ライフサイエンスコーパス: lengthy

1 ay is necessary because the current assay is lengthy.

2 ceptibility to polymyxins is problematic and lengthy.

3 red to acquire a hologram with OSH is rather lengthy.

4 ttenuated phase 2 but not phase 1, whereas a lengthy (30 min) incubation in Ca2+-free physiological s

5 t used routinely as the result of artifacts, lengthy acquisition, and processing, a 3D-MTEE probe was

6 ls suitable for the compact accommodation of lengthy acyl chains.

7 psy material and cell stress incurred during lengthy adaptation to atmospheric oxygen (20% O2) in cel

8 patients with central vision loss suggest a lengthy adjustment period, but the nature and dynamics o

9 mptoms, which impair functioning and require lengthy admission.

10 The acyl moiety of acyl-CoA can be bulky or lengthy, allowing a large extent of diversity in new der

11 igh in information density and often require lengthy analyses to separate the overlapping fluorescent

12 ial diversity in complex samples without the lengthy analysis and/or high cost associated with high-t

13 associated with instrumentation complexity, lengthy analysis time, and limited duty cycle.

14 ngs, including extensive sample handling and lengthy analysis times.

15 rane protein is a critical step and can be a lengthy and "protein-expensive" process.

16 is that starting ART in many countries is a lengthy and burdensome process, imposing long waits and

17 Tuberculosis (TB) treatment is lengthy and complicated and patients often develop chron

18 Current tuberculosis therapy is lengthy and consists of multiple antimicrobials, which c

19 Current therapy of TB is lengthy and consists of multiple expensive antibiotics,

20 Drug Discovery is a lengthy and costly process and has faced a period of dec

21 gene should be taken into account to prevent lengthy and costly research trials.

22 methodologies used to discover them are both lengthy and costly.

23 methods for describing critical residues are lengthy and costly; therefore, there is a need for compu

24 However, drug development is lengthy and costs are staggering.

25 sis control programs has been limited by the lengthy and cumbersome nature of current chemotherapeuti

26 is the customary procedure, which involves a lengthy and cumbersome second-order (in wave-amplitude)

27 n of atrophic maxillae with bone grafts is a lengthy and demanding procedure.

28 datasets, greatly simplifying this otherwise lengthy and difficult process and assuring optimal infor

29 Despite high prevalence, lengthy and dramatic features, PS as well as autonomic s

30 a, males instinctively pursue females with a lengthy and elaborate courtship ritual triggered by acti

31 in such fields as pediatrics, and avoids the lengthy and expensive process of modifying U.S. Food and

32 ller scale experiments without repetition of lengthy and expensive RCTs.

33 urrent preexposure vaccination schedules are lengthy and expensive.

34 Drug development in cancer research is lengthy and expensive.

35 erived from the SAE cell line, we identified lengthy and highly conserved gene-specific nucleotide se

36 Cushing's syndrome results from lengthy and inappropriate exposure to excessive glucocor

37 he process to make a glass chip, however, is lengthy and inconvenient, with the most difficult step o

38 Production of transgenic pigs, however, is a lengthy and inefficient process that hinders research us

39 This has typically been achieved through lengthy and intricate ex situ procedures.

40 the typical detection procedures are rather lengthy and involve the use of labeled secondary antibod

41 A lengthy and laborious procedure is an additional challen

42 widely used for disease diagnosis, involves lengthy and laborious tissue preparation.

43 x, followed by much slower binding of a more lengthy and less flexible domain (domain 2) to Cdk2.

44 omplex polycyclic architectures that require lengthy and low-yielding syntheses; for example, one glu

45 drug regimens for treating tuberculosis are lengthy and onerous, and hence complicated by poor adher

46 elective synthesis of Trp analogues is often lengthy and requires the use of protecting groups, enzym

47 In contrast to the lengthy and small-scale "flask in the sun" procedures of

48 owever, from slow analysis time and required lengthy and stringent purification of hybridization prob

49 n during chronic HCV, but treatment is still lengthy and SVR rates are suboptimal.

50 physiological and biochemical analyses is a lengthy and tedious process.

51 eaction pathway(s) for these conversions are lengthy and unclear.

52 grade a target protein within cells can be a lengthy and unpredictable process, and it remains unclea

53 orted syntheses of these compounds are quite lengthy, and every chemical step costs time and energy,

54 However, the methods can be complex, lengthy, and expensive.

55 ver, full genome sequencing is still costly, lengthy, and labor intensive.

56 s in the developing world are often complex, lengthy, and not transparent.

57 signatures of pathogenesis in the absence of lengthy, and often problematic, technical manipulations.

58 wever, the resulting protocol is tedious and lengthy, and requires too many user steps to be practica

59 e, anti-tubercular treatment (ATT) is toxic, lengthy, and severely impairs host immunity, resulting i

60 tuberculosis), responsible, in part, for the lengthy antibiotic regimen required for treatment.

61 time in the host is inconsistent with their lengthy antihyperalgesia.

62 s and medical staff should be prepared for a lengthy, arduous rehabilitation process.

63 rtably in the D pocket, incorporation of the lengthy Arg-3 is predicted to require local conformation

64 Larval midges survive the lengthy austral winter encased in ice, and when the ice

65 s transplanted sensory neurons to regenerate lengthy axons and enhances the ability of a trophic fact

66 witch into an active growth state and extend lengthy axons down the nerve.

67 nglion (DRG) neurons were able to regenerate lengthy axons within the reactive glial environment of t

68 s at other genetic loci without the need for lengthy backcrossing.

69 burnetii, as it allows the completion of the lengthy bacterial replication cycle.

70 The lengthy biodegradation half-life of EtFOSE and recalcitr

71 By 17 hours, novel, lengthy cable structures are evident, and these are prim

72 dependent techniques also frequently require lengthy calibration steps for each cell or cell type mea

73 dure, however, has limitations in that it is lengthy, can be inconsistent, and is prone to nonspecifi

74 entasaccharide that is synthesized through a lengthy chemical process.

75 Patients who have TB require lengthy chemotherapy, possibly because of poor penetrati

76 We also demonstrate that lengthy chromatographic separation is no longer required

77 RM) quantification methods have necessitated lengthy chromatography to obtain accurate quantification

78 d does not require chromogenic substrates or lengthy chromatography, was successfully benchmarked aga

79 yl furanyl fentanyl, is demonstrated without lengthy chromatography.

80 uids and fogging occlude the lens, requiring lengthy cleaning procedures that include irrigation, tis

81 atients by providing realistic estimates for lengthy clinical development timelines and positioning c

82 and emerging cancer drugs without a need for lengthy clinical studies.

83 institutions complying with HIPAA by adding lengthy, complex language to their research consent docu

84 standard treatment for tuberculosis (TB) is lengthy, complex, and significantly toxic.

85 r values affect the result before starting a lengthy computation, the user's learning curve is enhanc

86 digms for drug safety evaluation are costly, lengthy, conservative, and impede efficient drug develop

87 Interestingly, a significant lengthy control of the gastrointestinal bleeding in one

88 risk of IA included prolonged hemodialysis, lengthy corticosteroid treatment posttransplant, and use

89 le endospores to complement the conventional lengthy, culture-based surface sterility validation, whi

90 d adoption is poor long-term reliability and lengthy daily recalibration times.

91 However, its lengthy data acquisition time greatly limits the wide bi

92 bers of reticulocytes per sample and require lengthy data acquisition times.

93 s into a single tool eliminates the need for lengthy data handling and parsing, significantly expedit

94 There is a lengthy delay in time from HT to CRP referral, though on

95 study demonstrates a malignant phenotype and lengthy delay to diagnosis in catecholaminergic polymorp

96 We link detailed local climate data to a lengthy demographic record, and combine both with a popu

97 e events were concentrated near ribbons, but lengthy depolarization also triggered release from more

98 izing synthetic networks in cells results in lengthy design-build-test cycles, minimal data collectio

99 rametric distribution, removing the need for lengthy development of novel methods for differently dis

100 Lengthy developmental programs generate cell diversity w

101 These results are consistent with a lengthy developmental time course for automatic sublexic

102 enomena that drives innovation rather than a lengthy device fabrication process that hinders it.

103 Based on thorough review and lengthy discussion, the work group proposed that the inf

104 apy studies in patients with stroke requires lengthy discussions about several issues unique to clini

105 are unusual enzymes, capable of recognizing lengthy DNA sequences and cleaving site-specifically wit

106 enomic DNA or RNA in rod-shaped viruses, the lengthy double-stranded genome of other viruses is packa

107 ntrol of the TB epidemic has been limited by lengthy drug regimens, antibiotic resistance, and lack o

108 syndrome with morphine is associated with a lengthy duration of therapy and hospitalization.

109 The lengthy duration required for culture growth and identif

110 g concern regarding its radiation burden and lengthy duration.

111 tional prediction of ablation targets avoids lengthy electrical mapping and could improve the accurac

112 Hispanic patients were less likely to have a lengthy eligibility period as compared with other cohort

113 nsing layer is random and might be extremely lengthy, especially in case of low concentration of mole

114 eutic application of human MSC (hMSC) is the lengthy ex vivo expansion time for preparing a sufficien

115 Where treatment is available, it is lengthy, expensive, and associated with poor adherence a

116 ymerase elongation rates is often done via a lengthy experimental process involving radiolabeled subs

117 We speculate that this lengthy exposure to azole antifungal drugs may have caus

118 fe declines on a global scale, must confront lengthy exposure to environmental barriers before contac

119 hout the need of collecting soil samples and lengthy extraction for further analysis.

120 quence similarity, is robust to inclusion of lengthy extraneous flanking sequence and/or completely u

121 However, this mechanism, which requires a lengthy extrinsic incubation period before a short infec

122 The lengthy feathered tail of the new fossil provides insigh

123 Lengthy follow-up demonstrates a significant incidence o

124 The expense and lengthy follow-up periods for randomized clinical trials

125 es mellitus (DM) in adulthood because of the lengthy follow-up required.

126 Breast cancer heterogeneity dictates lengthy follow-up to assess outcomes.

127 n in this population with access to care and lengthy follow-up, only a fraction of expected viral hep

128 ders can be difficult and costly and require lengthy follow-up.

129 ghly complex and expensive, and they require lengthy follow-up.

130 RR-defective rad18Delta mutant stalls into a lengthy G2 arrest associated with the accumulation of si

131 ely used microarray analytical methods yield lengthy gene candidate lists that are difficult to apply

132 To determine the biological relevance of a lengthy gene list, the usual solution is to perform enri

133 versity of parent tumors and often require a lengthy generation time with variable efficiency.

134 They have a lengthy geological history, and there is an emerging und

135 with retro-orbital optic nerve crush injury, lengthy growth of severed retinal ganglion cell (RGC) ax

136 or substrate grain enlargement followed by a lengthy growth period.

137 though an increasing number of examples with lengthy (>11 aa) peptides, presented mostly by HLA-B all

138 , without treatment, skin ulcers occur and a lengthy healing process may be observed associated with

139 e therefore suggest that digitoxin, with its lengthy history of human use, deserves consideration as

140 e the evolutionary puzzle of altruism have a lengthy history, and recent years have seen many importa

141 The main reason for lengthy hospital stay is bowel complication including pa

142 ality leading to clinical treatment failure, lengthy hospital stay, intravenous therapy and accretion

143 studied primarily from clinical outcomes in lengthy human studies.

144 ng duplex sequencing with target enrichment, lengthy hybridization enrichment was required.

145 ade 3/4 asparaginase-related toxicities were lengthy hyperbilirubinemia and transaminitis, occasional

146 because of their inability to cooperate with lengthy imaging procedures or painful treatments, form t

147 After lengthy immersion in a NaOH solution, most of the epoxy

148 rticularly appealing to tree breeders, where lengthy improvement cycles are the norm.

149 avily weighted on traditional endpoints from lengthy in vivo studies.

150 A lengthy incubation (>6 years) revealed iso-alkane biodeg

151 to 3 days for a single batch analysis due to lengthy incubation and digestion steps.

152 -N-glycosylation protocols usually require a lengthy incubation time.

153 th media, specialized wash protocols and the lengthy incubation times required by other published rec

154 of media, require manual manipulations, have lengthy incubation times, are limited to one collection,

155 esidues, but this two-step reaction requires lengthy incubations and produces highly incomplete cleav

156 Lengthy incubations of routine analytical assays were re

157 The observation of considerably lengthy individual supramolecular polymer molecules indi

158 rasitophorous vacuole where it carries out a lengthy infectious cycle with minimal cytopathic effects

159 sm to sustain the host for completion of its lengthy infectious cycle.

160 of patients with multiple myeloma involves a lengthy infusion that affects quality of life, and infus

161 te DVT or gastrointestinal prophylaxis (9%), lengthy initial operative procedures rather than damage

162 act predictions to users without requiring a lengthy installation process.

163 CTLs may be further subverted during lengthy interactions with tumor-associated macrophages (

164 Any technique that minimizes lengthy interruptions of chest compressions during the f

165 In cytokinesis, there is a lengthy interval between cleavage furrow ingression and

166 However, SELEX is a lengthy, labor-intensive, iterative process requiring mu

167 icult to obtain, although they required more lengthy laboratory processing.

168 the majority of development occurring over a lengthy lactation period.

169 CD4+ T cell expansion was nonlinear, with a lengthy lag phase followed by 2 days of explosive prolif

170 erform these operations hands on, there is a lengthy learning curve to utilize the vast number of pro

171 ps for heterologous prime-boost-boost can be lengthy, leaving the host vulnerable for an extensive pe

172 This topic is timely, given the lengthy list of immune checkpoint inhibitors and vaccine

173 charged with guideline development find the lengthy list of standards developed by such organization

174 throughout the world, rather than just be a lengthy listing of all available databases.

175 nctional evaluation of individual genes from lengthy lists of candidate genes from genomic data sets

176 Protein biomarker discovery produces lengthy lists of candidates that must subsequently be ve

177 case under existing antitrust doctrine, and lengthy litigation is possible.

178 ce, many patients still undergo multiple and lengthy medication trials before experiencing relief of

179 oblems with telephone communication, such as lengthy message menus.

180 RATIONALE: Lengthy, multidrug, toxic, and low-efficacy regimens lim

181 esult of multiple dysregulatory events, is a lengthy multistep process manifested by accrual of mutan

182 hetic routes to thionated NDIs are generally lengthy, nonselective, and low yielding and their polyme

183 have been proposed, most are too expensive, lengthy or limited in specificity for clinical use.

184 Evidence suggests lengthy or repeated AASD exposures are associated with i

185 Contaminated diced celery caused a baffling, lengthy outbreak of hospital-acquired listeriosis.

186 to the HLA-B*0702 and HLA-B*4402 restricted, lengthy peptides (>11 aa) arising from the B-cell ligand

187 The pharmacologic utility of lengthy peptides can be hindered by loss of bioactive st

188 nitially with manic excitement followed by a lengthy period of mutism, immobility, and food and fluid

189 hosphorylation and dephosphorylation, with a lengthy period of phosphorylation preceding apoptosis in

190 that DN1 cells move very little during this lengthy period of proliferation and lineage commitment.

191 tuberculosis relapse and reinfection over a lengthy period.

192 to be infected with a single serovar over a lengthy period.

193 st patients require multiple injections over lengthy periods of time and the prevalence of treatable

194 Despite lengthy persistence of the stress and activation of apop

195 two growth stages are separated by an often lengthy phase of arrested growth, the so-called lag-phas

196 es to yield unnatural products from complex, lengthy plant pathways have not been widely explored.

197 these reviews are practically inaccessible: lengthy, poorly organized, and weakly summarized.

198 Human life history incorporates childhood, a lengthy post-weaning period of dependency.

199 s, such as surface phosphonation requiring a lengthy postprocessing annealing step at 140 degrees C w

200 nd eliminate the need for operator input and lengthy postprocessing.

201 A lengthy preclinical disease is predicted by these models

202 Uniquely, this method does not depend on lengthy precursor syntheses, the separation of isomers,

203 m environmental matrices requires the use of lengthy prefractionation steps and high-resolution mass

204 ime interval (deltat) between cessation of a lengthy preillumination of a sample and the actinic flas

205 We eliminate lengthy preparation procedures for direct functionalisat

206 Due to the lengthy procedure and the difficulties in removing DPCP

207 This approach is a lengthy procedure, especially in cereals.

208 er analysis is not a trivial task due to the lengthy procedures for fluid manipulation and high reage

209 To avoid such tedious and lengthy procedures, vacuum matrix-assisted laser desorpt

210 enging to produce, often involving harsh and lengthy procedures.

211 D) for pediatric antiretrovirals (ARVs) is a lengthy process and lags considerably behind drug develo

212 e simulation approaches due to the extremely lengthy process and very complex landscape.

213 um isolate using these standard methods is a lengthy process based on subjective data interpretation.

214 biogenic mineral deposition, is a relatively lengthy process in many mineral-producing organisms, res

215 otypes in different accessions and/or by the lengthy process required to construct a particular mappi

216 Drug discovery is a high-risk, expensive and lengthy process taking at least 12 years and costing upw

217 inical evidence in the post-market stage - a lengthy process that often takes years, during which tim

218 specific manufacturing challenges and form a lengthy process that precludes acute treatment modalitie

219 Medication management in schizophrenia is a lengthy process, as the lack of clinical response can on

220 age fate among noncommitted progenitors is a lengthy process, the absence of B cell potential in earl

221 cooperative oncology group is a complex and lengthy process, with the majority of decision points ex

222 Activation of clinical trials is a lengthy process.

223 velopment of HIV drugs is an expensive and a lengthy process.

224 blish circuits, making functional recovery a lengthy process.

225 opment time for phase III clinical trials is lengthy, process laden, and highly variable.

226 ctures were limited and required complex and lengthy processing and assembly steps.

227 ) currently requires expensive equipment and lengthy processing times to isolate and concentrate the

228 ension of NaOH-free olive debittering is its lengthy processing.

229 cycle transition, and genes that promote the lengthy prophase unique to meiosis I.

230 t overcomes need of complex instrumentation, lengthy protocols and surface modification of GNP.

231 ted by high cost, narrow scope of detection, lengthy protocols and/or cross-contamination.

232 st methods with human cells have complicated lengthy protocols or a progressive decline in differenti

233 d ELISA is difficult to prepare and involves lengthy protocols.

234 ical interpretation of the spectra relies on lengthy quantum-chemical computations, which are difficu

235 nctionally limited by their sequestration to lengthy rCGG repeats.

236 Current methods require lengthy reaction times or difficult synthetic strategies

237 t group I introns by binding to and cleaving lengthy recognition sequences that are typically centere

238 combination treatment allows for remarkably lengthy regeneration of certain subtypes of brainstem an

239 nerve autograft, ChABC treatment resulted in lengthy regeneration of serotonin-containing axons and o

240 logues cladribine and pentostatin results in lengthy remissions in nearly all patients with HCL, most

241 ng neurons of the rat hypothalamus discharge lengthy, repeating bursts of action potentials in respon

242 oncontaminated needle (53 [19%] of 282), too-lengthy reporting process (37 [13%] of 282), and associa

243 cular NHL, the R-CHOP combination provides a lengthy response duration in patients with relapsed or n

244 inherently lower diffusivities, suffer from lengthy response times and lower sensitivity, limiting t

245 on and familiarity of emotional memory after lengthy retention intervals.

246 n of retrieval processes, particularly after lengthy retention intervals.

247 Injured axons of the adult CNS undergo lengthy retraction from the initial site of axotomy afte

248 g for manuscripts to undergo multiple, often lengthy, rounds of review, resulting in significant dela

249 mbient stable, open-shell molecules required lengthy routes and displayed intermolecular spin-spin co

250 ntly become more apparent by reason of their lengthy run time, large reaction volume, and complex pro

251 MS-MS), but the measurement with ISEs avoids lengthy sample preconcentration, can be performed in sit

252 current methods for miRNA detection require lengthy sample preparation and amplification steps that

253 ) methods are the norm but typically involve lengthy sample preparation including tissue homogenizati

254 e from the fabric allows the omission of the lengthy sample preparation involved in extraction, there

255 es and the subsequent need for compensation, lengthy sample preparation, and multiple control tests t

256 ple treatments, sample-size restrictions and lengthy scan times.

257 with diseases that do not permit time for a lengthy search.

258 nd noncoding DNA fragments or on a number of lengthy sequence-typing methods.

259 in social behaviors in developing mice with lengthy Sevo exposure.

260 ogenesis, permitting proper placement of the lengthy small intestine within the confines of the body

261 Individuals in this population experience a lengthy struggle with disabling conditions in adulthood,

262 Nevertheless, these lengthy studies mandate the use of analytical methods wi

263 place of donor blood during emergencies and lengthy surgeries.

264 uclear aggregates of mutant huntingtin, such lengthy survival does reveal cortical and striatal abnor

265 ection of the benzoin carbonyl group and the lengthy synthesis.

266 e stages of the parasite's life cycle, but a lengthy synthetic route to these compounds may affect th

267 nhibitors has been underexplored, due to the lengthy synthetic routes and the lack of structure-activ

268 l product analogue is limited because of the lengthy synthetic scheme.

269 grochemistry, but their preparation requires lengthy synthetic sequences, which has likely limited th

270 enols, on the other hand, generally requires lengthy synthetic sequences.

271 can be achieved can be accepted, avoiding a lengthy systematic review.

272 arable to the optimal strategy found through lengthy systematically planned control experiments.

273 Using substrates where lengthy targeted regions are excised, these modification

274 derlie particular phenotypes has been a very lengthy task that many laboratories could not afford bec

275 the potential of consumer electronics to cut lengthy test waiting times, giving patients on the spot

276 nosis require labor-intensive, expensive and lengthy tests using sophisticated equipment.

277 lysis reveals, however, that the addition of lengthy text often is unnecessary.

278 The L5-domain of Eg5 was sufficiently lengthy that portions of L5 could be located in proximit

279 Given how arduous and lengthy this process can be, we sought to determine whet

280 iversity are applied to samples collected in lengthy time series.

281 Unfortunately, they are usually too lengthy to be applied in time-resolved experiments perfo

282 reening of colonies by PCR, due to being too lengthy, too laborious or yielding poor quality DNA and

283 multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcom

284 to prevent protein degradation during their lengthy travels through the epididymis.

285 However, lengthy treatment courses and follow-up periods are not

286 The current status quo of the lengthy treatment duration and poor treatment outcomes a

287 associated with GBV, they typically require lengthy treatment programs that may limit scaling up in

288 t treatment options are plagued by toxicity, lengthy treatment regimens, and growing evidence of drug

289 granulomas could contribute to reducing the lengthy treatment required for tuberculosis and provide

290 have been discovered through serendipity or lengthy trials using known anticancer agents with simila

291 The lengthy tuberculosis treatment duration and poor treatme

292 ional culture identification methods and the lengthy turnaround time of antimicrobial susceptibility

293 It has been hypothesized that lengthy untreated psychosis is toxic or that it reflects

294 Lengthy use of general anesthetics (GAs) causes neurobeh

295 Here, since ageing studies are inherently lengthy, we used an ex vivo model of the proximal tubule

296 ork on the tens of minute time scale, become lengthy when hundreds of samples are to be analyzed.

297 mass spectrometry data, but analysis can be lengthy when thousands of compounds are detected in a si

298 need for extensive sample preparation or the lengthy window between infection and measurable immune r

299 RP are preserved into adult life such that a lengthy window of opportunity should exist for intervent

300 ically, Fkh1 and Fkh2 are expressed during a lengthy window of the cell cycle, thus are potentially a