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1 rity affect the expression of the genes they lie within.
2 servations of four additional G objects, all lying within 0.04 parsecs of the black hole and forming
4 nation, in which the vast majority of values lay within 1 sd of the consensus value, irrespective of
5 We designed over 300 ZF-TFs whose targets lie within 1 kb of the transcriptional start sites (TSSs
6 rt of a greater than 550-kb contig that must lie within 1 of the 11 sequence gaps currently remaining
13 s that are predicted by homology modeling to lie within 2.8 A of each other at the interface between
15 cies, the majority of open chromatin regions lie within 3 kb upstream of a transcription start site i
17 tronic instances of their reverse complement lie within 380,084 nonoverlapping regions, typically 60-
20 Furthermore, this alcohol binding pocket lies within 7 A of Leu-120 and Gly-121, residues in whic
21 ferred directions or biases, with directions lying within 90 degrees of the bias direction nearly alw
22 netrating capability have been identified to lie within a 35-amino-acid region containing the nuclear
23 constraints, such as requiring GC-content to lie within a certain range, requiring the number of stro
24 rmore, we demonstrate that IRS4(PVH) neurons lie within a complex hypothalamic circuitry that engages
25 Most planetary rings in the Solar System lie within a few radii of their host body, because at th
26 the 15q13.1 locus (rs1129038 and rs12913832) lie within a genomic region that has profound effects on
28 all segment of roughly a dozen residues that lie within a natively unstructured sub-domain of RNase E
29 pG loci associated with later risk of asthma lie within a NF-kappaB binding site and that methylation
30 to affinity cross-linking, was determined to lie within a periplasmic loop between transmembrane heli
32 imated from previous theoretical studies but lie within a reasonable range for phenyl rotation in hyd
34 pitopes were mapped, but all of the epitopes lie within a single major antigenic site, suggesting tha
35 mapped 12-amino acid immunodominant epitope lies within a "hinge" region between the N-terminal intr
37 involved in minus-strand DNA synthesis that lies within a 27-nucleotide region between DR2 and the 3
38 SVG-CRFR1 complex, residue 17 of the ligand lies within a 9 angstroms distance from residue 117 of t
41 The genetic lesion in the frimousse mutant lies within a connexin gene (cx-11) that is transiently
45 (LOD score = 7.5 at reduced penetrance) and lies within a founder haplotype that is also shared by 3
46 two C. sordellii strains revealed that tcsR lies within a genomic region that encodes TcsL, TcsH, an
49 ase-associated mutation in VAPB, VAPB(P56S), lies within a highly conserved N-terminal region of the
50 gle nucleotide polymorphism rs6983267, which lies within a MYC enhancer and confers colorectal cancer
52 vious studies suggested that the active site lies within a positively charged cleft formed at the sub
57 ies, the predicted optimal number of spacers lies within a range that agrees with experimentally-obse
62 iability, model shortcomings, and because CA lies within a transition zone, where mid-latitude region
63 that the highly conserved lower half of TM7 lies within a water-filled cavity easily accessible from
64 ion events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequence whi
65 sensitive to transient point-source stimuli lying within a range of angles that are oblique with res
66 Noting that the activities of many compounds lie within achievable blood concentrations, these result
70 GWAS-related single-nucleotide polymorphisms lie within an essential erythroid enhancer of the BCL11A
71 e genome sequences revealed that CYP1A genes lie within an extended region of conserved fine-scale sy
74 the 8q24 cancer-associated variant rs6983267 lies within an in vivo prostate enhancer whose expressio
77 tent (respectively, extinction prone) models lies within an open set of persistent (resp. extinction
80 By contrast, mRNA isoforms with 3' ends that lie within annotated 5'-UTRs were overrepresented in pol
82 determined that a second and a third hotspot lie within blade 5 of the SEMA domain and IPT domains 2-
83 also observe that the RNAP II molecules that lie within BMP4 have inappropriate persistence of serine
85 T cells to a nonpersistent virus (influenza) lie within CCR7(+)CD45RA(-) central memory, whereas memo
86 -protein coding pseudogene, which completely lies within CD93's genomic coordinates, thereby explaini
88 ough the causal variants in the 16p13 region lie within CLEC16A, DEXI is an unappreciated autoimmune
89 at less common, functional polymorphisms may lie within common haplotypes and drive gene-environment
94 as to data from other source databases that lie within ENCODE regions; this provides the user a comp
100 pitope and the previously identified epitope lie within fragments contained in different vaccines, th
102 in monogenic or syndromic diabetes and genes lying within genomic regions associated with T2D common
103 e and normal phenotypic variation, but those lying within heavily duplicated, highly identical sequen
104 he NvAMD-associated synonymous polymorphisms lie within HtrA1's putative insulin-like growth factor 1
105 -331, the hydroxyl groups of the hexose only lie within hydrogen bonding distance to ordered water mo
107 etermining which intracranial EEG electrodes lie within it; (ii) validating a brain network model on
112 rphisms from genome-wide association studies lie within noncoding regions and perturb transcription f
113 vast majority of the AF-associated variants lie within noncoding regions of the genome where causal
114 jority of suppressor mutations were found to lie within nsrR, which encodes a nitric oxide (NO)-sensi
116 possible to say whether these multiple sites lie within one receptor or on two linked receptors of a
120 at fail to bind to the ligand-occupied state lie within, or very close to, the integrin-fibronectin i
121 improved biofuel and biochemical production lies within our limited understanding of the transcripti
122 es Y263, C265, and K267 of the alpha1 region lie within overlapping ComA- and Spx-binding sites for a
124 The vast majority of bacterial diversity lies within phylum-level lineages called "candidate phyl
125 iously identified visual map, is observed to lie within posterior IPS and to share a foveal represent
128 ity of the system being in an attractor that lies within prescribed boundaries decreases approximatel
130 olecule within PrP-(23-33); the second motif lies within PrP-(98-110); and the third is contained wit
135 ial impact of putative off-target sites that lie within regions of functional genomic annotation (e.g
136 iants that affect disease susceptibility may lie within regulatory elements that influence gene expre
137 nd in many cases the final structural models lie within root mean square deviation of 1 approximately
138 was initially attributed to MYLIP, rs6924995 lies within RP1-13D10.2, an uncharacterized long noncodi
139 The endings of sensory receptor cells often lie within specialized compartments formed by glial cell
140 extensive tidal flats and salt marshes that lie within specific ranges of elevation, whereas interme
142 UC) spanning symptom onset to 30 days, 96.9% lay within the first 7 days, and 99.7% within 10 days.
143 The dendrites of A- and B-group motoneurons lay within the oculomotor nucleus, but those of the C-gr
144 cts showed that the NGF-responsive sequences lay within the proximal -392 base pairs (bp) of PNMT pro
145 ore linear, and the KBC values approached or lay within the range of KOC values reported for SMT in 1
148 cks exist, no currently known Archean strata lie within the appropriate thermal maturity window for s
149 mline-derived PTEN missense mutations, which lie within the ATP-binding motifs, result in mutant PTEN
150 g in human and mouse ESCs and preferentially lie within the boundaries of topological domains for hum
151 ble if the energies of the topological modes lie within the bulk bandgap, which is not required for m
154 unction and that the site of interaction may lie within the C-terminal portion that is common to all
156 we report that two genes, DSCR1 and DYRK1A , lie within the critical region of human chromosome 21 an
157 lent mutation, NPC1(I1061T), is predicted to lie within the cysteine-rich luminal domain and is assoc
160 g conditions on both aluminium and titanium, lie within the different ranges predicted for each metal
161 ssing neurons of the abdominal ganglion that lie within the expression pattern of the enhancer-trap l
166 amino acid differences between RAS isoforms lie within the hypervariable region, the additional conf
167 ntal data imply that the regulatory elements lie within the interface between the FAD- and FMN-bindin
169 cPINK1 explains how PD-linked mutations that lie within the kinase domain result in hPINK1 loss-of-fu
170 Remarkably, retinopathy-associated mutations lie within the mechanical hinges of the conformational c
172 containing 1913 alternative amino acids that lie within the molecular weight range of the encoded ami
173 ore conserved bases, though they did not all lie within the most broadly conserved portions of the re
175 to distinguish thin-section CT findings that lie within the normal range from those that represent ea
176 ins, the sorting determinants of proglucagon lie within the ordered hormone domains of glucagon and G
177 pid spike-inactivation cells, preferentially lie within the periventricular zone; the other cell type
178 ble for dimerization, folding, and stability lie within the predicted coiled-coil region of HBHA, whi
179 Three functional LEF-1/TCF binding sites lie within the promoter of the hAR gene as shown by CHIP
180 that Eeff(0) values for CoOx, MnOx, and NiOx lie within the range 1.9-2.1 V vs reversible hydrogen el
181 lagic shrimp biomass (1700 million tons) may lie within the range reported for mesopelagic fishes (es
183 Aspects of symbolic arithmetic therefore lie within the reach of children who have learned no alg
186 glycosylation substrate recognition features lie within the reducing-end moiety of the O repeat and t
188 The majority of the constitutive mutations lie within the same residues of the N-terminal regulator
189 ues, such as piglet mortality, are likely to lie within the scientific disciplines of environmental d
190 dentified a suppressor mutation predicted to lie within the second periplasmic loop of TatC, a region
191 tion for post-transcriptional regulation can lie within the sequence or structure of the RNA transcri
192 f this deglacial deep-water warming does not lie within the tropics, nor can its early onset between
194 positively selected sequence is expected to lie within the wealth of functional 'dark matter' presen
195 T-Box transcription factor gene, Tbx1, which lies within the 22q11.2 region and is responsible for mo
197 rmation of Michael adducts on His 173, which lies within the active site catalytic triad of hDDAH-1.
200 he right superior temporal sulcus (STS) that lies within the auditory cortex, and is activated by aud
204 on 55 of the rat alpha7 nAChR subunit, which lies within the beta2 strand, was studied by mutating it
205 fficient for cellular adherence and invasion lies within the C-terminal 12 to 24 amino acids and is c
206 show that specificity toward UBA6 and UBE2Z lies within the C-terminal CYCI tetrapeptide in FAT10.
207 (HP) determined the polar localization motif lies within the central domain of the protein and that t
208 or reliably detects 0.06 ug/mL of NS1, which lies within the clinical limit observed during the first
210 glial over neuronal fate, a difference that lies within the combined properties of amino terminal an
211 pB (residues 51-59), which reveals that PopB lies within the concave face of PcrH, employing mostly b
212 istent with the hypothesis that this residue lies within the conduction path, but the observed reacti
213 up to a plateau at approximately 1100, which lies within the consensus equilibrium range, 1000 +/- 10
214 onine (Thr-38) on the substrate Ets-1, which lies within the consensus sequence 36phi-chi-Thr-Pro39 (
218 ly, because the locus encoding human SHROOM2 lies within the critical region for two distinct forms o
219 tralia's Flat Rocks locality (121-112.5 Ma), lies within the crown clade Monotremata, as a basal plat
220 in G:A at position 10 of the serT gene that lies within the D-stem of the essential tRNA((cmo)5)UGA(
225 lopment, the bulk of the dendritic structure lies within the electrode, underneath the polymer/electr
226 ted with a distinct root of the Archaea that lies within the Euryarchaeota, challenging the tradition
232 ne H3 lysine 56 (H3K56) is unique in that it lies within the globular core domain near the entry-exit
233 We also find that the G134R mutation, which lies within the glycine zipper packing interface and cau
236 encoding 12/15-LO (gene designation Alox15) lies within the Idd4 diabetes susceptibility interval in
237 ding domain for BoNT was selected because it lies within the immunodominant H chain as a beta-trefoil
238 Our results now reveal that the CHD6 protein lies within the infrastructure of multiple transcription
242 ng RNA SPRIGHTLY (formerly SPRY4-IT1), which lies within the intronic region of the SPRY4 gene, is up
243 ditary erythromelalgia mutation (N395K) that lies within the local anaesthetic binding site of the ch
244 domain within the N-terminal of the protein lies within the lumen and is thought to represent the se
247 c risk for developing adult and juvenile IIM lies within the major histocompatibility complex, recent
248 in Ae. tauschii that also produces miRW1 and lies within the marker-based location of Iw2 We propose
249 egion with the strongest evidence of linkage lies within the minimum critical region for FTLD-U.
251 es within the activation loop, and the other lies within the N-terminal acidic region (N region).
252 (RBRs) and discover that the major ATRX RBR lies within the N-terminal region of the protein, distin
259 g domain on amino acids 40-49 of YpkA, which lies within the previously identified membrane localizat
260 ase I footprinting showed that this sequence lies within the protected regions of the pfr and hydA pr
263 out one degree of latitude per decade, which lies within the range of estimates of the observed expan
264 of 5-7 years, the distribution parameter rho lies within the range that indicates infinite variance.
266 leotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT
272 evealed that the central binding determinant lies within the segment of residues 293-380, also known
276 he lytic cycle of the virus and its promoter lies within the terminal repeat which contains the bindi
281 We explored whether the zinc-binding site lies within the vestibules running down the central axis
283 vated by phosphorylation of a serine residue lying within the activation loop signature sequence S-E-
284 pattern showing clear 2/3 PL preference and lying within the alpha band was observed exclusively abo
285 fine a single AzBCQ covalent attachment site lying within the digestive vacuolar-disposed loop betwee
286 ified a primary disease susceptibility locus lying within the major histocompatibility complex (MHC),
287 ssels seen on FA and/or color, aided by OCT) lying within the maximum footprint of the neovascular le
288 se data also suggest that a boundary element lying within the PWS critical region prevents UBE3A-ATS
291 Hsp72 with regard to tau clearance kinetics lies within their C-terminal domains, which are essentia
297 The packaging signals in each of these RNAs lie within two separate regions at the 3' and 5' termini
299 ividuals against background sets of variants lying within VDR-binding regions that had been matched i
300 n event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing