ライフサイエンスコーパス: lethal

1 1 domains (R35E,R118E), which were embryonic lethal.

2 , and the fact that severe sleep loss can be lethal.

3 ygous Kcnt1(R455H/R455H) mice were embryonic lethal.

4 rigenic but a complete depletion of BCCIP is lethal.

5 s loss of plus-end targeted Kar3 and Ase1 is lethal.

6 UNC80 knockout mice are neonatal lethal.

7 es, as Plk1 null mutations are embryonically lethal.

8 us activation of MYC activity is potentially lethal.

9 Mice lacking Ankmy2 are mid-embryonic lethal.

10 ly are severely debilitating and may even be lethal.

11 In Drosophila, the polarity protein Lethal (2) giant larvae [L(2)gl], negatively regulates H

12 The evolutionarily conserved lethal-7 (let-7) microRNAs (miRNAs) are well-known activ

13 , achieving 90% survival at 50 mg/kg against lethal 9-Gy TBI.

14 s in which suicidal ideation is converted to lethal actions via decreased top-down inhibition of beha

15 om mild respiratory infection to potentially lethal acute respiratory distress syndrome.

16 These delayed and often lethal adverse events should be studied further to impro

17 protect against disease following stringent lethal aerosol challenge of mice with highly pathogenic

18 disrupting a target gene, forming recessive lethal alleles, while rescuing drive-carrying individual

19 at dgk2-1/- dgk4-1/- plants were gametophyte lethal, although parental single homozygous plants were

20 15 in RNA splicing, cwc15 mutants are embryo lethal and additionally display strong defects in the fe

21 Lethal and edema toxins are critical virulence factors o

22 plasticity when comparing the structures of lethal and edema toxins.

23 annual fecundity of humpback whales via non-lethal and minimally invasive methods.

24 struggled to control FRD, despite using both lethal and non-lethal methods.

25 Monarch lethal and sub-lethal responses were tracked over their

26 ng BBT-059 administration in mice exposed to lethal and supralethal doses of total body gamma-radiati

27 into one or more subtypes: early onset (EO), lethal, and/or clinically significant.

28 ing of both pathways is likely necessary for lethal anthrax infection.

29 ide evidence for why most reported synthetic lethals are not reproducible which is addressable using

30 Using this strategy we probed several lethal arginine mutants and found that they retain appre

31 in knockout syndrome (TKOS) is a potentially lethal arrhythmia disorder caused by recessively inherit

32 inant-acting calsequestrin mutations provoke lethal arrhythmias.

33 ral biology approach to demonstrate that the lethal Australian funnel-web spider produces 33 superfam

34 ions, and led to immune protection against a lethal bacterial dose.

35 ty confers broad-spectrum protection against lethal bacterial infections.

36 mice lacking both PAXX and XLF are embryonic lethal because postmitotic neurons undergo massive apopt

37 ughput quantitative characterization of this lethal behavior.

38 w therapeutic strategies for these presently lethal brain cancers.

39 gnant growth of glioblastoma (GBM), the most lethal brain tumor.

40 Desiccation of plants is often lethal but is tolerated by the majority of seeds and by

41 SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 a

42 ockout alleles of mouse Rabl3 were embryonic lethal, but a viable hypomorphic allele (xiamen [xm]) ca

43 Lung cancer is a prevalent and lethal cancer type that leads to more deaths than the ne

44 ncreatic ductal carcinoma (PDAC) is a highly lethal cancer, and early detection and accurate staging

45 SCP and identify actionable targets for this lethal cancer, we applied DNA content flow cytometry to

46 tion, diagnosis, and treatment of this often lethal cancer.

47 Breast cancer is one of lethal cancers among women with its metastasis leading t

48 tal adenocarcinoma (PDAC) is one of the most lethal cancers in humans due to late detection and highl

49 ors cured with surgical resection and highly lethal cancers with no efficacious therapies.

50 as protein networks could identify synthetic lethal candidates that are more reproducible than those

51 n indolent castration-sensitive phenotype to lethal castration-resistant prostate cancer (CRPC) are p

52 tly, these immunogens protected animals from lethal challenge with both the African and Asian lineage

53 ection and reduced viral dissemination after lethal challenge with HSV-1 or HSV-2.

54 e protected from disease and death following lethal challenges.

55 nical models, offering new modality for this lethal childhood malignancy.

56 findings might pave a way for new synthetic lethal combination therapies.Significance: These finding

57 We describe a lethal combined nervous and reproductive systems disease

58 Cardiac rupture is a major lethal complication of acute myocardial infarction (MI).

59 Perforation is a rare but potentially lethal complication of duodenal diverticular disease.

60 ffectively treat, the most frequent and most lethal complications.

61 lastoma (NBL) tumor subtypes for selectively-lethal compounds revealed metabolic dependencies that de

62 s per liter) at toxic concentrations (median lethal concentration of 0.8 +/- 0.16 micrograms per lite

63 umber of sea lice potentially exposed to sub-lethal concentrations of EMB while fish clear the drug a

64 glucose deficit, constituting a potentially lethal condition known as hypoglycemia-associated autono

65 eases; the capacity for lifelong rescue of a lethal condition related to Wallerian degeneration in mi

66 nto the natural history of these potentially lethal conditions.

67 nd reductions in that energy supply can have lethal consequences.

68 B10 or NA9D7 provide 100% protection against lethal CVA16 infection in a neonatal mouse model.

69 TNF-alpha and IFN-gamma caused a lethal cytokine shock in mice that mirrors the tissue da

70 of MltG-defective mutants as suppressors of lethal deficits in either aPBP or SEDS/bPBP PG synthase

71 tinct biomarker that underlies the synthetic lethal dependence on WRN, and support the development of

72 rus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus (EBOV).

73 , enteropathy, X-linked (IPEX) syndrome is a lethal disease caused by mutations in a transcription fa

74 7BL/6 (B6) mice are resistant to mousepox, a lethal disease caused by the orthopoxvirus ectromelia vi

75 These hamsters demonstrated a systemic and lethal disease in response to infection.

76 ial therapy with potential efficacy for this lethal disease.

77 he host, from asymptomatic to severe or even lethal disease.

78 igher in the ~50% of tumors that progress to lethal disease.

79 ential for clinical translation against this lethal disease.

80 ncreasing numbers of patients with otherwise lethal diseases.

81 s or effects in MEA bursting behavior at sub-lethal dosages.

82 Mice were exposed to a lethal dose (9.75 Gy) of Cobalt-60 gamma radiation and e

83 ss and death in mice challenged with ten 50% lethal dose (LD(50)) inoculums of either H1N1, H3N2, B/V

84 Fentanyl and its derivatives have a low lethal dose and street drugs which contain such compound

85 24 h prior to infection, prevented against a lethal dose of HSV-2 infection in a murine model.

86 ed lungs, and increased survival following a lethal dose of IAV.

87 in clinical disease following exposure to a lethal dose of LPS.

88 A lethal dose of ST615 administered intranasally to mice l

89 In mice administered with a lethal dose of venomous PLA2, L&K-NPs also inhibit hemol

90 green monkeys (AGMs) after challenge with a lethal dose of Y. pestis delivered as an aerosol, in 4 i

91 itoes and other flying insects and can apply lethal doses of laser light to them.

92 -11 in mediating septic shock in response to lethal doses of lipopolysaccharide (LPS).

93 herapeutic window from 24 h and beyond after lethal doses of radiation exposure.

94 tramuscular (im) route) prior to exposure to lethal doses of total-body radiation.

95 2 studies, AGMs were challenged with inhaled lethal doses of Yersinia pestis.

96 timates of total 'bee toxic load' (honey bee lethal doses) for insecticides applied in the US between

97 hortages were less resilient to previous non-lethal droughts, relative to coexisting surviving trees

98 practical approach in identifying synthetic lethal drug combinations for cancer treatment.

99 de possible systematic screens for synthetic lethal drug targets in human cancers.

100 lenging because the loss of both proteins is lethal due to induction of prophage Pf4 and subsequent s

101 ated interferon-mediated inflammation and is lethal during the perinatal period.

102 /Tg), a model for male-biased HSCR), Piebald-lethal (Ednrb(s-l//s-l), a model for EDNRB mutation-asso

103 on is expected to derive from the chemical's lethal effect but delayed biting and the negative effect

104 Currently, the lethal effect of microwaves on insects is considered to

105 The combination of two tTA-dependent lethal effectors could improve strain stability under ma

106 ble TSS of L. cuprina (DH6) that carries two lethal effectors was successfully generated, by crossing

107 raction network to identify robust synthetic lethal effects associated with passenger gene alteration

108 fe hosts of the virus, do not succumb to the lethal effects of infection.

109 e present study was conducted to revisit the lethal effects of UVB on crustaceans, generate new exper

110 ebrate predators by male spiders, with their lethal effects on humans being an unfortunate evolutiona

111 Genetic interactions, including synthetic lethal effects, can now be systematically identified in

112 alterations and validated two new synthetic lethal effects.

113 sms of action' that converge to irreversible lethal effects.

114 umerous interactions that suppress synthetic lethal effects.

115 ication, and spread as well as to impair its lethal effects.

116 Densoviruses cause lethal epidemic disease in invertebrates, including shri

117 which consequently potentiates Pi triggered lethal epithelial-mesenchymal transition (EMT).

118 11A both confer effective protection against lethal EV71 challenge in hSCARB2-transgenic mice.

119 ytoprotection involving the clearance of the lethal excess of ROS molecules through mitophagy, trigge

120 Previously, we determined lethal exposure levels for a variety of lasers and pulse

121 of HDAC3 in macrophages safeguards mice from lethal exposure to lipopolysaccharides, but this protect

122 con that unfolds and translocates either its lethal factor (LF) or edema factor (EF) into the host ce

123 igate the diffusion of edema factor (EF) and lethal factor (LF), we use sensitive quantitative method

124 nding protein calsequestrin cause the highly lethal familial arrhythmia catecholaminergic polymorphic

125 -like1 peptide has a ShKT cysteine motif, is lethal for fish larvae and packaged into nematocysts, th

126 Glioblastoma is a universally lethal form of brain cancer that exhibits an array of pa

127 utic target in metastatic melanoma, the most lethal form of skin cancer.

128 in Merkel cell carcinoma (MCC), an extremely lethal form of skin cancer.

129 A highly rare and lethal form of the disease shows survival rates of less

130 man gle1 disease mutants found in prenatally lethal forms of arthrogryposis.

131 However, the lethal function of T can be blocked by an antiholin (RI)

132 essential, perform functional analyses of a lethal gene, and analyze corresponding heterologous gene

133 activities of Scrib, Discs-large (Dlg), and Lethal giant larvae (Lgl) using the Drosophila follicle

134 Scribble (Scrib) and Lethal giant larvae 1 (Lgl1) are conserved polarity prot

135 s untamed allo-immune responses will lead to lethal graft-versus-host disease (GVHD).

136 dents, where the grin1 knockout is embryonic lethal, grin1 double-mutant fish (grin1a (-/-) ; grin1b

137 ppress alloreactive immune cells and prevent lethal GVHD in mice.

138 Epithelial ovarian cancer (EOC) is a highly lethal gynecologic malignancy arising from the fallopian

139 serous ovarian carcinoma (HGSOC) is the most lethal gynecologic malignancy in industrialized countrie

140 serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective, targeted

141 ndotheliotropic herpesvirus (EEHV) can cause lethal hemorrhagic disease in juvenile Asian elephants,

142 ever virus (ASFV) causes incurable and often lethal hemorrhagic fever in domestic pigs.

143 for producing severe vasculitis, colitis and lethal hemorrhagic pneumonia in interferon gamma recepto

144 Though homozygous deletion of Poldip2 is lethal, heterozygous mice are viable and show protection

145 -based vaccine provided protection against a lethal high dose (10(5) PFU) ZIKV challenge, but mtdVSV-

146 ttenuated (att) in mice, and protects from a lethal homologous challenge.

147 e OMVs, we constructed an Asd-based balanced-lethal host-vector system that oversynthesized the LcrV

148 nd Hextend in a preclinical porcine model of lethal HS, despite decreased OCC from substantial volume

149 its safety and efficacy in a murine model of lethal HSV-2 infection.

150 ment, cancer continues to be one of the most lethal human maladies.

151 animal cell membranes, is also needed by the lethal human malaria parasite Plasmodium falciparum.

152 As one of the most aggressive and lethal human malignancies with extremely poor prognosis,

153 lize the virus in vitro, and protect against lethal IBV infection in mice in prophylactic and therape

154 is is a severe allergic reaction that can be lethal if not treated adequately.

155 es neuronal cell death, systemic stress, and lethal immunodepression.

156 of damage-responsive lung fibroblasts drives lethal immunopathology during severe influenza virus inf

157 expression in bone marrow and spleen and is lethal in a hemolytic anemia mouse model.

158 The perception that prostate tumors are more lethal in AAs than in EAs is reasonable regarding AAs' h

159 Loss of APE2 is lethal in cells with mutated BRCA1 or BRCA2, making APE2

160 Loss of SMN entirely is embryonic lethal in mammals.

161 essed, partially because NMD inactivation is lethal in many organisms.

162 letion of BCCIP arrested cell growth and was lethal in mice.

163 reas their genetic ablation is embryonically lethal in mice.

164 Although generally safe they are potentially lethal in overdose.

165 ts suggest that COVID-19 can be particularly lethal in patients with cancer.

166 We further show that P301R substitution is lethal in strains lacking Poldelta proofreading or misma

167 ved in PII-deficient strains; however, it is lethal in this genetic background.

168 es, indicating a high frequency of recessive lethals in the ancestral population.

169 fic lethal) in humans and MSL (male-specific lethal) in flies.

170 in two distinct complexes: NSL (nonspecific lethal) in humans and MSL (male-specific lethal) in flie

171 CFTR mutations cause cystic fibrosis, a lethal incurable disease.

172 that only ESCRT-III components are synthetic lethal, indicating that Vps4 and other ESCRT complexes d

173 le, and provided complete protection against lethal infection in a Sendai virus mouse surrogate model

174 as been shown to confer potent protection to lethal infection in mice despite lacking neutralization

175 nt (muMT(-/-)) mice were highly resistant to lethal infection with a virulent poxvirus strain and tha

176 was clinically silent in this patient until lethal infection with CMV.

177 ta protected TNF(-/-) mice from an otherwise lethal infection.

178 cterial burden in mice and rescues mice from lethal infections with clinical isolates of Acinetobacte

179 s replication in cells, prevented death in a lethal influenza A virus mouse challenge model, and dram

180 interval between LGR5(+) lineage tracing and lethal injury, we show that ISC regeneration is explaine

181 Furthermore, we showed that the synthetic lethal interaction between Haspin depletion and VX-680 w

182 A synthetic lethal interaction between PPP2R2A deficiency and ATR or

183 As a result of this lethal interaction, wasps and their hosts have coevolved

184 onse and resistance, we identified synthetic lethal interactions with BBDIs and genes that, when dele

185 ir, and has the greatest number of synthetic lethal interactions with Saccharomyces cerevisiae genome

186 thetic Lethals (MiSL), to identify synthetic lethal interactions with the loss of VHL through analysi

187 In turn, NRF2 mitigates lethal intestine degeneration upon autophagy loss.

188 nses like parasite intensity, as long as the lethal limit of the parasite is not crossed, on average,

189 lethal temperate phase in healthy hosts to a lethal lytic stage as host cells become physiologically

190 subtype of lung cancer and remains a highly lethal malignancy and one of the leading causes of cance

191 Renal medullary carcinoma (RMC) is a highly lethal malignancy that mainly afflicts young individuals

192 eatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with an immunosuppressive microenviron

193 new clinical trials for this rare but highly lethal malignancy.

194 al defects in this pathway through synthetic lethal mechanisms.

195 hern platyfish and green swordtails leads to lethal melanocyte tumorigenesis.

196 hexia, characterized by muscle wasting, is a lethal metabolic syndrome without defined etiology or es

197 Lethal metastatic prostate cancer seems to arise from a

198 illustrated by Pten heterozygosity, elicited lethal metastatic prostate cancer.

199 ntrol FRD, despite using both lethal and non-lethal methods.

200 computational platform, Mining of Synthetic Lethals (MiSL), to identify synthetic lethal interaction

201 s, HENV-26 and HENV-32, protected ferrets in lethal models of infection with NiV Bangladesh 3 days af

202 eficient NK cells efficiently protected from lethal mousepox and controlled MCMV titers in the spleen

203 ffective pre-exposure prophylactic in highly lethal murine models of aerosolized human pulmonary meli

204 Duchenne Muscular Dystrophy (DMD) is a lethal muscle disorder, caused by mutations in the DMD g

205 e the load due to lethal mutations (i.e. the lethal mutation rate), we manipulate thousands of indivi

206 riment, in order to estimate the load due to lethal mutations (i.e. the lethal mutation rate), we man

207 us (MCMV) combines with a potyvirus in maize lethal necrosis disease (MLND), a serious emerging disea

208 ' CITEs.IMPORTANCE In the past decade, maize lethal necrosis disease has caused massive crop losses i

209 t-generation treatments for the world's most lethal neglected tropical disease.

210 phenotype was purely myopathic, ranging from lethal neonatal to mild ambulatory adult patients.

211 he life span of treated animals, rescued the lethal neurodegeneration, normalized the locomotor behav

212 fuscinosis (ANCL), a rapidly progressing and lethal neurodegenerative disease with no treatment.

213 protected up to 70% of Syrian hamsters from lethal NiV challenge, despite animals having suboptimall

214 OF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator.

215 ew, we consider the mechanisms that the most lethal of malaria parasites, Plasmodium falciparum, uses

216 e of lung cancer that remains among the most lethal of solid tumor malignancies.

217 ry cultured hippocampal neurons by using non-lethal oligomycin A treatment.

218 We show that the V330 variant is lethal on both virus strain backgrounds, whereas the L33

219 tion with DeltaybjG DeltalpxT DeltabacA, are lethal or reduce fitness.

220 Acetaminophen (APAP) is a proven lethal oral toxicant in reptiles but the physiological m

221 Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as

222 ted by partial complementation of homozygous lethal OXA2a transfer-DNA insertional mutants using the

223 al through NOD2 activation upon an otherwise lethal oxidative stress-mediated signal.

224 sely, mutations capable of blocking the more lethal P. falciparum have not succeeded in malarious zon

225 latin response beyond those of the synthetic lethal p53 mutant/MK2 combination alone.

226 MiSL identified FTO as a synthetic lethal partner of VHL because deletions of FTO are mutua

227 pment of new strategies for the treatment of lethal PC.

228 Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer whose median survival time

229 Posterior fossa type A (PFA) ependymoma is a lethal pediatric brain tumor proposed to be driven solel

230 nstrate that posterior fossa A ependymoma, a lethal pediatric brain tumor with a silent genome, is de

231 of the inflammation and at least 1 h in the lethal phase.

232 the three mtACPs was indicated by the embryo-lethal phenotype associated with simultaneous loss of al

233 Unlike the embryo-lethal phenotype caused by the absence of AtNAA10 and At

234 nce of all three proteins caused a synthetic lethal phenotype due to extreme Cu sensitivity, indicati

235 arcinoma of the bladder (SCCB) is a rare and lethal phenotype of bladder cancer.

236 than technical limitations as most synthetic lethal phenotypes are strongly modulated by changes in c

237 sufficient to rescue the small eye and adult lethal phenotypes caused by rrp4 inhibition.

238 r survival, null mutations often have embryo lethal phenotypes that prevent elucidation of subtle, bu

239 alone were only partially protected against lethal pneumonia, whereas those vaccinated with all 3 to

240 Homozygous mutant mice develop lethal postnatal inflammation of the salivary glands and

241 Glioblastoma, the most lethal primary brain cancer, is extremely proliferative

242 hed KRAS biology, identified novel synthetic lethal proteins that were experimentally validated in th

243 Sub-lethal pyrethroid exposure did not induce significant de

244 f plasma from a mouse model of sublethal and lethal R. conorii identified RC0497 in the blood, and it

245 ifically kills resistant cells via intrinsic lethal reactive oxygen species and unresolved DNA damage

246 In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkp

247 in HGSOC cells and in vivo models by causing lethal replication stress and DNA damage.

248 f RRM1 S559 phosphorylation and ATR triggers lethal replication stress and profound antitumor effects

249 pathways fail to control IAV and succumb to lethal respiratory infection, RIPK3-mediated apoptosis b

250 Monarch lethal and sub-lethal responses were tracked over their complete develo

251 protected Syrian hamsters from a subsequent lethal SARS-CoV-2 challenge.

252 f KRAS, we identify that published synthetic lethal screen hits significantly overlap at the pathway

253 tagonists significantly delayed the onset of lethal seizures but did not prevent them.

254 using the Cre-loxP system protects mice from lethal sepsis (caecal ligation and puncture or infection

255 plant (FMT) reverses the course of otherwise lethal sepsis by enhancing pathogen clearance via the re

256 egation potential, which always results in a lethal situation for the pancreas.

257 he potential of small peptides to neutralize lethal snake toxins in vitro, establishing a potential r

258 tal adenocarcinoma (PDAC) is one of the most lethal solid tumours despite the use of multi-agent conv

259 Genetically modified conditional lethal strains have been created to improve the control

260 rain resulted in significant protection from lethal subcutaneous ZIKV challenge, further eliciting ro

261 led an increase in CYP450 metabolites during lethal superinfection.

262 reduced contractile function is a common and lethal syndrome in which the heart cannot pump blood to

263 le component tetracycline repressible female lethal system where females died at late larval/pupal st

264 llator (ICD) therapy terminating potentially lethal tachyarrhythmias, with no difference in frequency

265 with viruses switching from a long-term non-lethal temperate phase in healthy hosts to a lethal lyti

266 larvae and fertile adults from an otherwise lethal terminal signaling mutant.

267 maximum temperature anomalies, which crossed lethal thresholds in both regions.

268 PROC, PROS1 and SERPINC1 result in perinatal lethal thrombosis in homozygotes and markedly increased

269 tumorigenesis, complete deletion of BCCIP is lethal to cells.

270 ound that mortalin depletion was selectively lethal to tumor and immortalized normal cells expressing

271 nce of rigosertib at concentrations that are lethal to wild-type cells.

272 weeks of age, and all homozygotes exhibited lethal tonic-clonic seizures by mid-third week.

273 Lethal total body irradiation (TBI) triggers multifactor

274 Furthermore, acute lethal toxicity (96 h) of Cd in D. pulex was ~60x that o

275 Anthrax lethal toxin (LT) is a protease virulence factor produce

276 These findings provide evidence that lethal toxin plays a determinative role in bacterial dis

277 tivate NLRP1 and/or CARD8, including anthrax lethal toxin, Toxoplasma gondii, Shigella flexneri and t

278 lecular functions, we transformed the embryo-lethal tps1-1 null mutant with various forms of TPS1 and

279 d their presence in blood products can cause lethal transfusion-related acute lung injury (TRALI).

280 Pine wilt disease is a lethal tree disease caused by nematodes carried by pine

281 -2 infects the lung, leading to a frequently lethal triad of respiratory insufficiency, acute cardiov

282 Identification of the lethal tumour cell clones is required to improve surviva

283 pan to 3 mo due to neurodegeneration, and is lethal upon fasting.

284 Pulmonary arterial hypertension (PAH) is a lethal vasculopathy.

285 ing a plausible molecular mechanism for some lethal ventricular arrhythmias.

286 o be explained by QT prolongation leading to lethal ventricular arrhythmias.

287 trioventricular (His)-bundle associated with lethal ventricular arrhythmias.

288 cient to prevent death in mice infected with lethal viral doses, even when treatment is started as la

289 ults in enhanced ability to prevent or treat lethal viral respiratory infection in mice, with increas

290 hat targeting specific domains in LTs can be lethal, which opens the possibility that LTs are useful

291 hen the gene's conventional knockout (KO) is lethal, which precludes studying the consequences of its

292 aled that over-expressing CENH3 in callus is lethal while over-expressing GFP-CENH3 and CENH3-YFP in

293 Aldh3a2 inhibition was synthetically lethal with glutathione peroxidase-4 (GPX4) inhibition;

294 a rsc1Delta mutation, but not rsc2Delta, is lethal with histone mutations that confer partial unwrap

295 ns, we establish that ALC1 loss is synthetic lethal with homologous recombination deficiency (HRD), w

296 CTF4, YKE2, DCC1, and GIM4) as synthetically lethal with ISC1 The second group, to which ISC1 belongs

297 Marburg virus (MARV) disease is lethal, with fatality rates up to 90%.

298 Mutation of her9 was larval lethal, with no mutants surviving past 13 days post fert

299 Duchenne muscular dystrophy (DMD) is a lethal, X-linked disease characterized by progressive mu

300 iratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in hu