ライフサイエンスコーパス: leucyl-tRNA synthetase

1 e mechanochemical motions in T. thermophilus leucyl-tRNA synthetase.

2 nate amino acids that can be misactivated by leucyl-tRNA synthetase.

3 he ser-tRNACAG and preventing binding of the leucyl-tRNA synthetase.

4 le inhibiting the Mycobacterium tuberculosis leucyl-tRNA synthetase.

5 Leu is a very poor substrate for full-length Leucyl-tRNA synthetase.

6 editing of mischarged tRNA similar to other leucyl-tRNA synthetases.

7 out mischarging by glycyl-, glutaminyl-, and leucyl-tRNA synthetases.

8 use HSPE71, Rat RhoGAP protein, S cerevisiae leucyl tRNA synthetase and S cerevisiae chromosome II OR

9 Binding of gold-labeled tRNA(Leu) places leucyl-tRNA synthetase and the bifunctional glutamyl-/pr

10 y a constitutive protein complex composed of leucyl-tRNA-synthetase and folliculin, which regulates m

11 ein, different mutations in Escherichia coli leucyl-tRNA synthetase are combined to unmask the pretra

12 of onychomycosis, inhibits yeast cytoplasmic leucyl-tRNA synthetase by formation of a stable tRNA(Leu

13 he collective motion in Thermus thermophilus leucyl-tRNA synthetase by studying the low frequency nor

14 gnment we have analyzed the Candida albicans leucyl-tRNA synthetase (CaLeuRS) gene (CaCDC60).

15 We present structures of leucyl-tRNA synthetase complexed with analogs of the dis

16 These mutations that altered or abolished leucyl-tRNA synthetase editing were introduced into comp

17 overcome this limitation, we have adapted a leucyl-tRNA synthetase from Methanobacterium thermoautot

18 n identified a mutation in the mitochondrial leucyl-tRNA synthetase gene (lrs-2) that impaired mitoch

19 Leucyl-tRNA synthetases have a hydrolytic active site th

20 d mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase: homozygous c.1565C>A (p.Thr522As

21 Human mitochondrial leucyl-tRNA synthetase (hs mt LeuRS) achieves high amino

22 ell, Bonfils et al. and Han et al. implicate leucyl-tRNA synthetase in this evolving story.

23 is activated by methionyl-, isoleucyl-, and leucyl-tRNA synthetases in vivo.

24 A point mutation in CP1 of class I leucyl-tRNA synthetase inactivates deacylase activity an

25 Epetraborole (EBO), a leucyl-tRNA synthetase inhibitor, represents a novel the

26 rving cells of leucine or treating them with leucyl-tRNA synthetase inhibitors did not elicit nuclear

27 ted that the transfer of human mitochondrial leucyl-tRNA synthetase into the cybrid cells carrying th

28 re we report the surprising observation that leucyl-tRNA synthetase (LARS) becomes repressed during m

29 kocyte-specific exon skipping event in human leucyl-tRNA synthetase (LARS).

30 er the overexpression of human mitochondrial leucyl-tRNA synthetase (LARS2) in the cytoplasmic hybrid

31 Escherichia coli leucyl-tRNA synthetase (LeuRS) aminoacylates up to six d

32 Yeast mitochondrial leucyl-tRNA synthetase (LeuRS) binds to the bI4 intron a

33 c and editing activities of Escherichia coli leucyl-tRNA synthetase (LeuRS) demonstrate that the enzy

34 rmatics analyses, we identified two distinct leucyl-tRNA synthetase (LeuRS) genes within all genomes

35 Leucyl-tRNA synthetase (LeuRS) has been identified as a

36 Leucyl-tRNA synthetase (LeuRS) has evolved an editing fu

37 Mitochondrial leucyl-tRNA synthetase (LeuRS) in the yeast Saccharomyce

38 Leucyl-tRNA synthetase (LeuRS) is a class I enzyme, whic

39 Leucyl-tRNA synthetase (LeuRS) is an essential RNA splic

40 In one case, Mycoplasma mobile leucyl-tRNA synthetase (LeuRS) is uniquely missing its e

41 Leucyl-tRNA synthetase (LeuRS) misactivates non-leucine

42 Leucyl-tRNA synthetase (LeuRS) performs dual essential r

43 Leucyl-tRNA synthetase (LeuRS) relies on its editing fun

44 Instead, leucyl-tRNA synthetase (LeuRS) was overexpressed in mdx

45 this biocontrol agent targets A. tumefaciens leucyl-tRNA synthetase (LeuRS), an essential enzyme for

46 In leucyl-tRNA synthetase (LeuRS), editing activities that

47 targeting an unprecedented Wolbachia enzyme, leucyl-tRNA synthetase (LeuRS), effectively inhibiting i

48 n-based compounds (benzoxaboroles) targeting leucyl-tRNA synthetase (LeuRS), including an antibiotic

49 Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetas

50 Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetas

51 a unique tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase (LeuRS), while the TM84-producer

52 thanogenesis, protein-modifying factors, and leucyl-tRNA synthetase (LeuRS).

53 synthetase (GluRS):tRNA(Glu) and an archaeal leucyl-tRNA synthetase (LeuRS):tRNA(Leu) complex.

54 lpha was found to form a stable complex with leucyl-tRNA synthetase (LeuRS; K(D) = 0.7 microM).

55 erminal domain extension is required by most leucyl-tRNA synthetases (LeuRS) for aminoacylation.

56 cluding a complex between prolyl-(ProRS) and leucyl-tRNA synthetases (LeuRS) in Methanothermobacter t

57 Aminoacylation and editing by leucyl-tRNA synthetases (LeuRS) require migration of the

58 Leucyl-tRNA synthetases (LeuRSs) have an essential role

59 Mycoplasma leucyl-tRNA synthetases (LeuRSs) have been identified in

60 ing pocket within the editing active site of leucyl-tRNA synthetases (LeuRSs).

61 s caused by decreased protein content of the leucyl tRNA synthetase (LRS) leucine sensor.

62 ulting from cancer-associated MTOR mutations.Leucyl-tRNA synthetase (LRS) is a leucine sensor of the

63 Leucyl-tRNA synthetase (LRS) is known to function as leu

64 The inhibition of leucyl-tRNA synthetase represents a unique molecular tar

65 carboxy-terminal domain (Cterm) of human mt-leucyl tRNA synthetase rescues the pathologic phenotype

66 cid editing active site for Escherichia coli leucyl-tRNA synthetase resides within the CP1 domain tha

67 hreonine-rich region of the Escherichia coli leucyl-tRNA synthetase's CP1 domain that is hypothesized

68 tational analysis within yeast mitochondrial leucyl-tRNA synthetase showed that the enzyme has mainta

69 4-Azaleucine, a competitive inhibitor of leucyl-tRNA synthetase, surprisingly triggered the heat

70 roach exploits an engineered E. coli-derived leucyl tRNA synthetase-tRNA pair that incorporates a pho

71 ed conformational changes of T. thermophilus leucyl-tRNA synthetase upon substrate binding and analyz

72 red the refolding of the human mitochondrial leucyl-tRNA synthetase variant H324Q to that of wild typ

73 be aminoacylated by the human mitochondrial leucyl-tRNA synthetase, we examined the aminoacylation k

74 The yeast mitochondrial leucyl-tRNA synthetase (ymLeuRS) performs dual essential