ライフサイエンスコーパス: led

1 -type monocytes (~3-fold increase; P < 0.05) led to reductions in cerebral soluble amyloid-beta1-42,

2 ein intake (>2.1 g protein . kg LBM-1 . d-1) led to a significantly higher net protein loss in the fa

3 king temperatures in the winter of 2015/2016 led to a February onset of plant growth and the ecosyste

4 ing to New York City hospitals in March 2020 led to a sharp increase in blood culture utilization, wh

5 e of the most advanced compounds, 30 and 27, led to significantly better in vivo exposure compared to

6 ivorous crab (Maguimithrax spinosissimus)(9) led us to test the effectiveness of their grazing on sea

7 CXL146-induced UPR activation led to a series of downstream events, including extracel

8 A US Food and Drug Administration-led environmental assessment, which tested water, soil,

9 ulations tested, the results showed that ADO led to 0.95 or higher test-retest reliability of the dis

10 The gain in affinity led to almost equal inhibition of wildtype PfFNT and the

11 type, disease-free mice and found that aging led to elevated IL (interleukin)-6 levels and mitochondr

12 This conditional depletion also led to a reduction of mature mycolic acid production and

13 that caused poor nucleosome positioning also led to defects in both heterochromatin stability and the

14 al nearby tissue types in this data set also led to our identification of functional convergence in e

15 Everolimus treatment also led to decreased PD-1 expression on certain T cell subse

16 Although generic language always led children to believe that properties were nonaccident

17 on studies, followed by exome-wide analyses, led to identification of genetic risk variants (eg, PNPL

18 trictly dependent on oxygen availability and led to enrichment of (13) C in residual methane.

19 larization and tight junction breakdown, and led to inhibition of RPE65 expression, diminishment of R

20 first noted in the early 20(th) century and led some researchers to later question its value as a mo

21 on, which favored bactericidal clearance and led to a better survival rate.

22 ESCRTs, compromised spindle disassembly, and led to defects in nuclear integrity and DNA damage.

23 1/5/8 in the mouse submandibular glands, and led to a recovery of SG function and a decrease in infla

24 of previously unavailable organic matter and led to increased liberation of "old" (6855 +/- 120 years

25 erpetration of IPV when delivered to men and led to more equitable household task-sharing when delive

26 ell culture conditions or in Balb/C mice and led to an over 2-fold increase in CTC attachment to ECs

27 sed on their OAB characteristic symptoms and led to the identification of a low OAB symptomatic score

28 heart failure (ADHF) was well-tolerated and led to improved outcomes.

29 elivery of multiple dmAbs to a single animal led to increased neutralization breadth.

30 The domestication of animals led to a major shift in human subsistence patterns, from

31 A strategic screening approach led to the discovery of this novel ligand, which was suc

32 This approach led to the identification of seven novel genetic causes

33 of each region of the molecular architecture led to the identification of N-[1-(3-fluoropropyl)azetid

34 eatment of mono-substituted activated arenes led to para-brominated products (2u-z) in excellent 83-9

35 Aridification led to systemic and abrupt changes in multiple ecosystem

36 bined treatment with a polypill plus aspirin led to a lower incidence of cardiovascular events than d

37 n of Smyd2 by its specific inhibitor, AZ505, led to increased protective proinflammatory response and

38 In vitro, AZM198 led to a significant reduction in neutrophil extracellul

39 icient mice, bile duct ligation injury (BDL) led to significantly reduced eNOS activity and to a dram

40 n-native kelp washed up on Antarctic beaches led us to question the permeability of these barriers to

41 tency, selectivity, and oral bioavailability led to the discovery of the potent, highly selective, or

42 pressure to reduce reflected bioluminescence led to the evolution of ultra-black skin (reflectance <0

43 Cefoxitin BMD led to 4.9% VMEs and 1.6% MEs.

44 d DNA double-strand break repair, which both led to improved radiosensitivity.

45 compromising bipolar filament formation but led to divergent adhesion phenotypes and NMIIA contracti

46 nce of almond fat increased gel strength but led to a more heterogenous microstructure, which may be

47 to beta-adrenergic-stimulated cardiomyocytes led to prolonged SERCA activation, presumably because 14

48 ozygous deletion of ETV4, using CRISPR/Cas9, led to greatly reduced ER binding at the majority of loc

49 t room temperature using previous catalysts, led to the design of a new dialkylbiaryl monophosphine l

50 lture of MAIT cell supernatants with B cells led to greater tissue like memory B cell frequencies.

51 tion of the TMEM189 gene in human HAP1 cells led to a total loss of plasmanylethanolamine desaturase

52 e noncanonical EphA2-S897E in melanoma cells led to a mesenchymal-to-amoeboid transition driven by Cd

53 goats, SSCT with allogeneic donor stem cells led to sustained donor-derived spermatogenesis.

54 Loss of Tfr cells led to greatly increased nonspecific IgE levels, showing

55 Inflammatory challenge led to robust eGFP-L10a upregulation in kidney, confirmi

56 These changes led to a -96.1 ml (95% confidence interval [CI] -144.2 t

57 In our department, these circumstances led to an immediate restructuring of the working dynamic

58 while relative stability in tropical climes led to older, slower-evolving but still species-rich com

59 At the histological level, CMH led to significant reductions in vascular disruption, le

60 High doses of the initial lead compound led to tumor stasis in an activated B-cell-like (ABC) di

61 m scale of the most representative compounds led to the discovery that (S)-isomers were more potent t

62 ies of CDP-naphthalimide (CDP-NI) conjugates led to the identification of two AIEgenic fluorophores.

63 ibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable

64 of IHH, another Hh ligand, by in vivo CRISPR led to more aggressive tumor growth suggesting that IHH,

65 Multiphasic (68)Ga-PSMA PET/CT led to a better determination of equivocal findings.

66 Cyclosporine led to a more pronounced global transcriptome reversion

67 , including vemurafenib (VEM) and dabrafenib led to initial excitement due to high response rates and

68 its C-terminal lysine residue; its deletion led to modest reductions in complement resistance.

69 Structure-based design led to AA139, an antibiotic with broad-spectrum in vitro

70 nic profile in several cases, and one design led to improvement of cross-neutralization of heterologo

71 Switching mice to a high lysine/low PN diet led to vigorous seizures and a quick death in KO mice.

72 allenging tetraorthosubstituted biaryl diol, led to highly enantioenriched products (14 examples, up

73 (H)17 cell/IL23 signaling, whereas dupilumab led to a stronger increase in level of epidermal differe

74 WIC implementation in DVS led to a 31-unit increase in sales of the original WIC f

75 Irradiation of the dyads led to photoproducts arising from formal hydrogen abstra

76 Hippo pathway kinase LATS2, and this effect led to subsequent activation of oncogenic YAP.

77 sis to address potential pleiotropic effects led to no substantive change in estimates.

78 The combination of these emissions led to near-perfect white emission with a photoluminesce

79 Studying genome and epigenome led to the fundamentals of development and progression o

80 Systematic evaluations led to benzophenone-containing probes that efficiently a

81 ts and photoreceptor death, which eventually led to decline of visual function in older mice between

82 al Delphi survey represents the first expert-led process for developing a standardized approach for e

83 cal Society, set up an international, expert-led consensus project to develop evidence- and experienc

84 -suppressive role where decreased expression led to increased metastasis.

85 associated with misregulated gene expression led us to identify SCC25 enriched regulatory sequences a

86 MMP1 expression led to a reduction in collagen 1A1 levels.

87 Interference with U3 snoRNA expression led to reduction of rRNA levels and translational capaci

88 GG pathway analysis revealed that GB feeding led to the enriched accumulation of proteins important f

89 Contradictory findings led to a more recent proposal that sustained MOR signali

90 These findings led us to separate the two chiral species and test their

91 py and mass spectrometry of active fractions led to the identification of phosphatidylcholines (PCs).

92 Similarly, genetic loss of JNK function led to precocious stream departure ex vivo, and stream d

93 5 mutant plants, loss of the ZmNLP5 function led to changes in expression for a significant number of

94 Overexpression of Rig-G led to significantly reduced cell growth and suppressed

95 ita gross domestic product (GDPpc) generally led to an increase in cooperation-related words.

96 ific deletion of TRIM71 in the male germline led to reduction of the undifferentiated spermatogonial

97 MRD positive patients by the addition of GO led to a significantly lower CIR rate (4-year CIR, 29.3%

98 wo or more steps between duplicate gradings, led to some improvement in reproducibility for most char

99 Adding a single methoxy group led to significant reduction in EA in all cases, relativ

100 Mixing explosive functional groups led to changes in the explosive sensitivity, explosive p

101 m cell death executioner gasdermin D (GSDMD) led to an initial reduction in cell death followed by a

102 Loss of H3K79me2 led to low expression of STAT5 and impaired T cell immun

103 ssed simultaneously Isovolumic haemodilution led to a marked increase in brachial artery flow-mediate

104 at 4 degrees C, whereas the mutation of hapR led to fast entry into the VBNC state.

105 drome-related coronavirus-2 (SARS-CoV-2) has led to the infection of millions of people and has claim

106 atically characterizing these algorithms has led to important insights, including the discovery of gu

107 lution of these procedures is unique and has led to improved vector delivery.

108 es in the literature where this approach has led to substantial progress in understanding host-microb

109 t the organism level-a top-down approach-has led to definition of unifying properties, a hallmark of

110 tomation analysis (i.e., sensing arrays) has led to their ubiquitous use in molecular sensing, alongs

111 This random assembly has led some ecologists to question the relevance of biodive

112 ogen Batrachochytrium dendrobatidis (Bd) has led to the rapid loss of amphibian populations here and

113 The prevalence of DWV in honey bees has led to significant concerns about spillover of the virus

114 1/GLP-1R system in pancreatic beta cells has led to the development of established GLP-1R-based thera

115 This circumstance has led to an understanding of highly constrained dispersal

116 ady availability of multi-omics datasets has led to the development of numerous methods for identifyi

117 of the genomic landscape of this disease has led to the identification of the serine/threonine kinase

118 illustration of how genotypic divergence has led to behavioral phenotypic divergence in a vertebrate.

119 tree mortality concomitant with drought has led to short-term (mean 5 y, range 1 to 23 y after morta

120 Identification of canonic gene fusions has led to development of sensitive and specific immunohisto

121 n the health benefits of soy isoflavones has led to research in the isolation of individual isoflavon

122 This limitation has led to models of early life in which the first cells use

123 integral role in coordinating metabolism has led to their scrutiny in a number of diseases, including

124 The rise in metagenomics has led to an exponential growth in virus discovery.

125 nductive metal-organic frameworks (MOFs) has led to applications in chemical sensing and electrical e

126 clerosis (MS) and primary progressive MS has led to a conceptual shift in the understanding of MS pat

127 Widespread application of neonicotinoids has led to their proliferation in waters.

128 ions as a driving mechanism in neoplasia has led to development of U.S. Food and Drug Administration-

129 H) Scientific Workforce Diversity office has led the charge to develop and implement evidence-informe

130 navirus disease 2019 (COVID-19) pandemic has led to a large increase in mortality in the United State

131 -resistance amongst food-borne pathogens has led to severe deficit of available therapeutics and requ

132 ry with discrete photochemical processes has led to the creation of a new class of click reactions, c

133 cosal but also systemic immune responses has led to investigations into the impact on cancer immunoth

134 d DNA endonuclease CRISPR-Cas technology has led to radical advances in biology.

135 for reforms of the research culture that has led to shortcomings in rigor.

136 novative development of cancer therapies has led to an unprecedented improvement in survival outcomes

137 es responsible for resistance to therapy has led to a Darwinian model of clonal selection.

138 This has led to the development of pharmacogenetic screening test

139 This has led to the perception that the microflora proliferate in

140 population trend and associated threats has led to the IUCN categorising the Mediterranean subpopula

141 ng the immune system in cancer treatment has led to remarkable responses in a subset of patients.

142 standing of the mechanisms underlying UC has led to the emergence of new treatments.

143 al event in type 1 and 2 diabetes, which has led to efforts to identify molecules to promote beta-cel

144 ) lack specificity or sensitivity, which has led to guideline recommendations for multistep testing a

145 have focused on kinase inhibition, which has led to molecules that lack specificity due to the multip

146 systems have been reported so far, which has led to the common opinion that carotenes are essential f

147 can be time-consuming and costly, which has led to the development of programmes for performing comp

148 se health effects in humans and wildlife has led to the development of scientific and regulatory appr

149 This work has led to the identification of new, unexplored genomic reg

150 ic, and geochemical modeling approaches have led to new paradigms and questions.

151 tients and/or those with comorbidities, have led to the use of reduced-intensity conditioning regimen

152 Global financial crises have led to the understanding that classical econometric mode

153 These discoveries have led to numerous clinical trials that have aimed to reduc

154 Large-scale sequencing efforts have led to the classification of melanoma into four major su

155 These features have led to many techniques for screening and diagnosis, but

156 These findings have led to the initiation of clinical trials using approved

157 ence of complement activation in humans have led to the hypothesis that SARS-CoV-2 triggers complemen

158 anging health and resource implications have led to a need to improve its early detection.

159 These insights have led to a new model for the disorder-to-order transition

160 the Nobel Prize, in this instance, may have led scientists to discount compelling evidence.

161 al observations suggest the Big Dry may have led to more significant tree mortality than the Millenni

162 riteria classifying tumor-induced MDSCs have led to unified descriptions and also promoted MDSC resea

163 but small samples and variable methods have led to contradictory results.

164 Together, these repurposing periods have led to advances in the treatment for many RAIDs.

165 gnition of objects, decades of research have led to the pervasive notion that the object processing p

166 However, these studies have led to very different conclusions: the global absence of

167 Recent advances in molecular techniques have led to significant progress in the elucidation of the ro

168 synthesis and fabrication technologies have led to the development of integrated soft electronic dev

169 cent and bioluminescent biosensors that have led to scientific or technological breakthroughs.

170 etastases and their response to therapy have led to adoption of some of these methods into routine cl

171 -CM and the advent of effective therapy have led to rapid adoption of diagnostic scintigraphy, there

172 improvements in diagnosis and treatment have led to a decline in mortality rates, morbidity rates hav

173 ivity and low positive predictive value have led critics to argue that these tools have no clinical v

174 es of liver injury, PDGFR-alpha loss in HSCs led to a significant albeit transient reduction in fibro

175 roxide with adenine (HAd) and thymine (HThy) led to hydrated salts of deprotonated adenine, [N(4444)]

176 nflammatory or neuropathic hyperexcitability led to a change in the temporal pattern of AP firing, em

177 The absence of PAP I led to improved aminoacylation of 5'-immature tRNAs.

178 Asah1(fl/fl)/SM(Cre) mice, high dose of P(i) led to a significantly increased calcium deposition, phe

179 Coculturing these two strains with Cd(II) led to the production of biofilm, H(2)S, and succinic ac

180 The dichalcogenation of imidazoheterocycles led to the first functionalization of imidazo[1,2-a]pyri

181 asing human population, which has inevitably led to new biomedical and environmental issues.

182 Infection led to a 3-fold depletion of ILC3 in the colon and an in

183 ing "exhaustion" markers, yet oHSV infection led to a reduction in PD-1+ CD8+ T cells in injected GBM

184 have similar growth defects, which initially led to the assumption that the signaling pathways were l

185 ys between symptom onset and first injection led to less optimistic vision gains and were associated

186 We found that agricultural intensification led to declines in modularity but increases in nestednes

187 ion of Shank3 in vS1 inhibitory interneurons led to pyramidal neuron hyperactivity and increased stim

188 ter where discovery of an HIV-specific issue led to a turndown of an organ offer.

189 is selectively pro-inflammatory in the joint led us to hypothesise that SDC3 might play an important

190 cell population, yet absence of this kinase led to increased rates of Ig production and elevated ser

191 the small-molecule ERBB inhibitor lapatinib led to prolonged clinical benefit and a lasting radiogra

192 s mouse liver injury from lipopolysaccharide led to an examination of autophagy's function in hepatot

193 -affinity receptor, plexinD1, on macrophages led to the improvement in clinical disease following exp

194 -shifted clocks in a tissue-dependent manner led to intertissue circadian clock misalignment.

195 Adoptive transfer of these three MDSCs led to differential graft survival: control (6 days), tx

196 Pharmaco- and optogenetic inhibition of MEC led to a disruption of border coding in RSC, but not vic

197 d that the presence of RBD near the membrane led to a local enrichment of anionic lipids that could p

198 sis of bruceol, a pentacyclic meroterpenoid, led to the anticipation, isolation, and synthesis of iso

199 This new method led to the identification of another 145 oligosaccharide

200 stration of avacincaptad pegol 2 mg and 4 mg led to a significant reduction of GA growth in eyes with

201 e of ST615 administered intranasally to mice led to the rapid onset of disease symptoms and resulted

202 ntly, co-manipulation of GPR17 and microglia led to extensive myelination of regenerated axons.

203 Seminal studies using squid as a model led to breakthroughs in neurobiology.

204 der and race), and found that the ANN models led to the most accurate predictions.

205 ice without any additional immune modulation led to permanent acceptance of F1 skin grafts.

206 A CA inter-hexamer dimer interface mutation led to a loss of induced PIP2 clustering in MACA, indica

207 y delivered tAPC-reprogramming nanoparticles led to a significant cell-mediated cytotoxic immune resp

208 Activation of DA-PB neurons led to reduced sleep in normally fed but not yeast-depri

209 tion of CTK complex components in Neurospora led to high CAT-3 expression level and resistance to H(2

210 In 2018, the NIH-led Discovery and Validation of Biomarkers to Develop No

211 identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 x 10(-10)).

212 tion point signals, this information has not led to effective strategies to treat RB1-deficient tumor

213 In a community-based, nurse-led, university-affiliated diabetes center (UDC), the JA

214 c environment where patients underwent nurse-led structured evaluation (blood/urine/eye/feet) in publ

215 This observation led to the identification of DTMGM-SEGPHOS, a bisphosphi

216 This observation led us to identify a pelX paralogue, PFL_5533, which we

217 emonstrated that combining Enz plus olaparib led to better suppression of the HCC progression.

218 Removal of oleate led to dissociation of CCTalpha from the NE and increase

219 treatment within 7 days after symptom onset led to lower 90-day mortality than use of placebo (relat

220 The hit-to-lead optimization led to the discovery of a novel chemotype series exempli

221 Likewise, Gas5 overexpression led to decreased cocaine intake, decreased motivation, a

222 Exposure by overspray led to greater pesticide accumulation in the eggshell or

223 howed that water added to methane and oxygen led to surface methoxy groups and accelerated methanol p

224 t of PHH with both HBV particles and Pam3Cys led to phosphorylation of ERK (extracellular signal-regu

225 In contrast, alterations in both pathways led to ACC with pulmonary metastases.

226 re, we found that the rd10 mutation in Pde6b led to a reduction in the assembled PDE6alphabetagamma2

227 olescent Asthma Action) programme and a peer-led camp based on the Power Breathing Programme.

228 The peer-led interventions included the Triple A (Adolescent Asth

229 Finally, decreasing the pH led to the decrease of the glass transition temperature

230 This phenomenon led to generate a blue color of the solution that enable

231 ides, or antibodies against phosphoepitopes) led to conflicting results regarding the extent of Tau p

232 nd OTUs were assigned to 10 bacterial phyla, led by Bacteroidetes (51.2%) and Firmicutes (27.1%), and

233 across Europe, the ELIXIR Training Platform, led by the ELIXIR EXCELERATE Quality and Impact Assessme

234 val of the tip with a scalpel) 6 hours prior led to increased targeting by black sea bass, resulting

235 Although either extraction procedure led to cholesterol enrichment, the UAE-E:W conditions fa

236 This process led to a phase transformation to an anhydrous calcium su

237 The suppression of storage proteins led to the elaboration of membrane stacks enriched with

238 In some mice, acute pneumonia quickly led to sepsis and death, accompanied by increasing inten

239 T2D comorbidities utilizing Danish registers led to consistent albeit modest performance improvements

240 lance between ongoing injury and restitution led to worsening of the Mdr2 KO phenotype, suggesting ca

241 These collective results led to MELK being classified as essential for cancer pro

242 mpared with ceCT, (68)Ga-FAPI PET/CT results led to changes in TNM staging in 10 of 19 patients.

243 The results led to the proposed underlying chemical mechanism.

244 Computational analysis revealed that reward led to both an increase in feedback correction in the mi

245 ting the small RNA RybB which represses rluD led to faster persister resuscitation.

246 Targeting SIRT1 by RNAi led to elevated H3 lysine 9 acetylation on the promoter

247 In vivo, TTK inhibition combined with RT led to a significant decrease in tumor growth in both he

248 Broad preoperative screening led to 1 positive COVID-19 test in an asymptomatic patie

249 Further optimization of the series led to identification of the lead compound 3a that displ

250 Furthermore, attenuated cGMP signals led to impaired phosphodiesterase two dependent negative

251 nalysis revealed that exocyst gene silencing led to the striking appearance of novel electron-dense s

252 Concomitantly, XPR1 silencing led to intracellular P(i) accumulation and a potential i

253 We found that cold storage led to a global reduction in gene expression, including

254 This strategy led to the synthesis of new conformationally restrained

255 ogy produced in the adult: adolescent stress led to circuit deficits that recapitulates schizophrenia

256 d extended longevity, and exposure to stress led to splicing and activation of xbp-1 in these neurons

257 Interestingly, abiotic stresses led to the re-directing of transcriptional output into n

258 Previous studies led to the surprising observation that alternative splic

259 Moreover, data from a phase I study led to the FDA granting breakthrough therapy designation

260 re to e-cigarette aerosols in human subjects led to increased blood pressure and heart rate, similar

261 Swabbing led to a smaller change in cortisol release and behaviou

262 compounds extracted by emerging technologies led to a sustainable alternative to control microorganis

263 gical processes and technical artifacts that led to the disagreements in the first place.

264 clusters had 1118 eligible index cases that led to 342 interventions covering 8948 individuals.

265 ven by a metabolic switch in Th17 cells that led to the induction of the amino acid starvation respon

266 diated by the oxygen and sulfur cycles, that led to permanent state change in biogeochemical cycling,

267 Interventions that led to changes in degree of AI and AS did not seem to in

268 a colorectal zebrafish xenograft model that led to significant reductions in tumor size.

269 Continuing the boronic acid program that led to vaborbactam, efforts were directed toward expandi

270 This review explores the properties that led to such widespread use, why there is now an increasi

271 lared 2017 nuclear release of ruthenium that led to widespread detections of the radioisotope (106)Ru

272 sleep disorders were the core symptoms that led to the description of this disease, whereas in anti-

273 constitutive activation of SARM1 and thereby led to axonal degeneration.

274 This led to a significant expansion of APCs, resulting in an

275 This led to elevated plasma free fatty acids (FFAs), which we

276 This led to the discovery of compound BAY 1214784, an orally

277 This led to the successful synthesis of a novel and potent co

278 For topological reasons, this led to the generation of four defects in the resulting h

279 hage subpopulations from human spleen tissue led to the identification of erythrocytes that are devoi

280 Spartalizumab plus dabrafenib and trametinib led to an objective response rate (ORR) of 78%, includin

281 when greater equator-to-pole heat transport led to a warmer Northern Hemisphere(2).

282 Depletion of RN-tre led to a punctate NMII phenotype, similar to what is obs

283 Lipopolysaccharide treatment led to the deposition of NETs along the arterial lumen,

284 2 binding over tetramerization; this in turn led to preferred integration of single spacers over two

285 Interestingly, deletion of the uORF led to higher shoot Pi content and was associated with i

286 ation costing an estimated $588 M (2016 USD) led to predicted pintail population sizes <3 M when assu

287 Tdap vaccination led to short-term potentiation and long-term repression

288 ggesting that PnV-activated macrophages were led preferentially to the tumor.

289 many gene discovery studies in the past were led by knowledge in the field (through the candidate gen

290 Only 24.7% of the projects were led by female PIs, who were predominantly nonphysician P

291 the best strategy was threshold-based, which led to the fewest infections of all strategies tested (9

292 d stable-isotope labeling experiments, which led to the assignment of the fused pyridine-isothiazolin

293 ased production of lipid peroxidation, which led to STING carbonylation at C88 and inhibited its traf

294 was the high-affinity R-state PolyhHb, which led to no improvement in hypoxic tumors and significantl

295 er IPA compared with chewed prasugrel, which led to higher active metabolite concentration but not gr

296 ency, selectivity, and ADME properties which led to the identification of the clinical candidate PF-0

297 d for mammalian cell lysate and serum, which led to estimates of low-mM ribose in a HeLa cell line.

298 tional approach to anticancer therapy, which led to the development of farnesyltransferase inhibitors

299 agement and existing community health worker-led mobile health-supported early detection, initial tre

300 Mutation of CD226 at tyrosine 319 (Y319) led to increased CD226 surface expression, enhanced anti