ライフサイエンスコーパス: left heart

1 ventricular septal defects, and hypoplastic left heart.

2 clinical consequences as those affecting the left heart.

3 elopmental defect referred to as hypoplastic left heart.

4 ation and the retrograde contribution of the left heart.

5 rophysiologic ablation procedures within the left heart.

6 ructures principally affected in hypoplastic left heart.

7 underpinnings of CHDs, including hypoplastic left hearts.

8 ent/degreasing agent exposure in hypoplastic left heart, 4.6%; 5) sympathomimetics in coarctation of

9 s or about patterns of reintervention on the left heart after neonatal BAVP.

10 Hydraulic forces are a consequence of left heart anatomy and aid LV diastolic filling.

11 Microspheres are injected directly into the left heart and a reference tissue is used to calculate r

12 Is defined for the cavities of the right and left heart and for the descending aorta by comparing the

13 ral plate mesoderm and, subsequently, in the left heart and gut of mouse, chick and Xenopus embryos.

14 ratio is associated with underfilling of the left heart and low cardiac output.

15 MYH6 mutations in patients with hypoplastic left heart and reduced systemic right ventricular ejecti

16 For the left heart and the coronary arteries, there were no sign

17 chocardiography in patients with hypoplastic left heart and their first-degree relatives identified 5

18 eart with the anatomically-supposedly-normal left heart and to derive from cardiac magnetic resonance

19 ns (endocardial cushion defects, hypoplastic left heart, and aberrant trabeculation) observed in pati

20 Additional left heart anomalies were present in 82 patients (76%).

21 The molecular underpinnings of hypoplastic left heart are poorly understood.

22 y responses of the pulmonary vessels and the left heart attached in series.

23 e affecting multiple organ systems including left heart, brain, kidneys, liver, gastrointestinal trac

24 In contrast, partial left heart bypass is more complex but virtually eliminat

25 the descending thoracic aorta using partial left heart bypass that has evolved over the past 25 year

26 c aorta can be safely repaired using partial left heart bypass.

27 Of the 41 patients with abnormal MPI, 18 had left heart catheterization (9 were false-positive); ther

28 ass surgery within 72 hours after diagnostic left heart catheterization (LHC; primary end point).

29 referred for diagnostic evaluation underwent left heart catheterization and coronary angiography from

30 Simultaneous left heart catheterization and Doppler echocardiography

31 rticipants undergoing simultaneous right and left heart catheterization and estimated associations of

32 nus [CS]) in 9 patients undergoing right and left heart catheterization as part of their CHF assessme

33 tissue Doppler imaging, simultaneously with left heart catheterization before and after NSRT.

34 n the 1950s of the transseptal technique for left heart catheterization is described.

35 icant for elevated troponins, and subsequent left heart catheterization revealed findings consistent

36 ents undergoing a first diagnostic right and left heart catheterization were included in this study.

37 For patients with abnormal MPI, left heart catheterization were reviewed if performed.

38 underwent simultaneous echocardiography and left heart catheterization with pressure-conductance ins

39 The 25 HOCM patients had left heart catheterization, and 16 were re-examined afte

40 kers, left ventricular hypertrophy, previous left heart catheterization, and higher exposure to dialy

41 At the time of right and left heart catheterization, stents were placed in pulmon

42 measured by both echocardiography and right/left heart catheterization.

43 Ten patients underwent right and left heart catheterization.

44 Ten adult patients underwent right- and left-heart catheterization.

45 entury, commencing with pressure tracings in left heart chambers with the use of needle puncture in t

46 icates a surplus leaflet area that adapts to left-heart changes.

47 rve in patients with HFpEF without worsening left heart congestion.

48 chararacteristics of both the right and the left heart correlate with disease severity and outcome i

49 assessment of surgical repair (21 patients), left heart decompression (12 patients), myocarditis/card

50 ry pressure, its association with increasing left heart diastolic pressures and systemic vascular sti

51 bnormal mitral valve (MV) and MR can lead to left heart dilation, with consequent compression of the

52 or adverse clinical outcome, particularly in left heart disease (LHD) patients.

53 Pulmonary hypertension (PH) due to left heart disease (LHD), or group 2 PH, is the most pre

54 erial hypertension (n = 142; 61%); group II, left heart disease (n = 31; 14%); group III, respiratory

55 capillary pulmonary hypertension (Cpc-PH) in left heart disease (PH-LHD).

56 -term results, even in patients with complex left heart disease and multiple prior interventions.

57 Some patients present with risk factors for left heart disease but pre-capillary PH, whereas patient

58 cal correction of tricuspid regurgitation in left heart disease can definitively improve clinical out

59 revalence of obesity, diabetes mellitus, and left heart disease compared with patients with Ipc-PH.

60 Additional left heart disease in the complex group included subaort

61 more common group of patients with PH due to left heart disease is challenging because there are few

62 eased pulmonary venous pressure secondary to left heart disease is the most common cause of pulmonary

63 e hypothesis that an increased prevalence of left heart disease might explain the higher mortality in

64 the total PH cohort and in PH not related to left heart disease occurrence of AF was associated with

65 The diagnosis of PH due to left heart disease relies on a clinical probability asse

66 (PH) is a common and morbid complication of left heart disease with 2 subtypes: isolated post-capill

67 The presence of left heart disease, although more common in PAH-Scl, was

68 dary causes of PASP elevation, most commonly left heart disease, are far more prevalent than isolated

69 l TR, either isolated or in combination with left heart disease, is associated with unfavorable natur

70 result from a number of disorders, including left heart disease, lung disease, and chronic thromboemb

71 atients were excluded if PH was secondary to left heart disease, not present before surgery, or the p

72 Pulmonary hypertension (PH) associated with left heart disease, or Group 2 PH, includes heart failur

73 ter adjustment for age, sex, and evidence of left heart disease, those subjects with eRVSP levels wit

74 al tricuspid regurgitation in the setting of left heart disease.

75 sk of death in PAH-Scl after controlling for left heart disease.

76 e in simple aortic valve disease and complex left heart disease.

77 urs in 12% to 13% of patients with PH due to left heart disease.

78 tcapillary pulmonary hypertension because of left heart disease.

79 and prevalence, severity, and chronicity of left heart disease.

80 AH from pulmonary venous hypertension due to left heart disease; and (4) understanding the appropriat

81 = 421), atypical IPAH (>/=3 risk factors for left heart disease; n = 139), and PH-HFpEF (n = 226) rec

82 ients with typical IPAH (<3 risk factors for left heart disease; n = 421), atypical IPAH (>/=3 risk f

83 , symptomatic TR in the absence of untreated left-heart disease and deemed inoperable because of unac

84 hypertension (PH), a common complication of left heart diseases (LHD), negatively impacts symptoms,

85 sensus view is that reduced flow through the left heart during development is a key factor in the dev

86 Left heart dysfunction was associated with abnormal PASP

87 n in the 2 groups, whereas a predominance of left heart dysfunction was observed in patients with PAH

88 stance (IR) are established risk factors for left heart dysfunction, their clinical impact in group 1

89 rmance deteriorated, ultimately resulting in left heart failure (decompensated hypertrophy).

90 55), pulmonary arterial hypertension without left heart failure (n=18), and control subjects (n=30) u

91 n hemodynamic abnormalities in patients with left heart failure and global and regional lung perfusio

92 hors highlight differences between right and left heart failure and outline key areas of future inves

93 ehind and many proven targeted therapies for left heart failure do not appear to provide similar bene

94 Contrasting with the major attention that left heart failure has received, right heart failure rem

95 onally relevant heart disease, predominantly left heart failure in combination with right heart failu

96 In PH due to left heart failure the prevalence of AF was particularly

97 and comorbidities such as coronary disease, left heart failure, and chronic obstructive pulmonary di

98 monary edema, high-altitude pulmonary edema, left heart failure, and overinflation of the lung.

99 ympathetic stimulation have been reported in left heart failure, but whether it would be beneficial f

100 een implicated in the development of chronic left heart failure, data describing such metabolic remod

101 ulmonary microvessel pressure experienced in left heart failure, head trauma, or high altitude can le

102 nts with kidney failure and may be driven by left heart failure, high cardiac output from arterioveno

103 diac investigation revealed a combination of left heart failure, right heart failure and moderate-to-

104 y role of beta-blockers in the management of left heart failure, some authors have proposed to use th

105 As well, relative to our understanding of left heart failure, the basis for RHF remains poorly und

106 rtality in acute or chronic lung disease and left heart failure.

107 ion in determining pulmonary hemodynamics in left heart failure.

108 clops, lefty2 and pitx2 are expressed in the left heart field; and cyclops and pitx2 are expressed in

109 ight and left atria arise from the right and left heart fields.

110 forces render PAOP inaccurate as an index of left heart filling pressure, resulting in misleading ass

111 sumes that this pressure accurately reflects left heart filling pressure.

112 e in patients with HFpEF, without increasing left heart filling pressures.

113 e left ventricle, and selectively toward the left heart follows the direction of capillary perfusion

114 mplies that the upstream transmission of the left heart frequency-response has favourable effects on

115 The left heart function was assessed 4 weeks postoperatively

116 rough plasma concentration ~180 nM) improves left heart function, reduces volume/mass ratio, and blun

117 tal balloon aortic valvuloplasty may improve left heart growth and function, possibly preventing evol

118 deal fetal and cannula positioning, prevents left heart growth arrest, and may result in normal ventr

119 tration that a successful valvotomy promotes left heart growth in utero.

120 Resumed left heart growth led to a 2-ventricle circulation at bi

121 se who declined the procedure, while ongoing left heart growth was seen in successful cases.

122 Eight had hypoplastic left heart (HLH) syndrome, 10 had pulmonary atresia, and

123 ging because unbalance entails a spectrum of left heart hypoplasia.

124 stage 21 to reduce LV volume load and create left heart hypoplasia.

125 can produce structural malformations such as left heart hypoplasia.

126 Therefore, congenital or acquired left-heart inflow/outflow obstructive lesions and congen

127 microbubbles after reperfusion from a single left heart injection performed during coronary occlusion

128 Hypoplastic left heart is a severe human congenital heart defect cha

129 Interestingly, in the left heart, Kir6.2 protein and its immunohistochemical d

130 gement strategy intended to rehabilitate the left heart (LH) in patients with LH hypoplasia who have

131 mposed by the pulmonary circulation, and the left heart (LH) retrogradely contributes significantly t

132 s of this study were to assess the growth of left heart (LH) structures, to evaluate midterm outcomes

133 of LV geometry, myocardial O(2) demand, and left heart longitudinal mechanics.

134 ystem and its interaction with the right and left heart may be more useful.

135 Left heart morphology over time suggests less age-relate

136 Patients with >/=2 areas of left heart obstruction or hypoplasia, diagnosed at </=3

137 hat is frequently associated with additional left heart obstructions.

138 esult of this unexpected finding, associated left heart obstructive lesions and pulmonary and left ve

139 versed atrial shunting was found with severe left heart obstructive lesions, including 19 with hypopl

140 ventricular repair for infants with multiple left heart obstructive lesions.

141 ventricular repair for infants with multiple left heart obstructive lesions.

142 wn to be inapplicable to patients with other left heart obstructive lesions.

143 ily represented by patients with cyanotic or left heart obstructive lesions.

144 surgical strategy in patients with multiple left heart obstructive or hypoplastic lesions often must

145 y epinephrine to the anterior surface of the left heart of swine in either point-sourced or distribut

146 Although associated with left heart pathologies, functional tricuspid regurgitati

147 dicated by an association of the hypoplastic left heart phenotype with terminal 11q deletions that sp

148 Left heart pressures are elevated with exercise in subje

149 iencephalon and developing gut and pitx2a in left heart primordium.

150 Right heart pressures and flow and left heart PV relations (conductance catheter) were meas

151 PH was present without substantial left heart remodeling: the mean left ventricular ejectio

152 and the limiting of transeptal access to the left heart should it be required for the later treatment

153 Larger left heart structures and higher left ventricular pressu

154 logists rated the visualization of right and left heart structures and the degree of streak artifacts

155 olecular mechanisms leading to hypoplasia of left heart structures are unknown.

156 With advancing gestation, growth arrest of left heart structures became evident in fetuses developi

157 tervention demonstrated growth arrest of the left heart structures in unsuccessful cases and in those

158 Among early survivors, initially small left heart structures may be associated with worse subac

159 le is known about the growth and function of left heart structures or about patterns of reinterventio

160 Morphometric measurements of the left heart structures were obtained, and comparisons wer

161 there was no difference for visualization of left heart structures.

162 impact of intervention on in utero growth of left heart structures.

163 ction predicting unsuccessful univentricular left heart support; and (3) adults with complex congenit

164 itation (FTR) is often left untreated during left heart surgery.

165 Diagnoses were hypoplastic left heart syndrome (66%), other congenital heart diseas

166 patients, except for those with hypoplastic left heart syndrome (79% vs 71%; HR: 1.58; 95% CI: 0.85-

167 ight ventricle (66% vs. 36%) and hypoplastic left heart syndrome (HLHS) (47% vs. 13%).

168 taged reconstructive surgery for hypoplastic left heart syndrome (HLHS) and assess current outcome fo

169 ned to identify disease loci for hypoplastic left heart syndrome (HLHS) and evaluate the genetic rela

170 arctation of the aorta (COA) and hypoplastic left heart syndrome (HLHS) are congenital cardiovascular

171 of stage 1 palliation (S1P) for hypoplastic left heart syndrome (HLHS) has improved coincident with

172 flow patterns in the fetus with hypoplastic left heart syndrome (HLHS) have been correlated with res

173 Results of staged palliation for hypoplastic left heart syndrome (HLHS) have improved in recent years

174 es for preoperative infants with hypoplastic left heart syndrome (HLHS) include increased inspired ni

175 Hypoplastic left heart syndrome (HLHS) is a complex congenital heart

176 Hypoplastic left heart syndrome (HLHS) is a fatal congenital heart d

177 Hypoplastic left heart syndrome (HLHS) is a severe cardiac malformat

178 Hypoplastic left heart syndrome (HLHS) is among the most severe form

179 after the Norwood operation for hypoplastic left heart syndrome (HLHS) is critical to early survival

180 Hypoplastic left heart syndrome (HLHS) is frequently diagnosed prena

181 groups: "HLHS/TGA" fetuses with hypoplastic left heart syndrome (HLHS) or transposition of the great

182 ity) in families identified by a hypoplastic left heart syndrome (HLHS) proband.

183 of fetal aortic stenosis (AS) to hypoplastic left heart syndrome (HLHS) requires identification of fe

184 e regurgitation in children with hypoplastic left heart syndrome (HLHS) undergoing staged surgical re

185 ctors for one-year mortality for hypoplastic left heart syndrome (HLHS) using intention-to-treat anal

186 bicuspid aortic valve (BAV) and hypoplastic left heart syndrome (HLHS) was postulated.

187 Hypoplastic left heart syndrome (HLHS) with intact or very restricti

188 Hypoplastic left heart syndrome (HLHS) with risk of poor outcome has

189 of structural CHD that resembles hypoplastic left heart syndrome (HLHS), a life-threatening CHD prima

190 Here, we show that hypoplastic left heart syndrome (HLHS), a severe CHD, is multigenic

191 nt type in staged palliation for hypoplastic left heart syndrome (HLHS), and strategies for selective

192 heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and

193 stage of surgical palliation of hypoplastic left heart syndrome (HLHS), the NO, includes augmentatio

194 nnection (TCPC) in children with hypoplastic left heart syndrome (HLHS).

195 h, management, and outcomes than hypoplastic left heart syndrome (HLHS).

196 unprecedented high frequency of hypoplastic left heart syndrome (HLHS).

197 ssion of aortic stenosis (AS) to hypoplastic left heart syndrome (HLHS).

198 after staged reconstruction for hypoplastic left heart syndrome (HLHS).

199 e optimal treatment strategy for hypoplastic left heart syndrome (HLHS).

200 rgone reconstructive surgery for hypoplastic left heart syndrome (HLHS).

201 with post-stage I palliation for hypoplastic left heart syndrome (HLHS).

202 V) is critical for patients with hypoplastic left heart syndrome (HLHS).

203 genital heart disease, including hypoplastic left heart syndrome (HLHS).

204 ttempt to prevent progression to hypoplastic left heart syndrome (HLHS).

205 drainage (HR, 4.0; P<0.001) and hypoplastic left heart syndrome (HR, 2.0; P=0.01).

206 Fifty-two patients with hypoplastic left heart syndrome (median age, 6.6; range 2.9-22.2 yea

207 n of tricuspid atresia (n = 13), hypoplastic left heart syndrome (n = 10) or other forms of functiona

208 ), tetralogy of Fallot (n = 66), hypoplastic left heart syndrome (n = 51), and coarctation of the aor

209 Diagnoses were hypoplastic left heart syndrome (n=346), tricuspid atresia (n=103),

210 The most common diagnosis was hypoplastic left heart syndrome (n=80, 36.7%).

211 .002), the anatomic diagnoses of hypoplastic left heart syndrome (P<0.001) and "other complex" (P=0.0

212 scores included the diagnoses of hypoplastic left heart syndrome (P=0.004) and "other complex" (P=0.0

213 e for follow-up of patients with hypoplastic left heart syndrome after Fontan palliation.

214 Hypoplastic left heart syndrome anatomic subtype did not influence s

215 Infants born with hypoplastic left heart syndrome and an intact or highly restrictive

216 r the treatment of neonates with hypoplastic left heart syndrome and an intact or restrictive atrial

217 ns of FOXF1 were associated with hypoplastic left heart syndrome and gastrointestinal atresias, proba

218 gate the outcome in infants with hypoplastic left heart syndrome and intact atrial septum and to eval

219 n, outcome for infants born with hypoplastic left heart syndrome and intact atrial septum is poor.

220 ment of outcomes in fetuses with hypoplastic left heart syndrome and intact atrial septum.

221 t 26 to 34 weeks' gestation with hypoplastic left heart syndrome and intact or highly restrictive atr

222 A diagnosis of hypoplastic left heart syndrome and longer operative support times w

223 and nitrogen dioxide and between hypoplastic left heart syndrome and particulate matter were supporte

224 ess in the 3-stage palliation of hypoplastic left heart syndrome and related single right ventricular

225 rvival, particularly in cases of hypoplastic left heart syndrome and single ventricle.

226 ith aortic stenosis and evolving hypoplastic left heart syndrome and, in a subset of cases, appeared

227 Patients with hypoplastic left heart syndrome are at higher risk of failure.

228 r was positively associated with hypoplastic left heart syndrome but inversely associated with atrial

229 First-stage palliation of hypoplastic left heart syndrome has been performed as a hybrid proce

230 Surgical management of hypoplastic left heart syndrome has changed the prognosis of the con

231 d a home surveillance system for hypoplastic left heart syndrome improves outcomes.

232 The proportion with hypoplastic left heart syndrome increased from 1/173 (1%) before 199

233 Hypoplastic left heart syndrome is a rare congenital heart defect in

234 Hypoplastic left heart syndrome is a severe form of cardiovascular m

235 r (RV) function in patients with hypoplastic left heart syndrome is important during long-term follow

236 odified Blalock-Taussig shunt in hypoplastic left heart syndrome or variants is currently in progress

237 d indices of RV contractility in hypoplastic left heart syndrome patients after Fontan palliation.

238 , and Hybrid, currently used for hypoplastic left heart syndrome pose a risk of myocardial injury at

239 was collected from patients with hypoplastic left heart syndrome post-Fontan and controls (n=6/group)

240 improvement in surgical results, hypoplastic left heart syndrome remains one of the congenital heart

241 Their role in management of hypoplastic left heart syndrome remains to be defined, especially as

242 Of 316 infants with hypoplastic left heart syndrome seen at our center over a 6.5-year p

243 re was 79% (95% CI, 61%-89%) for hypoplastic left heart syndrome versus 92% (95% CI, 87%-95%) for oth

244 Hypoplastic left heart syndrome was the primary predictor of Fontan

245 Infants with hypoplastic left heart syndrome were smaller in all measured dimensi

246 tricle predictably progresses to hypoplastic left heart syndrome when associated with certain physiol

247 ng hypotheses: (1) patients with hypoplastic left heart syndrome who develop significant tricuspid re

248 e reviewed for 138 children with hypoplastic left heart syndrome who underwent stage I surgical palli

249 achieves stage 1 palliation for hypoplastic left heart syndrome with different flow characteristics

250 "Hypoplastic left heart syndrome" is an unsatisfactory term describin

251 associated with smaller HC, eg, hypoplastic left heart syndrome, -0.39 (95% CI, -0.58 to -0.21); com

252 ctive lesions, including 19 with hypoplastic left heart syndrome, 3 with critical aortic stenosis, 2

253 survival varied by defect type: hypoplastic left heart syndrome, 38.0% (95% confidence interval, 32.

254 The rarest CHD found was hypoplastic left heart syndrome, a phenotype never seen in mice prev

255 teries, interrupted aortic arch, hypoplastic left heart syndrome, and aortic coarctation, but in no p

256 r ORs for atrial septal defects, hypoplastic left heart syndrome, aortic stenosis, pulmonic stenosis,

257 single-ventricle palliation for hypoplastic left heart syndrome, attrition after the Norwood procedu

258 osis of aortic stenosis/evolving hypoplastic left heart syndrome, more than twice as many were discha

259 nsposition of the great vessels, hypoplastic left heart syndrome, oral cleft, abdominal wall defect).

260 ptal defect, aortic coarctation, hypoplastic left heart syndrome, patent ductus arteriosus, valvar pu

261 Patients with hypoplastic left heart syndrome, pulmonary atresia intact ventricula

262 In the hypoplastic left heart syndrome, severe restriction at the atrial le

263 surgery in infant patients with hypoplastic left heart syndrome, where surgical removal of EFE tissu

264 interstage AVVR in children with hypoplastic left heart syndrome.

265 going first-stage palliation for hypoplastic left heart syndrome.

266 al aortic stenosis with evolving hypoplastic left heart syndrome.

267 possibly preventing evolution to hypoplastic left heart syndrome.

268 ernative management strategy for hypoplastic left heart syndrome.

269 congenital heart disease such as hypoplastic left heart syndrome.

270 he survival of infants born with hypoplastic left heart syndrome.

271 ervention, to severe, as seen in hypoplastic left heart syndrome.

272 valve, aortic root dilation, or hypoplastic left heart syndrome.

273 entricle defects, in particular, hypoplastic left heart syndrome.

274 treatment of children born with hypoplastic left heart syndrome.

275 was performed for palliation of hypoplastic left heart syndrome.

276 ternative palliative surgery for hypoplastic left heart syndrome.

277 tal defects to a high of 28% for hypoplastic left heart syndrome.

278 from stem cells of patients with hypoplastic left heart syndrome.

279 st, and these primarily focus on hypoplastic left heart syndrome.

280 of heterogeneous origin, such as hypoplastic left heart syndrome.

281 midgestation aortic stenosis to hypoplastic left heart syndrome.

282 ongenital heart disease, such as hypoplastic left heart syndrome.

283 luding the first mouse models of hypoplastic left heart syndrome.

284 r under the unsatisfactory term "hypoplastic left heart syndrome."

285 nt type in staged palliation for hypoplastic left heart syndrome; strategies for SCP.

286 ge from 13.6% (four factors) for hypoplastic left heart to 30.2% (seven factors) for transposition of

287 cally successful aortic valvuloplasty alters left heart valvar growth in fetuses with aortic stenosis

288 al of 539 consecutive patients with previous left heart valve procedure (time interval from valve pro

289 cant tricuspid regurgitation (TR) late after left heart valve procedure is frequent and associated wi

290 sess the impact of significant TR late after left heart valve procedure.

291 endently associated with survival late after left heart valve procedure.

292 ulticenter study to compare the frequency of left heart valve regurgitations in diabetic patients exp

293 h a significant increase in the frequency of left heart valve regurgitations in diabetic patients.

294 elative risk (odds ratio) of mild or greater left heart valve regurgitations were significantly incre

295 measure was the frequency of mild or greater left heart valve regurgitations.

296 tricuspid annuloplasty is recommended during left-heart valve surgery when the tricuspid annulus (TA)

297 spect to perfusion of the inferior/posterior left heart, which can branch from either the right arter

298 s identification of fetuses with salvageable left hearts who would progress to HLHS if left untreated

299 identify genetic determinants of hypoplastic left heart with latent right ventricular dysfunction in

300 Left heart workload was unchanged.