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1 axis to CCL19 that was restored by exogenous leukotriene C4 .
2 tion of the membrane-derived lipid mediator, leukotriene C4.
3  A with one of its physiological substrates, leukotriene C4.
4 pe I receptors by the physiological trigger, leukotriene C4.
5 secrete Th2-type cytokines (IL-4, IL-13) and leukotriene C4.
6 strates by MRP1 and abrogated the binding of leukotriene C4.
7 be further stimulated by anticancer drugs or leukotriene C4.
8 NA and had elevated transport activities for leukotriene C4.
9                      Mast cell production of leukotriene C4 20 min after activation or IL-6 16 h afte
10  displayed elevated transport activities for leukotriene C4, a known substrate for MRP.
11 of metabolism to the 5-lipoxygenase products leukotriene C4 and 5-HETE and in A23187-treated cells to
12  as well as for the glutathione S-conjugates leukotriene C4 and azidophenacyl-S-glutathione.
13 ions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid
14                Zymosan-induced generation of leukotriene C4 and prostaglandin E2 was attenuated appro
15                 We found that AngaD7L1 binds leukotriene C4 and thromboxane A2 analog U-46619; AngaD7
16  and tumor necrosis factor-alpha, as well as leukotriene C4 and thromboxane B2, by human monocyte-der
17 ifferential release of either acetylcholine, leukotriene C4 and/or interleukin-25 depending on the ac
18 port of the glutathione-platinum complex and leukotriene C4, and intracellular glutathione (GSH) leve
19 and 77 microM for daunorubicin, vincristine, leukotriene C4, APA-SG, and ATP, respectively.
20      Prostaglandin E2, prostaglandin I2, and leukotriene C4 are produced by cPLA2alpha+/+ but not cPL
21 activated receptor-2-dependent production of leukotrienes C4 associated with an overexpression of leu
22 ia significantly increased concentrations of leukotrienes C4, D4, and E4 and leukotriene B4, whereas
23 oup had consistently lower concentrations of leukotrienes C4, D4, and E4 than all other groups.
24 cyclin infusion suppressed concentrations of leukotrienes C4, D4, and E4, suggesting that endogenous
25                The levels of leukotriene B4, leukotriene C4/D4, 6-keto-prostaglandin F1alpha, and thr
26 choalveolar lavage levels of leukotriene B4, leukotriene C4/D4, and thromboxane B2 above those of sal
27 avage fluid was analyzed for leukotriene B4, leukotriene C4/D4, thromboxane B2, prostaglandin E2, 6 k
28 rved large conformational changes induced by leukotriene C4, explaining how substrate binding primes
29  with IL-5 or NGF did not affect C5a-induced leukotriene C4 generation or alter C5a-induced intracell
30 of this activity in mast cell degranulation, leukotriene C4 generation, and IL-6 production was exami
31 of these three cytokines on 18-h priming for leukotriene C4 generation, their ability to induce Fc(ep
32 idant GSH and the pro-inflammatory cysteinyl leukotriene C4 have been identified as key physiological
33 ted with the smooth muscle contraction since leukotriene C4, histamine and tachykinins, which all cau
34 able release of tumor necrosis factor-alpha, leukotriene C4, histamine, or serotonin.
35 eutrophils capable of leukotriene synthesis, leukotriene C4, leukotriene D4, 5-hydroperoxyeicosatetra
36 on of MCP-1 in normal animals was related to leukotriene C4 levels in the bronchoalveolar lavage and
37 ogen estradiol-glucuronide (E(2)17betaG) and leukotriene C4 (LTC(4)) significantly stimulated ABCC10
38 (f-Met-Leu-Phe; FMLP) induces the release of leukotriene C4 (LTC4) and histamine in human basophils.
39                                              Leukotriene C4 (LTC4) and its extracellular metabolites,
40 nhibitor, genistein.The peptidoleukotrienes, leukotriene C4 (LTC4) and leukotriene D4 (LTD4) also pro
41 se, we compared the contractile responses of leukotriene C4 (LTC4) and leukotriene D4 (LTD4) and thei
42  Orai3/Orai1 channels are gated by cytosolic leukotriene C4 (LTC4) and require STIM1 downstream LTC4
43 hydrophobic glutathione S-conjugates such as leukotriene C4 (LTC4) and S-dinitrophenyl glutathione (D
44 + T cells also caused augmented secretion of leukotriene C4 (LTC4) from eosinophils.
45       We have investigated the metabolism of leukotriene C4 (LTC4) in gamma-glutamyl transpeptidase (
46 ced activities of ATP-dependent transport of leukotriene C4 (LTC4) in plasma membrane vesicles.
47        Human basophils secrete histamine and leukotriene C4 (LTC4) in response to various stimuli, su
48 ion of MEK and ERK-2, which are required for leukotriene C4 (LTC4) release, and production of LTC4 wa
49                                              Leukotriene C4 (LTC4) synthase (LTC4S), an integral memb
50                                              Leukotriene C4 (LTC4) synthase catalyzes the conjugation
51  was to determine whether cytokines modulate leukotriene C4 (LTC4) synthase expression in mononuclear
52 hospholipase A2 (cPLA2), and (2) blockade of leukotriene C4 (LTC4) synthesis in isolated human eosino
53 A2-induced arachidonic acid (AA) release and leukotriene C4 (LTC4) synthesis in isolated human periph
54 a-glutamyl leukotrienase (GGL) that converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).
55 n and significantly affect the ATP-dependent leukotriene C4 (LTC4) transport.
56 653Y or Y1302W, did not affect ATP-dependent leukotriene C4 (LTC4) transport.
57        The cysteinyl leukotrienes (cys-LTs), leukotriene C4 (LTC4), a conjugation product of glutathi
58 hat airway challenges with the parent CysLT, leukotriene C4 (LTC4), given in combination with low-dos
59             Cysteinyl leukotrienes (cysLTs), leukotriene C4 (LTC4), LTD4, and LTE4 are proinflammator
60 down reduced conversion of leukotriene A4 to leukotriene C4 (LTC4), suggesting a role for the activit
61 2,4-dinitrophenyl S-glutathione (DNP-SG) and leukotriene C4 (LTC4), the antimetabolite methotrexate,
62 system has been implicated in the release of leukotriene C4 (LTC4), we examined the roles of P-gp and
63  that mediates the biosynthesis of cysteinyl leukotriene C4 (LTC4).
64 mation of the proinflammatory lipid mediator leukotriene C4 (LTC4).
65 nzyme to generate the proinflammatory signal leukotriene C4 (LTC4).
66 ne, as well as for the glutathione conjugate leukotriene C4 (LTC4).
67                   The cysteinyl leukotrienes-leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotrie
68 r functions; there was neither production of leukotriene C4 or superoxide anion nor any detectable de
69                                              Leukotriene C4 production by mast cells was not enhanced
70  induces lipid body formation and subsequent leukotriene C4 production mediated by endogenous PAF.
71 inophil-derived neurotoxin and low levels of leukotriene C4 production; the latter was significantly
72  had decreased proinflammatory activity in a leukotriene C4 release assay using N-formyl-Met-Leu-Phe-
73 -5R beta-chain and inhibited IL-5 priming of leukotriene C4 release by human basophils.
74 used large increases in arachidonic acid and leukotriene C4 release from neighboring human eosinophil
75  of C component (C5a), which does not induce leukotriene C4 release without prior IL-3 treatment.
76 eukin-8 release) and basophil (histamine and leukotriene C4 release) stimulation assays, but usually
77                  Exogenous administration of leukotriene C4 restored trafficking of eosinophils to pa
78 ellular sensitivity also occurred when using leukotriene C4 secretion as a metric of the basophil res
79 ro-inflammatory mediators leukotriene B4 and leukotriene C4 Studies with small molecule inhibitors of
80 The deduced 150-amino-acid sequence of mouse leukotriene C4 synthase (differs from the human enzyme b
81                                              Leukotriene C4 synthase (EC 2.5.1.37) catalyzes the conj
82              We asked whether mRNA levels of leukotriene C4 synthase (LTC4 S), a key regulator of leu
83                                              Leukotriene C4 synthase (LTC4S) catalyzes the formation
84                     Hence, inhibition of the leukotriene C4 synthase (LTC4S) enzyme could provide a n
85                                              Leukotriene C4 synthase (LTC4S) is a glutathione S-trans
86                            The expression of leukotriene C4 synthase (LTC4S) was examined during the
87            The functional characteristics of leukotriene C4 synthase (LTC4S), which specifically conj
88  mitigated by deletions of either Cysltr2 or leukotriene C4 synthase (Ltc4s).
89                                        Mouse leukotriene C4 synthase cDNA is 667 bp in length, includ
90 eotide primers based on the translated human leukotriene C4 synthase cDNA sequence.
91                     We have now cloned mouse leukotriene C4 synthase CDNA using the polymerase chain
92 in and suggest that the C-terminal domain of leukotriene C4 synthase may not be critical for its conj
93    Northern blot analysis indicated that the leukotriene C4 synthase RNA transcript is widely distrib
94                                        Human leukotriene C4 synthase shares substantial amino acid id
95 ive against both human and mouse recombinant leukotriene C4 synthase with IC50 values of 3.1 microM a
96  eicosanoid-forming enzymes, 5-lipoxygenase, leukotriene C4 synthase, and cyclooxygenase, were immuno
97                                  Deletion of leukotriene C4 synthase, the terminal enzyme needed to g
98 s were used to test chemotactic responses of leukotriene C4 synthase-deficient and control airway eos
99 -sensitized and ovalbumin aerosol-challenged leukotriene C4 synthase-deficient and control mice.
100                                              Leukotriene C4 synthase-deficient eosinophils exhibited
101  from distal alveolar lung was diminished in leukotriene C4 synthase-deficient mice compared with wil
102 f eosinophils to paratracheal lymph nodes in leukotriene C4 synthase-deficient mice.
103 sed retention of eosinophils in the lungs of leukotriene C4 synthase-deficient mice.
104 iacylglycerol lipase, 5-lipo-oxygenease, and leukotriene C4 synthase.
105 nase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.
106 Ser and Tyr50-->Phe) were conserved in mouse leukotriene C4 synthase.
107                                              Leukotriene-C4 synthase (LTC4S) generates LTC4 from arac
108 iene-synthesizing enzymes 5-lipoxygenase and leukotriene-C4-synthase.
109              These findings confirm that the leukotriene C4 synthases belong to a gene family that in
110 n mast cells to secrete histamine, PGD2, and leukotriene C4 upon subsequent passive sensitization wit
111 rophages, prostacyclin, prostaglandin E2 and leukotriene C4 were produced within minutes of C. albica

 
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