistronic region increased e

147 The replacement of the native cyt b(562) leader sequence in this protein with that of a c-type cy

148 an exceptionally long (739-nucleotide [nt]) leader sequence in triticum mosaic virus (TriMV), a rece

149 the FR3 primer and subsequent analysis using leader sequences in negative cases.

150 ntified 10 new sRNAs and nine new regulatory leader sequences in the intergenic regions of E. coli.

151 initiates at the 13th start codon within the leader sequence independently of eIF4E but involves eIF4

152 The gene for NC contains a leader sequence indicating a periplasmic location.

153 e precursor deduced from the cDNA exhibits a leader sequence, indicating that it is synthesized throu

154 the acid-chain hypothesis to explain how the leader sequences interact with negatively charged recept

155 displays the most variability among class I leader sequences, interacts entirely with CD94, the inva

156 ent was further analyzed by inserting the 5' leader sequences into the intercistronic region of dicis

157 The T box leader sequence is an RNA element that controls gene exp

158 the MLS truncated form, indicating that the leader sequence is cleaved during or after mitochondrial

159 We show that 10 bp of the CRISPR leader sequence is critical for stimulating polarized in

160 on messages, demonstrating that part of the leader sequence is essential for trans splicing in vivo.

161 The coding region of the leader sequence is interrupted in codon 17 by a second i

162 This UCS leader sequence is necessary for initiation of translati

163 wo-hybrid system, it was determined that the leader sequence is the site of PSI-N that associates wit

164 The SL1 leader sequence is trans-spliced to many mRNAs in C. ele

165 pled to a human tissue plasminogen activator leader sequence led to pronounced in vitro cytotoxic T-l

166 The p8 protein is synthesized without a leader sequence, like that of bacteriophage Pf3 but unli

167 ns), suggests that a 4 kilodalton N-terminal leader sequence, like that responsible for mitochondrial

168 ding a polypeptide of 264 amino acids with a leader sequence likely targeting the protein to the chlo

169 Therefore, trans-splicing of the SL1 leader sequence may serve at least two functions in nema

170 All five leader sequences mediated internal initiation via intern

171 spot" within the region that encodes the HLA leader sequence mimic.

172 tified sequences contain predicted secretion leader sequences, N-linked glycosylation sites, and a pu

173 e conserved in the mycoplasmal gene, but the leader sequence necessary for its secretion by C. perfri

174 features of the Moloney murine sarcoma virus leader sequence necessary for RNA packaging function by

175 s an 81.4-kDa protein (pI 6.98) containing a leader sequence of 2.6 kDa; the deduced molecular mass a

176 unusually long, intronless, 5'-untranslated leader sequence of 715 bp.

177 d structural properties of the mitochondrial leader sequence of aldehyde dehydrogenase have been exte

178 Most often found in the 5'-leader sequence of bacterial mRNAs, they are generally c

179 tyltransferase reporter fused to the 5'-mRNA leader sequence of betaAPP without altering expression o

180 homologous set of peptides derived from the leader sequence of class Ia molecules, but its capacity

181 mino acids may therefore be conserved in the leader sequence of class II lantibiotics to direct other

182 Replacement of the N-terminal leader sequence of DmCSAS with the human CSAS N-terminal

183 The leader sequence of flaB transcript contains two conserve

184 eading frames are commonly present in the 5'-leader sequence of G protein-coupled receptor mRNAs.

185 To study the functional role of the unusual leader sequence of galectin-3, a mutant cDNA that causes

186 The upstream autoregulatory mRNA leader sequence of gene 32 of 17 T-even and related bact

187 indicated a nucleotide change, T-->C, in the leader sequence of GH, which suggested a polymorphism.

188 determinant modifier (Qdm), derived from the leader sequence of H-2D and L molecules.

189 le 9-aa peptide (AMAPRTLLL) derived from the leader sequence of many MHC class Ia proteins.

190 that binds nonamer peptides derived from the leader sequence of MHC class 1a molecules and is the maj

191 ific binding to a region in the untranslated leader sequence of Oskn2 was confirmed by yeast and in v

192 tation of a nonamer peptide derived from the leader sequence of other HLA molecules to CD94-NKG2 rece

193 rectly interacts with the single-stranded 5' leader sequence of pre-tRNA, and (ii) the orientation an

194 ponsible for cleaving the single-stranded 5' leader sequence of precursor tRNA molecules (pre-tRNA),

195 responsible for endonucleolytic removal of a leader sequence of precursor tRNA to generate the mature

196 This enzyme catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generati

197 etalloenzyme responsible for cleaving the 5'-leader sequence of precursor tRNAs during their maturati

198 nusual self-peptide epitope derived from the leader sequence of preproinsulin (PPI) and show that 50%

199 The results indicate that the full upstream leader sequence of rpoS mRNA influences Hfq-facilitated

200 The SYNCRIP-binding site was mapped to the leader sequence of the 5'-UTR, requiring the UCUAA repea

201 report, we found that CsrA(Bb) binds to the leader sequence of the bb0589 transcript and that the in

202 t lacked these sequences or contained the 5' leader sequence of the CLN3 mRNA in the intercistronic r

203 CGG trinucleotide repeat expansion in the 5' leader sequence of the FMR1 gene.

204 ne have shown that peptides derived from the leader sequence of the HLA-G binds and up-regulates the

205 The same peptide is present in the leader sequence of the human cytomegalovirus (HCMV) glyc

206 e 175-kDa HARE cDNA, fused to the N-terminal leader sequence of the Ig kappa-chain, was transfected t

207 ersed repeat (MIR) transposition into the 5' leader sequence of the mammalian POLG gene, which became

208 viously showed that a 9-nt segment in the 5' leader sequence of the mRNA encoding Gtx homeodomain pro

209 ve the potential to form base pairs with the leader sequence of the mRNA encoding the outer membrane

210 V12)-responsive element was mapped to the 5' leader sequence of the murine Dmp1 promoter, where endog

211 tive secondary-structural elements in the 5' leader sequence of the nascent mRNA is influenced by try

212 tudy, mutations of conserved residues in the leader sequence of the precursor peptide for lacticin 48

213 Although the leader sequence of the precursor peptide is often requir

214 bove data revealed FleQ binding to be in the leader sequence of these promoters, whereas FleQ binding

215 no acid biosynthetic genes is limited to the leader sequences of attenuator-regulated operons.

216 d regulatory elements found primarily in the leader sequences of bacterial mRNAs.

217 ule that tightly binds peptides derived from leader sequences of classical MHC-Ia molecules for prese

218 First, >32 N-terminal leader sequences of fungal type II membrane proteins wer

219 have evolved ion sensors embedded in the 5'-leader sequences of mRNAs encoding ion uptake or efflux

220 The 5' leader sequences of mRNAs encoding the activity-regulate

221 1(b) is to present peptides derived from the leader sequences of other MHC class I molecules for reco

222 contacts between the protein subunit and the leader sequences of pre-tRNAs may be common in bacterial

223 ribosome entry sites (IRESes) within the 5' leader sequences of Saccharomyces cerevisiae YAP1 and p1

224 We investigated the role of 5' untranslated leader sequences of simian immunodeficiency virus (SIV(m

225 t of data, heterogeneous coverage and shared leader sequences of some CRISPRs pose challenges for ide

226 Upstream ORFs are elements found in the 5'-leader sequences of specific mRNAs that modulate the tra

227 or extensive secondary structure of the long leader sequences of the dnaK transcripts, which could in

228 In the 5' leader sequences of transcripts with increased translati

229 The trans-spliced leader sequence on mRNAs reduces Dcp2 activity approxima

230 rences between JPV-BH and JPV-LW, one in the leader sequence, one in the GX gene, and three in the L

231 ogenetic conservation to identify regulatory leader sequences, only five of the newly discovered E. c

232 Deletion analysis revealed that the leader sequence or tail is alone insufficient to direct

233 on of a stable stem-loop upstream of the TEV leader sequence or upstream of either CIRE in dicistroni

234 rmined the structure of Qa-1(b) bound to the leader sequence peptide, Qdm (AMAPRTLLL), to a resolutio

235 All class I leader sequence peptides tested bound to HLA-E and were

236 eader sequence (Delta296nNOS) or missing the leader sequence plus the three core motifs (Delta349nNOS

237 tein-protein interactions or are missing the leader sequence plus three core structural motifs that i

238 ng only in the length of the 5' untranslated leader sequences preceding a common ORF.

239 Untranslated leader sequences predicted from 42 different Salmonella

240 erase chain reaction amplification using the leader sequence primers is the most sensitive method for

241 inal sequencing of secreted protein revealed leader sequence processing at two sites, a primary site

242 e target site bears clear resemblance to the leader sequence-repeat junction which is the target for

243 forms that are missing either an N-terminal leader sequence required for protein-protein interaction

244 brid rJPV-BH strains with sequences from the leader sequence (rJPV-BH-Le-LW), the GX gene (rJPV-BH-GX

245 ssess an evolutionarily conserved regulatory leader sequence (S-box) that positively controls these g

246 , a short region of the AAV5 capsid gene RNA leader sequence surrounding the AUG of VP1 could induce

247 TR was replaced with an irrelevant synthetic leader sequence (syn 5'-UTR), translation of syn 5'-UTR

248 ystem, we found that the TMG-cap and spliced leader sequence synergistically collaborate to promote e

249 equence of the Triticum mosaic virus (TriMV) leader sequence that distinguishes the preferred initiat

250 ulatory element called TAR, a 59-residue RNA leader sequence that folds into a specific stem-loop str

251 Their substrates contain a leader sequence that is excised by an N-terminal peptida

252 ent infection nuclear proteins have a common leader sequence that is spliced from the major internal

253 airpin structure located within the 130-base leader sequence that lies between the promoter of tetQ a

254 4 positioned downstream of its 20-amino-acid leader sequence that permitted cotranslational protein s

255 highly hydrophobic, suggesting that it is a leader sequence that targets ACC2 for insertion into mem

256 ined for the mitochondrial matrix space have leader sequences that are typically present at the most

257 Bacterial mRNAs often contain leader sequences that respond to specific metabolites or

258 erestingly, insertion of H5N1 HA between the leader sequence, the de facto promoter of PIV5, and the

259 ein does not contain a typical mitochondrial leader sequence, the enzyme is shown to colocalize with

260 eterminant camG encodes a lipoprotein with a leader sequence, the last 7 residues of which represent

261 The leader sequences, the fibronectin-binding domains, and t

262 ccurrence and length distribution of spliced leader sequences, the functional landscape of encoded pr

263 at when using the Caulobacter crescentus rrn leader sequence, there was little effect on terminator r

264 ly present peptides derived from MHC class I leader sequences, thereby monitoring MHC class I express

265 ted into the secretory pathway with a signal/leader sequence, they will be exposed to the host's glyc

266 nce was replaced with more typical bacterial leader sequences (those from the P. laminosum plastocyan

267 ne provides an m(7)G cap and a 39-nucleotide leader sequence to all cellular mRNAs via a trans-splici

268 cDNA and catalase cDNA with a mitochondrial leader sequence to allow comparison of the effectiveness

269 activity of DeltaCD79b depended on an intact leader sequence to ensure endoplasmic reticulum (ER) tra

270 y the ability of their N-terminal 80-residue leader sequence to guide a chimeric GFP protein to this

271 nucleic acid molecules as a model for the 5'-leader sequence to probe the propensity for generic sing

272 E Uncapped viral RNAs often rely on their 5' leader sequences to initiate translation, and the Tritic

273 dance of transcripts encoding the tripartite leader sequence (TPL) of the major late promoter.

274 globulin gamma 1 heavy chain with its native leader sequence, transmembrane and intracellular domains

275 egulatory sequences (TRSs) located in the 5' leader sequence (TRS-L) and upstream of each structural

276 In the K-12 leader sequence, two in-frame translation initiation cod

277 RNA fragments corresponding to leader sequence upstream of 12S rRNA accumulate upon TbD

278 The mitochondrial leader sequence was also present in mouse and rat Grx2 s

279 Recombinant NDM-1 bearing its native leader sequence was expressed in Escherichia coli BL21 c

280 The leader sequence was removed from the N terminus of a 30-

281 When the region encoding the cytochrome f leader sequence was replaced with more typical bacterial

282 e translation efficiency of specific 5' mRNA leader sequences was compromised in an eif3h mutant, inc

283 covarying residues in two B. subtilis S box leader sequences was employed to test the hypothesis tha

284 n the other hand, M-L1, lacking the putative leader sequence, was localized in the cytoplasm of E. co

285 FL-L1, containing the putative leader sequence, was localized in the periplasm of Esche

286 els of GM-CSF and retained the native GM-CSF leader sequence, was selected for further analysis.

287 Escherichia coli as fusions to a lipoprotein leader sequence, we demonstrated that all 5 antigens acc

288 esults from mutations made within the native leader sequence were consistent between the in vitro and

289 s, only five of the newly discovered E. coli leader sequences were present in the genomes of other en

290 terioopsin precursors with partially cleaved leader sequences were seen in all mass spectra.

291 s based upon their possession of hydrophobic leader sequences which presumably target these proteins

292 through sequence-specific recognition of the leader sequence, which is removed after the installation

293 nthetic oligonucleotides by replacing a pelB leader sequence with a gene 3 (g3) leader sequence and b

294 rcA and prtP genes contains a 5' hydrophobic leader sequence with a treponeme lipobox.

295 Soaks with a pre-tRNA 5' leader sequence with and without metal help to identify

296 slation of ATF4 mRNA through a regulatory 5' leader sequence with multiple upstream Open Reading Fram

297 he fepB transcript includes a 217-nucleotide leader sequence with several features suggestive of post

298 that this motif is conserved among potyviral leader sequences with multiple AUGs.

299 The conservation of the leader sequence within a given RiPP class, in otherwise

300 r magnitude but required, in addition to the leader, sequences within the first 100 nt of the coding